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Topic: Hergé

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1652 Herge

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Gail A. Robertson An acquired form of LQT is an unfortunate side effect of a surprisingly large and diverse collection of pharmaceutics that block HERG channels, including certain antihistamines and gastric motility drugs that were once widely prescribed but have since been removed from the market. Mutations in HERG cause congenital LQT by altering channel function or by disrupting the normal transport of the HERG ion channel complex from the endoplasmic reticulum to the plasma membrane. We are using electrophysiology to assay the effects of interacting proteins on HERG channel function or expression levels, immunocytochemistry with confocal microscopy to localize the proteins to their subcellular compartments, and yeast two-hybrid and biochemistry techniques to map interaction domains. www.wisc.edu /molpharm/faculty/robertson.html

The Blue Lotus From Chang, Hergé learned how to paint and draw according to Chinese techniques; it was Chang who told him about 'la ligne claire' (clear line), and who taught him how to paint Chinese characters. The impact Chang had on Hergé can hardly be overestimated, and it wasn't a big surprise that the two men became friends for life. Chang told Hergé about life in China - the real China, not China as Hergé had drawn her in Tintin au pays des Soviets. www.tintinologist.org /guides/books/05bluelotus.html   (1680 words)

The World of Tintin Study Day / Conference 15 May 2004 Paul charted the origins of Hergé's style from early influences such as Rabier (who designed the 'laughing cow' logo), Pinchon (Bécassine), Saint-Ogan (Zig et Puce) and Erté, through to the inheritors of his legacy such as the various Hergé Studio artists (Vandersteen, Jacobs, Martin, de Moor, Leloup), Swarte, Floc'h, Chaland, Stanislas and even Trondheim. His talk was on the evolution of the ligne clair style of bande dessiné, from who and what influenced Hergé, to who and what were influenced by Hergé - he really is at the head of a whole respected school of European comic art. If you have read Paul's articles 'Hergé and the Clear Line' from Comic Art magazine (thank you Paul Harrison for sending me those), then this was basically his talk. www.tintinologist.org /articles/studyday2004.html   (1680 words)

GeneCard for KCNH2 Missense mutation in the pore region of HERG causes familial long QT syndrome. A novel mutation (T65P) in the PAS domain of the human potassium channel HERG results in the long QT syndrome by trafficking deficiency. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. bioinfo.cnio.es /cgi-bin/genecards/carddisp?KCNH2   (1680 words)

Functional characterization of the C-terminus of the human ether-a-go-go-related gene K+ channel (HERG) -- Aydar and Palmer 534 (1): 1 -- The Journal of Physiology Online Our finding that deletion of 163 and 215 residues from the C-terminal end did not prevent the expression of a HERG-like current indicates that these residues are not necessary for the expression of functional channels, although these constructs showed reduced current amplitude. Inactivation in double-deletion mutants was significantly slower than in the individual deletion mutants, indicating that the C- and N-termini make additive contributions to the inactivation kinetics of HERG channels. Deletion of 163 and 215 residues from the C-terminal end resulted in authentic HERG currents, essentially indistinguishable from those of the WT channel in terms of the voltage dependence of conductance, inactivation, deactivation and activation kinetics. jp.physoc.org /cgi/content/full/534/1/1   (1680 words)

Hergé Hergé agreed, and in the spring of 1934 Gosset introduced him to Chang Chong-chen, a young sculpture student at the Brussels Académie des Beaux-Arts. Hergé died on March 3 1983, aged 75, due to complications arising from anemia, which he had suffered from for several years. Hergé was mobilized as a reserve lieutenant, and had to interrupt Tintin's adventures in the middle of The Land of the Black Gold. www.encyclopedia-1.com /h/he/herge.html   (2200 words)

Hergé's Adventures of TINTIN tickets - Hergé's Adventures of TINTIN information - London The Young Vic is delighted to present the first major UK stage adaptation of Hergé's Adventures of TINTIN. For more information on Hergé's Adventures of TINTIN: www.barbican.org.uk Hergé's Adventures of TINTIN tickets - Hergé's Adventures of TINTIN information - London www.theatermania.com /content/show.cfm/show/117006   (183 words)

