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Topic: Hepatic steatosis

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Fatty liver

Autoimmune hepatitis

Cirrhosis

Glycogenolysis

Metabolic syndrome

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Hemochromatosis

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To Kill a Mockingbird

HbA1c

Halakha

	New CDC HIV Prevention Funding Emphasizes Effectiveness, Focuses on Those Already Infected
		The aims of this retrospective study were to determine the prevalence of and the risk factors for hepatic steatosis and to assess the association of being overweight/obese and steatosis with activity and progression of CHC in U.S.patients.
		Steatosis was graded on a scale of 0–3: 0=absence of steatosis; grade 1=30% of hepatocytes affected; grade 2=30 to about 70% of hepatocytes affected; grade 3=70% of hepatocytes affected.
		Grade II/III steatosis was not associated with age at the exposure, elevated ALT and ferritin at entry, hepatic iron staining, hypoalbuminemia, thrombocytopenia, and splenomegaly.
	www.natap.org /2003/dec/122903_9.htm (2647 words)

	Hepatic Steatosis Is a Significant Risk Factor for Hepatocellular Carcinoma in Patients with Chronic HCV (Site not responding. Last check: 2007-11-05)
		Hepatic steatosis (fatty liver) is one of the histopathologic features of chronic hepatitis C. It was reported recently that the expression of hepatitis C virus (HCV) core protein in transgenic mice induced hepatocellular carcinoma (HCC) in association with steatosis.
		The objective of this study was to determine the relation between hepatic steatosis and hepatocarcinogenesis (origin of liver cancer) in patients with chronic HCV infection.
		Hepatic steatosis is a risk factor for hepatocellular carcinoma in patients with chronic hepatitis C virus infection.
	www.hivandhepatitis.com /hep_c/news/062003a.html (341 words)

	Prevalence of hepatic steatosis (fatty liver) in an urban population in the United States: Impact of ethnicity
		The higher prevalence of hepatic steatosis in Hispanics was positively correlated with obesity and insulin resistance, whereas the lower prevalence of hepatic steatosis in fls was not attributable to these factors, or to ethnic differences in ethanol intake.
		Finally, although hepatic steatosis was associated with a higher prevalence of elevated serum ALT levels, the vast majority of subjects with excess hepatic triglyceride had normal serum aminotransferase levels.
		Hepatic steatosis develops for a variety of reasons but is most commonly associated with obesity, insulin resistance, and hyperlipidemia, all of which are components of the metabolic syndrome.
	www.natap.org /2004/HCV/121304_03.htm (3516 words)

	Hepatitis C Outreach Project (Site not responding. Last check: 2007-11-05)
		Identification of hepatic macrosteatosis is an important component of the evaluation of live liver donors for 2 reasons: (1) hepatic steatosis is common in the general population, paralleling obesity, and (2) depending on the degree, hepatic steatosis is a risk factor for primary nonfunction of the liver allograft.
		Liver biopsy is the gold standard for quantifying steatosis and is relatively safe, but the risks (albeit small) of significant bleeding and death have prompted clinicians to establish a valid and reliable noninvasive method.
		However, when imaging studies reported no fat, steatosis was observed on biopsy in 3 of 10 patients who had MRI (all grade 1a) and 4 of 17 who had CT (3 with grade 1a and 1 with grade 2).
	www.hcop.org /hcvinfo/articles/index.cfm?articleid=198 (1428 words)

	JPMA ::: (Site not responding. Last check: 2007-11-05)
		Hepatic steatosis is increasingly being recognized as a condition that may progress to end-stage liver disease.
		Hepatic steatosis can occur with the use of alcohol (alcohol-related fatty liver) or in the absence of alcohol (nonalcoholic fatty liver disease).2 Fatty liver associated with the use of alcohol may occur with as little as 10 oz of alcohol ingested per week.
		Steatosis and hepatitis C virus: mechanisms and significance for hepatic and extrahepatic disease.
	jpma.org.pk /JPMA/3Mar04/fulltext1.htm (1055 words)

	The Turkish Journal of Gastroenterology
		In the current study, causes of liver steatosis were as follows: manifested diabetes mellitus in 14(27.45%), impaired diabetes in 11(21.56%), potential diabetes in 5(9.8%), alcoholism in 7(13.72%), hyperlipoproteinemia in 7(13.72%), long term use of prednisone in 3(5.98%), estrogen use in 2(3.92) and anemia in 2 patients (3.92%).
		The rate of hepatic steatosis was 27.45% in manifested and 21.56% in chemical diabetes mellitus in our study group (p= 0.05).
		Cushing syndrome is not frequently associated with liver steatosis (9), but long term corticosteroid use could lead to a fatty liver causing an increase in free fatty ascites (10).
	www.turkgastro.org /text.php?id=202 (1996 words)

