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Topic: Hepatoblastoma

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	eMedicine - Hepatoblastoma : Article by Mary Elizabeth McCarville
		In one study of 31 children with primary unresectable hepatoblastoma, a large, early fall in AFP level (defined as greater than or equal to 2 logs) in response to chemotherapy was the strongest independent predictor of outcome.
		Common infantile hemangioma may be distinguished from hepatoblastoma by the presence of enlargement of the hepatic artery and a tapering of the aortic dimension distal to the celiac axis.
		Hepatoblastomas are considered resectable at presentation in approximately 30% of patients.
	www.emedicine.com /radio/topic331.htm (4462 words)

	Rare Cancer News » Hepatoblastoma
		Hepatoblastoma and heart transplantation in a patient with cardio-facio-cutaneous syndrome.
		Although hepatoblastoma is not known to have an increased frequency in immunocompromised patients, questions were raised as whether the post-transplant immuno-suppressive therapy played a role in tumor development.
		The incidences of hepatoblastoma were significantly increased in 500 and 1,000 mg/L males, and the incidences of hepatocellular carcinoma were significantly increased in 1,000 mg/L males and 500 mg/L females.
	news.rare-cancer.org /Hepatoblastoma (8282 words)

	Childhood liver cancer
		Hepatoblastomas usually occur before 3 years of age, whereas the incidence of hepatocellular carcinoma in the United States varies little with age between 0 and 19 years.[2] The overall survival rate for children with hepatoblastoma is 70% [3-5] but is only 25% for hepatocellular carcinoma.[6]
		Hepatoblastoma is part of the constellation of findings associated with the Beckwith-Wiedemann syndrome.[9] Loss of the allele of maternal origin at the 11p15.5 familial Beckwith-Wiedemann syndrome locus occurs in many hepatoblastomas.
		Chemotherapy has been much more successful in the treatment of hepatoblastoma than in hepatocellular carcinoma.[1-4] In recent years, virtually all children with hepatoblastoma have been treated with chemotherapy, and in some centers, even children with resectable hepatoblastoma are treated with preoperative chemotherapy, which may reduce the incidence of surgical complications at the time of resection.
	www.meds.com /pdq/childliver_pro.html (3698 words)

	Childhood Liver Cancer: (Site not responding. Last check: 2007-10-29)
		Hepatoblastoma is part of the constellation of findings associated with the Beckwith-Wiedemann syndrome or its variant, isolated hemihypertrophy.
		Histopathology and prognosis in childhood hepatoblastoma and hepatocarcinoma.
		In recent years, virtually all children with hepatoblastoma have been treated with chemotherapy, and in some centers, even children with resectable hepatoblastoma are treated with preoperative chemotherapy, which may reduce the incidence of surgical complications at the time of resection.
	www.acor.org /cnet/62836.html (6511 words)

	Hepatoblastoma - Overview
		Hepatoblastoma is a malignant (cancerous) tumour of the liver which usually occurs in young children.
		Hepatoblastoma is not associated with previous hepatitis, unlike hepatocellular carcinoma.
		There may be an increased risk of hepatoblastoma in children who have a family history of familial polyposis coli, or if the child has a condition called Beckwith-Wiedemann syndrome.
	www.royalmarsden.nhs.uk /RMH/cancer/paediatriccancers/hepatoblastoma (116 words)

	Hepatoblastoma
		Hepatoblastoma is a cancer of the liver that most commonly occurs in infants.
		The most common symptoms of hepatoblastoma in an infant or young child are a bulge in the upper right part of the abdomen and general failing health.
		Hepatoblastoma is treated with a combination of surgery and chemotherapy to remove as much of the tumor as possible and kill the cancer cells.
	www.hmc.psu.edu /childrens/healthinfo/h/hepatoblastoma.htm (529 words)

	Child Health Library - Oncology - Hepatoblastoma
		Hepatoblastoma is a very rare cancerous tumor that originates in the liver.
		Although the exact cause of liver cancer is unknown, there are a number of genetic conditions that are associated with an increased risk for developing hepatoblastoma, including Beckwith-Wiedemann syndrome, hemihypertrophy, and familial adenomatous polyposis.
		Treatment for hepatoblastoma is generally aimed at resecting (removing) as much of the tumor as possible while maintaining adequate liver function.
	www.chp.edu /greystone/oncology/hepato.php (992 words)

