| |
| | Histamine, anxiety and alcoholism |
 | | In the brain, histamine regulates a wide variety of physiological processes, including water and food intake, sleep-wake cycles, endocrine homeostasis, locomotion, and memory and learning. |
 | | In a new study, researchers have found that decreased levels of brain histamine, which are associated with a functional polymorphism of histamine N-methyltransferase (HNMT) called Thr105 allele, may also result in higher levels of anxiety which may, in turn, confer vulnerability to alcoholism. |
 | | "Our explanation of how the altered histamine levels lead to differences in alcoholism vulnerability and alter harm avoidance is hypothetical, based on previous studies addressing the activity of the enzyme," he said. |
| www.eurekalert.org /pub_releases/2005-03/ace-haa030705.php (734 words) |
|