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Topic: Hibernating myocardium

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Stunned myocardium

Myocardial infarction

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	Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations (Site not responding. Last check: 2007-10-21)
		Background: Hibernating myocardium is defined as a state of persistently impaired myocardial function at rest due to reduced coronary blood flow that can partially or completely be restored to normal if the myocardial oxygen supply/demand relationship is favorably altered.
		Methods: A model of hibernating myocardium was created by placement of an ameroid constrictor in the proximal left anterior descending artery of a 35 kg male Yorkshire pig.
		The presence of hibernating myocardium was confirmed with dobutamine stress echocardiography (DSE) and defined as severe hypocontractility at rest, with an improvement in systolic wall thickening with low-dose dobutamine in myocardial regions with a subsequent deterioration in function at peak stress (biphasic response).
	www.osti.gov /energycitations/product.biblio.jsp?osti_id=20601292 (520 words)

	UpToDate Pathophysiology of stunned or hibernating myocardium
		The approach to diagnosis and therapy of hibernation, the clinical syndromes associated with stunned or hibernating myocardium, and the role of nuclear imaging and dobutamine echocardiography to assess myocardial viability are discussed elsewhere.
		— Hibernating myocardium must be distinguished from the stunned myocardium and from transient LV dysfunction that is a result of ischemia induced by stress (eg, exercise, dobutamine).
		In the clinical setting, stunned myocardium may be superimposed on ischemia (including variant angina and during and after coronary revascularization), hibernation, or infarction when blood flow is reestablished [8].
	patients.uptodate.com /topic.asp?file=chd/46551&...+heart+disease (449 words)

	Hibernating and Stunned Myocardium - Cardiovascular Physiology - Medstudents (Site not responding. Last check: 2007-10-21)
		Hibernating myocardium (HM) must be differentited by stunning, although both processes may coexist on clinical grounds (7), and in some instances, it is difficult to say which of them predominates in a individual patient (3).
		In hibernating cells, there is increased uptake in glucose (1,2,8), which was comproved by studies with PET and fluordeoxyglucose and by the presence of glycogen on these cells.
		Although improvement of regional dysfunction (hibernating segments) may perhaps be associated with better outcome, there is no clearly documented effect on mortality.
	www.medstudents.com.br /basic/cardfs/cardfs7.htm (1449 words)

	UB Reporter: Seeking answers to cardiac condition
		These adaptations, termed hibernating myocardium, occur commonly in one or more regions of the heart in many patients with depressed heart function, said Canty.
		In a hibernating region of the heart, muscle cells don't receive enough blood due to long-standing coronary-artery narrowing, but they adapt to this impairment by reducing their function and oxygen needs.
		Hibernating myocardial cells, with their depressed function, appear to be out of sync with adjacent healthy myocardial cells.
	www.buffalo.edu /reporter/vol36/vol36n10/articles/SCDstudy.html (1000 words)

	Myocardial infarction (Site not responding. Last check: 2007-10-21)
		The medical term for a heart attack is myocardial infarction, where "myo" refers to muscle, and "cardium" refers to the heart (myocardium is the heart muscle) and "infarction" means tissue death (necrosis) caused by an obstruction of blood flow.
		All risk factors for atherosclerosis are also (modifiable) risk factors for ischemic heart disease: older age, smoking, hypercholesterolemia, diabetes (or insulin resistance) and obesity.
		The ultimate goal of the management in the acute phase of the disease is to salvage as much myocardium as possible and restore contractile function of heart chambers.
	www.sciencedaily.com /encyclopedia/myocardial_infarction (1546 words)

	Hibernating Myocardium : An Incomplete Adaptation to Ischemia -- Elsässer et al. 96 (9): 2920 -- Circulation
		In hibernating myocardium; disturbance of the arrangement of the sarcomeres (red) and a large extracellular space (green for collagen XI) are evident in this computer-reconstructed confocal microscopy picture (b).
		Vimentin was absent in myocytes in hibernating myocardium.
		In hibernating myocardium: the septa between myocytes are thickened, indicating slight degeneration (b).
	circ.ahajournals.org /cgi/content/full/96/9/2920 (5745 words)

