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Topic: Hemoprotein

Related Topics

Globular protein

Heme

Haemoglobin

Cytochrome C

Ferryl

Hemoglobin

Leghemoglobin

Quaternary structure

Hemocyanin

Myoglobin

Red blood cell

Oxidation

Porphyrin

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	Hemoprotein Examples
		Also given is information about their turnover to emphasize the need for resynthesis of the protein and the heme.
		Tryptophan oxygenase is a hemoprotein of intermediary metabolism.
		It catalyzes the conversion of tryptophan to N-formylkynurenine, using oxygen as the oxidant.
	www.porphyrin.net /mediporph/_netbiochem/importance.html (165 words)

	Hemoprotein - Wikipedia, the free encyclopedia (Site not responding. Last check: 2007-11-05)
		A hemoprotein (also haemoprotein), or heme protein, is a metalloprotein containing a heme prosthetic group, either covalently or noncovalently bound to the protein itself.
		The iron in the heme is capable of undergoing oxidation and reduction (usually to +2 and +3, though stabilized ferryl [Fe ] compounds are well known in the peroxidases).
		Hemoproteins are found in such diverse roles as:
	en.wikipedia.org /wiki/Hemoprotein (105 words)

	Encyclopedia: Hemoprotein
		Hemoproteins such as hemoglobin, myoglobin, hemalbumin and methemalbumin, for example, are useful when administered to a hypotensive patient.
		A therapeutically effective amount of iron hemoprotein is an amount sufficient to bind and/or oxidize substantially all of the free nitric oxide and thus removing it from the circulation.
		The amount of iron hemoprotein administered, the effective amount, is an amount sufficient to bind substantially all of the nitric oxide present, thus removing free nitric oxide from circulation.
	www.nationmaster.com /encyclopedia/Hemoprotein (600 words)

	Aberration of heme and hemoprotein in aged female rats.
		In this study, the regulation of heme metabolism and hemoprotein content was examined in livers of aged female rats.
		The activities of hexobarbital hydroxylase and aniline hydroxylase, indicators of mono-oxygenase function, were decreased in aged rats by 31% and 24%, respectively, as compared to values in young rats.
		In view of these findings, we suggest that the high activity of MHO and the low level of ALA-S may be a significant causative factor for the decreased microsomal concentration of heme, cytochrome-P-450 and its dependent monooxygenase activities in senescent female rats.
	www.arclab.org /medlineupdates/abstract_3600051.html (266 words)

	Inhibition of nitric oxide-mediated hypotension and septic shock with iron-containing hemoprotein - Patent 5296466
		The iron hemoprotein therapy of the present invention may be used to reverse this loss of sensitivity.
		In a preferred embodiment, the iron hemoprotein is hemoglobin or myoglobin and is administered intravascularly.
		The preferred iron hemoprotein, hemoglobin, used in the present invention is mixed with a pharmaceutically acceptable carrier.
	www.freepatentsonline.com /5296466.html (5764 words)

	Julian A. Peterson, Ph.D. (Site not responding. Last check: 2007-11-05)
		This includes destruction, i.e., loss of the hemoprotein nature (Soret peak), as well as denaturation, conversion of a proportion of the P450 to P420.
		Thus, intact P450 is not required for phosphorylation nor is phosphorylation a prerequisite for hemoprotein destruction.
		Further, when the P450 IIB1 was kept stable as P450 in the absence of cytochrome b5 and without loss of hemoprotein during the incubation period, using phosphate-glycerol buffer containing 0.4% Emulgen 911, the phosphorylation of the P450 was greatly diminished, with only minor effects on the protein kinase reaction itself.
	www.swmed.edu /home_pages/peterlab/ref31.htm (411 words)

	Proteins may help clean up pollutants and find cures for diseases
		Proteins -- strings of amino acids -- are found in all living cells and are where the work of a cell occurs.
		The heme, which consists of a ring of carbons and nitrogens, is the portion of a "hemoprotein" that clasps the protein's iron atom in place.
		A single protein may contain as few as one heme or as many as ten.
	www.sandia.gov /media/protein.htm (1043 words)

