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Topic: Hepadnavirus


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In the News (Tue 25 Jun 19)

  
  REPLICATION AND PATHOGENESIS OF HEPATITIS B VIRUSES
In hepadnavirus, one possibility to keep pathways leading to virus destruction and production separated from each other is that DNA containing particles are inherently unstable in the cytoplasm of infected cells and that "escape" into the lumen of the endoplasmic reticulum shelters them from uncoating.
Regurgitation of cores leads to the amplification of viral DNA in nuclei of infected hepatocytes and is believed to be responsible for the persistence of virus infection, a hallmark of the hepadnavirus life cycle.
SEEGER, C., MASON, W.S. Chronic hepadnavirus infections of the woodchuck and duck.
www.fccc.edu /research/reports/current/seeger.html   (1374 words)

  
 Antiviral therapy for hepatitis B with 2',3'-dideoxypurine nucleosides - Patent 5039667
Potent in vivo efficacy of the 2,6-diaminopurine 2',3'-dideoxynucleoside for clearance of duck hepatitis B virus from the sera of Pekin ducks is demonstrated.
The selective effect on hepadnavirus replication by the purine 2',3'-dideoxynucleosides is based on the discovery of an unexpected sensitivity of hepadnavirus to purine 2',3'-dideoxynucleoside analogs.
After the hepadnavirus penetrates the target cells (hepatocytes), the virus is uncoated and the DNA enters the nucleus.
www.freepatentsonline.com /5039667.html   (4877 words)

  
 A new hepadnavirus endemic in arctic ground squirrels in Alaska -- Testut et al. 70 (7): 4210 -- The Journal of Virology
A new hepadnavirus endemic in arctic ground squirrels in Alaska -- Testut et al.
cross-reactivity with antibodies to hepadnavirus surface and core antigens.
Hepadnavirus evolution and molecular strategy of adaptation in a new host.
jvi.asm.org /cgi/content/abstract/70/7/4210   (614 words)

  
 Hepadnavirus Receptor
The p170 receptor binds the large envelope protein to mediate or induce entry of hepadnavirus virion.
Antibodies that recognize hepadnavirus receptor on the intact cells are screened for their ability to compete with a form of hepadnavirus envelope protein.
A reactive peptide was shown to inhibit avian hepatitis B viral infection in duck hepatocytes.
www.masstechportal.org /IP637.aspx   (333 words)

  
 Covalently Closed Circular DNA Is the Predominant Form of Duck Hepatitis B Virus DNA That Persists following Transient ...
These observations suggest that residual DHBV DNA is largely inactive, possibly in a subset of long-lived liver cells with a low capacity for hepadnavirus replication, and that this state represents a second form of persistent hepadnavirus infection quite distinct from classical chronic infection with extensive intrahepatic viral expression and antigenemia.
The significance of residual hepadnavirus DNA, apart from the problems of transmission with liver transplantation and reactivation with immunosuppression, is not fully understood.
Probably of greater significance is the fact that the existence of residual hepadnavirus DNA represents a host-parasite relationship in which a noncytopathic virus escapes eradication by an apparently effective immune response but is normally prevented from reactivation.
www.natap.org /2005/HBV/092005_01.htm   (3002 words)

  
 Visuals Unlimited Stock Photography
vu899007 - Hepatitis B virus (HBV) is the cause of serum hepatitis or hepatitis B. Human hepatitis B virus is the prototype virus of the Hepadnavirus family and is a DNA virus (partly double stranded).
vu899008 - Hepatitis B virus (HBV) is the cause of serum hepatitis or hepatitis B. Human hepatitis B virus is the prototype virus of the Hepadnavirus family and is a DNA virus (partly double stranded).
vu899009 - Hepatitis B virus (HBV) is the cause of serum hepatitis or hepatitis B. Human hepatitis B virus is the prototype virus of the Hepadnavirus family and is a DNA virus (partly double stranded).
www.visualsunlimited.com /browse/vu899/dirpage.html   (11256 words)

  
 Hepadnavirus Infection in Captive Gibbons -- Lanford et al. 74 (6): 2955 -- The Journal of Virology
Hepadnavirus Infection in Captive Gibbons -- Lanford et al.
The core gene sequences from three human and four gibbon hepadnaviruses and one woolly monkey hepadnavirus were aligned by using the MEGALIGN program of LASERGENE (DNAstar, Madison, Wis.).
The surface gene sequences from three human and four gibbon hepadnaviruses and one woolly monkey hepadnavirus were aligned as described in the legend to Fig.
jvi.asm.org /cgi/content/full/74/6/2955   (2525 words)

  
 hepadnavirus   (Site not responding. Last check: 2007-10-10)
hepadnavirus n : a group of animal DNA viruses including viruses of ducks and woodchucks and squirrels and others as well as the virus causing hepatitis B in humans
Hepadnavirus, hepadnavirus : Dorland's Illustrated Medical Dictionary [home, ]
, hepadnaviru/, hepadnaviru0, hepadnaviru1, hepadnaviru2, hepadnaviru3, hepadnaviru4, hepadnaviru5, hepadnaviru6, hepadnaviru7, hepadnaviru8, hepadnaviru9, hepadnaviru:, hepadnaviru;, hepadnaviru, hepadnaviru=, hepadnaviru, hepadnaviru?
www.vocamania.com /hepadnavirus.aspx   (157 words)

