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Topic: Histamine receptor

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Receptor (biochemistry)

GTPase

Transmembrane helix

Amino acid

	Histamine
		Agonist binding was regulated by guanyl nucleotides, implying that the receptor belonged to the superfamily of receptors coupled to G proteins.
		receptor were known to occur in distinct cell lines or brain slices but could have been due to stimulation of isoreceptors.
		Histamine release from the anterior hypothalamus of freely moving rats, evaluated by in vivo microdialysis, gradually increased in the second half of the light period and was maintained at a maximal level during the active phase (
	www.acnp.org /g4/GN401000037/CH037.html (4444 words)

	HRH2 - histamine receptor H2
		HRH2 - histamine receptor H2 For this study, we investigated the effects of histamine on NADPH oxidase activity in human neutrophil granulocytes triggered by a lipoxin A4 receptor agonist [the hexapeptide Trp-Lys-Tyr-Met-Val-Met (WKYMVM), a formyl peptide receptor (FPR) agonist (the chemotactic tripeptide formylmethionyl-leucyl-phenylalanine (fMLF)) and an activator of protein kinase C (phorbol myristate acetate (PMA)].
		The effect of histamine, prometasin (the blocker of histamine H-1 receptor) and cimetidin (the blocker of histamine H-2 receptor) on the frequency of the isolated right atrium of rat was studied.
		HRH2 is a homologue of Hrh2 (histamine receptor H 2) from Mus musculus.
	www.ihop-net.org /UniPub/iHOP/gg/89177.html (959 words)

	Histamine - Wikipedia, the free encyclopedia
		Histamine is a biogenic amine chemical involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter.
		Histamine is derived from the decarboxylation of the amino acid histidine, a reaction catalyzed by the enzyme L-histidine decarboxylase.
		histamine receptor - found on smooth muscle, endothelium, and central nervous system tissue; causes vasodilation, bronchoconstriction, smooth muscle activation, and separation of endothelial cells (responsible for hives), and pain and itching due to insect stings; the primary receptors involved in allergic rhinitis symptoms and motion sickness.
	en.wikipedia.org /wiki/Histamine (747 words)

	Abbott's H3 histamine receptor antagonist, ABT-239, a candidate treatment of cognitive disorders, ADHD, Alzheimer's and ...
		Histamine H3 receptors, which are predominantly expressed in the CNS, act as autoreceptors in presynaptic neurons, and control histamine turnover.
		Histamine H3 antagonists were first investigated as possible modulators of food intake however it is now clear that histamine H3 receptors are involved in arousal disorders (eg attention deficit hyperactivity disorder - ADHD) and conditions associated with reduced cognition (eg Alzheimer's disease).
		The identification of H3 receptor antagonists has received considerable attention in the field of attention and cognitive disorders since first generation antagonists were shown to promote attention and wakefulness and improve short-term and social memory in rodents.
	www.bioportfolio.com /LeadDiscovery/PubMed-120407.html (1701 words)

	International Union of Pharmacology. XIII. Classification of Histamine Receptors -- Hill et al. 49 (3): 253 -- ...
		-receptor by histamine and the nonimidazole agonist, 2-pyridylethylamine.
		-subclasses of histamine receptor by Ash and Schild (1966)
		of histamine release in rat cerebral cortex (Taylor and Kilpatrick,
	pharmrev.aspetjournals.org /cgi/content/full/49/3/253 (4312 words)

	Allergy & Asthma Disease Management Center: Ask the Expert: Antihistamine
		Histamine- is a chemical released in the body mainly from two types of cells,-mast cells and basophils.
		Airway hyperresponsiveness to histamine is a hallmark of asthma, and histamine inhalation reproduces asthma symptoms.
		Plasma histamine concentrations are elevated during the early and later responses to inhaled allergens, and may also increase during spontaneous acute asthma episodes.
	www.aaaai.org /aadmc/ate/antihistamine.html (9595 words)

	Histamine alters E-cadherin cell adhesion to increase human airway epithelial permeability -- Zabner et al. 95 (1): 394 ...
		histamine receptor and E-cadherin to an E-cadherin-Fc fusion
		Histamine increased cell calcium in L cells expressing the human histamine receptor (L-H1) or the human histamine receptor and E-cadherin (L-H1-Ecad) but not in L cells alone.
		Histamine decreased adhesion to the E-cadherin-Fc fusion protein of L cells expressing both E-cadherin and the human histamine receptor (L-H1-Ecad) but not L cells expressing either E-cadherin (L-Ecad) or the histamine receptor (L-H1) alone.
	jap.physiology.org /cgi/content/full/95/1/394 (4554 words)

