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| | Current Drug Targets – Inflammation & Allergy, Vol. 2, No. 4, 2003 |
 | | Hemopoiesis in an allergic inflammation site differs greatly from steady-state (homeostatic) hemopoiesis in the bone-marrow, due to differences in the hemopoietic factors present, as well as on their targets. |
 | | One major aspect concerns the role of GM-CSF, which seems unnecessary for steady-state hemopoiesis in the absence of infection, but plays a central role in the immunobiology of the lungs, especially in the instructive phase of imunity, by its ability to influence dendritic cell differentiation and function. |
 | | This is changing our perception of the effects of glucocorticoids on hemopoiesis, and especially on eosinophil differentiation. |
| www.bentham.org /cdtia/contabs/cdtia2-4.htm (1931 words) |
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