APStracts 7:0008J, 2000. The goal of the present study was to determine whether carotid body glomus cells express HERG-like K+ current, and if so, to determine whether a HERG-like current regulates the resting membrane potential. These results demonstrate that glomus cells express a HERG-like current that is active at, and responsible for controlling the resting membrane potential. The biophysical and pharmacological characteristics of this inward tail current suggest that it is conducted by a HERG-like channel. www.uth.tmc.edu /apstracts/2000/jn/January/8j.html   (183 words)

Yang BF et al / Acta Pharmacol Sin 2004 May; 25 (5): 554-560 Based on the present and previous studies, we postulated that preferential inactivation block might be a common mechanism for drug action on HERG channels, or in the other words, the inactivation gating determined to a large extent the potency of drug block of HERG channels. Effects of azimilide on HERG channels have also been characterized by Busch et al AIM: To determine the mechanisms of interactions between different drugs and HERG channels. www.chinaphar.com /1671-4083/25/554.htm   (183 words)

Hergé's Fanstasy Kingdom: The Land of the Black Pelikan It Should be noted that Hergé appears as himself in many albums, a little like Hitchcock, and it is the case in "King Ottokars Sceptre" in which he can be seen in crowd greeting Tintin the coronation Hall. Beaux Art Magazine with Hergé's portrait by with Andy Warhol and Hergé portrait at the summit of his carreer. Interestingly Iran's capital is mentioned in Flight 714 For Sydney, where after landing in Djakarta Tintin and his friends meet "Skutz" an old Estonian pilot friend who has just flown in from Teheran ( See www.payvand.com /news/03/may/1087.html   (183 words)

King Ottokar's Sceptre Hergé then changed it to "Le Sceptre d'Ottokar IV" ("The Sceptre of Ottokar IV"), but his publisher objected because it was less commercial, difficult to remember, and "almost impossible to pronounce" (in French). Hergé wanted to have a colour double-spread of the Battle of Zileheroum, but due to the cost required for such an idea, it was abandoned. Hergé was very much opposed to this—"Tintin has always had fair hair, and it would be a commerical mistake to give him brown hair, and also make him less recognisble." Ultimately, the sceptre and armour was printed in yellow—like Tintin's hair. www.tintinologist.org /guides/books/08king.html   (616 words)

Books Tintin's Nazi spin When the Nazi panzer divisions rolled across Tintin's Belgian homeland in May 1940, the boy reporter and his creator, Hergé, were both in big trouble. He even persuades himself that Hergé was an anti-fascist who hid his hatred of the Germans during the war years. Michael Farr, a former Daily Telegraph and Reuters correspondent, cannot bear to think of Hergé as a collaborator - such is his nostalgic love of the Tintin books. books.guardian.co.uk /print/0,3858,4266997-99931,00.html   (616 words)

Comic creator: Hergé (Georges Remi) While the books 'Tintin au Tibet' (1959) and 'Le Bijoux de la Castafiore' (1962) are regarded as his best works, the last completed book, 'Tintin et les Picaros' (1974), is generally held to be Hergé's worst effort. Recently, the trio of Stanislas, Fromental and Bocquet added an excellent Hergé comic biography to the must-have list for all Tintin fans. In 1950 Hergé started his own studio because, although he was a workaholic, he could not get the work done on his own anymore. www.lambiek.net /herge.htm   (616 words)

sharks.html So we meet once again in this story the Emir Ben Kalish Ezab and his son Abdullah, General Alcazar, Dawson, the former chief of police in Shanghai, Dr Muller, here going under the name of Mull Pasha, Allan and Rastapopoulos, whose character Hergé refines even further. It is also, in some respects, a continuation of Land of Black Gold and a chance for Hergé to bring back some characters from other adventures, who had faded from view for a while. Having read in an article that slavery still existed, and given his old interest in gun-running, Hergé was provided with a basis for one of his most intriguing tales. www.tikkel.nl /kuifje/engels/sharks.html   (616 words)

Encyclopedia: The Blue Lotus Tintin in the Land of the Soviets (Les Aventures de Tintin, reporter du Petit Vingtième, au pays des Soviets) is one of a series of classic comic-strip albums written and illustrated by Belgian writer and illustrator Hergé. Tintin and the Picaros (originally Tintin et les Picaros) is one of a series of classic comic-strip albums, written and illustrated by Belgian writer and illustrator Hergé, featuring young reporter Tintin as a hero. As a result of this experience, Hergé would strive in The Blue Lotus, and in subsequent Tintin adventures, to be meticulously accurate in depicting the places which Tintin visited. www.nationmaster.com /encyclopedia/The-Blue-Lotus   (2057 words)

