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Topic: Hereditary nonpolyposis colorectal cancer

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	Hereditary nonpolyposis colorectal cancer - Genetics Home Reference
		Hereditary nonpolyposis colorectal cancer, often called HNPCC or Lynch syndrome, is a type of inherited cancer of the digestive tract, particularly the colon (large intestine) and rectum.
		Hereditary nonpolyposis colorectal cancer is responsible for approximately 2 percent to 7 percent of all diagnosed cases of colorectal cancer.
		Hereditary nonpolyposis colorectal cancer risk is inherited in an autosomal dominant pattern, which means one inherited copy of the altered gene is sufficient to increase cancer risk.
	ghr.nlm.nih.gov /condition=hereditarynonpolyposiscolorectalcancer (662 words)

	Hereditary nonpolyposis colorectal cancer - Wikipedia, the free encyclopedia
		Hereditary nonpolypsis colorectal cancer (HNPCC) is characterized by an increased risk of colon cancer and other cancers such as endometrium, ovary, stomach, small intestine, hepatobiliary tract, upper urinary tract, brain, and skin.
		HNPCC-associated ovarian cancers have an average age of diagnosis of 42.5 years-old; approximately 30% are diagnosed before age 40 years.
		Other HNPCC-related cancers have been reported with specific features: the urinary tract cancers are transitional carcinoma of the ureter and renal pelvis; small bowel cancers occur most commonly in the duodenum and jejunum; the central nervous system tumor most often seen is glioblastoma.
	en.wikipedia.org /wiki/Hereditary_nonpolyposis_colorectal_cancer (530 words)

	Colorectal Cancer: Risk Factors and Recommendations for Early Detection - June 1999 - American Academy of Family ...
		The ability of colonoscopy to reduce deaths from colorectal cancer has been demonstrated indirectly through studies showing that the detection and removal of polyps reduces the incidence of colorectal cancer and that the detection of early cancers lowers the mortality rate for this malignancy.
		Patients who have a second-degree relative with colorectal cancer or a relative with adenomatous polyps diagnosed after the age of 60 years can be screened in accordance with the recommendations for persons at average risk.
		Colorectal cancer has not received much publicity, even though it is the second leading cause of cancer-related deaths in this country and even though it has a well-defined, identifiable and treatable precursor lesion--the adenomatous polyp.
	www.aafp.org /afp/990600ap/3083.html (4654 words)

	hMLH1 and hMSH2 Gene Mutation in Brazilian Families With Suspected Hereditary Nonpolyposis Colorectal Cancer -- Rossi ...
		Predominant germ-line mutation of the hMSH2 and hMLH1 gene in Japanese hereditary non-polyposis colorectal cancer kindreds.
		Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer.
		Germ-line mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer.
	www.annalssurgicaloncology.org /cgi/content/full/9/6/555 (3353 words)

	Sloan-Kettering - Hereditary Cancer & Genetics: Colon Cancer, Hereditary
		A person who is diagnosed with colorectal cancer and who has a family history of the disease is more likely to have inherited a cancer gene than is a person with no family history of colorectal cancer.
		Though colorectal cancer is the most common malignancy reported in families with HNPCC, the syndrome is also associated with an increased risk for cancers of the uterus, ovaries, stomach, small intestine, biliary system, pancreas, and urinary tract.
		It is not an absolute indication of a germline mutation in one of a mutation because RER positive tumors arise sporadically (in the absence of family history or germline mutation) in ~15 percent of colorectal cancers.
	www.mskcc.org /mskcc/html/8624.cfm (2647 words)

	Scientific Articles: Hereditary Nonpolyposis Colorectal Cancer (Site not responding. Last check: 2007-10-15)
		Molecular genetic evidence of the occurrence of breast cancer as an integral tumor in patients with the hereditary nonpolyposis colorectal carcinoma syndrome.
		Chromosome 2p linkage analysis in hereditary non-polyposis colon cancer J Gastroenterol Hepatol 10, 76-80.
		Hereditary nonpolyposis colon cancer: analysis of linkage to 2p15-16 places the COCA1 locus telomeric to D2S123 and reveals genetic heterogeneity in seven Canadian families.
	www.csu.edu.au /learning/ncgr/gpi/odyssey/colon/hnpcc_at.html (764 words)

