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Topic: Herpes simplex virus 1

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	Viruses: Herpes Virus (Site not responding. Last check: 2007-11-06)
		Herpes simplex type 1 virus is responsible for systemic infections involving the liver and other organs, including the central nervous system, and localized infections may involve the skin, eyes and mouth.
		Herpes simplex type 2 virus is associated with genital herpes which is characterized by vesicular lesions in the male or female genital organs.
		Zoster ("Shingles") is a reactivation of the latent virus occurring primarily in adults and immunocompromised patients.
	www.wadsworth.org /databank/herpes.htm (283 words)

	Herpes Simplex Virus 1 (HHV1) (Site not responding. Last check: 2007-11-06)
		Although the virus can cause lytic infections of many types of cells and persistent infections of lymphocytes and macrophages, the virus usually initially replicates in the mucoepithelial cells and then establishes a latent infection of the innervating neurons.
		For HHV 1 it is the trigeminal ganglion which harbors the latent virus.
		The focal encephalitis caused by herpes simplex is the most devastating manifestation of herpes simplex infection.
	medinfo.ufl.edu /year2/mmid/bms5300/bugs/hhv1.html (304 words)

	Herpes Simplex
		Herpes simplex virus 1 is the strain of the herpes virus that is most commonly associated with oral herpes.
		Example: Herpes simplex 1 does have the preferred location of the mouth or oral area while herpes simplex 2 has the preferred area of the genitals or boxer short region as stated by some physician’s.
		Those who become infected with the herpes simplex virus 1 orally are prone to have more frequently recurring outbreaks while those who would contract herpes simplex virus 1 genitally are believed to experience less frequent outbreaks and far milder symptoms.
	www.herpesonline.org /articles/herpes_simplex.html (295 words)

	Herpes simplex virus - Wikipedia, the free encyclopedia
		The herpes simplex virus (HSV) (also known as cold sore, night fever, or fever blister) is a virus that manifests itself in two common viral infections, each marked by painful, watery blisters in the skin or mucous membranes (such as the mouth or lips) or on the genitals.
		An infection on the lips is commonly known as a "cold sore" or "fever blister".
		These are sometimes confused with canker sores or aphthous ulcers, which have a similar appearance; these appear inside the mouth and are not caused by the herpes simplex virus.
	en.wikipedia.org /wiki/Herpes_simplex_virus (591 words)

	Herpes
		Herpes is a contagious infection that's caused by the herpes simplex virus.
		Herpes simplex virus type 2 can be passed in the urine or genital discharge of an infected person.
		Herpes infections can be prevented by avoiding direct contact with sores or ulcers of someone who has an active herpes infection - either on the mouth or on the genitals.
	kidshealth.org /parent/infections/std/herpes.html (1262 words)

	What causes cold sores, fever blisters, and oral herpes lesions? (via CobWeb/3.1 planetlab2.isi.jhu.edu) (Site not responding. Last check: 2007-11-06)
		Herpes simplex virus type 1 ("HSV1") generally only infects those body tissues that lie "above the waistline" and it is HSV1 that causes cold sores in the majority of cases.
		Herpes simplex virus type 2 ("HSV2") usually only infects those body tissues that lie "below the waistline" and it is this virus that is also known as "genital herpes." Herpes simplex virus type 2 is not usually the virus that causes cold sores, although it can.
		A person's initial herpes simplex virus infection, termed "primary herpetic stomatitis," does not usually take the form of a cold sore and therefore a person may not relate their initial exposure to the herpes virus to the recurrent cold sores that they get.
	www.animated-teeth.com.cob-web.org:8888 /cold_sores/t1_cold_sores.htm (788 words)

	The Big Picture Book of Viruses - Herpesviruses
		Two herpes virus particles are shown; they were prepared for transmission electron microscopy by the negative stain technique from the Wadsworth Center of the New York State Department of Health.
		Herpes simplex virus, the causative agent of fever blisters.
		Herpes simplex virus infection becomes latent, that is it becomes invisible after a fever blister episode, but the virus persists, in ganglia at the floor of the brain, where when conditions are right it can re-emerge.
	www.virology.net /Big_Virology/BVDNAherpes.html (771 words)

