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Topic: Hepatosplenomegaly

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	eMedicine - Niemann-Pick Disease : Article by Margaret McGovern, MD, PhD
		The original description of NPD referred to what is currently termed NPD type A, which is a fatal disorder of infancy characterized by failure to thrive, hepatosplenomegaly, and a rapidly progressive neurodegenerative course that leads to death by age 2-3 years.
		NPD type A: The clinical presentation and course of type A is relatively uniform and is characterized by normal appearance at birth.
		In most patients, hepatosplenomegaly is particularly prominent in childhood; however, with increasing linear growth, the abdominal protuberance decreases and becomes less conspicuous.
	www.emedicine.com /ped/topic2889.htm (2022 words)

	s000913b - Hepatosplenomegaly, Thrombocytopenia, Fever
		Anerythremic form of acute erythremic myelosis (Di Guglielmo's syndrome) causing hepatosplenomegaly due to the infiltration of hemoglobin-bearing blast cells: an autopsy case.
		Hepatosplenomegaly, lymphnode swelling in abdominal cavity, pleural effusion and pericardial effusion were detected.
		The common clinical fetures of the disease were: fever (94%), headache (85%), hepatosplenomegaly (74%), body and joint pains (66%), abdominal pain and tenderness (63%), jaundice (46%) and epistaxis (40%).
	www.emory.edu /WHSCL/grady/amreport/litsrch00/s000913b.html (5449 words)

	GlycoWord / Glycopathology-A05
		Hepatosplenomegaly occurs in all forms of the disease.
		The former is an early-onset severe type associated with a rapidly progressive neurological disorder and hepatosplenomegaly.
		The latter is a phenotypically heterogeneous disorder, although many patients with this type are diagnosed in infancy or childhood based on the presence of hepatosplenomegaly.
	www.glycoforum.gr.jp /science/word/glycopathology/GD-A05E.html (1592 words)

	Cecil Textbook of Medicine : />
		Hepatosplenomegaly, jaundice, and often a truncal petechial rash are common signs in louse-borne relapsing fever.
		Neonatal infection presents in both the tick- and louse-borne forms with jaundice, hepatosplenomegaly, and often sepsis and hemorrhage.
		Fever and hepatosplenomegaly are also common signs in children.
	www.merckmedicus.com /ppdocs/us/common/cecils/chapters/351_006.htm (150 words)

	Exposure to malaria affects the regression of hepatosplenomegaly after treatment for Schistosoma mansoni ...
		Severely enlarged and hard organs may be an indicator of increased portal pressure, as well as pointing to an increased risk of portal hypertension and its sequelae, including oesophageal varices and haematemesis 1.
		One prevailing suggestion has been that hepatosplenomegaly amongst younger children is attributable to malaria infection, whereas older children have acquired some level of immunity to malaria and hence if they do have hepatosplenomegaly it is likely to be attributable to schistosomiasis 6.
		infection and hepatosplenomegaly compared with children with infection but no hepatosplenomegaly 11, further implicating exposure to malaria in childhood as a risk factor for severe hepatosplenic morbidity.
	www.biomedcentral.com /content/xml/1741-7015-2-36.xml (4446 words)

	Revista do Instituto de Medicina Tropical de São Paulo - EXPERIENCE IN THE EVALUATION OF CHILDREN WITH ... (Site not responding. Last check: 2007-11-02)
		Sixty four children (71.9%) were referred by other services for hepatosplenomegaly investigation and/or follow-up and 25 (28.1%) presented liver and/or spleen enlargement detected during the physical examination, on admission, of children registered for other disorders.
		Hepatosplenomegaly can lead to hypersplenism, causing anemia and thrombocytopenia, and this diagnosis should be suspected in children with persistent hepatosplenomegaly and unexplained anemia
		Hepatosplenomegaly is not common in cases of Wilms' tumor, these are often asymptomatic and present as an abdominal mass often discovered on routine examination or by parents, even though the child does not generally appear to be ill
	www.scielo.br /scielo.php?script=sci_arttext&pid=S0036-46651998000500001&lng=es&nrm=iso&tlng=en (4453 words)

	Does anyone know anything about hepatosplenomegaly? - Page 2 - LI Islamic Forum (Site not responding. Last check: 2007-11-02)
		Hepatosplenomegaly = enlargement of the liver and spleen.
		The liver is somewhat enlarged and may be "felt" during physical exam while the enlargement of the spleen (a place designed to get rid of our old red blood cells) can sometimes be felt during exam or during X-Ray.
		Hepatosplenomegaly means ur liver and spleen is enlarged, it can be due to various causes as mentioned by another member.
	www.islamicboard.com /health-science/19547-does-anyone-know-anything-about-hepatosplenomegaly-2.html (613 words)

