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Topic: Hemophiliacs

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Haemophilia B

Factor IX

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	HIV & AIDS - Foreign-Protein-Mediated Immunodeficiency in Hemophiliacs With and Without HIV
		An obvious explanation for the chronological inconsistency between infection of hemophiliacs with HIV since the 1960s and the sudden increase in their mortality 20 years later is the introduction of the cytotoxic DNA chain terminator AZT as an anti-HIV drug in 1987.
		The prediction of the HIV hypothesis, that the distribution of immunodeficiency and non-immunodeficiency diseases among hemophiliacs is the same as in the rest of the American AIDS population, is not confirmed.
		Hemophiliac immunodeficiency: influence of exposure to factor VIII concentrate, LAV/HTLV-III, and herpesviruses.
	www.virusmyth.net /aids/data/pdhemogen.htm (12674 words)

	The Complications of Hemophilia
		Hemophiliacs with inhibitors are at risk for crippling from bleeding into their joints.
		When a hemophiliac has repeated bleeds into the same joint, he and his doctor may decide that prophylactic treatment for a period of three to six months is necessary.
		Many hemophiliacs around the world have been infected with HIV (Human Immuno-deficiency Virus), hepatitis B and hepatitis C. They received these infections from the plasma, cryoprecipitate and, especially, the factor concentrates which were supposed to make their lives normal.
	www.hemophilia.ca /en/2.1.9.php (2357 words)

	HIV & AIDS - Five Myths About AIDS That Have Misdirected Research and Treatment
		For one thing, most hemophilia studies differentiate between hemophiliacs age 2544 and those over the age of 44, because the rate of AIDS development in the over 44 group is two or four times faster than that of the 2544 age group.
		Less than a third of hemophiliacs have severe disease, however, and the incidence of AIDS in mild hemophiliacs is 1/7 that of severe hemophiliacs (Goedert et al., 1989; Hardy et al., 1985).
		It is believed that affected hemophiliacs are consequently predisposed to HIV infection and an increased rate of development of AIDS (Sabin et al., 1993; Goldsmitk et al., 1991; Higgins and Goodall, 1991; Madhok et al., 1991; Schulman, 1991; Webster et al., 1989; Daniel et al., 1989).
	www.virusmyth.net /aids/data/rrbmyths.htm (11404 words)

	CNN - Congress considers AIDS compensation for transfusion victims - September 23, 1998
		Hemophiliacs have been working for this legislation for five years, and they fear the bill will die if another group of victims is added in the final days.
		Hemophiliacs and transfusion recipients were infected in the early years of the AIDS crisis with blood donated by people who carried the virus.
		Hemophiliacs and their backers in Congress argue that adding the transfusion cases will make the legislation too expensive and too controversial to pass before Congress adjourns next month.
	www.cnn.com /HEALTH/9809/23/tainted.blood (639 words)

	Hemophiliacs and AIDS: Contracting a Killer
		At a meeting last spring for hemophiliacs and their loved ones, I noticed the fairly routine way in which subjects such as new treatments, patients’ rights and orthopedic problems were handled by the audience.
		Since 1985 all blood concentrate used for hemophiliacs has received a special heat treatment which has been shown to kill the AIDS virus and has almost completely removed the risk of infection for those born since then or not yet exposed.
		However, before taking their son to the center they received a call from the facility informing them that the family whose place they were taking had decided to return and that they would have to be placed on the waiting list again.
	www.religion-online.org /showarticle.asp?title=935 (1420 words)

	AEGiS-LT: GETTING HELP TO HEMOPHILIACS IS NO SIMPLE TASK
		Medical researchers estimate that 92% of people classified as severe hemophiliacs have already been exposed to the AIDS virus, principally those who received transfusions in the period between the discovery of the disease in the late 1970s and the development of adequate screening tests.
		The estimate that 92% of severe hemophiliacs are HIV-positive is tempered by the fact that less than half of all hemophiliacs are classified as "severe," Mahoney said.
		Hemophiliacs are missing one or more of the clotting factors in the blood.
	www.aegis.com /news/lt/1988/LT880701.html (1243 words)

	JPRI Working Paper No. 30
		Of the approximately 5,000 hemophiliacs in Japan, 40%, or 2,000, are estimated to be HIV-positive.
		Hemophiliacs in Japan bear not only the burden of high rates of HIV infection; they have also long suffered from the dual hardships of a genetic disease and the social prejudice resulting from that medical condition.
		For a female to have hemophilia, she would have to be the daughter of a male hemophiliac and a female carrier of the gene, an extremely rare occurrence.
	www.jpri.org /publications/workingpapers/wp30.html (5856 words)

