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Topic: Histamine

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In the News (Mon 18 Feb 19)

 HRH2 - histamine receptor H2
Histamine responses were sensitive to the H1 receptor antagonist triprolidine (10 microM) and the nonselective potassium channel blocker barium (1 mM) but were unaffected by the H2 receptor antagonist tiotidine (10 microM) and the H3 receptor antagonist, clobenpropit (5 microM).
Histamine, selective histamine H1- and H2-receptor agonists, and chemical analogues of these compounds lacking activity at histamine receptors, were tested as inhibitors of phytohaemagglutinin-induced human lymphocyte proliferation and zymosan-induced release of lysosomal enzymes from human polymorphs.
Recently, we have shown that histamine binds to the histamine H2 receptor as a monocation in its proximal tautomeric form, and, moreover, we suggested that a proton is donated from the receptor towards the tele-position of the agonist, thereby triggering the biological effect [Nederkoorn et al., J. Mol.
www.ihop-net.org /UniPub/iHOP/gg/89177.html   (4510 words)

 eMedicine - Toxicity, Marine - Histamine In Fish : Article Excerpt by: Daniel Noltkamper, MD, FACEP   (Site not responding. Last check: 2007-11-05)
Histamine fish poisoning—variously known in the past as scombroid fish poisoning, pseudoallergic fish poisoning, histamine overdose, or mahi-mahi flush—accounts for 5% of all food-borne outbreaks reported to the Centers for Disease Control and Prevention (CDC) and 37% of all seafood-related food-borne illnesses.
Histamine fish poisoning presents as a possible allergic reaction after consuming certain fish but actually is caused by ingesting toxins within the fish's tissues.
Elevated histamine levels in the urine of affected patients and elevated histamine levels in the tissue of the fish confirm that histamine is the causative agent.
www.emedicine.com /ped/byname/toxicity-marine---histamine-in-fish.htm   (580 words)

 CSAHS - CSLS - Fact Sheet
Urinary histamine metabolites including 1-methyl-histamine and 1-methyl-imidazole acetic acid are raised in conditions where there is increased histamine turnover, and this is generally due to proliferation of Mast Cells or Basophils.
Blood histamine and 1-methyl-histamine may not be at all raised as histamine is rapidly metabolised and 1-methyl-histamine is rapidly cleared.
Histamine and metabolites are stable for several days at room temperature in the presence of antibacterial preservatives such as hydrochloric acid and consequently samples may be transported unfrozen.
www.cs.nsw.gov.au /csls/handbook/FactSheetView.asp?Number=44   (1505 words)

Histamine is formed from the amino acid histidine by histidine decarboxylase.
Histamine is produced by and released from mast cells of the peritoneal cavity and connective tissues.
Histamine stimulates muscle contractions in the atrium and the uterus, as well as gastric acid secretion in the gut.
www.neurosci.pharm.utoledo.edu /MBC3320/histamine.htm   (586 words)

 What is Histamine
Histamine is the chemical (neuro-transmitter) your body produces when you're having an allergic reaction.
Although there is always some histamine in your body, a mosquito bite (for example), causes your body to release more histamine in the area of the bite, making your skin red and itchy.
In extreme cases, histamine levels in someone who is allergic to a bee sting or a particular food like strawberries can be elevated so high that it causes anaphylactic shock and possibly death.
www.goldbaum.net /balance/Whats_Histamine.html   (505 words)

 Histamine - Wikipedia, the free encyclopedia
Histamine is broken down by histamine-N-methyltransferase and diamine oxidase, and is also possibly taken up by a transporter.
Most tissue histamine is found in granules in mast cells (photo) or basophils.
This may be because of antipsychotics that have unwanted effect on histamine, such as Quetiapine.
en.wikipedia.org /wiki/Histamine   (774 words)

 The Histamine Factor, Chronic Histamine Reactions in Fibromylgia Gulf war syndrome, Lupus Arthritis
Histamines are released from mast cells as part of an allergic reaction in humans in response to abnormal proteins found in the blood!
Histamine causes small blood vessels to widen allowing fluid to pass from the bloodstream into the surrounding tissues, causing nasal conditions, runny eyes and nose and sometimes hives.
Histamine is the prime mediator in type 1 allergic reactions such as hay fever.
www.rainbowminerals.net /histamine_factor.html   (4331 words)

 Chapter 27: Scombrotoxin (Histamine) Formation
Histamine is more commonly the result of high temperature spoilage than of long term, relatively low temperature spoilage.
The potential for histamine formation is increased when the flesh of the fish is directly exposed to the enzyme-forming bacteria.
Because histamine is generally not uniformly distributed in a decomposed fish, a guidance level of 50 ppm has been set.
seafood.ucdavis.edu /haccp/compendium/Chapt27.htm   (2829 words)