	Hepatoblastoma
		Hepatoblastoma is a very rare cancerous tumor that originates in the liver.
		Although the exact cause of liver cancer is unknown, there are a number of genetic conditions that are associated with an increased risk for developing hepatoblastoma, including Beckwith-Wiedemann syndrome, hemihypertrophy, and familial adenomatous polyposis.
		Treatment for hepatoblastoma is generally aimed at resecting (removing) as much of the tumor as possible while maintaining adequate liver function.
	www.healthsystem.virginia.edu /uvahealth/peds_oncology/hepato.cfm (1002 words)

	eMedicine - Hepatoblastoma : Article by Jennifer R Willert, MD
		Annual incidence of hepatoblastoma in infants younger than 1 year is 11.2 cases per million; in 1990-1995, annual incidence in children overall was 1.5 cases per million, which is almost double the incidence from 1975-1979.
		The remaining 44% of hepatoblastomas are mixed tumors containing primitive mesenchymal tissue and specialized derived components, such as myofibroblastic, chondroid, and osteoid tissues in addition to epithelial elements.
		Hepatoblastoma can be resected completely at diagnosis in approximately one third of patients, those with stage I or II disease.
	www.emedicine.com /ped/topic982.htm (8237 words)

	RedOrbit - Science - Mixed Hepatoblastoma in an Adult
		Hepatoblastoma accounts for approximately half of the malignant liver tumors in children, with most occurring before the age of 5 years." Adolescents or young adults are rarely affected, and in older individuals comparable tumors are extreme rarities.
		Hepatoblastoma is a tumor of newborn and young children and is extremely rare even in adolescents and young adults.
		They have been called mixedtype hepatoblastoma/ hepatic embryonal mixed tumor,13 or malignant mixed tumor of the liver.14 We believe that this case of a mixed hepatoblastoma in an adult should be added to the growing number of presumed hepatic precursor cell neoplasms in adults.
	www.redorbit.com /news/display/?id=127137 (2275 words)

	Liver Cancer Childhood
		Therefore, resection is possible more often in hepatoblastoma than hepatocellular carcinoma, in which less than 30% are resectable.[7] The majority of patients with either hepatoblastoma or hepatocellular carcinoma have a serum tumor marker, alpha-fetoprotein, that parallels disease activity.
		Therefore, widespread hepatitis B immunization may decrease the incidence of hepatocellular carcinoma.[22] Compared to adults, the incubation period from hepatitis virus infection to the genesis of hepatocellular carcinoma is extremely short in some children with perinatally acquired virus.
		Due to the poor prognosis in patients with hepatocellular carcinoma, liver transplant should be considered early in the course for disorders such as tyrosinemia and familial intrahepatic cholestasis prior to the development of liver failure and malignancy.
	www.medhelp.org /lib/cancernet/100963.htm (4393 words)

	Hepatoblastoma - My Child Has - Children's Hospital Boston
		Children who are exposed to hepatitis B infection at an early age, or those who have biliary atresia, are also at increased risk for developing hepatoblastoma.
		It is important to note that studies have shown that after removal of the tumor, including removal of a major segment of the liver, the liver has a remarkable capacity to regenerate or grow towards the normal volume that it had prior to removal.
		liver transplant - the liver of the child affected with hepatoblastoma may be replaced with a liver from a donor.
	www.childrenshospital.org /az/Site1014/mainpageS1014P0.html (1640 words)

	Childhood liver cancer (Site not responding. Last check: 2007-10-29)
		For children with hepatocellular carcinoma the overall five-year disease-free survival rate was approximately 60%.[11] In this group of patients vascular invasion, distant metastases, lymph node involvement, tumor size, and male gender were significant risk factors for recurrence.
		Cisplatin-based chemotherapy has resulted in a survival rate of greater than 90% for children with stage I and stage II disease.[1,2] Comparable results were obtained in an international study in which children were treated with doxorubicin/cisplatin chemotherapy prior to attempted resection of the liver tumor.
		The outcome for hepatoblastoma that is metastatic at diagnosis is not good, but cure is possible in 25% to 30% of patients.[1-4] In a recent study employing a well tolerated regimen of doxorubicin/cisplatin chemotherapy, over 50% of patients with metastases at presentation survived five years from diagnosis.
	www.meb.uni-bonn.de /Cancernet/100963.html (4625 words)

	Medical Dictionary: Hepatoblastoma - WrongDiagnosis.com
		Hepatoblastoma: Hepatoblastoma is a malignant liver neoplasm that occurs almost exclusively in infants, although isolated instances in older children and adults have been reported.
		Hepatoblastoma is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH).
		Hepatoblastoma : malignant liver neoplasm occurring in children and composed of tissue resembling fetal or mature liver cells or bile ducts.
	www.wrongdiagnosis.com /medical/hepatoblastoma.htm (327 words)