	Genetics of Colorectal Cancer: (Site not responding. Last check: 2007-10-15)
		Two kinds of observations indicate a genetic contribution to colorectal cancer risk: (1) increased incidence of colorectal cancer among persons with a family history of colorectal cancer; and (2) families in which multiple family members are affected with colorectal cancer, in a pattern indicating autosomal dominant inheritance of cancer susceptibility.
		Colorectal tumors present with a broad spectrum of neoplasms, ranging from benign growths to invasive cancer and are predominantly epithelial derived tumors (i.e., adenomas or adenocarcinomas).
		Mitotic instability of microsatellites is the hallmark of MSI cancers.
	www.acor.org /cnet/62863.html (8309 words)

	Unusual tumors associated with the hereditary nonpolyposis colorectal cancer syndrome (Site not responding. Last check: 2007-10-15)
		Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant genetic disorder characterized by early onset colorectal carcinoma.
		For cancers that are common in the general population, such as breast cancer and prostate cancer, it is difficult to prove that these tumors are related to the molecular defect in HNPCC.
		Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer.
	www.nature.com /modpathol/journal/v17/n8/full/3800150a.html (4087 words)

	Thomas Jefferson University Hospital - Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
		The other 40 percent do not; and although their colorectal cancer rate is higher than normal (about two times), it is not as high as that of people with HNPCC (about six times).
		These are endometrial cancers, ovarian cancers, small bowel cancers, or cancer of the lining of the kidney or the ureters.
		Because several types of cancer can be associated with inherited colorectal cancer syndromes, all people should check their family medical history for polyps or any type of cancer.
	www.jeffersonhospital.org /cancer/article3094.html (736 words)

	Colon Cancer \| CancerBiopsies (Site not responding. Last check: 2007-10-15)
		Pre-malignant adenomas and cancers shed DNA markers from their cells which are not degraded during the digestive process and remain stable in the stool.
		Cancers on the right side (ascending colon and cecum) tend to be exophytic, that is, the tumour grows outwards from one location in the bowel wall.
		Colorectal cancer is a disease originating from the epithelial cells lining the gastrointestinal tract.
	www.cancerbiopsies.com /colon-cancer/colon-cancer.htm (3300 words)

	vgn-ext-hidden_Abstract (Site not responding. Last check: 2007-10-15)
		Background: Hereditary nonpolyposis colorectal cancer (HNPCC) is a genetic predisposition syndrome characterized by the early-onset, familial segregation of colorectal, endometrial, ovarian, small bowel, and urinary tract cancer.
		Conclusions: Malignant fibrous histiocytoma is an integral tumor of hereditary nonpolyposis colorectal cancer.
		BAX and caspase-5 frameshift mutations and spontaneous apoptosis in colorectal cancer with microsatellite instability.
	www.asco.org /ac/1,1003,_12-002636-00_18-0023-00_19-00103517,00.asp (677 words)

	Benefits of Colonoscopic Surveillance and Prophylactic Colectomy in Patients with Hereditary Nonpolyposis Colorectal ...
		cancer have a first-degree relative with the disease [2,3].
		0.89 for proctocolectomy, and 0.56 for distant colorectal cancer.
		Adenomas are the precursor lesions for malignant growth in nonpolyposis hereditary carcinoma of the colon and rectum.
	www.annals.org /cgi/content/full/129/10/787 (5034 words)

	genome.gov \| Learning About Colon Cancer
		These hereditary cancers typically occur at an earlier age than sporadic (non-inherited) cases of colon cancer.
		Other genes that cause susceptibility to colon cancer are harder to discover because the cancers are caused by an interplay among a number of genes, which individually exert a weak effect.
		Because of the limitations of available tests for hereditary colon cancer, testing is not recommended for the general population.
	www.genome.gov /10000466 (779 words)

	Lynch Syndromes,Hereditary Nonpolyposis Colorectal Cancer,Lynch Syndrome I,Lynch Syndrome II,Hereditary Nonpolyposis ... (Site not responding. Last check: 2007-10-15)
		The Lynch Syndromes are rare hereditary disorders that usually cause cancer to develop either in the colorectal area or in other sites.
		Primary cancers may develop in the female genital tract, stomach, brain, breasts, or urological system.
		The cancers of the colorectal area associated with the Lynch Syndromes usually develop at a younger age than is normally found in other persons with colorectal cancer.
	www.icomm.ca /geneinfo/lynch.htm (161 words)