	[No title]
		Although their activating ligands vary widely in structure and character, the amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7 transmembrane (TM) helices [2, 3, 4].
		Histamine is distributed within mast cells in all peripheral tissues and is a well-characterised mediator of inflammation and allergy [5].
		The receptor is distributed widely in the periphery, notably smooth muscle, where it stimulates contraction, and also in the adrenal medulla, vascular endothelium and heart.
	www.ebi.ac.uk /interpro/IEntry?ac=IPR000921 (326 words)

	Cellzome - H4 Receptor Project
		The » Histamine H4 receptor is an emerging target for the treatment of inflammatory diseases.
		The lead molecule binds to the human H4 receptor with high affinity and is highly selective over the other histamine receptors.
		In parallel, Cellzome is investigating the role of the receptor, and the therapeutic potential of its lead molecule, in other inflammatory diseases.
	www.cellzome.com /drug_h4.html (155 words)

	Clinical Trial: Histamine Responsiveness in McCune-Albright Syndrome
		Release of histamine from mast cells is primarily responsible for immediate hypersensitivity reaction in the skin.
		This cytokine response is mediated by H2 receptor activation and activation of Gαs.
		A published report of standard wheal and flare responses to histamine demonstrates that the sum of the longest (A) and orthogonal (B) (determined by the midpoint of A, labeled X) [Σ =A+B] diameter of the wheal and flare response to histamine was 7.0 cm ± 1.25 cm.
	www.clinicaltrials.gov /ct/show/NCT00318097 (1829 words)

	Histamine - 1
		Histamine is active biologically, but the first step for its inactivation involves the addition of a methyl group (CH followed by a chemical oxidation.
		Histamine Modulation is associated with the inflammatory responses.
		histamine receptor blockers are drugs of choice to treat allergic rhinitis and urticaria.
	www.pharmacology2000.com /Histamine/hist1a.htm (2918 words)

	Histamine-2 Receptor Blockers - Drug Comparisons - Compare Drugs - DrugDigest
		Histamine-2 receptor antagonists, also known as H2 blockers, are drugs that prevent or block the production of gastric (stomach) acid.
		A pump in the stomach releases hydrochloric acid when stimulated by histamine.
		H2 blockers prevent histamine from stimulating this pump, thereby reducing the amount of acid that is released into the stomach.
	www.drugdigest.org /DD/Comparison/NewComparison/0,10621,36-14,00.html (673 words)

	Histamine Antagonizes Tumor Necrosis Factor (TNF) Signaling by Stimulating TNF Receptor Shedding from the Cell Surface ...
		Histamine Antagonizes Tumor Necrosis Factor (TNF) Signaling by Stimulating TNF Receptor Shedding from the Cell Surface and Golgi Storage Pool -- Wang et al.
		HUVEC were treated with histamine for the times indicated, and the concentration of TNF receptors shed into the media was measured as described under "Experimental Procedures." Untreated cells spontaneously shed soluble TNF receptors into culture media.
		Treatment with histamine for 30 min did not alter the relative expression of the pro-enzyme and mature form in different cell fractions.
	www.jbc.org /cgi/content/full/278/24/21751 (6203 words)

	The human histamine H2 receptor regulates c-jun and c-fos in a differential manner -- Wang et al. 278 (6): C1246 -- AJP ...
		The stimulatory effect of histamine on ERK and JNK activation was examined by using a specific immune complex assay.
		The ability of a receptor to activate downstream effectors is in part dictated by the cell type in which it is found.
		receptor antagonists on melanogenesis and cellular proliferation in melanoma cells in culture.
	ajpcell.physiology.org /cgi/content/full/278/6/C1246 (5319 words)

	Histamine H2 Receptor Activated Chloride Conductance in Myenteric Neurons From Guinea Pig Small Intestine -- Starodub ...
		Nemeth, P. Ort, C. and Wood, J. Intracellular study of effects of histamine on electrical behavior of myenteric neurons in guinea pig small intestine.
		Starodub, A. Baidan, L. and Wood, J. Histamine blocks A-type potassium channels in myenteric neurons of guinea pig small intestine.
		Tamura, K., and Wood, J. Effects of prolonged exposure to histamine on guinea pig intestinal neurons.
	jn.physiology.org /cgi/content/full/83/4/1809 (4639 words)