 Untitled Document
Histamine, or 2-(4-imidazolyl)-ethyl-amine, is a dibasic vasoactive amine that is located in most body tissues but is highly concentrated in the lungs, skin, and gastrointestinal tract.
Extracellular histamine is rapidly metabolized, by enzymes present in leukocytes, to metabolites that are excreted in the urine (Paul, 1984).
Interestingly, patients with multiple sclerosis are deficient in histamine; in MS, the myelin sheath that insulates nerves of the CNS and spinal cord is destroyed, and nerve fibers “short circuit”.
www.bio.davidson.edu /Courses/Immunology/Students/Spring2003/Super/home.html   (2574 words)

 MedlinePlus Drug Information: Histamine Diagnostic   (Site not responding. Last check: 2007-11-05)
Histamine (HISS-ta-meen) is used to help diagnose problems or disease of the stomach.
Then the dose of histamine, which is based on body weight, is injected under the skin.
Histamine is to be used only under the supervision of a doctor.
www.nlm.nih.gov /medlineplus/druginfo/uspdi/202282.html   (799 words)

 International Union of Pharmacology. XIII. Classification of Histamine Receptors -- Hill et al. 49 (3): 253 -- ...
-receptor by histamine and the nonimidazole agonist, 2-pyridylethylamine.
-subclasses of histamine receptor by Ash and Schild (1966)
of histamine release in rat cerebral cortex (Taylor and Kilpatrick,
pharmrev.aspetjournals.org /cgi/content/full/49/3/253   (4312 words)

 Transdermal Histamine in MS   (Site not responding. Last check: 2007-11-05)
Histamine therapy is still employed by otolaryngologists today for a number of disorders, including Bell's palsy, vasculitis, Meniere's disease, and other vestibular disturbances.
Histamine at the Tahoma Clinic Histamine transdermal cream was prescribed for 55 consecutive patients with MS without regard to disease classification or time elapsed from formal diagnosis.
· Increased concentration of histamine in the synaptic clefts of histaminergic neural synapses (presuming a synaptic deficit of histamine).
www.thorne.com /altmedrev/fulltext/ms4-6.html   (1608 words)

 HON Allergy Glossary Histamine
When released from mast cells, histamine causes vasodilation and an increase in permeability of blood vessel walls.
When released in the lungs, histamine causes the airways to swell shut in an attempt to close the door on offending allergens and keep them out.
Unfortunately, the ultimate result of this response is the wheezing and difficulty in breathing seen in people with asthma - an occasionally deadly allergic complication which kills an estimated 4000 Americans yearly.
www.hon.ch /Library/Theme/Allergy/Glossary/histamine.html   (121 words)

Histamine is an important protein involved in many allergic reactions.
Histamine's second type of allergic response is one of the major causes for asthma.
If the effects of histamine during an allergic reaction are inhibited, the life of an allergic person can be eased (in the case of inflammation) or even saved by preventing or shortening asthma attacks.
www.bio.davidson.edu /courses/Immunology/Students/spring2000/lamar/mfirp.htm   (672 words)

 Allergy Symptoms are triggered by Histamine and Treatment often involves Antihistamines
Histamine carries its message to a large number of cells by attaching to a special receptor on the cells' surfaces.
The H1 and H2 receptors both receive histamine as a messenger, but the meaning taken by the different receptors is different.
Histamine dilates blood vessels and acts with prostaglandins, PGE2 and PGI2, to produce the early swelling, redness and heat of an inflammatory response.
www.nutramed.com /allergy/antihistamines.htm   (934 words)

 Histamine antibodies from RDI Divison of Fitzgerald Industries Intl
Description/Specificity Histamine is a neurotransmitter in the central nervous system a well as a mast cell constituent.
In addition, histamine is produced by endocrine cells (ECL-cells) in the oxynthic mucosa of the stomach.
Histamine immunohistochemistry: a new and highly sensitive method for studying cutaneous mast cells.
www.researchd.com /miscabs/histamab.htm   (325 words)

 Histamine alters E-cadherin cell adhesion to increase human airway epithelial permeability -- Zabner et al. 95 (1): 394 ...
Histamine increased cell calcium in L cells expressing the human histamine receptor (L-H1) or the human histamine receptor and E-cadherin (L-H1-Ecad) but not in L cells alone.
Histamine decreased adhesion to the E-cadherin-Fc fusion protein of L cells expressing both E-cadherin and the human histamine receptor (L-H1-Ecad) but not L cells expressing either E-cadherin (L-Ecad) or the histamine receptor (L-H1) alone.
Histamine and inositol phosphate accumulation in endothelium: cAMP and a G protein.
jap.physiology.org /cgi/content/full/95/1/394   (4554 words)

 Histamine Restricted Diet—ICUS - International Chronic Urticaria Society
Histamine occurs in food as a result of microbial enzymes converting the amino acid histidine (present in all proteins) to histamine.
Histamine levels reach a reactive level long before any signs of spoilage occur in the food.
Foods reported to release histamine directly from mast cells are uncooked egg whites, shellfish, strawberries, tomatoes, fish, chocolate, pineapple and alcohol.
www.urticaria.thunderworksinc.com /pages/lowhistamine.htm   (612 words)

