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Topic: Hepatocarcinoma

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Hepatocellular carcinoma

	Hepatoblastoma and hepatocarcinoma in infancy and childhood: report of 47 cases
		Half of the patients who underwent resection, including the 3 who received therapeutic radiation, died; the remaining 9 patients were alive at the time of writing, 6 surviving 4-13 yr without evidence of recurrence or metastasis.
		All of the patients with hepatocarcinoma died, regardless of the form of therapy administered; the survival from onset to death varied from 2 wk to 2 yr.
		Seven of these hepatocarcinoma patients were given only supportive treatment, one was treated with multiple doses of colloidal 198Au, one was treated with cyclophosphamide, and three were treated by surgical resection.
	www.meb.uni-bonn.de /cgi-bin/mycite?ExtRef=ICDB/87638618 (287 words)

	[No title] (Site not responding. Last check: 2007-10-19)
		Further, chronic hepatic disorders including hepatic cirrhosis, chronic hepatitis, etc. have a relatively high tendency to develop hepatocarcinoma, regardless of hepatitis B and C. In addition, it has been known that the frequency to develop hepatocarcinoma from chronic hepatitis and hepatic cirrhosis may be 6-8 times increased by alcohol or smoking.
		The galenic preparation for treatment of hepatocarcinoma according to claim 1, wherein in the injectable composition (A) Hedyotidis herba, Curcumae longae rhizoma, Polygoni cuspidati radix and Sophorae tonkinesis radix are contained in the ratio of 2-10: 2-10: 2-10: 0.1-5 on the basis of dry weight of natural drugs.
		The galenic preparation for treatment of hepatocarcinoma according to claim 2, wherein in the injectable composition (A) Hedyotidis herba, Curcumae longae rhizoma, Polygoni cuspidati radix and Sophorae tonkinesis radix are contained in the ratio of 5: 5: 5: 2 on the basis of dry weight of natural drugs.
	www.wipo.int /cgi-pct/guest/getbykey5?KEY=99/22749.990514&ELEMENT_SET=DECL (6542 words)

	Hepatitis.org
		The mutant may be selected by host immune pressure, which may explain the higher percentage of mutants found in late infected children (65%) as compared to children contaminated at birth (37.5%), who have a higher immune tolerance towards the virus 18.
		However, cirrhosis and hepatocarcinoma are a reality for young adults, and vaccination has been shown to reduce this risk.
		Treatment with interferon or lamivudine yield an insufficient success rate, and very long term studies and new therapeutic tools are needed to convince paediatricians that children in the early stage of the disease may benefit from treatment.
	www.hepatitis.org /hepaetenfant_angl.htm (2845 words)

	BioMed Central \| Full text \| δ-Aminolevulinic acid cytotoxic effects on human hepatocarcinoma cell lines
		We have determined the impact of ALA on HEP G2 and HEP 3B hepatocarcinoma cell lines survival as measured by the MTT assay.
		Human hepatocarcinoma cells were treated with various concentrations (0.5–5 mM) of ALA and the viability of cells was determined (Figure 1).
		In summary, ALA has a markedly cytotoxic effect on hepatocarcinoma cell lines at physiological levels, which could be attributed to an enhancement of apoptosis, independent of p53 but due to inhibition of cell cycle regulators CDKs.
	www.biomedcentral.com /1471-2407/2/6 (3102 words)

	World J Gastroenterol
		METHODS: Human hepatocarcinoma cell line (SMMC-7721) was treated in vitro with 0.5mg/L tanshinone for 4 days, and variation in cell differentiation wasdetected.RESULTS The morphology of cancer cells was tended toward well differentiation and cell growth was markedly inhibited.
		We used transretinoic acids as positive control to study the reversing effect of tanshinone on malignant phenotypes of human hepatocarcinoma cells in cellular morphology, cellular properties of growth and proliferation, cell cycle and expression of oncogene.
		Human hepatocarcinoma cells were treated with non-cytotoxic dose of tanshinone.
	www.wjgnet.com /1007-9327/4/317.asp (1664 words)