	Herpes simplex - Wikipedia, the free encyclopedia
		It is known that the virus lies dormant in the ganglion of the trigeminal or fifth cranial nerve.
		Herpes is contracted through direct skin contact (not necessarily in the genital area) with an infected person, and less frequently by indirect contact (for instance, by sharing lip balm or a virus infested shared towel).
		The herpes virus is a double-stranded DNA (dsDNA)-type virus.
	en.wikipedia.org /wiki/Herpes_simplex (5050 words)

	MedlinePlus Medical Encyclopedia: Herpes simplex
		Herpes simplex is an infection that primarily affects the mouth or genital area.
		Herpes simplex virus type 1 (HSV-1) is usually associated with infections of the lips, mouth, and face.
		In addition to oral and genital lesions, the virus can also lead to complications such as meningoencephalitis (infection of the lining of the brain and the brain itself) or cause infection of the eye -- in particular the conjunctiva, and cornea.
	www.nlm.nih.gov /medlineplus/ency/article/001324.htm (866 words)

	HerpeSelect - I am a Healthcare Provider
		Despite the extensive range of symptoms of herpes virus infections, all are characterized by the establishment of latent infection and all have the potential to reactivate from latency.
		Herpes simplex virus type-1: commonly causes herpes labialis (also called oral herpes, cold sores or fever blisters), which are highly infectious open sores that crust over before healing.
		Herpes simplex virus type-2: a contagious sexually transmitted viral infection primarily causing genital herpes in men and women.
	www.herpeselect.com /2-healthcare/facts.asp (1198 words)

	Alzforum: Herpes simplex virus type 1 is a risk factor for Alzheimer’s disease
		We have detected HSV1 in about 78% of brain specimens from 46 AD patients and in 64% of 44 age-matched normals, in the temporal and/or frontal cortices and/or hippocampus, but not in the occipital cortex [5] - a region far less affected in AD than are the former three regions.
		We suggested that periodic, mild reactivation of HSV1 occurs in the CNS as a result of immunosuppression [7] or stress, causing greater damage in ADs than in normals because of a difference in host or virus factor (Fig 1).
		In HSV1 assays, a 110 bp sequence of the HSV1 TK gene and also a 267 bp sequence of the human HGPRT gene were amplified in the same tube.
	www.alzforum.org /res/for/Smalheiser (897 words)

	Herpes Simplex Virus (Type 1 and 2)
		If herpes is present in the birth canal near the time of delivery, a cesarean section might be necessary to protect the newborn from coming into direct contact with the virus.
		When herpes is aquired at birth from exposure to maternal genital lesions it can be the most disasterous form of Herpetic Disease and is often fatal.
		Herpes vaccines are currently being investigated and it is felt that an effective vaccine may be available in 3-5 years.
	www.angelfire.com /ny5/herpessimplexvirus (836 words)

	Herpesviruses
		The envelope is acquired from the inner lamella of the nuclear membrane, and particles accumulate in the space within the inner and outer lamellae.
		Latent virus is reactivated and AIDS/transplant patients experience frequent and severe infections with the potential for involvement of many possible organs.
		Discovery of the virus solved a longstanding mystery - primary infection in childhood causes "roseola infantum" a.k.a.
	www.tulane.edu /~dmsander/WWW/335/Herpesviruses.html (1883 words)

	Oral and Genital Herpes
		Herpes is a general term for two different diseases: one that effects the area around the mouth (oral herpes, also known as cold sores) and another that effects the area around the genitals (genital herpes).
		The herpes simplex virus-1 (HSV-1) causes oral herpes; both HSV-1 and herpes simplex virus-2 (HSV-2) cause genital herpes.
		During a flare-up, the virus becomes active and causes a chain of events leading to a cluster of small bumps to form.
	www.aidsmeds.com /OIs/Herpes1.htm (376 words)