The Unknown TINTIN "Tintin and Alph-Art" was left unfinished at the time of Hergé's death on the 3rd of March, 1983. "Tintin was born from the pencil and pen of Hergé 75 years ago. I do not condone such an action, and believe they should be freely available for fans of Hergé to read an interpretation of the final adventure of Tintin. www.geocities.com /hergesadventuresoftintin03/alphart   (200 words)

Model Mart Tchang not only helped Hergé with his research but also drew the Chinese ideograms that appeared in the comic strip. Knowing that it was to be set in China, Hergé was contacted by Father Gosset, who was chaplain to the Chinese students at the University of Louvain and introduced to Tchang Tchong-Jen, a student at the Fine Arts Academy of Brussels. The latter had originally appeared in 1934-35 and with it Hergé had taken another important step forward. www.modelmart.co.uk /content/features?Category=Article&ID=532   (200 words)

Detective Fiction on Stamps: Blake et Mortimer - France, Belgium Jacob, who was a colorist for Hergé after having made a career as a lyric singer between the two wars, is one of the brilliant representatives of the Brussels school, with the creator of Tintin, Jacques Martin and Bob de Moor. Jacobs, qui fut le coloriste d'Hergé après avoir fait une carrière de chanteur lyrique durant l'entre-deux-guerres, est l'un des brillants représentants de l'école de Bruxelles, avec le créateur de Tintin, Jacques Martin et Bob de Moor. The saga of Blake and Mortimer was born in 1946 of the imagination of Edgar Pierre Jacobs, a Brussels artist who worked with Hergé: the first board of his "Secret of the Swordfish" appeared in the weekly Tintin. www.trussel.com /detfic/blake2.htm   (1236 words)

Hergé's Syldavian The adventures of Tintin, by the great Belgian artist Hergé, are enjoyed the world over; for the linguist, they offer the added attraction of providing tantalizing glimpses of a previously undocumented language, Syldavian. Hergé never, to my knowledge, provided any grammatical sketch of this language, and other sources on Syldavian are precious few. Hergé uses the Cyrillic letter sh for H-- an odd choice, especially when Syldavian has a sh sound (sz). www.zompist.com /syldavian.html   (4481 words)

Tintin News item: Piracy jeopardises Tintin's entry to China However, Casterman object to Haitun's use of the name, "Ding Ding", which has always been the Chinese name for Hergé's Tintin. Apparently, Haitun claims that The New Adventures of Ding Ding books are authorised Chinese language edition of Bob and Bobette1 by Belgian artist, the late Willy Vandersteen who was once a colleague of Hergé's. Qinghai People's Publishing House responded by claiming they were mislead by a Beijing based book dealer, who had told them that Hergé was dead for over fifty years, therefore his work was now in the public domain. www.tintinologist.org /news/19990616.html   (4481 words)

Researchers find table salt blocks crucial potassium channels Writing in the May issue of Nature Neuroscience, the investigators report that sodium blocks a crucial potassium channel called HERG, an effect that is especially powerful when there is little or no potassium around. "It was a surprise that the sodium-- the table salt -- in our bloodstream really wants to block the HERG channel completely. If given a drug that blocks HERG, these patients may be at exceptional risk for arrhythmias. www.vanderbilt.edu /News/register/Jun19_00/story8.html   (740 words)

Voltage-Dependent Profile of Human Ether-a-go-go-Related Gene Channel Block Is Influenced by a Single Residue in the S6 Transmembrane Domain -- Sanchez-Chapula et al. 63 (5): 1051 -- Molecular Pharmacology We reported previously that the voltage dependence for block of HERG channels by chloroquine was reversed by the Y652A mutation Effect of quinidine on the voltage dependence of Y652A and Y652F HERG channel activation. Like chloroquine, quinidine block of Y652F HERG channels was also molpharm.aspetjournals.org /cgi/content/full/63/5/1051   (740 words)