	Hepatitis Central, Hepatic Steatosis: Innocent Bystander or Guilty
		Regardless of the etiology, microvesicular steatosis is widely acknowledged as having a poor prognosis with death caused by both liver failure and extra-hepatic causes.
		Hepatic stellate cells are the principal cells involved in hepatic fibrogenesis.
		Hepatic stellate cell activation occurs in the absence of hepatitis in alcoholic liver disease and correlates with the severity of steatosis.
	hepatitis-central.com /hcv/liver/hepatic/steatosis.html (3557 words)

	Alcohol Research Center - Steatosis (fatty liver disease) - Louisiana State University Health Sciences Center New ... (Site not responding. Last check: 2007-11-05)
		Hepatic steatosis in chronic hepatitis B and C: Predictors...
		Worsening of steatosis is an independent factor of fibrosis...
		Steatosis in chronic hepatitis C: Relative contributions of obesity...
	alcoholresearch.lsuhsc.edu /effects/steatosis.asp (686 words)

	Nutrition Research Newsletter: Liver volume visceral obesity in women with hepatic steatosis undergoing gastric banding ...
		Hepatic steatosis is also frequently found in obesity and is associated both with impaired glucose tolerance and/or hyperinsulinemia and with hypertriglyceridemia with or without high-density lipoprotein (HDL) levels.
		However, the complex relationships between visceral fat accumulation, hepatic steatosis, and metabolic abnormalities largely remain to be elucidated.
		In the present study, the relationship between visceral obesity and hepatic steatosis was investigated in a small group of morbidly obese women treated by means of adjustable silicone gastric banding with the LAP-BAND.
	www.findarticles.com /p/articles/mi_m0887/is_6_21/ai_87852144 (642 words)

	Does High Body Mass Index Affect Hepatic Fibrosis, Steatosis and Inflammation in Patients with Chronic Hepatitis C? ...
		The impact of high BMI on hepatic fibrosis, steatosis and inflammatory activity in patients with chronic HCV is still under investigation.
		The aim of this study is to assess the potential association between body mass index and stage of hepatic fibrosis in HCV patients.
		High BMI was also associated with hepatic steatosis (P=0.03), although there was no statistically significant association between steatosis and fibrosis stages suggesting that the association between BMI and fibrosis is independent of that of BMI and steatosis.
	www.hepcassoc.org /news/article46.html (456 words)

	Prevalence of nonalcoholic fatty liver disease varies by ethnicity
		Nearly one-third of the sample was found to have hepatic steatosis (defined as HTGC greater than 95th percentile of healthy persons, or 5.5 percent liver fat content) and "striking differences in the prevalence of hepatic steatosis were present among the three major ethnic groups," the authors report.
		The prevalence of hepatic steatosis was significantly higher in Hispanics than in whites, and significantly lower in fls than in whites.
		Furthermore, while the prevalence of hepatic steatosis was similar between the sexes in fls and Hispanics, in whites, prevalence in men was twice as high than that in women.
	www.medicalnewstoday.com /medicalnews.php?newsid=17458 (667 words)

	The Healing Power of Herbs
		In a study of acute viral hepatitis, silymarin administered to twenty nine patients showed a definite therapeutic influence on the characteristic increased serum levels of bilirubin and liver enzymes compared with a placebo group.
		In a study in chronic viral hepatitis, silymarin was shown to result in dramatic improvement.
		Used at a high dose (420 milligrams of silymarin) for periods of 3 to 12 months, silymarin resulted in a reversal of liver cell damage (as noted by biopsy), an increase in protein level in the blood, and a lowering of liver enzymes.
	www.liversupport.com /info3.htm (3124 words)

	MVI Newsflash: Hepatic Cholestasis In Patients Receiving Chronic PN
		There is also substantial evidence that hepatic complications accompany many disease states (eg, major enterectomy in Crohn’s disease), so it is unclear if the administration of PN is a cause or associated cause of hepatic abnormalities.
		Hepatic steatosis is common in adults receiving PN, even when the PN is administered for relatively short time periods.
		In most cases, the hepatic steatosis is self-limiting, whether the PN is discontinued or not.
	www.imakenews.com /mvius/e_article000183277.cfm (1388 words)