	Patho-India - Case discussions
		He was found to have pancytopenia and hepatosplenomegaly.
		Mild hepatosplenomegaly, moderate anemia and a raised ESR were other notable findings.
		FNAB was done from the lytic lesion in the skull and from the sternal swelling, which showed similar features.
	www.pathoindia.com /telearc.html (979 words)

	Lipids Online Slides: tonsil, Tangier disease, hepatosplenomegaly
		Clinically, patients have yellow-orange tonsils, peripheral neuropathy, and hepatosplenomegaly thought to be related to the accumulation of cholesteryl esters in body tissues and macrophages.
		Sitosterolemia is an inherited autosomal recessive disorder resulting from a defect in enterocyte ABCG5 and/or ABCG8, responsible for the transport of intestinally absorbed cholesterol and plant sterols/stanols back to the intestinal lumen.
		Cholesterol accumulation in the reticuloendothelial system results in enlarged orange tonsils and hepatosplenomegaly.
	www.lipidsonline.org /slides/slide01.cfm?q=tonsil (450 words)

	WOLMAN'S DISEASE: THE KING FAISAL SPECIALIST HOSPITAL
		She had continuous vomiting and greasy stools from birth, with gradual abdominal distention, severe anemia, thrombocytopenia, shortness of breath and repeated chest infections, for which she was worked up for cystic fibrosis and malabsorption syndromes.
		Two maternal cousins died of the same disease with hepatosplenomegaly at the age of four and six months.
		Varying degrees of ascites, hepatosplenomegaly and lymph node enlargement were observed.
	www.kfshrc.edu.sa /annals/182/97-264.html (2560 words)

	Infotrieve Online
		Takayasu's arteritis in prepulseless stage manifesting lymph node swelling and hepatosplenomegaly.
		Biopsy specimens of the liver and lymph node disclosed nonspecific inflammation.
		Takayasu's arteritis is rarely manifested by hepatosplenomegaly and lymphadenopathy in its prepulseless stage.
	www4.infotrieve.com /newmedline/detail.asp?NameID=7647421&Session=&searchQuery=Chikatsu&count=18 (126 words)

	Hepatosplenomegaly - Karr.net (Site not responding. Last check: 2007-11-02)
		Looking For hepatosplenomegaly - Find hepatosplenomegaly and more at Lycos Search.
		Still searching for hepatosplenomegaly - We have the best sites for hepatosplenomegaly.
		Top hepatosplenomegaly Sites - The best of the best sites for your hepatosplenomegaly on the web.
	209.197.127.220 /encyclopedia/Hepatosplenomegaly (133 words)

	AEGiS-MMWR: Unexplained Immunodeficiency and Opportunistic Infections in Infants -- New York, New Jersey, California
		At 4 months, hepatosplenomegaly was observed, and at 7 months, he had staphylococcal impetigo.
		She responded to antifungal therapy, but at 5 months, candidiasis recurred, and she had hepatosplenomegaly.
		Clinical features seen in these 12 infants include: failure to thrive (83%), oral candidiasis (50%), hepatosplenomegaly (92%), generalized lymphadenopathy (92%), and chronic pneumonitis without a demonstrable infection (83%).
	www.aegis.com /PUBS/mmwr/1982/MM3149.html (1684 words)

	Bombay Hospital Journal - Original / Research (Site not responding. Last check: 2007-11-02)
		Hepatosplenomegaly was found in 40.32% of P vivax and 27.83% P falciparum malaria compared to 29.33% in smear negative cases (Table 1).
		In cases of fever with Hepatosplenomegaly, with or without dysfunction, malaria remains an important diagnosis to be excluded.
		Maximum incidence was seen in cases of Falciparum in the 0-1 year age group with splenomegaly - 70%, hepatomegaly - 44%, hepatosplenomegaly - 15% compared to 1-5 year age group which had splenomegaly - 20%, hepatomegaly - 0%, hepatosplenomegaly - 58%.
	www.bhj.org /journal/2005_4703_july/html/original_hepatic_225.htm (1995 words)

