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Topic: Heparin-induced thrombocytopenia

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Heparin-induced thrombocytopenia - Wikipedia, the free encyclopedia Heparin-induced thrombocytopenia (HIT) with or without thombosis (HITT) is thrombocytopenia (low platelet counts) due to the administration of heparin. Heparin (UFH) is used in cardiovascular surgery, as prevention or treatment for deep-vein thrombosis and pulmonary embolism and in various other clinical scenarios. It appears that heparin binding to platelet factor 4 causes a confomational change in the protein, rendering it antigenic. en.wikipedia.org /wiki/Heparin-induced_thrombocytopenia   (509 words)

Heparin Induced Thrombocytopenia Heparin in the serum and heparin sulfate bind antithrombin which is the major inhibitor protein of the coagulation cascade. Serum samples from patients with HIT released 5.5 to 352.5 and 6.6 to 1,533.3 ng/mL of serotonin from platelets in the presence of 0.2 IU/mL of heparin and LMWH, respectively. One fraction, the high-affinity heparin, is responsible for nearly all of the anticoagulant activity. www.thedoctorsdoctor.com /diseases/heparin_induced_thrombocytopenia.htm   (1713 words)

Hospital Practice: Drug-Induced Thrombocytopenia Heparin-induced thrombocytopenia is defined as a fall in the platelet count of at least 50%, accompanied by a positive serologic test for the responsible antibody. I believe that it is worthwhile to expand on some of the points Kelton makes in his overview of drug-induced thrombocytopenia--namely, the indications for treatment of thrombocytopenia, the medicolegal challenges of heparin therapy in a litigious era, and the role of low-molecular-weight heparin in current therapy. Nonimmune thrombocytopenia is the most common cause of drug-induced thrombocytopenia in hospitalized patients and is typically seen on cancer wards, particularly among leukemia patients. www.hosppract.com /issues/1998/05/dmmkelt.htm   (4175 words)

Thrombocytopenia Thrombocytopenia is diagnosed by having a blood sample taken and counting the platelets present in the sample. Thrombocytopenia is an abnormal drop in the number of blood cells involved in forming blood clots. Thrombocytopenia is a blood disease characterized by an abnormally low number of platelets in the bloodstream. www.healthatoz.com /healthatoz/Atoz/ency/thrombocytopenia.jsp   (886 words)

January 1997 - Heparin-Induced Thrombocytopenia HIT is an antibody-mediated process occurring in approximately 4-5% of all patients 3-15 days after starting standard unfractionated heparin for the first time. HIT is not dose dependent and can occur with minute doses of heparin, including heparin flushes and in patients with indwelling heparin-coated catheters. HIT largely remains a clinical diagnosis for which a high index of suspicion is recommended. www.itxm.org /TMU1997/tmu1-97.htm   (630 words)

Critical Care Full text Heparin-induced thrombocytopenia Heparin-induced thrombocytopenia (HIT) is a relatively common antibody-mediated drug reaction in the ICU and paradoxically is associated with thrombosis. The risk of recurrence of HIT with subsequent brief exposure to heparin is low in patients with undetectable levels of heparin-dependent antibodies. Thrombocytopenia in the ICU is a common phenomenon and causation is often multifactorial, making diagnosis problematic. ccforum.com /paperreport/ccf-2001-73302   (305 words)

Clinician Reviews: Heparin-Induced Thrombocytopenia Since it was first described by Silver et al in 1973, [1] heparin-induced thrombocytopenia (HIT) has been recognized as a significant potential complication of heparin therapy, with reported incidence rates ranging from 1% to 30% (depending on the patient population studied and diagnostic criteria used). HIT type I is thought to be a nonimmune reaction to heparin that results in direct platelet activation, aggregation, and thrombocytopenia. However, HIT should be strongly suspected in any patient who develops thrombocytopenia and unexpected thrombotic complications while undergoing heparin therapy. www.findarticles.com /p/articles/mi_m0BUY/is_2_11/ai_71710879   (1299 words)

Heparin-induced thrombocytopenia - FAQs What is the clinical importance of Heparin-Induced Thrombocytopenia? Heparin-induced thrombocytopenia is a serious side effect of a drug that is widely used in clinical practice. Thrombocytopenia in HIT is paradoxically associated with thrombosis, not with bleeding. www.argatroban.com /hit_02.htm   (1128 words)

HIT: Heparin-induced Thrombocytopenia Intravenous gamma globulin and ASA attenuate the thrombocytopenic response to heparin. In pts for CEA with HIT, a substitute for unfractionated heparin (UFH) should be used. ASA was effective by in vitro testing in only 50% of patients with HIT.Iloprost, a prostanoid inhibitor, effective in cardiac pts receiving heparin, but vasoconstrictors frequently are necessary to counteract the vasodilating effects of iloprost. www.unc.edu /~rvp/RP_Anesthesia/Basics/HIT.html   (677 words)

