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Topic: Histiocyte

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	Histiocyte - Wikipedia, the free encyclopedia
		All categories of Histiocytes are derived from the bone marrow by multiplication from a stem cell.
		Histiocytes have common histological and immunophenotypical characteristics (demonstrated by immunostains).
		Macrophages and dendritic cells are derived from common bone marrow precursor cells that have undergone different differentiation (as histiocytes) under the influence of various environmental (tissue location) and growth factors such as GM-CSF, TNF and IL-4.
	en.wikipedia.org /wiki/Histiocyte (609 words)

	S1C5-Cell Types
		In the blood, the progenitor of common histiocytes is the monocyte (a non-activated histiocyte).
		The migratory "histiocytic" cells in such lesions, particularly in some lichenoid reactions, are elongated with scanty, pale cytoplasm, and have characteristic, thin, elongated, wavy nuclei with delicate nuclear chromatin.
		Foamy histiocytes are characteristic of the reaction to leprae bacilli, particularly in the range of reactions near the lepromatous pole.
	www.mcl.tulane.edu /classware/pathology/medical_pathology/InflamDermato/S1C5CellTypes/s1c5celltypes.htm (1940 words)

	THE MERCK MANUAL, Sec. 11, Ch. 137, Histiocytic Syndromes
		Histiocytic syndromes: A broad grouping of disorders characterized by abnormal proliferation of macrophages or histiocyte-like cells.
		Classifying these disorders is difficult because of the ubiquitous nature of the macrophage, its extraordinary metabolic capabilities, its role as a regulator of hematopoiesis, and its prominence in the immune and inflammatory response and because of uncertainty regarding monocyte, macrophage, histiocyte, and dendritic cell ontogeny.
		However, three "classes" of histiocytic syndromes have been defined (see Table 137-1).
	www.merck.com /pubs/mmanual/section11/chapter137/137a.htm (82 words)

	Langerhans Cell Histiocytosis
		Langerhans cell histiocytosis (LCH) is a rare spectrum of disorders characterized by overproduction (proliferation) and accumulation of a specific type of white blood cell (histiocyte) in the various tissues and organs of the body (lesions).
		Langerhans cell histiocytosis was selected by the Histiocyte Society to replace the older, less specific term histiocytosis X. Histiocytosis X encompassed three entities known as eosinophilic granuloma, Hand-Schuller-Christian disease, and Letterer-Siwe disease that were characterized by the accumulation of histiocytes.
		Histiocytes are large phagocytic cells (macrophages) that normally play a role in responding to infection and injury.
	hw.healthdialog.com /kbase/nord/nord408.htm (2872 words)

	Histiocytosis
		Despite the large variation of clinical and pathological features of canine histiocytic diseases, the majority represent proliferations of cells of dendritic lineage.
		They are supplemented by migration of activated DC from skin and interstitial tissues, which arrive in lymph nodes as veiled cells in afferent lymph following contact with antigen.
		Important and distinctive surface markers of each type of histiocyte are listed on the right.
	www.histiocytosis.ucdavis.edu /lineages.html (365 words)

	SpecialTopic - Histiocyte - Hartford, Connecticut CT
		Histiocytes are cells of the immune system that ingest foreign antigens to protect against infection.
		They are fixed, meaning they remain in one part of the body rather than traveling through the bloodstream.
		Histiocytes are found in many organs and connective tissues:
	www.saintfranciscare.com /12445.cfm (172 words)

	Dorlands Medical Dictionary
		an abnormal foamy, granulated histiocyte, sea-blue in color, containing ceroid material; seen in the sea-blue histiocyte syndrome, adult varieties of Niemann-Pick disease, and some forms of hemolytic anemia.
		any of a group of malignant neoplasms containing cells that resemble histiocytes and fibroblasts, occurring predominantly in soft tissues in middle-aged adults; depending on the tumor location and the classification system, the term is sometimes used synonymously with or as a general term including similar lesions such as atypical fibroxanthoma and dermatofibrosarcoma protuberans.
		a disorder of the lymph nodes in which the distended sinuses are completely, or nearly completely, filled by histiocytes, as a result of active multiplication of the littoral cells.
	www.mercksource.com /pp/us/cns/cns_hl_dorlands.jspzQzpgzEzzSzppdocszSzuszSzcommonzSzdorlandszSzdorlandzSzdmd_h_12zPzhtm (3541 words)

	[No title]
		A histiocyte is a form of white blood cell which is found in every human body.
		A Langerhans cell is one of several types of histiocytes in the body.
		There is a close working relationship with doctors and scientists in the Histiocyte Society.
	www.kelt.com /lch/lch.txt (825 words)