  
 VRISD: Vaccine Research Institute of San Diego
The hepatitis B virus core protein (HBcAg) is a uniquely immunogenic particulate antigen and as such has been used as a vaccine carrier platform.
The use of other hepadnavirus core proteins as vaccine carriers has not been previously explored.
This study published by VRISD scientists, demonstrates: 1) rodent core proteins are equal in immunogenicity to, or more immunogenic than HBcAg and 2) rodent core proteins are not significantly cross-reactive with HBcAg at the antibody level.
www.vrisd.org /news.php   (1285 words)

  
 Hepatitis B Virus Biology -- Seeger and Mason 64 (1): 51 -- Microbiology and Molecular Biology Reviews
The majority of hepadnavirus infections (90 to 95%) in adults are transient, while ~90% of perinatal infections are chronic
Hepadnavirus infections, and transient infections in particular, therefore raise difficult issues.
Expression of the precore region of an avian hepatitis B virus is not required for viral replication.
mmbr.asm.org /cgi/content/full/64/1/51   (10652 words)

  
 WHO | Hepatitis D
Complete viral replication cycles in vitro are limited to primary hepatocytes, generally of woodchucks or chimpanzees, that are coinfected with a hepadnavirus or cotransfected with hepadnavirus cDNA.
To replicate efficiently, a virus requires the cooperation of the host cell at all stages of the replicative cycle: attachment, penetration, uncoating, provision of appropriate metabolic conditions for the synthesis of viral macromolecules, the final assembly of viral subunits and the release of new virions.
HDV also requires the presence of a helper hepadnavirus to provide the protein components for its own envelope.
www.who.int /csr/disease/hepatitis/whocdscsrncs20011/en/index2.html   (2108 words)

  
 Dr. Charles E. Rogler
In the second area, we have developed an in vitro experimental system to study new hepadnavirus DNA integrations using the Duck hepatitis B virus, DHBV, animal model.
This approach will allow us to systematically investigate the role of host genes in the establishment of acute and persistent hepadnavirus infections.
Petersen, J., Dandri, M., Gupta, S. and Rogler, C.E. Liver repopulation with xenogenic hepatocytes in B and T cell-deficient mice leads to chronic hepadnavirus infectioin and clonal growth of hepatocellular carcinoma.
www.aecom.yu.edu /liver/Facultyresearch/rogler.htm   (1038 words)

  
 In Vitro Inhibition of Hepadnavirus Polymerases by the Triphosphates of BMS-200475 and Lobucavir -- Seifer et al. 42 ...
In Vitro Inhibition of Hepadnavirus Polymerases by the Triphosphates of BMS-200475 and Lobucavir -- Seifer et al.
Synthesis of hepadnavirus particles containing replication-defective duck hepatitis B virus genomes in cultured Huh-7 cells.
Heterogeneous response for mammalian hepadnavirus infection to acyclovir: drug arrested intermediates of minus strand viral DNA are enveloped and secreted from infected cells as virion-like particles.
aac.asm.org /cgi/content/full/42/12/3200   (6147 words)

  
 Dr. John Taylor: Hepatitis Delta Virus
They are composed of lipid and a mixture of the three forms of the hepadnavirus envelope proteins.
In the serum of an infected human the titer of infectious particles might be as high as 109/ml.
No other hepadnavirus or animal virus has been reported to act as a source of envelope proteins.
www.fccc.edu /docs/research/hdv.html   (7847 words)

  
 Presence of replicating virus in recombinant hepadnavirus stocks resul
Presence of replicating virus in recombinant hepadnavirus stocks results from recombination and can be eliminated by the use of a packaging cell line
Subject: Presence of replicating virus in recombinant hepadnavirus stocks results from recombination and can be eliminated by the use of a packaging cell line
J Virol 2003 Mar;77(5):2873-81 Presence of replicating virus in recombinant hepadnavirus stocks results from recombination and can be eliminated by the use of a packaging cell line.
archive.mail-list.com /hbv_research/msg04781.html   (330 words)

  
 010: LIFE-LONG PERSISTENCE OF INFECTIOUS HEPADNAVIRUS IN WOODCHUCKS AFTER RECOVERY FROM ACUTE VIRAL HEPATITIS   (Site not responding. Last check: 2007-10-10)
To determine overall duration, molecular characteristics and pathological outcomes of this serologically occult virus carriage, we have analyzed hepadnavirus replication and its infectivity during the natural lifetime of woodchucks which spontaneously recovered from an acute episode of hepatitis experimentally induced by woodchuck hepatitis virus (WHV).
Serial liver biopsies, sera and peripheral lymphoid cell samples, as well as autopsy materials, were analyzed for the presence and transcription of WHV genomes by molecular amplification and hybridization techniques for up to >5 years after resolution of acute infection.
Our results show that traces of infectious virus are produced for life after resolution of acute infection and that despite recovery HCC may ultimately develop.
www.pulsus.com /cddw2000/abs/010.htm   (375 words)

