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Topic: Histiocytosis

	Histiocytosis - Wikipedia, the free encyclopedia
		Though histiocytosis can refer to any of several specific diseases, the term is generally used to refer to a rare blood disease that is caused by an excess of white blood cells called histiocytes.
		It is estimated that histiocytosis affects 1 in 200,000 children born each year in the United States.
		Histiocytosis is frequently associated with diabetes insipidus, even after several years of diagnosis and successful therapy.
	en.wikipedia.org /wiki/Histiocytosis (348 words)

	Histiocytosis
		Histiocytosis is the most prevalent cancer in Bernese Mountain Dogs and is a common cause of early death.
		Histiocytosis is a cancer in which histiocytes proliferate rapidly and invade a wide variety of tissues.
		Histiocytosis is quite rare in other breeds with the exception of Flat Coated Retrievers, but it is the most common cancer in Bernese Mountain Dogs comprising 25% of all cases.
	www.bmd.org /health/histiocytosis.html (522 words)

	NBC10.com - Health Encyclopedia - Histiocytosis
		Histiocytosis is a generic name for a group of syndromes characterized by an abnormal increase in the number of certain immune cells called histiocyte cells.
		Histiocytosis X is thought to affect roughly 1 in 200,000 people each year.
		Histiocytosis X has typically been thought of as a cancer-like condition, but more recently researchers have begun to suspect that it is actually an autoimmune phenomenon, in which rogue immune cells attack the body, rather than fighting infections.
	www.nbc10.com /encyclopedia/6859317/detail.html (960 words)

	Histiocytosis (Site not responding. Last check: 2007-10-07)
		Histiocytosis, also referred to as Langerhans Cell Histiocytosis (LCH), and formally called Histiocytosis X, represents a group of rare disorders involving specific cells that normally have important roles as part of the immune system.
		Histiocytosis is a generic name for a group of syndromes characterized by an abnormal increase in the number of certain immune cells called histiocytes.
		Histiocytosis is thought to affect roughly one to two out of 200,000 people each year.
	www.hopkinskimmelcancercenter.org /scout/types/histiocytosis.cfm (697 words)

	Histiocytosis X Information on Healthline
		Histiocytosis X is a generic term that refers to an increase in the number of histiocytes, a type of white blood cell that acts as a scavenger to remove foreign material from the blood and tissues.
		Histiocytosis X or LCH is a family of related conditions, which are characterized by a distinct inflammatory and proliferative process but which differ from each other regarding what parts of the body are involved.
		Histiocytosis X is a rare disorder affecting only approximately one in 200,000 children or adults each year.
	www.healthline.com /galecontent/histiocytosis-x (1131 words)

	Histiocytid Diseases
		Systemic histiocytosis was first described as being separate and distinct from malignant histiocytosis; later it was defined as a variation of malignant histiocytosis; and most recently it is back to being considered a separate and distinct form of histiocytosis.
		But malignant histiocytosis is a disease that attacks many organs simultaneously, or that metastasizes rapidly, so the dog eventually succumbs from the involvement of the other organs.
		Necropsy confirmed malignant histiocytosis, with marked jaundice of body tissues, fluid in the lungs, abdominal and thoracic cavities.
	www.jersey.net /~mountaindog/berner1/histio.htm (8055 words)

	Disease: Pulmonary Histiocytosis X (Site not responding. Last check: 2007-10-07)
		The combination of nodules and multiple, irregular-shaped, thin-walled cysts is highly suggestive of Pulmonary Histiocytosis X(also known as Pulmonary Eosinophilic Granulmona.This condition of unknown etiology is uncommon, occurring predominantly in smokers (>90%) with mean age at presentation of 32 years.
		The recognized features of Pulmonary Histiocytosis X are 1- 5mm nodules and multiple thin-walled cysts which tend to coalesce to form bizarre shapes in a centrilobular/peribronchiolar distribution with an upper lung predominance.
		Helpful differentiating features are nodules and bizarre-shaped cysts with an upper lung predominance in Histiocytosis X, while LAM is associated with chylous effusions, female of child-bearing age, and more uniformly shaped cysts in a diffuse distribution.
	www.uchsc.edu /radiology/teaching/case5b.html (440 words)

	ENLmedical.com: Conditions And Concerns: Medical Encyclopedia: Histiocytosis
		Pulmonary histiocytosis is characterized by inflammation of the small airways (bronchioles) and the small blood vessels in the lungs.
		Letterer-Siwe disease, which is a type of histiocytosis (a disorder of the immune cells).
		Letterer-Siwe disease is a type of histiocytosis (a disorder of the immune cells).
	www.enlmedical.com /article/000068.htm (453 words)

	Histiocytosis X
		The least severe of the histiocytosis X/LCH family is eosinophilic granuloma.
		The symptoms of histiocytosis are caused by substances called cytokines and prostaglandins, which are normally produced by histiocytes and act as messengers between cells.
		Histiocytosis Association of America, 302 North Broadway, Pitman, NJ 08071.
	www.healthatoz.com /healthatoz/Atoz/ency/histiocytosis_x.jsp (1180 words)

	Langerhans Cell Histiocytosis
		Langerhans cell histiocytosis (LCH) is a rare spectrum of disorders characterized by overproduction (proliferation) and accumulation of a specific type of white blood cell (histiocyte) in the various tissues and organs of the body (lesions).
		Langerhans cell histiocytosis was selected by the Histiocyte Society to replace the older, less specific term histiocytosis X. Histiocytosis X encompassed three entities known as eosinophilic granuloma, Hand-Schuller-Christian disease, and Letterer-Siwe disease that were characterized by the accumulation of histiocytes.
		Langerhans cell histiocytosis was chosen because it is now known that Langerhans cells play the central role in the development of these disorders.
	hw.healthdialog.com /kbase/nord/nord408.htm (2872 words)