	OCA Atlas for 2HPD
		Nadph + n oxidized hemoprotein = nadp(+) + n reduced hemoprotein.
		Catalyzes hydroxylation of medium and long-chain fatty acids at omega-1, omega-2 and omega-3 positions, with optimum chain lengths of 14-16 carbons (lauric, myristic, and palmitic acids).
		Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450's., Ravichandran KG, Boddupalli SS, Hasermann CA, Peterson JA, Deisenhofer J, Science 1993 Aug 6;261(5122):731-6.
	oca.ebi.ac.uk /oca-bin/ocashort?id=2hpd (437 words)

	Nature
		The visible spectrum of a solution of purified FixL* from 350-650 nm is unmistakably that of a hemoprotein (Fig.
		The absorption maxima of aerobic FixL, at 576.5 (alpha), 542.5 (beta), and 417 nm (gamma, or Soret), and their relative heights are characteristic of hemoproteins*.
		The finding that FixL is a hemoprotein with kinase activity raises a major question as to whether or not the oxygenation state of the heme moiety affects its kinase activity.
	www.biosci.ohio-state.edu /~mgonzalez/nature/nature.html (2423 words)

	Molecular Characterization of the Hemin Uptake Locus (hmu) from Yersinia pestis and Analysis of hmu Mutants for Hemin ...
		Molecular Characterization of the Hemin Uptake Locus (hmu) from Yersinia pestis and Analysis of hmu Mutants for Hemin and Hemoprotein Utilization -- Thompson et al.
		hemin but also the various hemoproteins as iron sources (24).
		hemoprotein solutions were prepared as described previously (24).
	iai.asm.org /cgi/content/full/67/8/3879 (7439 words)

	(WO 00/02580) THERAPIES USING HEMOPROTEINS (Site not responding. Last check: 2007-11-05)
		(57) Herein it is shown that hemoproteins (e.g., Ascaris hemoglobin, myoglobin, flavohemoglobins) have NO-consuming and deoxygenase activities.
		The method of the invention comprises administering a therapeutically effective amount of a hemoprotein having NO-activated deoxygenase activity or an enzymatically active fragment thereof to a mammal.
		The NO-consuming activity of a hemoprotein (e.g., a flavorhemoglobin) can be used in a treatment where constriction of blood vessels is desirable, or where it is otherwise desirable to reduce NO concentration, as in inflammation.
	wipo.int /cgi-pct/guest/getbykey5?KEY=00/02580.000120&ELEMENT_SET=DECL (242 words)

	Structural studies of sirohaem-Fe4S4 enzymes
		Janick, P.A., Rueger, D.C., Krueger, R.J., Barber, M.J. and Siegel, L.M. Characterization of complexes between Escherichia coli sulfite reductase hemoprotein subunit and its substrates sulfite and nitrite.
		Ostrowski, J., Wu, J.Y., Rueger, D.C., Miller, B.E., Siegel, L.M. and Kredich, N.M. Characterization of the cysJIH regions of Salmonella typhimurium and Escherichia coli B. DNA sequences of cysI and cysH and a model for the sirohemeFe active center of sulfite reductase hemoprotein based on amino acid homology with spinach nitrite reductase.
		Siegel, L.M., Rueger, D.C., Barber, M.J., Krueger, R.J., OrmeJohnson, N.R. and OrmeJohnson, W.H. Escherichia coli sulfite reductase hemoprotein subunit.
	metallo.scripps.edu /PROMISE/SIROHAEM_REF.html (1052 words)

	Julian A. Peterson, Ph.D. (Site not responding. Last check: 2007-11-05)
		Cytochromes P450 are members of a superfamily of hemoproteins that are involved in the metabolism of various physiologic and xenobiotic organic compounds.
		To understand the details of the structure-function relationships within and between the two classes, structural studies on additional cytochromes P450 are crucial.
		Diffraction data for the crystals of these two proteins were obtained to a resolution better than 2.2 A. Assuming the presence of two molecules in the asymmetric unit for the hemoprotein domain of P450BM-3 and one molecule for P450terp, the calculated values of Vm are 2.6 and 3.3 A3/Da, respectively.
	www.swmed.edu /home_pages/peterlab/ref18.htm (265 words)

	Neuroglobin, A Novel Member of the Globin Family, Is Expressed in Focal Regions of the Brain -- Mammen et al. 50 (12): ...
		is a cytoplasmic hemoprotein that is restricted to cardiomyocytes
		Neuroglobin is a recently identified hemoprotein that is expressed
		hemoproteins and to define the spatial expression pattern for
	www.jhc.org /cgi/content/full/50/12/1591 (3422 words)