	Phagocytic histiocyte (macrophage) (Site not responding. Last check: 2007-09-01)
		The large cell in the center of this slide is a phagocytic histiocyte or macrophage.
		Phagocytic histiocytes are increased in hemolytic anemia, infection, exposure to toxic chemicals, leukemia, and solid tumors.
		If histoplasmosis or kalaazar is suspected, one looks for the inclusions in the macrophages, cells that are generally increased in number in these diseases.
	www.academic.marist.edu /~jzmz/topics/bonemarrow/microexambm23.html (141 words)

	Langerhans Cell Histiocytosis
		This disorder is characterized by an abnormal increase in certain immune cells called histiocyte cells.
		Histiocyte cells are a form of white blood cells that help the immune system destroy foreign materials and fight infection.
		The extra immune cells produced by this condition may form tumors, which can affect parts of the body like the bones and possibly spread to other areas.
	cms.clevelandclinic.org /childrenshospital/body.cfm?id=551 (720 words)

	Langerhan's Cell Histiocytosis (Site not responding. Last check: 2007-09-01)
		Histiocytes are normal cells found throughout the body, in this disease abnormally large numbers are found.
		Histiocyte Society Hosted at The Texas Children's Cancer Center and Hematology Service this Web site provides details about the Histiocyte Society, information about histiocytosis etc.
		Physician's statement for Histiocytic Non-Malignant Syndromes (START, European School of Oncology) Referenced statement including sections on epidemiology, pathology, diagnosis, staging, treatment and follow-up produced by an editorial board of top European oncologists.
	www.cancerindex.org /ccw/guide2v.htm (383 words)

	ACTA Sep2003: Value of Histiocyte Detection in Pap Smears for Predicting Endometrial Pathology: An . . . (Site not responding. Last check: 2007-09-01)
		The PPV for significant uterine pathology for women with the isolated finding of histiocytes on a Pap smear was 5.5% and 60% with additional clinical and/or Pap smear findings.
		The PPV for endometrial cancer was 1.3% in women with the isolated finding of histiocytes on a Pap smear but 20% for women with histiocytes and additional clinical/or Pap smear findings.
		Conclusion: Based on the findings of this study and recently published data, we conclude that the isolated finding of increased histiocytes in the absence of postmenopausal bleeding, endometrial cells or atypical glandular cells on a Pap smear is a poor indicator of uterine disease.
	www.acta-cytol.com /Abs/ACTA1377.htm (353 words)

	healthfinder® — Histiocytosis Association of America
		The Histiocytosis Association of America was founded to coordinate a network of patients, families, physicians and others interested in providing support and solutions to the special problems caused by histiocytosis.
		Histiocytosis is a general term for a group of rare disorders brought on by having too many histiocyte cells.
		The Association works closely with the Histiocyte Society, has a parent/patient directory and sponsors regional meetings.
	www.healthfinder.gov /orgs/HR2387.htm (84 words)

	Histiocyte-rich B-cell lymphoma. A distinct clinicopathologic entity possibly related to lymphocyte predominant ... (Site not responding. Last check: 2007-09-01)
		This study reports six non-Hodgkin's lymphoma cases that we called histiocyte-rich B-cell lymphoma (BCL) because of the prominent reactive histiocytic infiltrate obscuring the malignant B-cell population.
		The involved lymph nodes are characterized by a mixed nodular and diffuse infiltrate and occasionally feature prominent sinuses.
		The infiltrate is composed of reactive lymphocytes and numerous histiocytes obscuring a tumor population composed of variably sized scattered cells with irregular or multilobar vesicular nuclei.
	www.meb.uni-bonn.de /cgi-bin/mycite?ExtRef=MEDL/92095416 (246 words)

	histiocyte - OneLook Dictionary Search
		Tip: Click on the first link on a line below to go directly to a page where "histiocyte" is defined.
		Histiocyte : MEDLINE plus Illustrated Medical Encyclopedia [home, info]
		Phrases that include histiocyte: sea-blue histiocyte disease, sea blue histiocyte, sea-blue histiocyte s, sea blue histiocyte s
	www.onelook.com /?ls=a&w=histiocyte (161 words)

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	Foamy histiocyte (Site not responding. Last check: 2007-09-01)
		The two large cells shown here are foamy histiocytes.
		They are similar to the cells seen in Niemann-Pick and Hand-Schiiller-Christian disease, which are congenital storage diseases.
		The histiocyte has one nucleus that contains heavy chromatin.
	www.academic.marist.edu /~jzmz/topics/bonemarrow/microexambm24.html (55 words)

	Clinical Research - Histiocytosis - Clinical Services - Children's Hospital Boston
		A clinical database has been established to identify patterns of disease in patients with LCH and to determine the effectiveness of their treatments.
		In collaboration with the laboratory of Barrett Rollins, MD, PhD, of Dana-Farber, the program is evaluating the biology of histiocytic disorders.
		The families of patients undergoing biopsies of histiocytic lesions are offered the chance to participate in a study that uses pathologic material that would otherwise be discarded.
	www.childrenshospital.org /clinicalservices/Site1983/mainpageS1983P8.html (197 words)