	Niemann-Pick disease - Genetics Home Reference
		This disorder is divided into four main types based on the genetic cause and the signs and symptoms exhibited by the patient.
		Type A Niemann-Pick disease begins during infancy and is characterized by an enlarged liver and spleen (hepatosplenomegaly), failure to thrive, and progressive deterioration of the nervous system.
		Type B disease may include signs of hepatosplenomegaly, growth retardation, and problems with lung function including frequent lung infections.
	ghr.nlm.nih.gov /condition=niemannpickdisease (891 words)

	Medical Symptom: Hepatosplenomegaly - CureResearch.com
		Hepatosplenomegaly: Hepatosplenomegaly is listed as an alternate name or description for symptom Enlarged liver and spleen.
		For a medical symptom description of 'Hepatosplenomegaly', the following symptom information may be relevant to the symptoms: Enlarged liver and spleen (symptom).
		However, note that other causes of the symptom 'Hepatosplenomegaly' may be possible.
	www.cureresearch.com /symptom/hepatosplenomegaly.htm (253 words)

	Toxocariasis (Site not responding. Last check: 2007-11-02)
		Symptoms are fever, anorexia, hepatosplenomegaly, rash, pneumonitis, asthma, or visual impairment.
		Visceral larva migrans (VLM) consists of fever, anorexia, hepatosplenomegaly, rash, pneumonitis, and asthmatic symptoms, depending on the affected organs.
		Tissue damage is caused by focal eosinophilic granulomatous reactions to the migrating larvae.
	www.tripdatabase.com /spider.html?itemid=311987 (451 words)

	Reference.com/Encyclopedia/Niemann-Pick disease
		Genetic counseling and genetic testing is recommended for families who may be carriers of Niemann-Pick.
		Type A Niemann-Pick disease begins during infancy and is characterized by an enlarged liver and spleen (hepatosplenomegaly), failure to thrive, and progressive deterioration of the nervous system.
		Type B disease may include signs of hepatosplenomegaly, growth retardation, and problems with lung function including frequent lung infections.
	www.reference.com /browse/wiki/Niemann-Pick_disease (801 words)

	Arch Pediatr Adolesc Med -- Fever, Hepatosplenomegaly, and Pancytopenia in a 5-Month-Old Infant, February 2003, Kane et ...
		Arch Pediatr Adolesc Med -- Fever, Hepatosplenomegaly, and Pancytopenia in a 5-Month-Old Infant, February 2003, Kane et al.
		Fever, Hepatosplenomegaly, and Pancytopenia in a 5-Month-Old Infant
		Hepatosplenomegaly in a young child can be an ominous physical
	archpedi.ama-assn.org /cgi/content/extract/157/2/201 (165 words)

	Hepatosplenomegaly Courses from MediaLab, Inc. (Site not responding. Last check: 2007-11-02)
		The background condition in Alder-Reilly syndrome is mucopolysaccharidosis with various types of bone and cartilage disorders, reported first in gargoylism, then in Hunter and Hurler syndromes.
		Accompanying conditions are hepatosplenomegaly, corneal opacities, and mental retardation.
		An accelerated lymphoma-like phase occurs, with lymphadenopathy, hepatosplenomegaly, and pancytopenia.
	www.medialabinc.net /keyword-details.asp?keyword=hepatosplenomegaly&courseid=970 (349 words)

	Congenital and Perinatal Cytomegalovirus Infection (CMV): Infections in Neonates: Merck Manual Professional
		Signs at birth, if present, are intrauterine growth restriction, prematurity, microcephaly, jaundice, petechiae, hepatosplenomegaly, periventricular calcifications, chorioretinitis, and pneumonitis.
		Later in infancy, signs are pneumonia, hepatosplenomegaly, hepatitis, thrombocytopenia, and atypical lymphocytosis.
		Infants who acquire CMV after birth may develop pneumonia, hepatosplenomegaly, hepatitis, thrombocytopenia, and atypical lymphocytosis, especially if they are premature.
	www.merck.com /mmpe/print/sec19/ch279/ch279b.html (616 words)

	Lysosomal Storage Disorders: Inherited Disorders of Metabolism: Merck Manual Professional
		Symptoms and signs vary by type but are most commonly hepatosplenomegaly or CNS changes.
		The disease is characterized by hepatosplenomegaly, failure to thrive, and rapidly progressive neurodegeneration.
		These are rare, autosomal recessive disorders that result in accumulation of cholesteryl esters and triglycerides, mainly in lysosomes of histiocytes, resulting in foam cells in the liver, spleen, lymph nodes, and other tissues.
	www.merck.com /mmpe/print/sec19/ch296/ch296f.html (1858 words)