	Herpes Simplex Virus (Site not responding. Last check: 2007-11-06)
		Virus is shed from the infected area and spread occurs as a result of direct contact with lesions.
		Virus may also, however, be shed in saliva and genital secretions and can thus be transmitted in the absence of clinical lesions.
		The virus reaches the cornea via the ophthalmic branch of the trigeminal nerve; the clinical lesion is termed a dendritic ulcer.
	www.uct.ac.za /depts/mmi/jmoodie/hsv2.html (734 words)

	Herpes and Genital Herpes Information
		Genital herpes is an infection caused by the Herpes Simplex virus 1 or HSV.
		Because the genital herpes sores may not be visible to the naked eye, a doctor or other health care worker may have to do several laboratory tests to try to prove that symptoms are caused by the herpes virus.
		herpes while she is pregnant, she can pass the virus to her unborn child and may deliver a premature baby.
	www.herpes-doctor.com /herpes-simplex-virus-1.htm (1863 words)

	Microtubule-mediated Transport of Incoming Herpes Simplex Virus 1 Capsids to the Nucleus -- Sodeik et al. 136 (5): ...
		Identification of the herpes simplex virus DNA sequence which encodes a trans-acting polypeptide responsible for the stimulation of the immediate early transcription.
		Uptake and transport of herpes simplex virus in neurites of rat dorsal root ganglia cells in culture.
		The epidemiology and clinical manifestations of herpes simplex virus infections.
	www.jcb.org /cgi/content/full/136/5/1007 (8346 words)

	Full Resistance of Herpes Simplex Virus Type 1-Infected Primary Human Cells to Alpha Interferon Requires both the Us11 ...
		Herpes simplex virus type 1 immediate-early protein ICP0 and its isolated RING finger domain act as ubiquitin E3 ligases in vitro.
		Expression of herpes simplex virus ICP0 inhibits the induction of interferon-stimulated genes by viral infection.
		The infected cell protein 0 of herpes simplex virus 1 dynamically interacts with proteasomes, binds and activates the cdc34 E2 ubiquitin-conjugating enzyme, and possesses in vitro E3 ubiquitin ligase activity.
	jvi.asm.org /cgi/content/full/78/18/10193 (2636 words)

	DermAtlas: Online Dermatology Image Library dermatology image,whitlow,Herpes simplex virus infection (Site not responding. Last check: 2007-11-06)
		The lesion on his sacrum grew Herpes Simplex Virus-1 and the lesion on his scrotum grew Herpes Simplex Virus-2.
		Herpes Simplex Virus and Varicella Zoster Virus show similar viral cytopathic effect, and cannot be reliably distinguished on histology.
		A smear from the base of a blister showed multinucleated giant cells typical of Herpes virus infection and serologic studies were positive for Herpes simplex virus type II.
	dermatlas.med.jhmi.edu /derm/result.cfm?Diagnosis=199 (878 words)

	Overview of Herpes Simplex Virus-1 (HSV-1) : ViraCor Laboratories
		Herpes simplex virus (HSV) infections are extremely common in humans.
		Reactivation of the virus is common with HSV-1, with frequency varying from 1 attack per month to less than 1 attack per 6 months.
		Simmons A. Clinical Manifestations and Treatment Considerations of Herpes Simplex Virus Infection.
	www.viracor.com /diagnostic-virals-hsv_overview.htm (772 words)

	Virus Vectors & Gene Therapy
		Herpes simplex virus type 1 (HSV-1) is a human neurotropic virus, consequently interest has largely focused on using HSV-1 as a vector for gene transfer to the nervous system.
		The wild type HSV-1 virus is able to infect neurones and either proceed into a lytic life cycle or persist as an intranuclear episome in a latent state.
		Though the latent virus is transcriptionally almost silent, it does possess neurone specific promoters that are capable of functioning during latency.
	www.tulane.edu /~dmsander/WWW/335/peel/peel5.html (945 words)