 Histamine Patch
Her Invention of the histamine patch Procarin to treat MS symptoms has catapulated the 41 year-old from obscurity to celebrity.
"Histamine is a substance that is found in the body, and acts as a mediator, affecting many systems.
I believe MS patients are deficient in histamine, which accounts for their immune cells.
www.tahoma-clinic.com /berger3.shtml   (723 words)

 Arthropod-Derived Histamine-Binding Protein Prevents Murine Allergic Asthma -- Couillin et al. 173 (5): 3281 -- The ...
Histamine is an intracellular messenger mediating platelet aggregation.
Histamine up-regulates Th1 and down-regulates Th2 responses due to different patterns of surface histamine 1 and 2 receptor expression.
Differential inhibition of histamine release from mast cells by protein kinase C inhibitors: staurosporine and K-252a.
www.jimmunol.org /cgi/content/full/173/5/3281   (3950 words)

 Definition: Histamine
Histamine - a chemical found in some of the body's cells - causes many of the symptoms of allergies, such as a runny nose or sneezing.
When a person is allergic to a particular substance, such as a food or dust, the immune system mistakenly believes that this usually harmless substance is actually harmful to the body.
The histamine then acts on a person's eyes, nose, throat, lungs, skin, or gastrointestinal tract, causing allergy symptoms.
www.kidshealth.org /parent/asthma_basics/dictionary/histamine.html   (175 words)

 Histamine selectively interrupts VE-cadherin adhesion independently of capacitive calcium entry -- Winter et al. 287 ...
to histamine of a monolayer of polarized cells (24).
Histamine does not alter the binding of L cells (A) or L cells expressing the H1 receptor (L-H1, B) to fibronectin-coated 96-well tissue culture plates.
The histamine (10 µM)-induced change in binding of L-H1-VEcad cells to immobilized VEcad-Fc was measured in the absence (Control) and presence of 1 mM lanthanum, and the results were normalized to mock-treated cells (zero time point).
ajplung.physiology.org /cgi/content/full/287/4/L816   (4985 words)

 Histamine - 1
Histamine is active biologically, but the first step for its inactivation involves the addition of a methyl group (CH followed by a chemical oxidation.
Histamine Modulation is associated with the inflammatory responses.
Histamine cause the stimulation of release by secretory tissues.
www.pharmacology2000.com /Histamine/hist1a.htm   (2918 words)

 Histamine & Multiple Sclerosis
The authors investigated the amount of blood Histamine in 92 patients with Multiple Sclerosis, depending on the length of the disease and its clinical form.
It was established that the patients showed a high level of blood Histamine (disease length - under 5 years) and a low level (disease length - over 5 years).
MS Killer Cells were more sensitive in vitro to the boosting effects of both Histamine and Insulin than either OND or normal controls, both in dose response and magnitude of the increased ADCC.
members.tripod.com /thjuland/histamine.html   (1011 words)

 Histamine Antagonizes Tumor Necrosis Factor (TNF) Signaling by Stimulating TNF Receptor Shedding from the Cell Surface ...
Histamine Antagonizes Tumor Necrosis Factor (TNF) Signaling by Stimulating TNF Receptor Shedding from the Cell Surface and Golgi Storage Pool -- Wang et al.
HUVEC were treated with histamine for the times indicated, and the concentration of TNF receptors shed into the media was measured as described under "Experimental Procedures." Untreated cells spontaneously shed soluble TNF receptors into culture media.
Treatment with histamine for 30 min did not alter the relative expression of the pro-enzyme and mature form in different cell fractions.
www.jbc.org /cgi/content/full/278/24/21751   (6203 words)

 The Individualist: Histamine
The release of histamine (hist = because it's made up of histidine residues, amine = because it's a vasoactive amine) causes several allergic symptoms.
This is accomplished due to histamine's ability to induce phosphorylation of an intercellular adhesion protein (called (VE)-cadherins) found on vascular endothelial cells.
That is why histamine is known as being vasoactive.
www.dadamo.com /wiki/wiki.pl/Histamine   (340 words)

 Histamine, anxiety and alcoholism
In the brain, histamine regulates a wide variety of physiological processes, including water and food intake, sleep-wake cycles, endocrine homeostasis, locomotion, and memory and learning.
In a new study, researchers have found that decreased levels of brain histamine, which are associated with a functional polymorphism of histamine N-methyltransferase (HNMT) called Thr105 allele, may also result in higher levels of anxiety which may, in turn, confer vulnerability to alcoholism.
"Our explanation of how the altered histamine levels lead to differences in alcoholism vulnerability and alter harm avoidance is hypothetical, based on previous studies addressing the activity of the enzyme," he said.
www.eurekalert.org /pub_releases/2005-03/ace-haa030705.php   (734 words)

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