	Forrest -- A wonderful boy who had liver cancer (hepatoblastoma)
		Our son Forrest was born August 23, 1998, and like all new parents, my husband Peter and I couldn’t believe how deeply we could feel love until we were holding him in our arms.
		I was 2 months shy of my 40th birthday, Forrest was my first and only child and I was the happiest woman alive.
		This is not intended to be a comprehensive list of all cancer related sites-- we are trying to be somewhat selective to keep the list useable/effective.
	www.barscott.com /forrest (1747 words)

	Childhood liver cancer
		One large survey of liver tumors in children found that hepatoblastomas usually occur before 3 years of age, whereas hepatocellular carcinomas had two age-related incidence peaks, the first peak in children 0-4 years of age and the second in children 12-15 years of age.
		Lack of a significant decrease of alpha-fetoprotein levels with treatment may predict a poor response to therapy.[6] Absence of elevated alpha-fetoprotein may be a poor prognostic sign in hepatoblastoma; it is associated with the small-cell (anaplastic) histologic variant and responds very poorly to therapy.
		In approximately 75% of children with initially unresectable hepatoblastoma, the tumors can be rendered resectable using cisplatin-based preoperative chemotherapy, and 60%-65% will have disease-free survival.
	www.uoc.muni.cz /guidelines/1deti/LIVERCH.htm (2700 words)

	Hepatoblastoma Survivor Andres Peralta is Honored by Heidi Wolcott
		Andres was diagnosed with Hepatoblastoma in March of 2004 during a routine examination and subsequent hernia operation.
		He has inspired many with his courageous fight with Hepatoblastoma over the last year and is a shining light in the lives of many.
		Hepatoblastoma is the most common malignant liver tumor in early childhood.
	www.pressbox.co.uk /Detailed/20517.html (371 words)

	Hepatoblastoma (Site not responding. Last check: 2007-10-29)
		Hepatoblastoma is a form of liver cancer that usually occurs in infants.
		In contrast to hepatocellular carcinoma, prior hepatitis infection is not associated with an increased risk of hepatoblastoma.
		Unlike hepatocellular carcinoma, hepatoblastoma is usually sensitive to chemotherapy and with treatment the tumor will shrink enough to allow total resection.
	www.stjude.org /disease-summaries/0,2557,449_2167_7426,00.html (530 words)

	Liver cancer, childhood: Treatment - Health Professional Information [NCI PDQ] - Quest Diagnostics Patient Health ...
		Lack of a significant decrease of alpha-fetoprotein levels with treatment may predict a poor response to therapy.[15] Absence of elevated alpha-fetoprotein may be a poor prognostic sign in hepatoblastoma; it is associated with the small-cell (anaplastic) histologic variant, which responds very poorly to chemotherapy.
		This staging system is used to determine treatment.[1,2,3,4] Children diagnosed with stage I and stage II hepatoblastoma have a cure rate of greater than 90% compared with 60% for stage III and approximately 20% for stage IV.
		The outcome for hepatoblastoma that is metastatic at diagnosis is not good, but cure is possible in 25% to 30% of patients.[1,2,3,4] In a study employing a well-tolerated regimen of doxorubicin/cisplatin chemotherapy, over 50% of patients with metastases at presentation survived 5 years from diagnosis.
	www.questdiagnostics.com /kbase/nci/ncicdr0000062836.htm (5692 words)

	Clinical Trial: Hepatoblastoma Biology Study and Tissue Bank (Site not responding. Last check: 2007-10-29)
		Although tremendous improvement in the treatment of childhood cancer has resulted from the use of clinical trials, it is clear that additional significant progress will require a better understanding of the molecular makeup of pediatric malignancies.
		Hepatoblastoma, an embryonal tumor of the liver, is rare in the general population.
		Thus the occurrence of Hepatoblastoma suggests the need for both careful investigations into the family history of malignancies in relatives, as well as a search for genetic alterations that may contribute to tumor development.
	www.clinicaltrials.gov /ct/show/NCT00228683 (653 words)

	Childhood Liver Cancer: (Site not responding. Last check: 2007-10-29)
		There are two types of cancer that start in the liver (hepatoblastoma and hepatocellular cancer), based on how the cancer cells look under a microscope.
		Hepatoblastoma is more common in young children before age 3 and may be caused by an abnormal gene.
		Treatments for childhood liver cancer depend on the type (hepatoblastoma or hepatocellular carcinoma) and stage of your child's disease and your child's age and general health.
	www.acor.org /cnet/62682.html (2205 words)