	[HIV infection among type A and B hemophiliacs]
		Evolution of HIV infection was studied in 480 hemophiliacs A and 78 hemophiliacs B treated in the Centre-West Region.
		The fact that hemophiliacs B were significantly older than hemophiliacs A might be one of the reasons, but it must be noted that the contamination often occurred earlier in hemophiliacs B and was perhaps more important.
		The more severe evolution in the hemophiliac B group noted in our region is not found in American studies, which may be due to the different ways of preparing Factor IX concentrates in France and the United States.
	www.aegis.com /aidsline/1994/mar/M9430451.html (384 words)

	BLOOD TRAIL: (JAPAN) HIV-positive activist takes fight to Diet [Free Republic]
		Back in 1983, we hemophiliacs were relying on highly concentrated blood products from the United States, although we were worried about the news reports of a strange disease that was likely linked with the blood products hemophiliacs use.
		Hemophiliacs suffer from a bleeding disorder caused by a deficiency of a substance that helps blood clot.
		While hemophiliacs were using more imported blood products and had growing concerns about HIV infection, the media began to report in the mid-1980s on AIDS patients who had contracted the virus often through homosexual intercourse.
	www.freerepublic.com /forum/a37f059055612.htm (3973 words)

	THE MERCK MANUAL, Sec. 11, Ch. 131, Hemostasis And Coagulation Disorders
		Newly diagnosed hemophiliacs should be vaccinated against hepatitis B. As described for VWD (see Von Willebrand's Disease under Hereditary Disorders of Platelet Function in Ch.
		Treatment of bleeding in hemophiliacs who develop a factor VIII inhibitor is difficult, and a specialist should be consulted.
		Most hemophiliacs treated with plasma concentrates in the early 1980s are infected with HIV (see Ch.
	www.merck.com /pubs/mmanual/section11/chapter131/131c.htm (1349 words)

	Hemophilia (Site not responding. Last check: 2007-11-05)
		Once this product is shown to be safe and effective, all hemophiliacs will have available a treatment for bleeding which is totally free of any contaminating agents.
		While current treatment has greatly improved the outlook for most hemophiliacs, the development of antibodies (inhibitors) that block the activity of the clotting factors has complicated treatment for some patients.
		Several European countries are treating hemophiliacs by periodic infusion (prophylaxis) regardless of bleeding status.
	www.medceu.com /tests/hemophilia.htm (1342 words)

	AZT HELPS HEMOPHILIACS INFECTED WITH AIDS VIRUS
		Because clotting factor concentrates are not screened for hepatitis C virus, 9 of 10 hemophiliacs become infected and may suffer hepatitis- induced liver disease.
		The liver is critical to the metabolism of zidovudine, so physicians were concerned that the drug might not be as effective in hemophiliacs as in other people infected by the AIDS virus.
		Unlike some populations at risk for HIV infection, hemophiliacs are not concentrated in big cities near ACTG centers but rather are dispersed uniformly throughout the United States.
	www.stanford.edu /dept/news/pr/91/910917Arc1192.html (609 words)

	The Body: Blood Brothers (Site not responding. Last check: 2007-11-05)
		Many hemophiliacs experience a disturbing lack of knowledge within the medical establishment regarding our particular situation.
		Drug interactions are typical with everyone who uses antiretrovirals; however, the effects of these drugs on hemophiliacs can be even more dangerous.
		I have hope that in the coming years the emerging gene replacement therapies and viral vectors under investigation will bring hemophiliacs and all people living with HIV relief from this horrible pandemic.
	www.thebody.com /step/fall98/blood.html (551 words)

	Haemophilia - Wikipedia, the free encyclopedia
		One of Alice's daughters, Princess Elizabeth, remained childless, while another, Princess May, died in childhood, so it is unknown if either would have been a carrier.
		Prince Leopold, a sufferer (one of the rare male hemophiliacs of such early era who himself had children), who passed it onto his daughter, Alice, who in turn passed it onto her older son, Rupert.
		The younger son, Maurice, died in infancy, so it is not known if he was a sufferer.
	en.wikipedia.org /wiki/Haemophilia (1211 words)