	Genital Herpes in Women: Causes, Symptoms, Diagnosis and Treatment by MedicineNet.com
		Genital herpes, also commonly called "herpes," is a viral infection by the herpes simplex virus (HSV) that is transmitted through intimate contact with the mucous-covered linings of the mouth or the vagina or the genital skin.
		Two types of herpes viruses are associated with genital lesions: herpes simplex virus-1 (HSV-1) and herpes simplex virus-2 (HSV-2).
		Part of the reason for the continued high infection rate is that most women infected with the herpes virus do not know that they are infected because they have few or no symptoms.
	www.medicinenet.com /genital_herpes_in_women/page2.htm (435 words)

	Herpes HSV-1 & HSV-2 (via CobWeb/3.1 planetlab2.isi.jhu.edu) (Site not responding. Last check: 2007-11-06)
		HSV-1 is also the usual cause of herpes whitlow, an infection on the finger, and "wrestler's herpes," (herpes gladiatorum) a herpes infection on the chest or face.
		As a number of readers have attested over the years, many people with genital herpes are at least as concerned about transmission-the likelihood of spreading the virus to a partner-as about their own health.
		Usually the first herpes simplex virus that people encounter, oral HSV-1, is typically spread simply by the kind of social kiss that a relative gives a child.
	www.herpes.com.cob-web.org:8888 /hsv1-2.html (2796 words)

	Virus particles produced by the herpes simplex virus type 1 alkaline nuclease null mutant ambUL12 contain abnormal ...
		Virus yields were determined by titration on S22 cells and the particle concentrations were determined by electron microscopy.
		virus particles, thereby increasing the likelihood of recombination.
		Herpes simplex virus type 1 alkaline nuclease is required for efficient processing of viral DNA replication intermediates.
	vir.sgmjournals.org /cgi/content/full/85/3/583 (5443 words)

	Herpes Facts: What is a Herpes Simplex Virus (HSV)
		It is thought that the virus sheds its envelope as soon as it has entered the nerve and uses the axon as a conduit, hiding from immune system attack, as if it were inside a “Trojan Horse”.
		This is why dormant virus from the trigeminal ganglion (oral or facial area) reactivates in the oral or facial region, whereas the dormant virus from the sacral ganglion (lower back/spine area) reactivate to the genital area or the buttock.
		According to most researchers, virus replication will not occur at this stage and no new virus particles will be formedThe precise molecular mechanisms for this event (establishment and maintenance of latency) are unknown, but appear to reflect an interplay between viral and nerve cell factors.
	www.herpesguide.ca /facts/herpes_simplex_virus.html (844 words)

	Herpes symptom herpes simplex virus 1 (via CobWeb/3.1 planetlab2.isi.jhu.edu) (Site not responding. Last check: 2007-11-06)
		Structured abstracts herpes virus 2 (less than 250 words) should be herpes simplex virus 1 submitted.
		Earnings Median herpes vaccine annual earnings picture of genital herpes symptom chemical properties herpes outbreak in 2002 herpes herpes symptom were $77,050.
		The growing elderly population and medication herpes simplex virus 1 distribution systems, is there a cure for herpes increasingly sophisticated consumers seeking more information about drugs, and by Medicare.
	herpes-symptom.hotinfocenter.com.cob-web.org:8888 (605 words)

	UpToDate Herpes simplex virus type 1 encephalitis
		— Herpes encephalitis is the most common cause of fatal sporadic encephalitis in the United States, accounting for approximately 10 to 20 percent of the 20,000 annual viral encephalitis cases [1,2].
		The infection arises in all age groups, with one-third of all cases occurring in children and adolescents [3].
		— In nearly all cases of herpes encephalitis beyond the neonatal period, the etiologic agent is herpes simplex virus type 1 (HSV-1).
	patients.uptodate.com /topic.asp?file=viral_in/12100 (330 words)

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