	We’ve learned of a little boy named Matt Johnson and Matt has recently been diagnosed with a rare but often deadly ...
		We’ve learned of a little boy named Matt Johnson and Matt has recently been diagnosed with a rare but often deadly childhood disease called HLH (hemophagocytic lymphohistiocytosis).
		Hemophagocytic lymphohistiocytosis is a rare disorder primarily affecting young children whereby their bodies contain too many histiocyte cells.
		In a case where too many of these cells are present, the histiocytes begin to penetrate and attack good tissue in the body causing severe organ damage and/or failure.
	www.acetj.com /mattjcardinfo.htm (320 words)

	Dr. Kenneth McClain - Perspectives on Childhood Cancer - Texas Children's Hospital
		By Kenneth McClain, M.D., Ph.D. Langerhans cell histiocytosis (LCH) is one of the rare diseases seen by pediatric oncologists that in the past was treated by several different methods – from surgery alone to radiation therapy and several types of chemotherapy.
		Many investigators are unaware of the organized clinical trials sponsored by the Histiocyte Society (HS).
		The trials have provided important data on efficacy of the best medications available, but more importantly have taught us about the long-term consequences of LCH, especially regarding central nervous system disease associated with skull lesions of the orbit, mastoid and temporal bone.
	www.texaschildrenshospital.org /CareCenters/Cancer/Perspectives/McClain.html (663 words)

	Rosai-Dorfman Disease - Quest Diagnostics Patient Health Library (Site not responding. Last check: 2007-09-01)
		Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
		Rosai-Dorfman disease is a rare disorder characterized by over-production (proliferation) and accumulation of a specific type of white blood cell (histiocyte) in the lymph nodes of the body (lymphadenopathy), most often those of the neck (cervical lymphadenopathy).
		In some cases, abnormal accumulation of histiocytes may occur in other areas of the body besides the lymph nodes (extranodal).
	www.questdiagnostics.com /kbase/nord/nord1122.htm (393 words)

	Dr. Koop - Histiocytosis
		Histiocytosis is a generic name for a group of syndromes characterized by an abnormal increase in the number of certain immune cells called histiocyte cells.
		There are 3 major classes of histiocytoses, but this article focuses on Langerhans cell histiocytosis, which is also called histiocytosis X. The other 2 classes are non-Langerhans cell histiocytosis (also known as hemophagocytic syndrome) and malignant histiocytosis syndrome (now known as T-cell lymphoma).
		You should promptly seek professional medical care if you have any concern about your health, and you should always consult your physician before starting a fitness regimen.
	www.drkoop.com /ency/93/000068.html (303 words)

	NCI Bethesda System Web Atlas
		Your search for 'Histiocyte' has returned 17 record(s).
		Click on the thumbnails to view image details.
		Note: Endometrial cells after age 40, particularly out of phase or after menopause may be associated with benign endometrium, hormonal alterations and less commonly, endometrial /uterine abnormalities.
	www.cytopathology.org /NIH/listing.php?keyword1=Histiocyte (94 words)

	Histiocyte
		Website of the Histiocyte Society, an international organization of physicians, scientists, and researchers.
		Thank you for using the medicality medical encyclopedia website.
		We hope that this medical encyclopedia has been of use in finding information regarding health.
	www.medicality.org.uk /medical-encyclopedia/histiocyte.php (88 words)

	Medical Dictionary: Sea-blue histiocyte disease - WrongDiagnosis.com
		Sea-blue histiocyte disease is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH).
		This means that Sea-blue histiocyte disease, or a subtype of Sea-blue histiocyte disease, affects less than 200,000 people in the US population.
		Terms that may be interchangeable with Sea-blue histiocyte disease:
	www.wrongdiagnosis.com /medical/sea_blue_histiocyte_disease.htm (187 words)

	Full Text: Editorial
		It is now increasingly recognized that MAS bears close resemblance to a histiocytic disorder, secondary hemophagocytic lymphohistiocytosis (HLH), which is seen in a heterogeneous group of diseases, including infections, neoplasms, hematological conditions, and autoimmune disorders
		In 1987, the writing group of the Histiocyte Society recommended a division of the histiocyte disorders into 3 classes: Langerhans cell histiocytosis (LCH) (Class I); non-Langerhans cell histiocytosis (Class II), to which belongs HLH; and malignant histiocyte disorders (Class III)
		Although there are no formal and universally accepted criteria for the diagnosis of MAS, many clinicians in practice use the HLH criteria.
	www.jrheum.com /abstracts/abstracts03/2513.html (1987 words)

	Home - Histiocytosis Association of America
		an international partnership of parents, patients, physicians and friends brought together by their mutual interest in the rare histiocytic disorders.
		In addition, the Association promotes examination of histiocytic disorders through scientific and medical research, with the aim of establishing better treatments, a cure, and ultimately, prevention of the diseases.
		Patients and their families should click on the links below for helpful resources and information.
	www.histio.org (111 words)

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