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Topic: Histidine


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  L-Histidine
Most often recognized as a precursor to the allergy symptom producing hormone histamine, both histidine and histamine have essential roles in the body beyond tormenting allergy sufferers.
Histamine is well known for its role in stimulating the inflammatory response of skin and mucous membranes such as those found in the nose - this action is essential in the protection of these barriers during infection.
Persons contaminated with heavy metals, suffering from chronic seasonal allergies, or following a low histidine diet are most susceptible to body depletion of adequate histidine stores - creating the possibility of mineral-enzyme deficiencies and dysregulation.
www.cfsn.com /histidine.html   (504 words)

  
  Histidine amino acid information page. All about histidine amino acid and the role it plays in your diet.
Histidine is an essential amino acid, manufactured in sufficient quantities in adults, but children may at some time have a shortage of this important vitamin.
Histidine is also a precursor of histamine, a compound released by immune system cells during an allergic reaction.
Histidinemia is an inborn error of the metabolism of histidine due to a deficiency of the enzyme histidase, where high levels of histidine are found in the blood and urine, and may manifest in speech disorders and mental retardation.
www.anyvitamins.com /histidine-info.htm   (586 words)

  
  Histidine
Histidine is used as a chelating agent in some cases of arthritis; tissue overload of copper, iron, or other heavy metal; and in the treatment of allergies since it goes on to become histamine.
Histidine also acts to lower blood pressure and relax blood vessels, and is used to treat various cardiac and circulatory problems.
Histidine is known to be vital in the maintenance of the myelin sheaths surrounding nerves, particularly the auditory nerve and is used to treat some forms of hearing disability.
www.innvista.com /health/nutrition/amino/histidin.htm   (466 words)

  
 Histidine
Histidine is an amino acid, essential for growth and repair of tissues.
Histidine is the precursor to histamine, which is a substance released during an allergic reaction.
Histidine is best taken with vitamins B3 and vitamine B6, which help its conversion to histamine.
www.myndonline.com /naturopathy-medicine-encyclopedia/histidine-information.html   (179 words)

  
 histidine - Encyclopedia.com
Histidine is the direct precursor of histamine ; it is also an important source of carbon atoms in the synthesis of purines.
It is thought that the side chain of this amino acid acts as a general acid and base as it participates in the catalytic functions of chymotrypsin, as well as those of a number of enzymes dealing with the metabolism of carbohydrates, proteins, and nucleic acids.
Histidine is considered to be an essential amino acid for infants (it must be supplied in the diet); experiments with adults indicate that they can go for at least short periods without dietary intake of this amino acid.
www.encyclopedia.com /doc/1E1-histidin.html   (640 words)

  
 Histidine   (Site not responding. Last check: 2007-11-06)
In this demographic (infants and children) histidine is considered essential and must be obtained from the diet.
Histidine is one of the most common of all naturally occurring amino acids.
In addition, histidinemia is an inborn error characterized by the inability to metabolize histidine, due to the deficiency of the enzyme histidase.
www.supplementnews.org /histidine   (819 words)

  
 Histidine - Amino Acid
Histidine is a nonessential amino acid in adults, which means that it is manufactured from other amino acids in their livers; it does not have to be obtained directly through the diet.
Histidine is essential in the infant for proper growth and development.
Histidine can be produced in the body as a result of increased muscle protein breakdown with the conversion to 3-methyl histidine.
www.springboard4health.com /notebook/proteins_histidine.html   (317 words)

  
 L-Histidine::CHEM-ONLINE.org::
In a pilot study, RA patients received up to 6 grams of supplemental histidine daily and were said to benefit with as little as 1 gram daily.
Although not conclusively proven ?it is thought that histidine may be beneficial to people suffering from arthritis and nerve deafness.
Histidinemia is an inborn error of the metabolism of histidine due to a deficiency of the enzyme histidase, where high levels of histidine are found in the blood and urine, and may manifest in speech disorders and mental retardation.
www.chem-online.org /amino-acid/l-histidine.htm   (887 words)

  
 Histidine   (Site not responding. Last check: 2007-11-06)
Histidine is an amino acid located within the proteins of all living organisms.
While the majority of histidine is found in proteins, there is a much lesser amount that also exists in some plants and fermented foods.
Histidine is considered by many in the health industry to be one of only 10 essential amino acids for infants.
www.nutrasanus.com /histidine.html   (419 words)

  
 Histidine containing nutriceutical compositions - Patent 5972985
In addtion to histidine's routine metabolic role as a protein building block, histidine is an effective scavenger of toxic oxygen species and therefore is useful in the protection of cells and tissues from a variety of inflammatory disease processes.
Histidine is a particularly preferred component of the nutriceutical of the present invention because it has been shown to protect cells and tissues from damage mediated by the hydroxyl radical (.circle-solid.OH) and singlet oxygen (.sup.1 O.sub.2).
Histidine is one of only a few agents that effectively scavenge singlet oxygen, a highly reactive form of molecular oxygen with an extra unpaired electron which has been shown to be an important cause of ischemia/reperfusion injury.
www.freepatentsonline.com /5972985.html   (9056 words)