	Directory of open access journals
		The objective of the present study was to investigate the multicellular resistance of human hepatocarcinoma cells BEL-7402 to pharmorubicin.
		The cells cultured as multicellular aggregates were resistant to pharmorubicin with IC50 4.5-fold and 7.7-fold that of monolayer culture as determined by flow cytometry and MTT assay, respectively.
		This three-dimensional culture model may be used to investigate the mechanisms of multicellular drug resistance of hepatocarcinoma and to screen new anticancer drugs.
	www.doaj.org /doaj?func=abstract&id=25101&recNo=15&toc=1 (215 words)

	HBPD INT
		This study was undertaken to assess therapeutic efficacy of transplantation of bone marrow mononuclear cells transferred with the mdr1 gene and over-dose chemotherapy with doxorubicin for VX2 hepatocarcinoma of rabbits.
		VX2 hepatocarcinoma cells could be killed rapidly and relapse and metastasis of the tumor could be prevented by over-dose chemotherapy.
		Hence over-dose chemotherapy is advisable to kill hepatocarcinoma cells, prevent relapse and metastasis, and increase the survival time and healing rate of rabbits.
	www.hbpdint.com /text.asp?id=892 (3520 words)

	Hepatocarcinoma definition - Medical Dictionary definitions of popular medical terms
		Hepatocarcinoma definition - Medical Dictionary definitions of popular medical terms
		Hepatocarcinoma: Carcinoma (a form of cancer) that originates in liver cells.
		Hepatocarcinoma is better known today as hepatocellular carcinoma.
	www.medterms.com /script/main/art.asp?articlekey=39872 (66 words)

	News - Intra-Arterial Folinic Acid and 5-Flurouracil Effective in Locally Advanced Hepatocarcinoma
		Hepatocarcinoma generally has a poor prognosis, and the optimal treatment of locally advanced hepatocarcinoma remains controversial.
		Transcatheter arterial chemoembolisation of hepatocarcinoma is widely used but has not been fully investigated.
		Roberto Mazzanti, MD, with the School of Medicine at the University of Florence, Italy, and colleagues wanted to determine whether intra-arterial chemotherapy with 5-flurouracil and folinic acid in locally advanced hepatocarcinoma is a viable alternative to existing therapies.
	www.docguide.com /news/content.nsf/news/8525697700573E1885256E87002B96C3 (497 words)

	WISH Research - The Inhibitory Effects of Qigong Emission on Transplanted Hepatocarcinoma In Mice (Site not responding. Last check: 2007-10-19)
		To transplant the hepatocarcinoma, each mouse was inoculated subcutaneously at right axilla with 0.2ml cell suspension.
		The morphological characteristics of the non-treated cancer cells included variation in the size and shape of cancer cells; enlarged and hyperchromatic nuclei with clumped hetero-chromatin; enlarged nucleoli; decreased cytoplasm, increased ratio of nucleus and cytoplasm.
		Given the fact that most people do not believe in the existence of Qi or effectiveness of Qigong in healing, and tend to consider the effects of Qigong mostly psychological, it is very important to minimize the potential psychological hint or placebo effect in a Qigong study.
	www.wishus.org /research.asp?cat=research&index=1 (714 words)

	Basqueresearch.com: News - Yttrium-90 to control hepatocarcinoma
		The treatment is complex and requires the close collaboration of the Departments of Nuclear Medicine, Conventional and Interventionist Radiology, Hepatology and Oncology.
		In the primary tumours of the liver, also called hepatocarcinomas, the results show that the treatment is very efficacious in preventing treated lesions from growing: it achieves control - not eradication – of the disease in over 90% of the cases, at times over quite prolonged periods.
		The technique incorporated at the University Hospital is particularly suitable for treating primary tumours of the liver (hepatocarcinomas) as well as secondary ones, above all, metastasis of cancer of the colon and endocrine tumours.
	www.basqueresearch.com /berria_irakurri.asp?Gelaxka=1_1&hizk=I&Berri_Kod=1000 (844 words)

	Histopathology and prognosis in childhood hepatoblastoma and hepatocarcinoma
		Histopathology and prognosis in childhood hepatoblastoma and hepatocarcinoma.
		To determine the relationship between outcome and histologic type, the authors examined data from 168 cases of hepatoblastoma (HB) and 28 cases of hepatocarcinoma (HC) accrued from children over a 14-year period.
		These observations may be important in designing future therapy for children with hepatic tumors.
	www.meb.uni-bonn.de /cgi-bin/mycite?ExtRef=MEDL/89336635 (188 words)