Review Similar to The Adventures of Tintin: Tintin in America / Cigars of the Pharaoh / The Blue Lotus (3 Complete Adventures in One Volume, Vol. 1) - Computer Toaster Be forewarned that the final adventure of Tintin collected in Volume 3 of Hergé is the first half of a two-part tale. Volume 2 of "The Adventures of Tintin" brings together a trio of stories by Hergé from the late 1930s, right before World War II. This is noteworthy because at this point Hergé is refining his attention to cultural detail in these stories, but also starting to get more fanciful and... computertoaster.com /reviews/similaritysearch_0316359408   (531 words)

The Cardiac Society of Australia and New Zealand - 47th ASM Abstracts Background: Azimilide is a new class III antiarrhythmic drug which has potential efficacy in the treatment of atrial and ventricular tachyarrhythmias, and acts via blockade of 1Kr (encoded by HERG) and 1Ks. Conclusion: Both azimilide and ambasilide are potent inhibitors of HERG channels with different mechanisms of action. We compared the effects of azimilide and ambasilide on HERG, stably transfected into CHO-K1 cells using a whole cell voltage clamp technique. www.csanz.edu.au /abstracts/47abstracts/259.htm   (531 words)

Travel Beautifully drawn boy Two of the largest items on display are related portraits: one of an actual Admiral Haddock from the 18th century (who Hergé discovered after creating his own) and a mock-painting of the fictional ancestor Sir Francis Haddock. As befits a maritime museum, there is plenty of space here devoted to that most human of Hergé's characters, Captain Haddock. In The Shooting Star, Tintin, Snowy and new-found friend Captain Haddock (met in the previous adventure) set off to the North Pole on a steam whaler, the Aurora. travel.guardian.co.uk /print/0,3858,4890807-106212,00.html   (531 words)

Books Astérix's creator sees off all rivals at Christmas While Goscinny books will sell in millions this Christmas, the eternal competition between the author's children's magazine, Pilote, and Hergé's rival Belgian weekly, Tintin, will be limited to memories of a 30-year struggle for juvenile minds that ended when the pair disappeared at the end of the 1980s. Oumpah-Pah, created when Goscinny was 25, was destined for Hergé's Tintin, and contained elements of chauvinism and distrust for the United States that were sublimated in Ast&. Goscinny, from an immigrant eastern European family, described himself as 'the other one' because he was 'only' the writer who thought up the characters and plots, while much of the glory fell on the shoulders of artists such as Albert Uderzo, who drew Ast&. books.guardian.co.uk /print/0,3858,4818977-99819,00.html   (523 words)

Essen Instruments As shown, the Essen system clamps and measures essentially the same signal with the same data fidelity as the patch-clamp system, yielding a classic hERG signature. Some pharmacological data on hERG were also collected using known blockers such as terfenadine and cisapride. As such, it is believed to be a good model for the assessment of potential toxic effects of new chemical entities on the heart. www.essen-instruments.com /electrophys/herg.asp?print=1   (523 words)

HERG, a Primary Human Ventricular Target of the Nonsedating Antihistamine Terfenadine -- Roy et al. 94 (4): 817 -- Circulation HERG, a Primary Human Ventricular Target of the Nonsedating Antihistamine Terfenadine -- Roy et al. Inhibition of the human ether-a-go-go-related gene (HERG) potassium channel by cisapride: affinity for open and inactivated states in human plasma may reach the 100 nmol/L range. circ.ahajournals.org /cgi/content/abstract/94/4/817   (523 words)

Comic Strips and Animation: The Belgian Tradition There is little chance though that Captain Haddock would be sold to one company and Milou to another, since the Hergé Foundation carefully preserves the integrity of his work, sometimes to the point of jealously, which, in Europe, gives rise to other kinds of controversy. As for the estate of Hergé, all the rights he controlled were ceded to Ellipse and Nelvana Studios, who are producing a series based on The Adventures of Tintin for Canal+ television. They produced such films as Pinocchio in Outer Space (1964), Asterix the Gaul (1967), Asterix and Cleopatra (1968), Tintin and the Temple of the Sun (1969), Daisy Town [Lucky Luke] (1972), Tintin and the Lake of Sharks (1972), Gulliver (1975), and The Flute of Six Smurfs (1975). www.awn.com /mag/issue2.4/awm2.4pages/2.4moinsbelgeng.html   (523 words)

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