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Topic: Hergé

    Note: these results are not from the primary (high quality) database.

 Gail A. Robertson
An acquired form of LQT is an unfortunate side effect of a surprisingly large and diverse collection of pharmaceutics that block HERG channels, including certain antihistamines and gastric motility drugs that were once widely prescribed but have since been removed from the market.
Mutations in HERG cause congenital LQT by altering channel function or by disrupting the normal transport of the HERG ion channel complex from the endoplasmic reticulum to the plasma membrane.
We are using electrophysiology to assay the effects of interacting proteins on HERG channel function or expression levels, immunocytochemistry with confocal microscopy to localize the proteins to their subcellular compartments, and yeast two-hybrid and biochemistry techniques to map interaction domains.
www.wisc.edu /molpharm/faculty/robertson.html

 The Blue Lotus
From Chang, Hergé learned how to paint and draw according to Chinese techniques; it was Chang who told him about 'la ligne claire' (clear line), and who taught him how to paint Chinese characters.
The impact Chang had on Hergé can hardly be overestimated, and it wasn't a big surprise that the two men became friends for life.
Chang told Hergé about life in China - the real China, not China as Hergé had drawn her in Tintin au pays des Soviets.
www.tintinologist.org /guides/books/05bluelotus.html   (1680 words)

 The World of Tintin Study Day / Conference 15 May 2004
Paul charted the origins of Hergé's style from early influences such as Rabier (who designed the 'laughing cow' logo), Pinchon (Bécassine), Saint-Ogan (Zig et Puce) and Erté, through to the inheritors of his legacy such as the various Hergé Studio artists (Vandersteen, Jacobs, Martin, de Moor, Leloup), Swarte, Floc'h, Chaland, Stanislas and even Trondheim.
Next up was Paul Gravett, someone I have long admired as a champion of quality comics in the UK, and who, if I remember correctly, would like to set up a permanent comic strip museum for the country, similar to Brussels' amazing and inspiring Musée de Bande Dessinée.
Paul Gravett (blue shirt with black bag) and Benoit Peeters (cream jacket with black bag) can be seen walking together towards the museum.
www.tintinologist.org /articles/studyday2004.html   (1680 words)

 GeneCard for KCNH2
Missense mutation in the pore region of HERG causes familial long QT syndrome.
A novel mutation (T65P) in the PAS domain of the human potassium channel HERG results in the long QT syndrome by trafficking deficiency.
A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome.
bioinfo.cnio.es /cgi-bin/genecards/carddisp?KCNH2   (1680 words)

 Functional characterization of the C-terminus of the human ether-a-go-go-related gene K+ channel (HERG) -- Aydar and Palmer 534 (1): 1 -- The Journal of Physiology Online
Our finding that deletion of 163 and 215 residues from the C-terminal end did not prevent the expression of a HERG-like current indicates that these residues are not necessary for the expression of functional channels, although these constructs showed reduced current amplitude.
Fitting began within 5 ms of the peak of the tail current, with the first cursor of the fitting window advanced to the first point in time that did not force a fit to the recovery phase; the second cursor was at the end of the 1.5 s pulse to -120 mV.
Inactivation in double-deletion mutants was significantly slower than in the individual deletion mutants, indicating that the C- and N-termini make additive contributions to the inactivation kinetics of HERG channels.
jp.physoc.org /cgi/content/full/534/1/1   (1680 words)

Hergé agreed, and in the spring of 1934 Gosset introduced him to Chang Chong-chen, a young sculpture student at the Brussels Académie des Beaux-Arts.
Hergé died on March 3 1983, aged 75, due to complications arising from anemia, which he had suffered from for several years.
Hergé was mobilized as a reserve lieutenant, and had to interrupt Tintin's adventures in the middle of The Land of the Black Gold.
www.encyclopedia-1.com /h/he/herge.html   (2200 words)

 Hergé's Adventures of TINTIN tickets - Hergé's Adventures of TINTIN information - London
Join Tintin, his loyal dog Snowy, and the curmudgeonly Captain Haddock as they battle to rescue their friend Chang lost in a plane crash in the high Himalayas.
With time running out, and rumours of the abominable Snowman prowling the peaks, this will be the most testing adventure yet for our fearless young reporter and his friends.
The Young Vic is delighted to present the first major UK stage adaptation of Hergé's Adventures of TINTIN.
www.theatermania.com /content/show.cfm/show/117006   (183 words)