	A Cytochrome c from a Lupanine-Transforming Pseudomonas putida Strain Is Expressed in Escherichia coli during Aerobic ...
		of a recombinant hemoprotein that exhibited a characteristic
		production of the hemoprotein was observed (data not shown).
		thus strongly indicated that hemoprotein was coded for by the
	aem.asm.org /cgi/content/full/69/8/4727 (2654 words)

	Myoglobin: an essential hemoprotein in striated muscle -- Ordway and Garry 207 (20): 3441 -- Journal of Experimental ...
		Myoglobin is a cytoplasmic hemoprotein, expressed solely in
		Key words: myoglobin, hemoprotein, skeletal muscle, cardiac, myocyte, function, regulation, gene targeting
		Myoglobin is a cytoplasmic hemoprotein consisting of a single
	jeb.biologists.org /cgi/content/full/207/20/3441 (2733 words)

	Guanylate cyclase from bovine lung. Evidence that enzyme activation by phenylhydrazine is mediated by iron-phenyl ...
		Evidence that enzyme activation by phenylhydrazine is mediated by iron-phenyl hemoprotein complexes -- Ignarro et al.
		Evidence that enzyme activation by phenylhydrazine is mediated by iron-phenyl hemoprotein complexes
		O2-dependent reaction between phenylhydrazine and hemoproteins to generate
	www.jbc.org /cgi/content/abstract/259/9/5923 (310 words)

	Protein Conjugation
		A: The carrier molecule you select will depend on the species you are studying.
		Keyhole limpet hemocyanin (sea snail hemoprotein) is most often used for vertebrate research because there are no homologous vertebrate proteins resulting in little if any non-specific antibody activity.
		For invertebrate studies, it is best to use a carrier such as bovine serum albumin or ovalbumin.
	www.ucalgary.ca /antibody/conjugation.htm (927 words)

	Alphabetical listing of the Research Faculty
		Stefan Franzen: The application of spectroscopy to structure and determination of enzymatic reaction mechanisms in biology.
		Research is focused primarily on i) the elucidation of enzyme structure-function-spectroscopy relationships as they relate to disease states, primarily the activation of the anti-tubercular drug isoniazid by the hemoprotein KatG; ii) metalloprotein (re)engineering via incorporation of unnatural amino acids into enzyme active sites; and iii) design and synthesis of novel anti-tubercular PDT agents.
		Christopher B. Gorman: Design and synthesis of new optical and electronic materials for application in optoelectronic devices, nanoscale electronics, and information systems.
	www.ncsu.edu /chemistry/researchfaculty.html (831 words)

	Definition of hemoprotein - Merriam-Webster Online Dictionary
		Learn more about "hemoprotein" and related topics at Britannica.com
		Find more about "hemoprotein" instantly with Live Search
		See a map of "hemoprotein" in the Visual Thesaurus
	www.m-w.com /cgi-bin/dictionary?book=Dictionary&va=hemoprotein (43 words)

	From the Cover: The HP-1 maquette: From an apoprotein structure to a structured hemoprotein designed to promote ...
		From the Cover: The HP-1 maquette: From an apoprotein structure to a structured hemoprotein designed to promote redox-coupled proton exchange -- Huang et al.
		The HP-1 maquette: From an apoprotein structure to a structured hemoprotein designed to promote redox-coupled proton exchange
		The Johnson Research Foundation and Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104
	www.pnas.org /cgi/content/abstract/101/15/5536 (332 words)

	JUD COON: 35 YEARS OF P450 RESEARCH, A SYNOPSIS OF P450 HISTORY -- Porter 32 (1): 1 -- Drug Metabolism and Disposition
		Imai Y and Sato R (1966) Evidence for two forms of P-450 hemoprotein in microsomal membranes.
		Lu AYH and Coon MJ (1968) Role of hemoprotein P-450 in fatty acid omega-hydroxylation in a soluble enzyme system from liver microsomes.
		Sladek NE and Mannering GJ (1966) Evidence for a new P-450 hemoprotein in hepatic microsomes from methylcholanthrene treated rats.
	dmd.aspetjournals.org /cgi/content/full/32/1/1 (4010 words)

	heme
		The hemoprotein family represents a fascinating example of how similar metal-based prosthetic groups can perform many different specific functions, depending on the protein environment.
		With the aim of investigating the effects of peptide chain composition and folding in modulating the properties of the heme, we have undertaken the design, synthesis and spectroscopic characterization of a new class of heme-peptide conjugates named
		Nastri, F., Lombardi, A., Morelli, G., Maglio, O., D'Auria, G., Pedone, C., and Pavone, V. “Hemoprotein Models Based on a Covalent Helix-Heme-Helix Sandwich: 1.
	chemistry.unina.it /bioinorganic/heme.html (305 words)