	Thrombopoietin in Patients with Hepatoblastoma -- Komura et al. 16 (5): 329 -- Stem Cells
		Hepatoblastoma is the most common malignant liver tumor in childhood
		to the hypothesis that hepatoblastoma derives from a pluripotent
		Biological characteristics of human hepatoblastoma transplanted in nude mice.
	stemcells.alphamedpress.org /cgi/content/full/16/5/329 (1898 words)

	Hepatoblastoma definition - Medical Dictionary definitions of popular medical terms
		Hepatoblastoma occurs almost exclusively in young children, more commonly in boys than in girls.
		The diagnosis of hepatoblastoma is usually made after abdominal swelling (from liver enlargement caused by the tumor) is noticed.
		Although small tumors can sometimes be treated successfully with surgery, the prognosis with hepatoblastoma is generally poor.
	www.medterms.com /script/main/art.asp?articlekey=12669 (173 words)

	Childhood Liver Cancer Treatment - National Cancer Institute (Site not responding. Last check: 2007-10-29)
		Hepatoblastoma: A type of liver cancer that usually does not spread outside the liver.
		The type of liver cancer (hepatoblastoma or hepatocellular).
		Complete removal is possible more often for hepatoblastoma than for hepatocellular carcinoma.
	www.cancer.gov /cancerinfo/pdq/treatment/childliver/patient (1039 words)

	Hepatoblastoma
		This resource provides information on hepatoblastoma (rare tumours of the liver in children).
		It explains the investigations and types of treatment carried out (chemotherapy, radiotherapy and surgery), and describes the drugs used and their possible side effects.
		This video shows an infant with a large abdominal mass with a left hepatic hepatoblastoma.
	omni.ac.uk /browse/mesh/D018197.html (135 words)

	Hepatoblastoma
		Other genetic conditions associated with liver cancer include several inborn errors of metabolism such as tyrosinemia, glycogen storage disease type I, galactosemia and alpha1-antitrypsin deficiency.
		Anemia (pale skin and lips from decreased number of red blood cells).
		Stage I - usually a tumor that can be completely removed with surgery.
	www.chw.org /display/PPF/DocID/22008/router.asp (1053 words)

	Andres Peralta :: Hepatoblastoma :: Research & Funding Help
		Andres Peralta :: Hepatoblastoma :: Research and Funding Help
		Andres Miguel Peralta was diagnosed with Hepatoblastoma in March 2004.
		Andres underwent 6 rounds of Chemotherapy, 3 surgeries including a 50% liver resection and is doing great!
	baby.mperalta.com (71 words)

	Childhood liver cancer
		Bowman LC, Pediatric Oncology Group: Phase III Randomized Study of Postoperative Cisplatin, Vincristine, and Fluorouracil With or Without Amifostine Versus Carboplatin and Cisplatin With or Without Amifostine in Children With Hepatoblastoma (Summary Last Modified 03/2000), POG-9645, clinical trial, active, 03/15/1999.
		Studies in adults in China suggest that hepatic arterial chemoembolization before surgery may improve the outcome of subsequent hepatectomy.[7] (Refer to the PDQ summary on Adult Primary Liver Cancer Treatment for more information.)
		Several therapeutic options have produced successful outcomes in some adults with hepatocellular carcinoma, including cryosurgery, intratumoral injection of alcohol, radiotherapeutic approaches, and liver transplantation.[9-11] (Refer to the PDQ summary on Adult Primary Liver Cancer Treatment for more information.)
	cancerweb.ncl.ac.uk /cancernet/100963.html (4519 words)

	Peer Reviewed Pediatric Radiology Case : Pedrad :: Hepatoblastoma -- The peer reviewed Pediatric Radiology teaching ...
		Hepatoblastomas is a malignant embryonal mixed tumor, which derives from epithelial and/or mesechymal cellular elements.
		In increased alpha-fetoprotein in the blood and proof of a typical hepatic tumor in MRI, the diagnosis is relatively easy and there is no histological proof needed before starting chemotherapy.
		In good size reduction through chemotherapy and following complete surgical resection, the prognosis is very good.
	www.pedrad.info /?search=20041222171655 (669 words)

	ClinicalTrials.gov - Information on Clinical Trials and Human Research Studies: Browse: Hepatoblastoma (Site not responding. Last check: 2007-10-29)
		Conditions: Childhood Hepatoblastoma; Childhood Hepatocellular Carcinoma; Childhood Liver Cancer
		Intensive Neoadjuvant Chemotherapy in Treating Young Patients Undergoing Surgical Resection for High-Risk Hepatoblastoma
		Irinotecan in Treating Young Patients With Refractory or Recurrent Hepatoblastoma
	clinicaltrials.gov /ct/gui/action/FindCondition?ui=D018197&... (133 words)

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