 APStracts 7:0008J, 2000.
In an in-vitro carotid body preparation, DOF increased basal sensory discharge in the carotid sinus nerve in a concentration-dependent manner.
The goal of the present study was to determine whether carotid body glomus cells express HERG-like K+ current, and if so, to determine whether a HERG-like current regulates the resting membrane potential.
These results demonstrate that glomus cells express a HERG-like current that is active at, and responsible for controlling the resting membrane potential.
www.uth.tmc.edu /apstracts/2000/jn/January/8j.html   (183 words)

 Yang BF et al / Acta Pharmacol Sin 2004 May; 25 (5): 554-560
They found that azimilide blockade was reverse use-dependent, ie, the relative block and apparent affinity of azimilide decreased with an increase in channel activation frequency.
It is possible that inactivation block and open channel block are both contributing to azimilide's action, and our data from the present study seem to be in favor of this notion.
Based on the present and previous studies, we postulated that preferential inactivation block might be a common mechanism for drug action on HERG channels, or in the other words, the inactivation gating determined to a large extent the potency of drug block of HERG channels.
www.chinaphar.com /1671-4083/25/554.htm   (183 words)

 Herg's Fanstasy Kingdom: The Land of the Black Pelikan
Interestingly Iran's capital is mentioned in Flight 714 For Sydney, where after landing in Djakarta Tintin and his friends meet "Skutz" an old Estonian pilot friend who has just flown in from Teheran ( See
It Should be noted that Herg appears as himself in many albums, a little like Hitchcock, and it is the case in "King Ottokars Sceptre" in which he can be seen in crowd greeting Tintin the coronation Hall.
SAS Scandinavian Airline Brochure to Iran, Center Iran Air plane and Top and Below Flight 714.
www.payvand.com /news/03/may/1087.html   (183 words)

 King Ottokar's Sceptre
If the king does not carry King Ottokar's sceptre in the royal procession he will lose his throne, and when the rebels manage to steal the sceptre the detectives Thomson and Thompson are called in.
Hergé then changed it to "Le Sceptre d'Ottokar IV" ("The Sceptre of Ottokar IV"), but his publisher objected because it was less commercial, difficult to remember, and "almost impossible to pronounce" (in French).
It is odd that Tintin does not notice that he has dropped the Sceptre as it is made of pure gold and must be somewhat heavy.
www.tintinologist.org /guides/books/08king.html   (616 words)

 Books Tintin's Nazi spin
Tintin is infused not with fascism but with the spirit of arrested development: the driving force of all genuinely popular children's writing from Swallows and Amazons to The Simpsons and Harry Potter.
When the Nazi panzer divisions rolled across Tintin's Belgian homeland in May 1940, the boy reporter and his creator, Hergé, were both in big trouble.
Le Petit Vingtième, the children's newspaper where Tintin appeared, was immediately closed down by the Nazi occupiers - the final strip showing our hero trussed up by Dr Müller's henchmen and dumped in the desert to die.
books.guardian.co.uk /print/0,3858,4266997-99931,00.html   (616 words)

 Comic creator: Hergé (Georges Remi)
In fact, the character Tintin was often compared with the stereotype of a boy scout.
While the books 'Tintin au Tibet' (1959) and 'Le Bijoux de la Castafiore' (1962) are regarded as his best works, the last completed book, 'Tintin et les Picaros' (1974), is generally held to be Hergé's worst effort.
Especially the work on the Tintin reprints - which were being redrawn and colored - was too much of a burden by then.
www.lambiek.net /herge.htm   (616 words)

So we meet once again in this story the Emir Ben Kalish Ezab and his son Abdullah, General Alcazar, Dawson, the former chief of police in Shanghai, Dr Muller, here going under the name of Mull Pasha, Allan and Rastapopoulos, whose character Herg refines even further.
It is also, in some respects, a continuation of Land of Black Gold and a chance for Herg to bring back some characters from other adventures, who had faded from view for a while.
Having read in an article that slavery still existed, and given his old interest in gun-running, Herg was provided with a basis for one of his most intriguing tales.
www.tikkel.nl /kuifje/engels/sharks.html   (616 words)

 Encyclopedia: The Blue Lotus
Tintin is a direct witness to the South Manchurian railway incident (Mukden incident), Japan's excuse to attack and occupy China and start the second Sino-Japanese War (1937-1945).
Tintin in the Land of the Soviets (Les Aventures de Tintin, reporter du Petit Vingtième, au pays des Soviets) is one of a series of classic comic-strip albums written and illustrated by Belgian writer and illustrator Hergé.
Tintin and the Picaros (originally Tintin et les Picaros) is one of a series of classic comic-strip albums, written and illustrated by Belgian writer and illustrator Hergé, featuring young reporter Tintin as a hero.
www.nationmaster.com /encyclopedia/The-Blue-Lotus   (2057 words)