	Bayer Documents: AIDS Tainted Blood Killed Thousands of Hemophiliacs
		AHRP is a national network of lay people and professionals dedicated to advancing responsible and ethical medical research practices, to ensure that the human rights, dignity and welfare of human subjects are protected, and to minimize the risks associated with such endeavors.
		In the United States, AIDS was passed on to thousands of hemophiliacs, many of whom died, in one of the worst drug-related medical disasters in history.
		For his efforts on behalf of the hemophiliacs in Taiwan, Dr. Shen said, the government gave him a certificate and "a beautiful medal." As for the hemophiliacs themselves, 44 of Dr. Shen's patients got AIDS, including a 2-year-old.
	www.ahrp.org /infomail/0503/22.php (3417 words)

	Books on Hemophiliacs (Site not responding. Last check: 2007-11-05)
		The main topics are HIV infection and epidemiology, management of bleedings in Hemophiliacs with inhibitors, orthopedic problems and therapy in Hemophiliacs, therapy with protein C and pediatric hemostaseology.
		The Hemophiliacs have until Oct 15, 1996, to join the settlement, which would become one of the biggest mass tort settlements and pay each plaintiff about $100,000.
		During his agonizing hospital-bound convalescence, he is doped up on codeine, a drug that sends him spiraling into reveries about his disease and the way he'd combated it with the seemingly self-destructive pursuits of his adolescence.
	www.10books.com /Hemophiliacs (1090 words)

	Lieff Cabraser Announces Filing Of Lawsuit On Behalf Of Hemophiliacs Worldwide Including Argentines
		"Hemophiliacs in Latin America were part of the tragedy that saw tens of thousands of hemophiliacs worldwide die unnecessarily (switched word order) from AIDS, and many thousands more become infected with HIV or Hepatitis C," explained Lieff Cabraser attorney Lexi Hazam.
		Lieff Cabraser will be meeting hemophiliacs from Argentina and other nations later this week in Buenos Aires to provide them an update on the lawsuit and to discuss legal strategy.
		Hemophiliacs or the families of loved ones who have passed away who wish to learn more about the lawsuit are encouraged to visit the website http://www.hemophilia-litigation.com or send an email message to Lieff Cabraser attorney Lexi Hazam, who speaks Spanish, at lhazam@lchb.com.
	www.hemophilia-litigation.com /press_release_02.htm (588 words)

	Science News: Hemophiliacs and AIDS: really at risk
		A substantial majority of the approximately 15,000 hemophiliacs in the United States who received non-heat-treated clotting factor concentrates now have HIV antibodies.
		If so, the antibodies seen in hemophiliacs might in many cases be simply a response to a few noninfectious fragments of HIV proteins.
		In a study of 56 HIV-antibody-positive hemophiliacs who received non-heat-treated clotting factors, all but one had HIV DNA in their blood when tested with the extremely sensitive polymerase chain reaction test -- indicating they are indeed infected with the virus and at high risk of contracting AIDS.
	www.findarticles.com /p/articles/mi_m1200/is_n18_v134/ai_6809452 (316 words)

	Hemophiliacs allege papers destroyed linking Martin to scandal [Free Republic]
		But the hemophiliacs, whose ranks were devastated by AIDS and hepatitis-C from contaminated blood, aren't accepting the answer.
		I just feel that hemophiliacs like the two brothers (one deceased) who got their award summarily overturned by the bench will remain relegated to back pages here.
		Unlike hemophiliacs and others, the prisoners were hardly innocent victims of what should have been sound medical treatment.
	www.freerepublic.com /forum/a37a06c4934cd.htm (2003 words)

	Infrared Saunas
		Once a woman is aware that this may occur, she can choose to allow herself to possible experience this short term effect without worry or to simply avoid Infrared LuxSauna usage at that time of her cycle.
		Hemophiliacs and anyone predisposed to hemorrhage should avoid Infrared LuxSauna usage or any type of heating that would induce vasodilatation, which can potentate the tendency to bleed.
		Obviously, should any condition worsen with use of an Infrared treatment, the use of the system should be discontinued.
	www.phadvice.com /catalog/body-pH_-7_Infrared-Saunas.htm (18190 words)

	Prion disease
		Canada's hemophiliacs, who suffered the most in the tainted-blood tragedy, are, according to this story, outraged at the federal government for
		Hemophiliacs fear the quarantine was lifted prematurely because there isn't enough conclusive evidence to determine if Mr.
		He said he's been told the autopsy is not complete and vowed hemophiliacs will be given the results as soon as the department has them.
	www.mad-cow.org /apr99_news.html (5223 words)