	Prevalence of hibernating myocardium in patients with severely impaired ischaemic left ventricles -- Al-Mohammad et al. ...
		Hibernating myocardium is the chronically ischaemic myocardium with impaired contraction, which improves with revascularisation.
		The principles of the diagnosis of hibernating myocardium by PET lie in the biochemical behaviour of the ischaemic myocardium.
		NH3 by the myocardium on metabolic factors and its implications for quantitative assessment of perfusion.
	heart.bmjjournals.com /cgi/content/full/80/6/559 (3828 words)

	Hibernating myocardium - Wikipedia, the free encyclopedia
		In cardiology hibernating myocardium is a state when some segments of the myocardium exhibit abnormalities of contractile function.
		The regions of myocardium are still viable and can restore its function.
		There develops a new steady state between MBF and myo\cardial function, MBF reduced and in consequence function is reduced too.
	en.wikipedia.org /wiki/Hibernating_myocardium (149 words)

	Hibernating Myocardium -- HEUSCH 78 (4): 1055 -- Physiological Reviews
		Imposition of an inotropic stimulus on the short-term hibernating
		hibernating myocardium was at the expense of metabolic deterioration
		Not surprisingly, data on the prevalence of hibernating myocardium in patients with coronary artery disease are scanty.
	physrev.physiology.org /cgi/content/full/78/4/1055 (9406 words)

	Hibernating myocardium -- Schulz and Heusch 84 (6): 587 -- Heart
		Not surprisingly, data on the incidence of hibernating myocardium are scanty in patients with coronary artery disease.
		Adaptive responses of coronary circulation and myocardium to chronic reduction in perfusion pressure and flow.
		Hibernating myocardium: morphological correlates of inotropic stimulation and glucose uptake.
	heart.bmjjournals.com /cgi/content/full/84/6/587 (4756 words)

	Spatial Heterogeneity in Fasting and Insulin-Stimulated 18F-2-Deoxyglucose Uptake in Pigs With Hibernating Myocardium ...
		In hibernating myocardium (LAD, •), FDG accumulated at twice the rate of normal myocardium.
		of a pronounced transmural gradient in FDG uptake in hibernating myocardium
		F-2-deoxyglucose deposition and regional flow in pigs with chronically dysfunctional myocardium: evidence for transmural variations in chronic hibernating myocardium.
	www.circulationaha.org /cgi/content/full/102/8/908 (3472 words)

	IDENTIFICATION OF HIBERNATING MYOCARDIUM USING RUBIDIUM-82 KINETICS AND DYNAMIC POSITRON EMISSION TOMOGRAPHY (Site not responding. Last check: 2007-10-21)
		We studied the value of Rubidium-82 PET perfusion tracer kinetics compared to F-18-flurodeoxyglucose (FDG) PET imaging to delineate hibernating from scarred myocardium.
		70%, hibernating myocardium as relative perfusion < 70 % and FDG/Rb-82 >1.2, non-transmural scar as relative perfusion of 50 to 69% and FDG/Rb-82
		ROC analysis showed incremental value of clearance over perfusion data in separating hibernating from scarred myocardium (p=.01).
	www.pulsus.com /ccc2003/abs/a631.htm (384 words)

	Myocardial infarction (Site not responding. Last check: 2007-10-21)
		The medical term for a heart attack is myocardial infarction, where "myo" refers to muscle, and "cardium" refers tothe heart (myocardium is the heart muscle) and " infarction " means tissue death (necrosis)caused by an obstruction of blood flow.
		In the hospital, oxygen, aspirin, nitroglycerin and analgesia (usually morphine) are administered as soon as possible,if this has not already happened during transport.
		The ultimate goal of the management in the acute phase of the disease is to salvage as much myocardium as possible and restorecontractile function of heart chambers.
	www.therfcc.org /myocardial-infarction-7965.html (1377 words)

	Hibernating Myocardium: Chronically Adapted to Ischemia but Vulnerable to Sudden Death -- Canty et al. 94 (8): 1142 -- ... (Site not responding. Last check: 2007-10-21)
		Wall thickening was regionally reduced in animals with hibernating myocardium, with no differences between those that subsequently experienced SCD compared with survivors.
		Stability of hibernating myocardium in pigs with a chronic left anterior descending coronary artery stenosis: absence of progressive fibrosis in the setting of stable reductions in flow, function and coronary flow reserve.
		Hibernating myocardium retains metabolic and contractile reserve despite regional reductions in flow, function, and oxygen consumption at rest.
	circres.ahajournals.org /cgi/content/full/94/8/1142 (4685 words)