 The Unknown TINTIN
"Tintin and Alph-Art" was left unfinished at the time of Hergé's death on the 3rd of March, 1983.
"Tintin was born from the pencil and pen of Hergé 75 years ago.
I do not condone such an action, and believe they should be freely available for fans of Hergé to read an interpretation of the final adventure of Tintin.
www.geocities.com /hergesadventuresoftintin03/alphart   (200 words)

 Model Mart
Tchang not only helped Herg with his research but also drew the Chinese ideograms that appeared in the comic strip.
Knowing that it was to be set in China, Herg was contacted by Father Gosset, who was chaplain to the Chinese students at the University of Louvain and introduced to Tchang Tchong-Jen, a student at the Fine Arts Academy of Brussels.
In the story, Tintin continues on the opium trail and is kidnapped in Shanghai by the Sons of the Dragon, meets a young orphan boy named Tchang, and eventually thwarts the activities of the nasty Japanese agent Mitsuhirato and a corrupt Chief of Police at the International Settlement.
www.modelmart.co.uk /content/features?Category=Article&ID=532   (200 words)

 Detective Fiction on Stamps: Blake et Mortimer - France, Belgium
Jacob, who was a colorist for Hergé after having made a career as a lyric singer between the two wars, is one of the brilliant representatives of the Brussels school, with the creator of Tintin, Jacques Martin and Bob de Moor.
Jacobs, qui fut le coloriste d'Hergé après avoir fait une carrière de chanteur lyrique durant l'entre-deux-guerres, est l'un des brillants représentants de l'école de Bruxelles, avec le créateur de Tintin, Jacques Martin et Bob de Moor.
The saga of Blake and Mortimer was born in 1946 of the imagination of Edgar Pierre Jacobs, a Brussels artist who worked with Hergé: the first board of his "Secret of the Swordfish" appeared in the weekly Tintin.
www.trussel.com /detfic/blake2.htm   (1236 words)

 Hergé's Syldavian
The adventures of Tintin, by the great Belgian artist Hergé, are enjoyed the world over; for the linguist, they offer the added attraction of providing tantalizing glimpses of a previously undocumented language, Syldavian.
Hergé never, to my knowledge, provided any grammatical sketch of this language, and other sources on Syldavian are precious few.
Hergé uses the Cyrillic letter sh for H-- an odd choice, especially when Syldavian has a sh sound (sz).
www.zompist.com /syldavian.html   (4481 words)

 Tintin News item: Piracy jeopardises Tintin's entry to China
In May, the Executive Director of Casterman went to China to decide on the right candidate to be the new official Chinese Tintin publisher.
Outraged, Casterman immediately suspended discussions with the prospective licensee to pursue the matter with Dolphin and Qinghai.
Just as Tintin was to be given the passport to China, a new scandal arose: it had been discovered that in April unauthorised copies of The New Adventures Of Ding Ding published by Haitun began to appear on the bookstands.
www.tintinologist.org /news/19990616.html   (4481 words)

 Researchers find table salt blocks crucial potassium channels
Balser's colleagues in the departments of anesthesiology and pharmacology are Hirotaka Numaguchi, Ph.D.; J.P. Johnson Jr., Ph.D.; and Christina I. Petersen, Ph.D. The work was supported by the National Institutes of Health and the American Heart Association.
Writing in the May issue of Nature Neuroscience, the investigators report that sodium blocks a crucial potassium channel called HERG, an effect that is especially powerful when there is little or no potassium around.
"It was a surprise that the sodium-- the table salt -- in our bloodstream really wants to block the HERG channel completely.
www.vanderbilt.edu /News/register/Jun19_00/story8.html   (740 words)

 Voltage-Dependent Profile of Human Ether-a-go-go-Related Gene Channel Block Is Influenced by a Single Residue in the S6 Transmembrane Domain -- Sanchez-Chapula et al. 63 (5): 1051 -- Molecular Pharmacology
We reported previously that the voltage dependence for block of HERG channels by chloroquine was reversed by the Y652A mutation
Snyders DJ, Knoth KM, Roberds SL and Tankun MM (1992) Time-, voltage- and state- dependent block by quinidine of a cloned human cardiac potassium channel.
Effect of quinidine on the voltage dependence of Y652A and Y652F HERG channel activation.
molpharm.aspetjournals.org /cgi/content/full/63/5/1051   (740 words)