	Alibris: Histamine
		Presents the latest advances and current research in histamine, histamine receptors, and H1-receptor antagonists for practical application in allergy, immunology, dermatology, otolaryngology, and pulmonology, to control and reduce inflammation in major systems of the body.
		Histamine and H2 Antagonists in Inflammation and Immunodeficiency
		In the early eighties when the H3 receptor was identified, many thought that an H3 ligand, an agonist or an antagonist, would become available as a therapeutic agent.
	www.alibris.com /search/books/subject/Histamine (329 words)

	Ciproxifan, a Histamine H3-Receptor Antagonist/Inverse Agonist, Potentiates Neurochemical and Behavioral Effects of ...
		Bristow LJ, Bennett GW (1988) Biphasic effects of intra-accumbens histamine administration on spontaneous motor activity in the rat: a role for central histamine receptors.
		Kalivas PW (1982) Histamine induced arousal in the conscious and pentobarbital rat.
		Le Moine C, Bloch B (1995) D1 and D2 dopamine receptor gene expression in the rat striatum: sensitive cRNA probes demonstrate prominent segregation of D1 and D2 mRNAs in distinct neuronal populations of the dorsal and ventral striatum.
	www.jneurosci.org /cgi/content/full/22/16/7272 (5135 words)

	Histamine H4 Receptor Mediates Chemotaxis and Calcium Mobilization of Mast Cells -- Hofstra et al. 305 (3): 1212 -- ...
		receptor gene was disrupted by replacing exon 1 with a neomycin-resistant gene cassette.
		receptor expression is restricted to mast cells, basophils, and eosinophils.
		B, in the lower chamber, 10 µM histamine was added, while in both chambers 10 µM histamine receptor antagonists were added and mast cells were added in the upper chamber.
	jpet.aspetjournals.org /cgi/content/full/305/3/1212 (5173 words)

	Histamine H3 receptor antagonist/inverse agonists : ciproxifan
		e have explored the effect of histamine H3-receptor ligands on the regulation of neuropeptide mRNA expression in the striatum by using in situ hybridization performed with proenkephalin, prodynorphin, substance P and proneurotensin riboprobes.
		Acute administration of ciproxifan, an H3-receptor antagonist/inverse agonist, or (R)-alpha-methylhistamine, an H3-receptor agonist, did not modify the striatal expression of the neuropeptides by itself.
		They suggest that endogenous histamine and dopamine cooperate to modulate the activity of striatal projection neurons and strengthen the interest of H3-receptors as new targets for the treatment of psychotic disorders and drug abuse.
	www.biopsychiatry.com /histamineh3.htm (251 words)

	The H1 histamine receptor regulates allergic lung responses -- Bryce et al. 116 (6): 1624 -- Journal of Clinical ...
		Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors.
		Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation.
		Identification of Bphs, an autoimmune disease locus, as histamine receptor H1.
	www.jci.org /cgi/content/full/116/6/1624 (5043 words)

	Photoperiodic Regulation of Histamine H3 Receptor and VGF Messenger Ribonucleic Acid in the Arcuate Nucleus of the ...
		Photoperiodic Regulation of Histamine H3 Receptor and VGF Messenger Ribonucleic Acid in the Arcuate Nucleus of the Siberian Hamster -- Barrett et al.
		Photoperiodic Regulation of Histamine H3 Receptor and VGF Messenger Ribonucleic Acid in the Arcuate Nucleus of the Siberian Hamster
		Indicated are hybridizing regions in the ventromedial hypothalamic nucleus (VMH) and ARC regions of the hypothalamus.
	endo.endojournals.org /cgi/content/full/146/4/1930 (6263 words)

	Histamine Receptor Pathway (Site not responding. Last check: 2007-11-03)
		Digested food and distention also cause gastrin to be released from G cells in the stomach.
		Acetylcholine and gastrin both stimulate the ECL cells to release histamine.
		When histamine binds to its receptor, the parietal cell's permeability to calcium ions (Ca) is altered, and Ca move into the cell.
	www.gerd.com /intro/noframe/hrp.htm (215 words)