	Design, synthesis, and characterization of a novel hemoprotein -- Xu and Farid 10 (2): 236 -- Protein Science
		Design, synthesis, and characterization of a novel hemoprotein -- Xu and Farid 10 (2): 236 -- Protein Science
		Design, synthesis, and characterization of a novel hemoprotein
		Keywords: de novo proteins; heme; hemoprotein; protein design
	www.proteinscience.org /cgi/content/abstract/10/2/236 (175 words)

	Sessler Group: Publications
		J.; Iverson, B.; Sessler, J. "The 'Pocket' Porphyrin: A Hemoprotein Model with Lowered CO Affinity," J. Am.
		J.; Iverson, B. I.; Sessler, J. L.; Morris, R.; Gibson, Q. "The 'Pocket' Porphyrins: Hemoprotein Models with Lowered CO Affinities," Inorg.
		Sessler, J. L.; Collman, J. "The 'Pocket' Porphyrins: Hemoprotein Models with Lowered CO Affinities," Kagaku 1984, 39, 805-806.
	research.cm.utexas.edu /jsessler/publications.html (9111 words)

	Characterization of a New Hemoprotein in the Yeast Saccharomyces cerevisiae -- Sartori et al. 274 (8): 5032 -- Journal ...
		Characterization of a New Hemoprotein in the Yeast Saccharomyces cerevisiae -- Sartori et al.
		Characterization of a New Hemoprotein in the Yeast Saccharomyces cerevisiae
		polypeptide has been expressed in Escherichia coli, and the hemoprotein
	www.jbc.org /cgi/content/abstract/274/8/5032 (293 words)

	David R. Benson (Site not responding. Last check: 2007-11-05)
		2) Liu, D.; Williamson, D.A.; Kennedy, M.L.; Williams, T.D.; Morton, M.M.; Benson, D.R. “Aromatic Side Chain-Porphyrin Interactions in Designed Hemoproteins” J.
		3) Lee, K.-H.; Kennedy, M.L.; Buchalova, M.; Benson, D.R. “Thermodynamics of Carbon Monoxide Binding by Helical Hemoprotein Models: The Effect of a Competing Intramolecular Ligand” Tetrahedron 2000, 56, 9725-9732.
		4) Kennedy, M.L.; Silchenko, S.; Houndonougbo, N.; Gibney, B.R.; Dutton, P.L.; Rodgers, K.R.; Benson, D.R. “Model Hemoprotein Reduction Potentials: The Effects of Histidine to Iron Coordination Equilibrium” J.
	www.chem.ku.edu /dbenson (404 words)

	Epitomics Catalase rabbit antibody - 2024-1
		Immunohistochemical staining of paraffin-embedded human liver using anti-Catalase Rabbit polyclonal (cat.
		Description: Catalase is a tetrameric hemoprotein which degrades H2O2.
		Human catalase is a heme-containing peroxisomal enzyme that breaks down hydrogen peroxide to water and oxygen; it is implicated in ethanol metabolism, inflammation, apoptosis, aging and cancer (1).
	www.epitomics.com /products/2024-1.php (191 words)

	[No title] (Site not responding. Last check: 2007-11-05)
		68 : Q8EB00 0.61 0.72 99 457 204 563 359 1 1 565 Q8EB00 Sulfite reductase (NADPH) hemoprotein bet 69 : Q8X7U2 1.00 1.00 48 61 132 145 14 0 0 570 Q8X7U2 Sulfite reductase, alpha subunit.
		95 : Q8CMX5 0.50 0.63 99 452 212 566 353 2 3 572 Q8CMX5 Sulfite reductase (NADPH) hemoprotein bet 96 : O32213 0.65 0.80 64 97 147 180 34 0 0 571 O32213 YvgQ protein.
		120 : Q8KQT8 0.51 0.59 1 46 73 117 45 1 1 573 Q8KQT8 Sulfite reductase hemoprotein.
	www.infobiogen.fr /db/hssp/6gep.hssp (2119 words)

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