	Nitroglycerin Enhances the Ability of Dobutamine Stress Echocardiography to Detect Hibernating Myocardium -- Ma et al. ...
		The regional wall thickening was analyzed according to a modified centerline method (see text for details) with 100 equally divided chords around the cross section of the LV at midpapillary muscle level.
		for the noninvasive detection of viable hibernating myocardium.
		Dobutamine echocardiography in myocardial hibernation: optimal dose and accuracy in predicting recovery of ventricular function after coronary angioplasty.
	circ.ahajournals.org /cgi/content/full/96/11/3992 (5181 words)

	Hibernating Myocardium Retains Metabolic and Contractile Reserve Despite Regional Reductions in Flow, Function, and ... (Site not responding. Last check: 2007-10-21)
		However, in hibernating myocardium (n=16, left), vasodilated flow reserve was severely reduced with only a 2.5-fold increase in full-thickness flow (FT).
		In contrast to the responses of normal myocardium to graded epinephrine infusion, increases in flow and function were blunted in hibernating myocardium.
		The attenuation of oxygen consumption was not related to metabolic ischemia because lactate uptake increased progressively with increases in oxygen consumption in hibernating myocardium (bottom).
	circres.ahajournals.org /cgi/content/full/92/1/48 (4484 words)

	Improvement of Collateral Perfusion and Regional Function by Implantation of Peripheral Blood Mononuclear Cells Into ...
		PM-MNCs were selectively injected into the ischemic hibernating regions (akinetic wall motion area is indicated by red zone; where myocardium is viable is indicated by the purple/blue/green zones in the viability view).
		ischemic myocardium because of regional edema or that myocardial
		perfusion in hibernating myocardium in a relatively site-specific
	atvb.ahajournals.org /cgi/content/full/22/11/1804 (3652 words)

	Resting myocardial flow in hibernating myocardium: validating animal models of human pathophysiology -- Canty and ...
		Reductions in coronary flow under resting conditions in collateral-dependent myocardium of patients with complete occlusion of the left anterior descending coronary artery.
		Hibernating myocardium represents a primary downregulation of regional myocardial oxygen consumption distal to a critical coronary stenosis.
		Chronic alterations in SR calcium uptake protein expression in pigs with collateral-dependent hibernating myocardium (Abstract).
	ajpheart.physiology.org /cgi/content/full/277/1/H417 (3358 words)

	Adaptive mechanisms of intracellular calcium homeostasis in mammalian hibernators -- Wang et al. 205 (19): 2957 -- ...
		hibernator cells are characterized by downregulation of the activity
		are one of the keys to surviving hibernation.
		Kondo, N. Excitation—contraction coupling in myocardium of nonhibernating and hibernating chipmunks: effects of isoprenaline, a high calcium medium and ryanodine.
	jeb.biologists.org /cgi/content/full/205/19/2957 (3554 words)

	Pulsed wave tissue Doppler imaging for the quantification of contractile reserve in stunned, hibernating, and scarred ...
		Pulsed wave tissue Doppler imaging for the quantification of contractile reserve in stunned, hibernating, and scarred myocardium -- Bountioukos et al.
		Pulsed wave tissue Doppler imaging for the quantification of contractile reserve in stunned, hibernating, and scarred myocardium
		132 (52%) were classified as stunned, 25 (10%) as hibernating,
	www.heartjnl.com /cgi/content/abstract/90/5/506 (290 words)

	Controlled intermittent asystole cardiac therapy induced by pharmacologically potentiated vagus nerve stimulation in ...
		Controlled intermittent asystole cardiac therapy induced by pharmacologically potentiated vagus nerve stimulation in normal and hibernating myocardium -- Ronson et al.
		Controlled intermittent asystole cardiac therapy induced by pharmacologically potentiated vagus nerve stimulation in normal and hibernating myocardium
		of LAD myocardium (sonomicrometry; 6.2% ± 1.8% versus
	ats.ctsnetjournals.org /cgi/content/abstract/75/6/1929 (354 words)