	The Body: Hemophilia Group Says U.K. Government May Not Compensate Families of Hemophiliacs Who Acquired Hepatitis C ... (Site not responding. Last check: 2007-11-05)
		According to a report prepared by the society, 95% of the nation's hemophiliacs were treated with contaminated blood products between 1969 and 1985, resulting in 2,829 cases of hepatitis C among hemophiliacs who live in the United Kingdom today.
		The society said that compensation is needed because of the loss of income and difficulty obtaining insurance many hemophiliacs with the disease have experienced as a result of their progressive condition (Kaiser Daily HIV/AIDS Report, 6/20/02).
		It is not clear whether hemophiliacs coinfected with HIV and hepatitis C will be eligible for the payments, according to the Guardian.
	www.thebody.com /kaiser/2003/oct30_03/hemophilia.html (428 words)

	Inmagic DB/Text WebPublisher found 1 records (Site not responding. Last check: 2007-11-05)
		With a total US hemophiliac population of 17,000, then it is likely that at least 50% will have been treated with large-pool factor concentrates during the past 5 years and will have seroconverted.
		Another possibility is that some virus was inactivated during preparation even of non-heat-treated concentrates and that some of the seroconversions in hemophiliacs could be due to killed virus, but there is no direct evidence of this.
		There may be other reasons, but it is important to note that there may be epidemiological differences between AIDS in hemophiliacs and homosexuals beyond the obvious clinical differences, such as the lack of Kaposi's sarcoma in hemophiliacs.
	www.popline.org /docs/036694 (408 words)

	Duesberg on AIDS- Foreign-protein-mediated ....
		Even if the lag period from HIV to AIDS were 10 years, the mortality of hemophiliacs should have significantly decreased by 1989, 5 years after new infections had been stopped.
		Hemophiliacs 1.3-2 see textMale homosexuals 5-6 Lui et al., 1988, Anderson and May, 1988, Lemp et al., 1990Intravenous drug users 5-6 Lui et al.
		The apparent ability of AZT to cause AIDS defining and other diseases in hemophiliacs is just one aspect of the many roles that drugs play in the origin of AIDS (see footnote).1
	www.duesberg.com /books/ch11-2.html (12645 words)

	NIH Guide: TREATMENT OF HIV AND ASSOCIATED COMPLICATIONS IN HEMOPHILIACS
		This Request for Applications (RFA), Treatment of HIV and Associated Complications in Hemophiliacs, is related to Priority Area #18: HIV Infection Potential applicants may obtain a copy of "Healthy People 2010" at http://www.health.gov/healthypeople.
		Although the treatment and management of HIV in hemophiliacs broadly follows established standards of care, it has been recognized that HIV and its associated complications have unique effects on hemophiliacs that requires the joint endeavors of specialists in many disciplines, namely infectious disease, hepatology, immunology, hematology, and epidemiology.
		Scope and Objectives This initiative is intended to encourage innovative approaches to address aspects of pathogenesis, treatment, and management of HIV infection and its complications that are unique to the HIV-infected hemophilic population.
	grants.nih.gov /grants/guide/rfa-files/RFA-AI-00-011.html (2629 words)

	Hepatitis C
		The percentage of hemophiliacs infected with HCV is 75-90% and the percentage of hemophiliacs infected with HIV is 78-86%.
		In the hemophiliac population that are HIV/HCV coinfected the progression curve to developing ESLD separates considerably at 3.5 years (this is very similar to hemophiliacs with HIV/HBV coinfection).
		He stated that in his opinion the natural history was probably different for hemophiliacs due to the age difference between most patients that became infected by IDU as opposed to being a recipient of blood products.
	www.hcvadvocate.org /hepatitis/hepC/HIVforum-2.html (1844 words)

	HepNet - Hep C NEWS 31198 Canadian hemophiliacs file suit over tainted blood
		Some 22,000 hemophiliacs who were infected with hepatitis C through blood transfusions brought a multi-billion dollar class action lawsuit on Tuesday against Canada's federal and provincial governments and the Red Cross.
		TORONTO, March 10 (Reuters) - Some 22,000 hemophiliacs who were infected with hepatitis C through blood transfusions brought a multi-billion dollar class action lawsuit on Tuesday against Canada's federal and provincial governments and the Red Cross.
		Toronto lawyer David Harvey, who represents the hemophiliacs, said the suit seeks C$3.8 billion ($2.7 billion) in damages and he claimed it was the largest tainted-blood class action lawsuit in the world.
	www.hepnet.com /hepc/news31198.html (444 words)

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