  
 Histidine Molecule
Histidine is one of the 20 most common natural
The imidazole side chains of histidine and the relatively neutral pK (ca 6.0) mean that relatively small shifts in cellular pH will change its charge.
Histidine is necessary for growth and repair of tissue, production of red and white blood cells, and preservation of myelin sheaths.
www.worldofmolecules.com /life/histidine.htm   (103 words)

  
 Histidine Benefits - Histidine Deficiency - Histidine Sources   (Site not responding. Last check: 2007-11-06)
Histidine is used as a supplement for sufferers of rheumatoid arthritis, since it has been shown that in these patients, histidine levels are low.
There are no reported side effects with histidine, but too high levels of histidine may lead to stress and mental disorders such as anxiety and people with schizophrenia have been found to have high levels of histidine.
Histidine is an essential amino acid during infancy, and its synthetic pathways in older children and adults are not well understood.
www.healthvitaminsguide.com /aminoacids/histidine.htm   (757 words)

  
 Definition of Histidine
In catalytic triads, the basic nitrogen of histidine is used to abstract a proton from serine, threonine or cysteine to activate it as a nucleophile.
In a histidine proton shuttle, histidine is used to quickly shuttle protons, it can do this by abstracting a proton with its basic nitrogen to make a positively charged intermediate and then use another molecule, a buffer, to extract the proton from its acidic nitrogen.
In carbonic anhydrases, a histidine proton shuttle is utilized to rapidly shuttle protons away from a zinc-bound water molecule to quickly regenerate the active form of the enzyme.
www.wordiq.com /definition/Histidine   (322 words)

  
 Applied Health Histidine
An RDA has not been established for histidine because it is a nonessential amino acid.
Histidine is a nonessential amino acid in adults, which means it is manufactured from other amino acids in the liver; it does not have to be obtained directly through the diet.
Histidine supplementation to individuals with allergy or inflammatory problems can aggravate the condition due to the relationship with histidine.
www.appliedhealth.com /nutri/page6791.php   (409 words)

  
 MoonDragon's Health & Wellness: Nutrition - Amino Acids: Histidine
Histidine is significant in the growth and repair of tissues.
Histidine is one of the basic (with reference to pH) amino acids due to its aromatic nitrogen-heterocyclic imidazole side chain.
There are no reported side effects with histidine, but histidine levels that are too high may lead to stress and even psychological disorders such as anxiety and schizophrenia; people with schizophrenia have been found to have high levels of histidine in their bodies.
www.moondragon.org /health/nutritionbasics/aminoacids/histidine.html   (606 words)

  
 The Individualist: Histidine
In catalytic triads, the basic nitrogen of histidine is used to abstract a proton from serine, threonine or cysteine to activate it as a nucleophile.
In a histidine proton shuttle, histidine is used to quickly shuttle protons, it can do this by abstracting a proton with its basic nitrogen to make a positively-charged intermediate and then use another molecule, a buffer, to extract the proton from its acidic nitrogen.
In carbonic anhydrases, a histidine proton shuttle is utilized to rapidly shuttle protons away from a zinc-bound water molecule to quickly regenerate the active form of the enzyme.
www.dadamo.com /wiki/wiki.pl/Histidine   (426 words)

  
 Defective protein histidine phosphorylation in islets from the Goto-Kakizaki diabetic rat -- Kowluru 285 (3): E498 -- ...
Quantitation of histidine phosphorylation of NDP kinase in lysates
Significant reduction in the histidine phosphorylation of nucleoside diphosphate (NDP) kinase in islet homogenates derived from diabetic Goto-Kakizaki (GK) rats.
Significant reduction in ATP-sensitive (A) or GTP-sensitive (B) histidine phosphorylation of endogenous islet proteins and exogenous histone 4 in diabetic GK rats.
ajpendo.physiology.org /cgi/content/full/285/3/E498   (3608 words)

  
 Lipids in Health and Disease | Full text | L-histidine inhibits production of lysophosphatidic acid by the ...
Site-directed mutagenesis of human ATX established that a specific residue, T210, [7,16] and 3 histidine residues [7,9], corresponding to similar loci in other members of the alkaline phosphatase superfamily, were essential for the motility and enzymatic activities of ATX.
Histidine therefore inhibits a process that is required for the hydrolysis of both nucleotides and phospholipids.
While there are known inhibitors of histidine decarboxylase, such as the polyphenols of green tea [32], potent, stable, and non-toxic analogs of histidine would appear to be better therapeutic agents.
www.lipidworld.com /content/4/1/5   (5247 words)