  
 Hepatitis viruses
Hepatitis A virus is a picornavirus, a small single strand RNA virus; hepatitis B virus belongs to the hepadnavirus family of double stranded DNA viruses; hepatitis C virus is a flavivirus, a single stand RNA virus; hepatitis E, also an RNA virus, is similar to a calicivirus.
Hepatitis D which is also known as Delta agent is a circular RNA that is more similar to a plant a viroid than a complete virus.
Human hepatitis B virus (figure 3) is the prototype virus of the hepadnavirus family and causes serum hepatitis.
pathmicro.med.sc.edu /virol/hepatitis-virus.htm   (3405 words)

  
 Hepadnavirus receptor (US5929220)
The invention features a purified nucleic acid that encodes a member of the hepadnavirus family of cellular receptors.
The receptor is a 170 kD cell surface glycoprotein, and is referred to as the p170 receptor.
Yuasa et al., Virology 181:14-21, 1991; "Peptide Mapping of Neutralizing and Nonneutralizing Epitopes of Duck Hepatitis B Virus Pre-S Polypeptide".
www.delphion.com /details?pn=US05929220__   (742 words)

  
 Isolation of a hepadnavirus from the woolly monkey, a New World primate -- Lanford et al. 95 (10): 5757 -- Proceedings ...
Isolation of a hepadnavirus from the woolly monkey, a New World primate -- Lanford et al.
Identification of a Hepadnavirus from a Woolly Monkey.
a hepadnavirus core gene that was considerably divergent from
www.pnas.org /cgi/content/full/95/10/5757   (4153 words)

  
 Amazon.com: "avian hepadnavirus": Key Phrase page   (Site not responding. Last check: 2007-10-10)
This two-domain structure is conserved between mammalian and avian hepadnavirus core proteins, but their...
Construction of avian hepadnavirus variants with enhanced replication and cytopathicity in primary hepatocytes.
In contrast, the avian hepadnavirus genomes are shorter (3.0 kb) and show marked divergence at the nucleotide and amino acid level (see Chapter 14).
www.amazon.com /phrase/avian-hepadnavirus   (531 words)

  
 MECHANISMS OF HEPADNAVIRUS ASSEMBLY AND REPLICATION   (Site not responding. Last check: 2007-10-10)
Through a complex multi- step reverse transcription pathway, the pgRNA is subsequently converted, within the context of the nucleocapsids, into the characteristic, relaxed circular DNA genome which can then exit the cell.
The broad, long term objective of this proposal is to elucidate the molecular mechanisms of hepadnavirus replication, focusing on the virus-cell interactions critical for viral assembly and replication.
The first specific aim is to identify host factors required for the interaction between RT and pgRNA and for protein priming.
researchresources.bumc.bu.edu /abstract/5R01AI043453-05.htm   (502 words)

  
 ACRIA Update Summer 2002: The Other Hepatitis: The ABCs of HBV
HBV is a hepadnavirus, meaning that it contains DNA.
It infects liver cells (hepatocytes) in both humans and animals (HBV is the only hepadnavirus to infect humans).
While HCV also infects liver cells, it contains RNA and belongs to the flavivirus family, which includes a few viruses known to cause some unsavory tropical infections, most notably dengue and yellow fever.
www.acria.org /treatment/treatment_edu_summerupdate2002_abcs.html   (2870 words)

  
 00.030. Hepadnaviridae - ICTVdB References
Lanford, R.E., Chavez, D., Brasky, K.M., Burns, R.B., 3rd, and Rico-Hesse, R. Isolation of a hepadnavirus from the woolly monkey, a New World primate.
Newbold, J.E., Xin, H., Tencza, M., Sherman, G., Dean, J., Bowden, S. and Locarnini, S. The covalently closed duplex form of the hepadnavirus genome exists in situ as a heterogeneous population of viral minichromosomes.
Summers, J., Smolec, J. and Snyder, R. A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks.
www.ictvdb.rothamsted.ac.uk /Ictv/rf_hepad.htm   (481 words)

  
 Hepatocellular Carcinoma in Black-tailed Prairie Dogs (Cynomys ludivicianus): Tumor Morphology and Immunohistochemistry ...
The association between HCC and hepadnavirus infection in sciurids
hepatic tissue with hepadnavirus probes and in plasma by cross-reactivity
using antibodies to hepadnavirus surface and core antigens.
www.vetpathology.org /cgi/content/full/41/4/353   (2986 words)

  
 Hepadnavirus evolution and molecular strategy of adaptation in a new host -- Argentini et al. 80 (3): 617 -- Journal of ...
Hepadnavirus evolution and molecular strategy of adaptation in a new host -- Argentini et al.
In order to elucidate the mechanisms of hepadnavirus evolution in vivo and
Frequency of Spontaneous Mutations in an Avian Hepadnavirus Infection
vir.sgmjournals.org /cgi/content/abstract/80/3/617   (411 words)

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