	Concentration of Free Amino Acids in Blood Plasma of Dairy Cows with developing Hepatic Steatosis (Site not responding. Last check: 2007-11-05)
		The aim of this experiment was to study the changes in free amino acid (AA) concentration in blood plasma of dairy cows developing hepatic steatosis after parturition and to establish the diagnosis by means of Fischer´s index.
		They were divided into two groups (S - cows with steatosis, N - cows with no increased deposition of fat in the liver) based on morphological examination of hepatic tissue on day 4 after feed restriction.
		The concentration of free amino acids in blood is not a sensitive indicator of liver function impairment, therefore cannot be used in the diagnosis of liver steatosis.
	www.vfu.cz /acta-vet/vol69/093-00.htm (365 words)

	Non-alcoholic steatohepatitis and hepatic steatosis in patients with adult onset growth hormone deficiency -- Ichikawa ...
		Non-alcoholic steatohepatitis and hepatic steatosis in patients with adult onset growth hormone deficiency -- Ichikawa et al.
		GH deficiency no hepatic steatosis was present (p=0.035).
		Macrovesicular steatosis, pericellular and centrilobular fibrosis, and ballooned hepatocytes are all observed in this section.
	gut.bmjjournals.com /cgi/content/full/52/6/914 (396 words)

	Hepatitis Central, Body Composition and Hepatic Steatosis as Precursors of Fibrosis in Chronic Hepatitis C Patients
		Hepatitis C virus genotype and levels of viremia: correlation with histological alterations of chronic hepatitis C (CHC) patients [Abstract].
		Evidence that liver steatosis is virally-mediated in a subset of patients infected by hepatitis C virus genotype 3 [Abstract].
		Hepatitis C virus core protein induces hepatic steatosis in transgenic mice.
	hepatitis-central.com /hcv/hepatitis/body/composition.html (1386 words)

	Neonatal hepatic steatosis by disruption of the adenosine kinase gene. (Site not responding. Last check: 2007-11-05)
		Neonatal hepatic steatosis by disruption of the adenosine kinase gene.
		Neonatal hepatic steatosis (OMIM 228100) is a fatal condition of unknown etiology characterized by a pale and yellow liver and early postnatal mortality.
		Thus, a deficiency in adenosine metabolism is identified as a powerful contributor to the development of neonatal hepatic steatosis, providing a model for the rapid development of postnatally lethal fatty liver.
	www.arclab.org /medlineupdates/abstract_11997462.html (206 words)

	Hepatitis Neighborhood : Green Tea Ingredient Might Block Fatty Liver: Study
		Hepatic steatosis is a condition in which fat accumulates in the cells that make up the
		The latter is characterized by inflammation in the liver caused by the accumulation of fat.
		Hepatic steatosis is also associated with an increased risk of disease and death, resulting in fewer usable donors for transplantation.
	www.hepatitisneighborhood.com /content/in_the_news/archive_2263.aspx (1013 words)

	Concurrent exercise prevents high-fat-diet-induced macrovesicular hepatic steatosis -- Gauthier et al. 94 (6): 2127 -- ...
		(HF)-diet regimen on the induction of hepatic steatosis.
		Hepatic steatosis in rats fed diets with varying concentrations of sucrose.
		Hepatic Steatosis: A Mediator of the Metabolic Syndrome.
	jap.physiology.org /cgi/content/full/94/6/2127 (4987 words)

	Ruth Lilly Medical Library
		Methods: Correlation was made between the pathologistsâ grading of the hepatic steatosis and the measured hepatic TG content in liver tissue samples from 39 patients without hepatitis C or B or significant alcohol consumption (age: 46 + 15 yrs, males: 49%).
		TG content in the liver homogenate was determined by measuring the absorbance by UV spectrophotometer (520 nm).The TG content was normalized with the protein content of the liver sample, which was measured by the absorbance by UV spectrophotometer (595 nm).
		Histological grading of the macrovesicular steatosis was done in a blinded fashion by three experienced hepatopathologists.Kappa statistics was used to assess the inter-observer agreement for histological grading of the steatosis and ANOVA was used to test the association between pathologistsâ histological grading and the TG content.
	www.medlib.iupui.edu /faculty/scs2004/P1152004.html (409 words)

	Molecular mediators of hepatic steatosis and liver injury -- Browning and Horton 114 (2): 147 -- Journal of Clinical ...
		the pathogenesis of hepatic steatosis in insulin-resistant livers.
		of hepatic steatosis to NASH remains to be established in humans.
		Increase in long-chain polyunsaturated fatty acid n-6/n-3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease.
	www.jci.org /cgi/content/full/114/2/147 (4688 words)