	Exclusion of Breast Cancer as an Integral Tumor of Hereditary Nonpolyposis Colorectal Cancer -- Müller et al. 62 ...
		Exclusion of Breast Cancer as an Integral Tumor of Hereditary Nonpolyposis Colorectal Cancer -- Müller et al.
		Vasen H. F., Morreau H., Nortier J. Is breast cancer part of the tumor spectrum of hereditary nonpolyposis colorectal cancer?.
		-methylguanine DNA methyltransferase characterizes a subset of colorectal cancer with low-level DNA microsatellite instability.
	cancerres.aacrjournals.org /cgi/content/full/62/4/1014 (4323 words)

	Colorectal cancer - WrongDiagnosis.com
		Colorectal cancer refers to cancer of the colon (bowel) or cancer of the rectum, depending on the region affected.
		Colorectal adenocarcinoma can be divided in three grades: Grade I (low grade or well-differentiated), grade II (average grade or moderately differentiated) and grade III (poorly differentiated).
		The prognosis of Colorectal cancer may include the duration of Colorectal cancer, chances of complications of Colorectal cancer, probable outcomes, prospects for recovery, recovery period for Colorectal cancer, survival rates, death rates, and other outcome possibilities in the overall prognosis of Colorectal cancer.
	www.wrongdiagnosis.com /c/colorectal/intro.htm (1301 words)

	Featured Articles
		Patients with Lynch Syndrome, or hereditary nonpolyposis colorectal cancer (HNPCC), are typically diagnosed with colorectal cancer at a younger age
		Frequency of familial colon cancer and hereditary nonpolyposis colorectal cancer (Lynch syndrome) in a large population database.
		Results: Of the 6628 colorectal cancer cases in the population database, 1626 (24.5%) were diagnosed under the age of 50 or belonged to a first-degree relative pair.
	www.myriadtests.com /provider/feature.htm (304 words)

	vgn-ext-hidden_PubMed (Site not responding. Last check: 2007-10-15)
		Gynecologic cancer as a "sentinel cancer" for women with hereditary nonpolyposis colorectal cancer syndrome.
		OBJECTIVE: Women with hereditary nonpolyposis colorectal cancer syndrome have a 40-60% lifetime risk for colon cancer, a 40-60% lifetime risk for endometrial cancer, and a 12% lifetime risk for ovarian cancer.
		CONCLUSION: In this large series of women with hereditary nonpolyposis colorectal cancer syndrome who developed 2 primary colorectal/gynecologic cancers, endometrial cancer/ovarian cancer was the "sentinel cancer," preceding the development of colon cancer, in half of the cases.
	www.plwc.org /portal/site/ASCO/menuitem.a3fb42726842a82627c4c291ee37a01d/?vgnextoid=d70b3608f9958010VgnVCM100000f2730ad1RCRD&index=n&pmid=15738026 (329 words)

	MACGN - Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
		Nonpolyposis means that colorectal cancer can occur when only a small number of polyps is present (or polyps are not present at all).
		It deals with hereditary colon cancer and polyposis and is free to all individuals with these conditions and their families.
		The Cancer Information Service is a national toll-free telephone inquiry system that provides information about cancer and cancer-related resources to the general public, patients and their families, as well as health professionals.
	www.macgn.org /cc_hnpcc1.html (3618 words)

	the GASTROLAB Image Gallery: Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
		It is an autosomal dominant cancer syndrome, also known as the Lynch syndrome or the Cancer Family Syndrome.
		Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer.
		Mutation of a mutL homolog in hereditary colon cancer.
	www.gastrolab.net /c2ghere.htm (412 words)

	BAT-26, Microsatellite Instability (MSI) for Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
		While the vast majority (approximately 90%) of colorectal cancers associated with HNPCC are associated with mutated BAT-26, a certain percentage of colorectal cancer in these patients will not be detected.
		BAT-26 microsatellite instability is present in as many as 90% of the colorectal cancers that occur in patients with HNPCC.
		Aaltonen LA, Salovaara R, Kristo P, et al, “Incidence of Hereditary Nonpolyposis Colorectal Cancer and the Feasibility of Molecular Screening for the Disease,” N Engl J Med, 1998, 338(21):1481-7.
	www.labcorp.com /datasets/labcorp/html/chapter/mono/511253.html (452 words)