Heparin-Induced Thrombocytopenia Nand S, Wong W, Yuen B, et al, "Heparin-Induced Thrombocytopenia With Thrombosis: Incidence, Analysis of Risk Factors, and Clinical Outcomes in 108 Consecutive Patients Treated at a Single Institution,"Am J Hematol, 1997, 56(1):12-6. HIT is due to an antibody that recognizes heparin bound to platelet factor 4 (PF4) on the platelet surface. Heparin should be permanently discontinued in HIT patients (special arrangements are made for patients who require bypass surgery). www.mgh.harvard.edu /labmed/lab/coag/handbook/CO006400.htm   (1271 words)

Refludan Approved For Heparin-Induced Thrombocytopenia HIT type II is a rare, allergy-like adverse reaction to heparin, a standard anticoagulant therapy. HIT type II is caused by a complex immune mechanism and is characterised by a rapid and serious decline in the blood's platelet count, leading to an increased risk of severe thromboembolic (blood clotting) complications. The drug is derived from the saliva of the leech and is recreated through state-of-the-art recombinant technology to provide an alternative anticoagulant for patients with HIT type II. www.pslgroup.com /dg/608c2.htm   (311 words)

Heparin-Induced Thrombocytopenia (HIT) It should also be considered if the patient develops ‘resistance’ to normal doses of heparin (in terms of clotting times) or if new thromboses develop while on treatment. Platelet count rises on withdrawal of heparin, rapidly falls on re-exposure. Heparin combines with heparin-binding protein (PF4) in platelets. www.clinicalschool.swan.ac.uk /wics/itugl/hit.htm   (302 words)

International Symposium on Heparin-Induced Thrombocytopenia The frequency of HIT ranges from five to ten percent in patients receiving high doses of heparin (usually intravenously) and two to five percent in those receiving lower dosages (usually subcutaneously). HIT is an immune reaction to the anticoagulant, heparin. In our experience at Loyola, argatroban is the only available drug useful as a substitute for heparin," stated Jawed Fareed, Ph.D., Professor of Pathology and Pharmacology, Loyola University Medical Center, and Director of Hemostasis and Thrombosis Research Laboratory. www.docguide.com /dg.nsf/PrintPrint/CEF39A37196A2FD8852563FB00669BF7   (656 words)

thrombocytopenia (heparin-induced) - General Practice Notebook Heparin-induced thrombocytopenia: a prospective study of 142 patients. Heparin-induced thrombocytopenia in patients treated with low-molecular weight or unfractionated heparin. Heparin-induced thrombocytopaenia (HIT) and associated thrombotic events are relatively common side effects of heparin therapy. www.gpnotebook.co.uk /medwebpage.cfm?ID=1456472128   (1137 words)

Perfusion Line - Review Online thrombocytopenia induced by exposure to heparin and heparin-coated tubing. Cardiac surgery in patients with heparin-induced thrombocytopenia using disorder induced by the administration of heparin for therapeutic purposes. perfline.com /main/journal.cgi?folder=revonline&next=21   (12633 words)

[No title] The study was designed to reflect conventional clinical practice, whereby treatment of patients with HIT was initiated upon clinical suspicion. The safety and efficacy of argatroban in management of HIT were the subject of a single published clinical trial. In several of these patients, HIT antibodies could not be demonstrated. www.chez.com /orthopedix/text/hit_thromboses.html   (322 words)

Heparin Induced Thrombocytopenia - "HIT" • Heparin use is ubiquitous in hospitals and often not even documented when given, e.g. • Evidence of a clot somewhere in the body despite anti-coagulant (heparin) treatment and low platelet count. HIT is a clotting, not bleeding, disorder and platelets may worsen. aacn.org /chapters/hgcc.nsf/(articles)/6CE6760502484D0F88256CDE0078402F   (187 words)

NGC - NGC Summary Patients in whom heparin-induced thrombocytopenia (HIT) is infrequent (0.1 to 1%) For patients who are starting unfractionated heparin (UFH) or low-molecular-weight heparin (LMWH) treatment and who have received UFH within the past 100 days, or those patients in whom exposure history is uncertain, the guideline developers suggest obtaining a baseline platelet count and then a repeat platelet count within 24 hours of starting heparin (Grade 2C). Patient groups most likely to benefit from platelet count monitoring are those at the highest risk of HIT (1 to 5%) and include postoperative orthopedic, cardiac, and vascular surgery patients who are receiving unfractionated heparin for 1 to 2 weeks. www.guideline.gov /summary/summary.aspx?ss=15&doc_id=5891&nbr=3877   (4526 words)

Perfusion Line: Heparin_Induced_Thrombocytopenia Heparin-induced thrombocytopenia (HIT) - Manual of use and interpretation of pathology tests. Understanding Heparin Induced Thrombocytopenia: Historical and Clinical - Diane Wallis, MD, Theodore Warkentin, MD Heparin-Induced Thrombocytopenia- In pediatric Intensive Care Patients - Markus Schumugge www.perfline.com /links/Heparin_Induced_Thrombocytopenia   (212 words)