	Evaluation of abnormal liver function tests -- Limdi and Hyde 79 (932): 307 -- Postgraduate Medical Journal
		Hepatitis B and/or C are common causes and hepatitis serology
		Autoimmune hepatitis is an unresolving inflammation of the liver
		Hepatic ALP is present on the canalicular and luminal domain
	pmj.bmjjournals.com /cgi/content/full/79/932/307 (3045 words)

	Lecithin increases plasma free choline and decreases hepatic steatosis in long- (Site not responding. Last check: 2007-11-05)
		Lecithin increases plasma free choline and decreases hepatic steatosis in long-term total parenteral nutrition patients.
		A significant and progressive decrease in hepatic fat was indicated by increased liver-spleen CT Hounsfield units at 2 and 6 weeks (7.5 +/- 1.7 units, P = 0.02; 13.8 +/- 3.5 units, P = 0.03) in the lecithin supplemental group.
		It was concluded that hepatic steatosis in many patients receiving long term TPN is caused by plasma-free choline deficiency and may be reversed with lecithin supplementation.
	www.hankintatukku.com /medlineLecithin-1.html (219 words)

	Diagnosis and Control of the Development of Hepatic Steatosis in Dairy Cows in the Postparturient Period (Site not responding. Last check: 2007-11-05)
		Pechová A., Illek J., Halouzka R.: Diagnosis and Control of the Development of Hepatic Steatosis in Dairy Cows in the Postparturient Period.
		The objective of the present investigations was to help the early diagnosis of hepatic steatosis.
		day of this restriction hepatic biopsy was performed and according to the results the dairy cows were divided into group S (7 cows), i.e.
	www.vfu.cz /acta-vet/vol66/235-97.htm (291 words)

	Mechanisms of liver steatosis in rats with systemic carnitine deficiency due to treatment with ...
		Plasma and hepatic carnitine and coenzyme A pools in a patient with fatal, valproate induced hepatotoxicity.
		Rat hepatic coenzyme A is redistributed in response to mitochondrial acyl-coenzyme A accumulation.
		Hepatic zonation of the induction of cytochrome P450 IVA, peroxisomal lipid ß-oxidation enzymes and peroxisome proliferation in rats treated with dehydroepiandrosterone (DHEA).
	www.jlr.org /cgi/content/full/44/1/144 (5321 words)

	Liver Issues (Steatosis) - HCV News Articles
		Effect of Significant Histologic Steatosis or Steatohepatitis on Response to Antiviral Therapy in Patients with Chronic Hepatitis C
		Steatosis and Fibrosis in Patients with Chronic Hepatitis C
		Steatosis in Chronic Hepatitis B and C: Predictors, Distribution and Effect on Fibrosis
	www.hivandhepatitis.com /hep_c/hepc_news_liver_steatosis.html (383 words)

	Component Of Green Tea Protects Injured Livers In Mice
		A new study investigating the effects of the major flavonoid component of green tea on hepatic steatosis (fatty liver) found that it significantly protected livers that suffered ischemia/reperfusion (I/R) injury in mice.
		Approximately one-fifth of the U.S. population is afflicted with hepatic steatosis due to a rising incidence of obesity.
		Further tests revealed an increase in hepatic energy stores (one of the liver's functions is to store energy in the form of glycogen) in EGCG mice and showed that EGCG was acting as an antioxidant, thereby protecting fatty livers from I/R injury.
	www.sciencedaily.com /releases/2005/02/050223151300.htm (730 words)

	Liver Volume and Visceral Obesity in Women with Hepatic Steatosis Undergoing Gastric Banding -- Busetto et al. 10 (5): ...
		Relationship between visceral adipose tissue volume and liver volume in six premenopausal morbidly obese women with hepatic steatosis.
		hepatic steatosis with high sensitivity and specificity (5).
		between visceral obesity and hepatic steatosis (3) (4).
	www.obesityresearch.org /cgi/content/full/10/5/408 (2164 words)

	Hepatic Hyperplasia in Noncirrhotic Fatty Livers: Is Obesity-related Hepatic Steatosis a Premalignant Condition? -- ...
		Hepatic activity of the MAPKs, Erk-1 (p42) and Erk-2 (p44), in lean and ob/ob mice.
		Total hepatic RNA was analyzed by RNase protection assays using commercially available reagents that permit the concurrent evaluation of multiple cell-cycle-regulated genes and GAPDH, a housekeeping gene, in each of the same 10-µg RNA samples.
		Hepatic nuclear extracts were prepared from the livers of two lean and two ob/ob mice.
	cancerres.aacrjournals.org /cgi/content/full/61/13/5016 (5986 words)

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