	The relationship among hepatocarcinoma and hepatitis C virus infection
		The relationship among hepatocarcinoma and hepatitis C virus infection
		The incidence of hepatocarcinoma (HCC) has increased in industrialized countries.
		The assessment methods for patients with chronic liver diseases allow those patients with high risk for HCC to be identified and the process to identify this tumor at an early stage to be initiated.
	www.imbiomed.com.mx /Gastro/Gav67Supl2/english/Zga02s2-11.html (138 words)

	Pro-Pharmaceuticals - Our Technology (Site not responding. Last check: 2007-10-19)
		Enhanced biorecognition and internalization of HPMA copolymers containing multiple or multivalent carbohydrate side-chains by human hepatocarcinoma cells.
		The relationship between the content of saccharide moieties and three-dimensional arrangement of galactose residues and their biorecognition and internalization by human hepatocarcinoma HepG2 cells was investigated.
		The results underline the potential of glycosylated HPMA copolymers for delivery of pharmaceutical agents to hepatocarcinoma cells.
	www.pro-pharmaceuticals.com /our_scie_lit02.htm (194 words)

	Directory of open access journals
		The chemotactic effect of the expression of plasmid pCH510 on immunocytes was observed after in vivo transfection, tissue slicing and HE staining.
		The change of function and amount of mouse peritoneal macrophages and the peripheral blood immunocytes resulted from administration of chemotherapeutic agents were detected.
		The peptides mixture was prepared from H22 hepatocarcinoma cells.
	www.doaj.org /doaj?func=abstract&id=91020&toc=y (450 words)

	Discovery Challenge 2004 Guide to the Hepatitis Data (Site not responding. Last check: 2007-10-19)
		Hepatitis B and C chronically inflame the hepatocyte, whereas hepatitis A acutely inflames it.
		Hepatitis B and C are especially important because they have a potential risk of developing liver cirrhosis or hepatocarcinoma.
		The typical course from chronic hepatitis to hepatocarcinoma via liver cirrhosis is mainly observed on the patients of hepatitis C, but the detailed mechanism of disease progression is not unraveled yet.
	lisp.vse.cz /challenge/ecmlpkdd2004/HEP04-description.htm (1655 words)

	Tyrosinemia Management (Site not responding. Last check: 2007-10-19)
		Among patients who do not die from their symptoms in early childhood, a chronic form of the disorder eventually leads to liver failure or hepatocarcinoma and death, usually before 10 years of age.
		This strategy of using NTBC plus dietary restriction of phenylalanine and tyrosine has allowed for greater than 90% survival, normal somatic growth, correction of renal tubular acidosis, improvement of liver function, and prevention of cirrhosis.
		With the use of NTBC, however, liver failure is prevented and hepatocarcinoma may be prevented as well.
	www.meadjohnson.com /metabolics/tyrosinemia.html (2057 words)

	HLA Class II Expression in Uninducible Hepatocarcinoma Cells After Transfection of AIR-1 Gene Product CIITA: ...
		Hepatocarcinomas, as their normal cell counterpart (25), do
		RT-PCR was conducted by using total cytoplasmic RNA prepared from the various cell lines listed in the top of the figure.
		Raji, human B cell lymphoma; Alex, Alexander human hepatocarcinoma; CFPAC-1, human pancreatic adenocarcinoma.
	www.jimmunol.org /cgi/content/full/161/2/814 (5426 words)

	The relationship among hepatocarcinoma and hepatitis C virus infection
		The relationship among hepatocarcinoma and hepatitis C virus infection
		The incidence of hepatocarcinoma (HCC) has increased in industrialized countries.
		The assessment methods for patients with chronic liver diseases allow those patients with high risk for HCC to be identified and the process to identify this tumor at an early stage to be initiated.
	www.imbiomed.com /Gastro/Gav67Supl2/english/Zga02s2-11.html (138 words)

	FDA 1997 Science Forum Poster Abstract: Sahu (Site not responding. Last check: 2007-10-19)
		A choline-deficient (CD) diet leads to liver dysfunction in humans and hepatocarcinoma in rats.
		The placental GST (GST-P), which is not found in the normal adult rat liver, is present in highly elevated levels in hepatic preneoplastic foci and hepatocarcinoma.
		This study was undertaken to investigate what effects, if any, the CD diet has on the hepatic antioxidants (GSH and GST), GST-P, and macromolecules (proteins and lipids).
	vm.cfsan.fda.gov /~frf/forum97/97b18.htm (207 words)