FRAGMIN - About Blood Clots FRAGMIN injection is contraindicated in patients with active major bleeding or with known hypersensitivity to the drug, heparin, or pork products, and should be used with extreme caution in patients with history of heparin-induced thrombocytopenia. FRAGMIN cannot be used interchangeably (unit for unit) with unfractionated heparin or other low—molecular-weight heparins. Spinal or epidural hematomas can occur with the associated use of low—molecular-weight heparins or heparinoids and neuraxial (spinal/epidural) anesthesia or spinal puncture, which can result in long-term or permanent paralysis. www.fragmin.com /patient/about_blood_clots.asp   (520 words)

Search Tuna Report for Deep Vein Thrombosis In patients with a history of heparin-induced thrombocytopenia, LOVENOX should be used with extreme caution.... Heparin, low molecular weight heparin and physical methods for preventing deep vein thrombosis and pulmonary embolism following surgery for hip fractures... However, newer forms of heparin, known as low molecular weight heparin usually enoxaparin can be used in some circumstances.... www.searchtuna.com /ftlive2/591.html   (2876 words)

Heparin-Induced Thrombocytopenia-Associated Thrombosis in Pediatric Intensive Care Patients -- Schmugge et al. 109 (1): 10 -- Pediatrics Abbreviations: HIT, heparin-induced thrombocytopenia • HPF4 heparin/platelet factor 4 • PICU, pediatric intensive care unit • ELISA, enzyme-linked immunosorbent assay side effect of heparin therapy, occurs in 1% to 5% of adults were reviewed for fulfillment of clinical HIT criteria. pediatrics.aappublications.org /cgi/content/abstract/109/1/e10   (317 words)

Compare Prices on Heparin-Induced Thrombocytopenia at Smarter Home > Books > Medical > Hematology > Heparin > Heparin-Induced Thrombocytopenia Low-Molecular-Weight Heparins in Prophylaxis and Therapy of Thromboembolic Diseases Answers to your questions about Heparin and more. smarter.com /books-1/product/heparin-induced_thrombocytopenia-764295   (176 words)

Biotechnology Stocks -- Biotech100 Index Argatroban (FDA approved) was developed to treat heparin-induced thrombocytopenia (HIT), a serious immune reaction to heparin that causes abnormal clotting and often leads to limb amputation and even death. Encysive has one of the broadest product pipelines in the sector. www.pipelinedrugs.com /encysive.htm   (142 words)

Medical Books - Compare Shop Books Alloimmune Disorders of Pregnancy: Anaemia, Thrombocytopenia and Neutropenia in the Fetus and Newborn www.compareshopbooks.com /books_list.htm   (4457 words)

Heparin Induced Thrombocytopenia (Fundamental and Clinical Cardiology)-0824756258 Compare prices at Chambal.com Heparin Induced Thrombocytopenia (Fundamental and Clinical Cardiology)-0824756258 Compare prices at Chambal.com Title: Heparin Induced Thrombocytopenia (Fundamental and Clinical Cardiology) www.chambal.com /csin/9780824756253   (41 words)

Laboratory Diagnosis of Heparin-Induced Thrombocytopenia and Monitoring of Alternative Anticoagulants -- Leo and Winteroll 10 (5): 731 -- Clinical and Diagnostic Laboratory Immunology Determination of serotonin release from platelets by enzyme immunoassay in the diagnosis of heparin-induced thrombocytopenia. Diagnosis of heparin-induced thrombocytopenia in the vascular surgery patient. Heparin-induced thrombocytopenia with thromboembolic complications: meta-analysis of 2 prospective trials to assess the value of parenteral treatment with lepirudin and its therapeutic aPTT range. cdli.asm.org /cgi/content/full/10/5/731   (6311 words)

Heparin-induced thrombocytopenia and cardiac surgery -- Warkentin and Greinacher 76 (6): 2121 -- The Annals of Thoracic Surgery Heparin-induced thrombocytopenia and cardiac surgery -- Warkentin and Greinacher 76 (6): 2121 -- The Annals of Thoracic Surgery Heparin-Induced Thrombocytopenia: Recognition, Treatment, and Prevention: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy Severe Argatroban-Induced Coagulopathy in a Patient With a History of Heparin-Induced Thrombocytopenia ats.ctsnetjournals.org /cgi/content/abstract/76/6/2121   (392 words)

Thrombocytopenia, heparin-induced definition - Medical Dictionary definitions of popular medical terms Thrombocytopenia, heparin-induced: Low blood platelet count as a result of the medication heparin. Heparin-induced thrombocytopenia can be mild or serious and fatal. Thrombocytopenia, heparin-induced definition - Medical Dictionary definitions of popular medical terms www.medterms.com /script/main/art.asp?articlekey=14279   (157 words)

Congenital and Acquired Thrombocytopenia -- Cines et al. 2004 (1): 390 -- Hematology The incidence of heparin-induced thrombocytopenia in hospitalized medical patients treated with subcutaneous unfractionated heparin: a prospective cohort study. The anticoagulant therapy with bivalirudin to assist in the performance of percutaneous coronary intervention in patients with heparin-induced thrombocytopenia (ATBAT) study: main results. Warkentin TE, Greinacher A. Heparin-induced thrombocytopenia and cardiac surgery. www.asheducationbook.org /cgi/content/full/2004/1/390   (7752 words)

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