	Definition of Myocardial infarction
		The medical term myocardial infarction comes from "myo" referring to muscle, "cardium" referring to the heart (myocardium is the heart muscle) and "infarction" meaning tissue death caused by an obstruction of blood flow.
		When this process happens in the coronary vasculature, it leads to myocardial infarction (necrosis of downstream myocardium).
		This is achieved primarily with thrombolytic drugs, such as streptokinase, urokinase, alteplase (recombinant tissue plasminogen activator, rtPA) or reteplase.
	www.wordiq.com /definition/Myocardial_infarction (2065 words)

	Mechanisms of cell survival in hypoxia and hypothermia -- Boutilier 204 (18): 3171 -- Journal of Experimental Biology
		hibernation and during acute hypoxaemia in newborns and adults
		of the cardiac cells of the hibernating mammal (Wang et al., 1997).
		strategy during hibernation in the cold-submerged frog (Donohoe et al., 2000).
	jeb.biologists.org /cgi/content/full/204/18/3171 (6425 words)

	Myeloperoxidase and Plasminogen Activator Inhibitor 1 Play a Central Role in Ventricular Remodeling after Myocardial ...
		No significant differences in plasmin activity in non-infarct myocardium between strains were seen, and no MMP activity was seen in non-infarcted tissue from either strain.
		WT myocardium could be due to the decreased activity of its
		Increased myocardial gene expression of tumor necrosis factor-alpha and nitric oxide synthase-2: a potential mechanism for depressed myocardial function in hibernating myocardium in humans.
	www.jem.org /cgi/content/full/197/5/615 (5184 words)

	Predictive value of dobutamine echocardiography and positron emission tomography in identifying hibernating myocardium ...
		myocardium) in patients with coronary artery disease (CAD) and
		and 66%) in the identification of hibernating myocardium, but
		The natural history of myocardium awaiting revascularisation in patients with impaired left ventricular function
	heartjnl.highwire.org /cgi/content/abstract/79/3/281 (1053 words)

	Dobutamine-Induced Contractile Reserve in Stunned, Hibernating, and Scarred Myocardium in Patients with Ischemic ...
		Dobutamine-Induced Contractile Reserve in Stunned, Hibernating, and Scarred Myocardium in Patients with Ischemic Cardiomyopathy -- Schinkel et al.
		Dobutamine-Induced Contractile Reserve in Stunned, Hibernating, and Scarred Myocardium in Patients with Ischemic Cardiomyopathy
		infusion in a large group of patients with stunned and hibernating
	jnm.snmjournals.org /cgi/content/abstract/44/2/127 (339 words)

	Is chronically dysfunctional yet viable myocardium distal to a severe coronary stenosis hypoperfused? -- Hughes et al. ...
		Is chronically dysfunctional yet viable myocardium distal to a severe coronary stenosis hypoperfused?
		There was no difference in the percentage of hibernating versus
		Therapeutic angiogenesis in chronically ischemic porcine myocardium: comparative effects of bFGF and VEGF
	ats.ctsnetjournals.org /cgi/content/abstract/72/1/163 (515 words)

	Dobutamine Echocardiography Predicts Improvement of Hypoperfused Dysfunctional Myocardium After Revascularization in ...
		Dobutamine Echocardiography Predicts Improvement of Hypoperfused Dysfunctional Myocardium After Revascularization in Patients With Coronary Artery Disease -- Perrone-Filardi et al.
		Prediction of functional recovery of viable myocardium after delayed revascularization in postinfarction patients: Accuracy of dobutamine stress echocardiography and influence of long-term vessel patency
		Dobutamine echocardiography predicts functional outcome after revascularisation in patients with dysfunctional myocardium irrespective of the perfusion pattern on resting thallium-201 imaging
	circ.ahajournals.org /cgi/content/abstract/91/10/2556 (1888 words)

	Intramyocardial and intracoronary basic fibroblast growth factor in porcine hibernating myocardium: A comparative study ...
		Intramyocardial and intracoronary basic fibroblast growth factor in porcine hibernating myocardium: A comparative study -- Biswas et al.
		Intramyocardial and intracoronary basic fibroblast growth factor in porcine hibernating myocardium: A comparative study
		and documented hibernating myocardium by positron emission tomography
	jtcs.ctsnetjournals.org /cgi/content/abstract/127/1/34 (444 words)

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