	Internal Medicine and Liver Unit
		Patient care is carried out in three different settings: the inpatient ward, the outpatient clinic, and the especial units.
		The main research areas of our group include, among others: viral hepatitis, hepatocarcinoma, portal hypertension, and hepatic encephalopathy.
		Outpatient clinic focussed in patients with acute and chronic hepatitis, portal hypertension, hepatic encephalopathy, hepatocarcinoma, and the selection of candidates for liver transplantation, and the follow-up of transplanted patients.
	www.vhebron.es /mihep/apres.htm (202 words)

	HBPD INT
		Decection of autoantibodies in the serum of primary hepatocarcinoma; autoantibody; anti-nuclear antibody
		Objective: To study the significance of detecting autoantibodies in primary hepatocarcinoma (PHC) patients.
		The diversity of autoantibodies might result from a wide variety of etiological factors involved in PHC development, and from a wide variety of overexpressed or mutated proteins involved in repeated cycles of necrosis and regeneration in hepatocarcinoma development.
	www.hbpdint.com /text.asp?id=638 (734 words)

	Poster 325 - Inhibition of HBpreS2 by antisense RNA in hepatocarcinoma cells via EGFR mediated gene transfer system (Site not responding. Last check: 2007-10-19)
		HBV integrated hepatocarcinoma cells HepG2.2.15 were transfected by EGF receptor mediated gene transfer system, which was administered subcutaneously to nude mice.
		After Hygromycin B selection, the growth rate, colony forming ability, the expression of hTERT and HBsAg, HBeAg and the DNA contents of transfectants in S-phase and G2/M-phase were significantly suppressed in comparison with that of the parental cell line.
		The results demonstrated that the HBpreS2 antisense RNA could be successfully expressed only in hepatocarcinoma via this system and markedly suppress the growth of human liver tumor in nude mice.
	hgm2002.hgu.mrc.ac.uk /Abstracts/Publish/WorkshopPosters/WorkshopPoster07/hgm0325.htm (341 words)

	Antisense therapy for hepatocarcinoma
		AIM: Human Hepatocarcinoma (HCC) is the most frequent cancer of the liver.
		RESULTS: After selection with hygromycin whose resistant gene is harbored by the vector, we have isolated two cell lines which became poorly tumorigenic and are able to inhibit in vivo the growth of parental tumoral cells and/or to induce the regression of established tumors in the animal.
		CONCLUSIONS: The transfected hepatocarcinoma cells which do not produce IGF I induce in vivo a tumor immunity mediated by CD8 T. Furthermore, the expression of MHC class I was increased at last four fold as compared to parental cells.
	www.cancerprev.org /Journal/Issues/20/5/505/1551 (308 words)

	Untitled (Site not responding. Last check: 2007-10-19)
		The liver, the greatest organ in the body, plays a vital role in regulating life processes.
		These products can effectively prevent the development of hepatic diseases, for example, prevent the metastasis of hepatitis, fatty liver and hepatic cirrhosis into hepatocarcinoma and treatment of this by combined administration of two kinds of the composition.
		As synergism effect will be proved by selective combination of natural herbal sources, so UKG is safe and suitable for long term therapy in chronic hepatic disease.
	members.fortunecity.com /happyysg/ukg2.html (322 words)

	vgn-ext-hidden_Abstract (Site not responding. Last check: 2007-10-19)
		Efficacy of oxaliplatin and 5-fluorouracil in advanced hepatocarcinoma.
		Background: Hepatocarcinoma (HCC) is one of the commonest malignancies worldwide.
		Advanced HCC represents one of the most frustrating issue, when further loco-regional therapy is not available for tumor extension, major blood vessel thrombosis or poor liver function.
	www.asco.org /portal/site/ASCO/menuitem.34d60f5624ba07fd506fe310ee37a01d/?vgnextoid=76f8201eb61a7010VgnVCM100000ed730ad1RCRD&vmview=abst_detail_view&confID=40&index=y&abstractID=30355 (690 words)

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