	Niemann Pick Disease
		Abnormal enlargement of the liver and spleen (hepatosplenomegaly) occurs in all types of this disorder, but the severity of the symptoms varies greatly.
		Between the ages of six months to 12 months, low levels of the enzyme sphingomyelinase results in the abnormal enlargement of the liver and spleen (hepatosplenomegaly) and abnormalities of the nervous system.
		Symptoms may include a moderately enlarged liver and spleen (hepatosplenomegaly), a yellowish discoloration of the skin, eyes, and/or mucous membranes (jaundice), progressive impairment of voluntary muscle movements (psychomotor dysfunction), seizures, and/or tremors.
	hw.healthdialog.com /kbase/nord/nord93.htm (3364 words)

	prematuros
		On neurological examination, higher functions bone and power were normal though deep tendon reflexes were brisk.
		In view of multifocal convulsions, hepatosplenomegaly and intracranial calcifications, congenital infection was suspected, A differential diagnosis of hyperparathyroidism and AICARDI CONTRI syndrome was also considered.
		Findings include petechiae or purpura, hepatosplenomegaly, jaundice and “blue berry muffin spots” consistent with extra medullary hematopoiesis.
	www.prematuros.cl /weboctubre/infeccioncongenita/citomegalovirus.html (770 words)

	MEDLINE_1966-1995 - Resultado de la búsqueda <página 1>
		The present study was designed to examine the relationship between the development of schistosomal hepatosplenomegaly in Egyptian school children and the HLA antigens.
		Two groups of schistosome-infected children with similar fecal egg counts were examined: one group (23 children) had no clinically demonstrable hepatosplenomegaly whereas all the children (28) in the second group suffered from liver enlargement.
		Our results show that hepatosplenomegaly was related to the presence of two HLA antigens: HLA AI and B5.
	www.bireme.br /cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&nextAction=lnk&base=MEDLINE_1966-1995&exprSearch=479601&indexSearch=UI&lang=e (201 words)

	Directory of open access journals
		A case of nasopharyngeal carcinoma with hepatosplenomegaly, generalized lymphadenopathy and high fever
		In this case report, a 33 year-old female patient with high fever, lymphadenopathy and hepatosplenomegaly which continued for two years was presented.
		Due to the rare prevelance of high fever and hepatosplenomegaly in non-metastatic nasopharyngeal carcinoma, the present case is evaluated in the light of the literature.
	www.doaj.org /abstract?id=172795&toc=y (111 words)

	2007 ICD-9-CM Diagnosis 272.7 - Lipidoses
		Type B (non-neuronopathic form) presents in childhood with hepatosplenomegaly and pulmonary infiltrates.
		Type C (chronic neuronopathic form) is caused by defective intracellular cholesterol transport and is divided into severe infantile, late infantile, juvenile, and neonatal hepatitis forms.
		The most common subtype is the non-neuronopathic form, a slowly progressive condition characterized by hepatosplenomegaly and skeletal deformities.
	www.icd9data.com /getICD9Code.ashx?icd9=272.7 (468 words)

	WHAT'S YOUR DIAGNOSIS?
		He had developed abdominal distention and hepatosplenomegaly at two months of age.
		X-linked lymphoproliferative disease may have hepatosplenomegaly and pancytopenia resembling the accelerated phase of CHS.
		It is characterized by fever, jaundice, hepatosplenomegaly, lymphadenopathy, pancytopenia (due to hypersplenism), hyperferritinemia and hypertriglyceri-demia (which are commonly associated with the general inflammatory condition, although the exact pathophysiological mechanism is not fully understood),
	www.kfshrc.edu.sa /annals/192/98-178Q.html (780 words)

	vgn-ext-hidden_PubMed (Site not responding. Last check: 2007-11-02)
		A healthy 44-year-old man presented with upper abdominal pain, hepatosplenomegaly, thrombocytopenia, elevated AST, ALT and bilirubin, and marked elevation of lactate dehydrogenase and alkaline phosphatase.
		The abdominal CT scan showed only diffuse hepatosplenomegaly and uneven contrast enhancement of the spleen without any definite mass of the liver and spleen.
		Even in the absence of a mass lesion or lymphadenopathy, primary hepatic or hepatosplenic lymphoma should be considered in differential diagnosis of hepatitis or liver cirrhosis, especially for patients with diffuse hepatosplenomegaly and markedly elevated LDH.
	www.plwc.org /portal/site/ASCO/menuitem.a3fb42726842a82627c4c291ee37a01d/?vgnextoid=d70b3608f9958010VgnVCM100000f2730ad1RCRD&index=n&pmid=16177555 (229 words)

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