  
 Get To Know Histidine
In the conversion of malate to oxaloacetate, it is proposed that histidine acts as a general base, abstracting the proton from the hydroxyl of malate (MLT313), and driving the transfer of a hydride ion (not shown) onto the nicotinamide ring of NAD
If the proposal is correct, then before the proton transfer, the histidine ring is in the neutral imidazole form, tautomer C in the figure below.
of imidazole in a histidine residue of a protein should be near this value.
www.usm.maine.edu /~rhodes/Goodies/Get2NoHistidine.html   (561 words)

  
 Molecular Expressions: The Amino Acid Collection - Histidine
Histidine is one of the basic (with reference to pH) amino acids due to its aromatic nitrogen-heterocyclic imidazole side chain.
The disruption of histidine biosynthesis in bacteria is the basis for the famous Ames test, used to determine the mutagenability of various chemicals.
Histidine is incorporated into proteins and enzymes at a molar percentage of 2.1 compared to the other amino acids.
microscopy.fsu.edu /aminoacids/pages/histidine.html   (168 words)

  
 Ligand-dependent Conformational Plasticity of the Periplasmic Histidine-binding Protein HisJ. INVOLVEMENT IN TRANSPORT ...
The periplasmic histidine permease of Salmonella typhimurium is composed of a membrane-bound complex and a soluble histidine-binding protein (the periplasmic receptor), HisJ.
carbons of the ligand, histidine, and Trp-130 (15)), and is not on the surface (the solvent accessibility is <4%, and its fluorescence is quenched <5% by 0.1
The rate of association and dissociation of histidine with HisJ is very fast compared to the rate of 9D2 association with HisJ, and the latter is practically irreversible under the condition of the experiment (17).
www.jbc.org /cgi/content/full/271/35/21243   (6879 words)

  
 Histidine : by Ray Sahelian, M.D., histdine benefits
Histidine by Ray Sahelian, M.D. L Histidine is an amino acid.
Histidine -- or L histidine -- is one of the 22 most common natural amino acids present in proteins.
Histidine is extremely sensitive to a metal-catalyzed oxidation, generating 2-oxo-histidine and its ring-ruptured products, whereas the oxidation of lysine generates carbonyl products, such as aminoadipic semialdehyde.
www.raysahelian.com /histidine.html   (413 words)

  
 BioMed Central | Full text | Osmotic stress-dependent serine phosphorylation of the histidine kinase homologue DokA
DokA, a homologue of bacterial histidine kinases, is an element of the osmoregulatory pathway in the amoeba Dictyostelium.
Most of the corresponding eukaryotic gene products are part of a phosphoryl relay, which consists of a hybrid histidine kinase with a kinase and a receiver domain on the same polypeptide, a histidine phosphotransfer protein and a second receiver as part of a response regulator [3].
Eukaryotic phytochromes, another class of histidine kinase homologues, were shown to act as light-regulated serine/threonine kinases in vitro instead of acting according to the histidine kinase paradigm [8].
www.biomedcentral.com /1471-2091/2/2   (3597 words)

  
 Revisiting Purine-Histidine Cross-Pathway Regulation in Saccharomyces cerevisiae: A Central Role for a Small Molecule ...
of the IMP pathway, is prototrophic for histidine.
or increasing the flux in the histidine pathway.
that AICAR synthesis from the histidine biosynthesis pathway
www.genetics.org /cgi/content/full/170/1/61   (5427 words)

  
 Histidine
Histidine is a semiessential amino acid, which means your body normally makes as much as it needs.
This has led to some speculation that histidine supplements might be a good treatment for this kind of arthritis, but so far no studies have confirmed this.
Although histidine is not required in the diet, histidine deficiencies can occur during periods of very rapid growth.
www.jigsawhealth.com /nat.aspx?&chunkiid=21750   (461 words)

  
 Digging with Experimental Pick and Computational Shovel: a New Addition to the Histidine Kinase Superfamily -- Zhulin ...
The study by Karniol and Vierstra (10) not only predicts that the protein of unknown function Sma2063 is a histidine kinase but also proves it experimentally.
The pair of bacteriophytochromes from Agrobacterium tumefaciens are histidine kinases with opposing photobiological properties.
The HWE histidine kinases, a new family of two-component sensor kinases with potentially diverse roles in environmental signaling.
jb.asm.org /cgi/content/full/186/2/267   (1719 words)

  
 Cockatoo.com / Health Glossary / Histidine - the ejaculation-control amino acid   (Site not responding. Last check: 2007-11-06)
The importance of the amino acid histidine lies in the fact that the body uses it to manufacture histamine, and histamine is responsible for a wide range of physiological processes.
Contrarily, men and women having difficulties achieving orgasms may be helped by histidine supplementation, as this may result in increased histamine levels in the sexual tract, which in turn may make orgasms and ejaculations easier.
An additional pro-sexual effect of histidine may lay in its vasodilating effect, thus making blood flow to the sex organs easier.
www.cockatoo.com /histidine/index.htm   (278 words)

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