	Colorectal Neoplasms, Hereditary Nonpolyposis - Hereditary Nonpolyposis Colorectal Cancer - information page with ...
		The lifetime risk of colorectal cancer in these patients reaches 100 percent by age 60.
		Broader term(s): - Colorectal Neoplasms - Intestinal Neoplasms - Gastrointestinal Neoplasms - Neoplasms
		Hereditary Nonpolyposis Colorectal Cancer in Taiwan－Related Genetic Study and Clinical Applications
	www.hon.ch /HONselect/RareDiseases/EN/C04.588.274.476.411.307.190.html (427 words)

	Hereditary nonpolyposis colorectal cancer definition - Medical Dictionary definitions of popular medical terms
		Hereditary nonpolyposis colorectal cancer definition - Medical Dictionary definitions of popular medical terms
		Hereditary nonpolyposis colorectal cancer: See: Hereditary nonpolyposis colon cancer.
		Common Misspellings: hereditary nonpolyposis colorectal canser, hereditory nonpolyposis colorectal cancer, hereditory nonpolyposis colorectal canser
	www.medterms.com /script/main/art.asp?articlekey=38438 (122 words)

	Gynecologic Cancer as a "Sentinel Cancer" for Women With Hereditary Nonpolyposis Colorectal Cancer Syndrome -- Lu et ...
		Gynecologic Cancer as a "Sentinel Cancer" for Women With Hereditary Nonpolyposis Colorectal Cancer Syndrome -- Lu et al.
		Dana Farber Cancer Institute, Boston, Massachusetts; ¶University of California, San Francisco, California; and University of Michigan, Ann Arbor, Michigan.
		cancer first, the mean age at diagnosis of colon cancer was
	www.greenjournal.org /cgi/content/abstract/105/3/569 (521 words)

	Molecular Genetics of Hereditary Nonpolyposis Colorectal Cancer -- BOLAND 910 (1): 50 -- Annals of the New York Academy ...
		Molecular Genetics of Hereditary Nonpolyposis Colorectal Cancer -- BOLAND 910 (1): 50 -- Annals of the New York Academy of Sciences
		Cancer Res., August 15, 2006; 66(16): 7910 - 7919.
		Cancer Res., March 1, 2003; 9(3): 1112 - 1117.
	www.annalsnyas.org /cgi/content/abstract/910/1/50 (721 words)

	Population-Based Molecular Detection of Hereditary Nonpolyposis Colorectal Cancer -- Salovaara et al. 18 (11): 2193 -- ...
		Boland CR: Hereditary nonpolyposis colorectal cancer, in Vogelstein B, Kinzler KW (eds): The Genetic Basis of Human Cancer.
		Boland CR, Thibodeau SN, Hamilton SR, et al: A National Cancer Institute workshop on microsatellite instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer.
		Cancer Society: Cancer Incidence in Finland: Cancer statistics of the National Research and Development Centre for Welfare and Health.
	www.jco.org /cgi/content/full/18/11/2193 (5384 words)

	MedlinePlus: Colorectal Cancer
		The primary NIH organization for research on Colorectal Cancer is the National Cancer Institute
		Cancer of the colon or rectum is also called colorectal cancer.
		Everyone who is 50 or older should be screened for colorectal cancer.
	www.nlm.nih.gov /medlineplus/colorectalcancer.html (795 words)

	JAMA -- Abstract: Accuracy of Revised Bethesda Guidelines, Microsatellite Instability, and Immunohistochemistry for the ...
		JAMA -- Abstract: Accuracy of Revised Bethesda Guidelines, Microsatellite Instability, and Immunohistochemistry for the Identification of Patients With Hereditary Nonpolyposis Colorectal Cancer, April 27, 2005, Piñol et al.
		Identification of mismatch repair gene mutations in young patients with colorectal cancer and in patients with multiple tumours associated with hereditary non-polyposis colorectal cancer
		Cyclooxygenase 2 expression in colorectal cancer with DNA mismatch repair deficiency.
	jama.ama-assn.org /cgi/doi/10.1001/jama.293.16.1986 (546 words)

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