	Involvement of Hypothalamic Histamine H1 Receptor in the Regulation of Feeding Rhythm and Obesity -- Masaki et al. 53 ...
		Involvement of Hypothalamic Histamine H1 Receptor in the Regulation of Feeding Rhythm and Obesity -- Masaki et al.
		Receptor in the Regulation of Feeding Rhythm and Obesity
		The role of histamine H1 receptor and H2 receptor in LPS-induced liver injury
	diabetes.diabetesjournals.org /cgi/content/abstract/53/9/2250 (397 words)

	Modulation of H2 histamine receptor-mediated cAMP generation and granulocytic differentiation by extracellular ...
		Modulation of H2 histamine receptor-mediated cAMP generation and granulocytic differentiation by extracellular nucleotides via activation of protein kinase C -- Suh et al.
		histamine receptor-mediated cAMP generation and granulocytic differentiation by extracellular nucleotides via activation of protein kinase C
		nucleotides are negatively involved in the modulation of histamine
	www.jleukbio.org /cgi/content/abstract/69/1/169 (318 words)

	Augmentation of Antigen Receptor-mediated Responses by Histamine H1 Receptor Signaling -- Banu and Watanabe 189 (4): ...
		Augmentation of Antigen Receptor-mediated Responses by Histamine H1 Receptor Signaling -- Banu and Watanabe 189 (4): 673 -- The Journal of Experimental Medicine
		Augmentation of Antigen Receptor-mediated Responses by Histamine H1 Receptor Signaling
		Histamine is considered one of the important mediators of immediate hypersensitivity and inflammation, and acts via G protein-coupled
	www.jem.org /cgi/content/abstract/189/4/673 (518 words)

	Systematic review: the efficacy of intermittent and on-demand therapy with histamine H2-receptor antagonists or proton ... (Site not responding. Last check: 2007-11-03)
		Systematic review: the efficacy of intermittent and on-demand therapy with histamine H2-receptor antagonists or proton pump inhibitors for gastro-oesophageal reflux disease patients.
		Heartburn Research Today is a free monthly online journal that collates and summarizes the latest research about Heartburn, including details on symptoms, causes, prevention, treatment, diet, reflux, drugs.
		AIM: To perform a systematic review on the efficacy of intermittent and on-demand therapy with either histamine H2-receptor antagonists or proton pump inhibitors for patients with erosive oesophagitis or symptomatic heartburn.
	heartburn.researchtoday.net /archive/2/6/91.htm (328 words)

	UniProtKB/Swiss-Prot entry Q9Y5N1 [HRH3_HUMAN] Histamine H3 receptor
		: The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system.
		Isoform 4 is unable to bind to iodoproxyfan while isoforms 1 and 3 bind it with high affinity.
		Molecular function: histamine receptor activity (traceable author statement from ProtInc).
	www.expasy.org /uniprot/Q9Y5N1 (681 words)

	Texas Medicaid Vendor Drug Program, Histamine H2 - Receptor Antagonists
		The adult maximum daily dose for acute and maintenance therapy for peptic ulcer disease, esophagitis, gastroesophageal reflux disease (GERD), hypersecretory conditions, gastritis and duodenitis is based on the compendia, literature and package labeling.
		The maximum daily dose for histamine H2-receptor antagonists when prescribed as acute therapy is summarized in Table 1.
		The combination of two or more histamine H2-receptor antagonists or a histamine H2-receptor antagonist and misoprostol is not supported by the current literature.
	www.hhsc.state.tx.us /HCF/vdp/Criteria/histamin.html (1423 words)

	UniProtKB/Swiss-Prot entry P35367 [HRH1_HUMAN] Histamine H1 receptor
		: In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
		Molecular function: G-protein coupled receptor activity (traceable author statement from ProtInc).
		G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; Palmitate; Phosphorylation; Receptor; Transducer; Transmembrane.
	www.expasy.org /uniprot/P35367 (447 words)

	Histamine H1 Receptor (H-20) Antibody sc-19767
		Histamine H1 Receptor (H-20): sc-19767 is suitable for use as a control antibody for the following siRNAs.
		See how others have used Histamine H1 Receptor (H-20) antibody: sc-19767 and or Histamine H1 Receptor (H-20) antibody conjugates.
		Neutrophil serine proteinases activate human nonepithelial cells to produce inflammatory cytokines through protease-activated receptor 2.
	www.scbt.com /product.php?datasheet=19767 (109 words)

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