 Review Similar to The Adventures of Tintin: Tintin in America / Cigars of the Pharaoh / The Blue Lotus (3 Complete Adventures in One Volume, Vol. 1) - Computer Toaster
Be forewarned that the final adventure of Tintin collected in Volume 3 of Hergé is the first half of a two-part tale.
Although I have been a fan of Tintin since I was a kid, I actually did not learn of this tintin till I was an adult.
Volume 2 of "The Adventures of Tintin" brings together a trio of stories by Hergé from the late 1930s, right before World War II.
computertoaster.com /reviews/similaritysearch_0316359408   (531 words)

 The Cardiac Society of Australia and New Zealand - 47th ASM Abstracts
Background: Azimilide is a new class III antiarrhythmic drug which has potential efficacy in the treatment of atrial and ventricular tachyarrhythmias, and acts via blockade of 1Kr (encoded by HERG) and 1Ks.
In contrast to azimilide, channel inhibition was independent of pulse duration using an envelope of tails protocol.
Conclusion: Both azimilide and ambasilide are potent inhibitors of HERG channels with different mechanisms of action.
www.csanz.edu.au /abstracts/47abstracts/259.htm   (531 words)

 Travel Beautifully drawn boy
Two of the largest items on display are related portraits: one of an actual Admiral Haddock from the 18th century (who Hergé discovered after creating his own) and a mock-painting of the fictional ancestor Sir Francis Haddock.
In The Shooting Star, Tintin, Snowy and new-found friend Captain Haddock (met in the previous adventure) set off to the North Pole on a steam whaler, the Aurora.
As befits a maritime museum, there is plenty of space here devoted to that most human of Hergé's characters, Captain Haddock.
travel.guardian.co.uk /print/0,3858,4890807-106212,00.html   (531 words)

 Books Astérix's creator sees off all rivals at Christmas
Goscinny, from an immigrant eastern European family, described himself as 'the other one' because he was 'only' the writer who thought up the characters and plots, while much of the glory fell on the shoulders of artists such as Albert Uderzo, who drew Ast&.
While Goscinny books will sell in millions this Christmas, the eternal competition between the author's children's magazine, Pilote, and Hergé's rival Belgian weekly, Tintin, will be limited to memories of a 30-year struggle for juvenile minds that ended when the pair disappeared at the end of the 1980s.
Oumpah-Pah, created when Goscinny was 25, was destined for Hergé's Tintin, and contained elements of chauvinism and distrust for the United States that were sublimated in Ast&.
books.guardian.co.uk /print/0,3858,4818977-99819,00.html   (523 words)

 Essen Instruments
As shown, the Essen system clamps and measures essentially the same signal with the same data fidelity as the patch-clamp system, yielding a classic hERG signature.
As such, it is believed to be a good model for the assessment of potential toxic effects of new chemical entities on the heart.
Each successive data curve in the above family was taken 15 seconds apart, during which time the cell was maintained at a holding potential of —80 mV.
www.essen-instruments.com /electrophys/herg.asp?print=1   (523 words)

 HERG, a Primary Human Ventricular Target of the Nonsedating Antihistamine Terfenadine -- Roy et al. 94 (4): 817 -- Circulation
in human plasma may reach the 100 nmol/L range.
One human cardiac target is Kv1.5, which expresses
HERG, a Primary Human Ventricular Target of the Nonsedating Antihistamine Terfenadine -- Roy et al.
circ.ahajournals.org /cgi/content/abstract/94/4/817   (523 words)

 Comic Strips and Animation: The Belgian Tradition
They produced such films as Pinocchio in Outer Space (1964), Asterix the Gaul (1967), Asterix and Cleopatra (1968), Tintin and the Temple of the Sun (1969), Daisy Town [Lucky Luke] (1972), Tintin and the Lake of Sharks (1972), Gulliver (1975), and The Flute of Six Smurfs (1975).
There is little chance though that Captain Haddock would be sold to one company and Milou to another, since the Hergé Foundation carefully preserves the integrity of his work, sometimes to the point of jealously, which, in Europe, gives rise to other kinds of controversy.
In 1955 Raymond Leblanc, head of Lombard publisher of the Tintin comic books, founded the Belvision animation studio, which brought Belgian animation out of its provinciality by offering the first television version of The Adventures of Tintin.
www.awn.com /mag/issue2.4/awm2.4pages/2.4moinsbelgeng.html   (523 words)

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