	Histiocytosis
		Dogs with cutaneous histiocytosis are often bright, alert and outwardly unaffected by their disease.
		Systemic histiocytosis is a treatable disease, and even if left untreated it would not normally lead to organ failure and death which is commonly seen in malignant histiocytic diseases.
		In fact, one form of histiocytosis - the reactive form (or cutaneous and systemic histiocytosis) - occurs as a result of a defect in the interaction of dendritic cells and T lymphocytes - an immuno-regulatory disorder which is amenable to treatment with immuno suppressive drugs.
	www.histiocytosis.ucdavis.edu /faq.html (2328 words)

	May 2002 Newsletter (Site not responding. Last check: 2007-10-07)
		Systemic histiocytosis is a familial disease first described in Bernese Mountain dogs and lesions may be seen in mucous membranes, lymphoid organs and bone marrow.
		Malignant histiocytosis is a disseminated multisystem disease that involves spleen, lymph nodes, lung, bone marrow, skin and subcutis.
		Both malignant histiocytosis and histiocytic sarcoma warrant a poor prognosis for long term survival while systemic histiocytosis and the reactive histiocytosis lesions may respond to modulation of the immune response.
	www.centralvetlab.com /Newsletter/May2002.htm (1515 words)

	Home \| aHealthyme.com
		Since recent research demonstrated Langerhan cell involvement as well as histiocytes, this led to a proposal that the term Langerhans Cell Histiocytosis (LCH) be used in place of histiocytosis X. Either term refers to three separate illnesses (listed in order of increasing severity): eosinophilic granuloma, Hand-Schuller-Christian disease and Letterer-Siwe disease.
		Histiocytosis X or LCH is a family of related conditions characterized by a distinct inflammatory and proliferative process but differs from each other in which parts of the body are involved.
		It occurs most commonly from the age of one to three years and is a slowly progressive disease that affects the softened areas of the skull, other flat bones, the eyes, and skin.
	www.ahealthyme.com /article/gale/100084703 (1074 words)

	Rosai-Dorfman Disease (Sinus Histiocytosis with Lymphadenopathy)
		Children with sinus histiocytosis with massive lymphadenopathy (SHML) have a somewhat similar clinical phenotype in which prominent adenopathy also is associated with hypergammaglobulinemia, and autoimmune phenomena are reported in 10-15% of cases.
		Responsiveness of the histiocytic cells of SHML to B-cell derived cytokines is postulated as a mechanism for this phenomenon, an hypothesis previously raised in regard to the association of focal Langerhans cell histiocytosis with Hodgkin's disease and with non-Hodgkin's lymphomas.
		Sinus histiocytosis with massive lymphadenopathy (SHML) is generally regarded as a benign disorder in spite of its propensity to form large masses and to disseminate to both nodal and extranodal sites.
	www.thedoctorsdoctor.com /diseases/rosaidorfmandisease.htm (7508 words)

	Histiocytosis - CancerIndex
		Langerhan's Cell Histiocytosis (also known as Histiocytosis X) is a rare disease.
		Histiocytosis Association of America An international partnership of parents, patients, physicians and friends in search of a cure.
		Langerhan's Cell Histiocytosis (UK) a factsheet produced by the United Kingdom Children's Cancer Study Group and CancerBacup linked to the UKCCSG booklet "A Parent's Guide to Children's Cancers".
	www.cancerindex.org /clinks4z.htm (391 words)

	Langerhans cell Histiocytosis
		Langerhans cell Histiocytosis is a challenging disease and may be manifested in a variety of ways, ranging from a spontaneously regressing solitary lesion of bone to a multisystem life threatening disorder.
		Histiocytosis X is ordinarily a chronic disease, generally lasting for a period of 3 to 5 years, but some times continuing for 10 or more years.
		Their administration, as single agents and in combination, continuously or intermittently, is successful in producing improvement in the majority of affected children.
	www.pediaindia.net /archive/lch.shtml (1262 words)

	Histiocytoses (Site not responding. Last check: 2007-10-07)
		Langerhans' cell histiocytosis (LCH), the term now used to describe the group of diseases known as histiocytosis X, is a rare disorder of the bone marrow-derived histiocytes that may involve the skin, bone, bone marrow, liver, spleen, lungs, lymph nodes, and rarely the pancreas.
		Indeterminate cell histiocytosis is a rare disorder, in which the predominant cells have the characteristics of both Langerhans cells and macrophages.
		In an ultrastructural study of 24 cases of histiocytosis X, we were able to demonstrate Langerhans cell granules in all of 18 cases from which tissues had been submitted primarily for electron microscopy and in 4 of 6 cases from which only tissue retrieved from paraffin blocks was available for examination.
	www.thedoctorsdoctor.com /diseases/histiocytoses.htm (11041 words)

	Histiocytosis - PetPlace.com
		Histiocytosis is a disorder resulting from the proliferation or multiplication of cells from the cells that are involved in the inflammatory response, which are the monocyte-macrophage line.
		The cause of histiocytosis is unknown though it is thought to be hereditary.
		There is no definitive treatment for histiocytosis, and prognosis, especially the malignant form, is poor.
	www.petplace.com /dogs/histiocytosis/page1.aspx (334 words)

	eMedicine - Histiocytosis : Article by Cameron K Tebbi, MD (Site not responding. Last check: 2007-10-07)
		Background: Histiocytosis encompasses a group of diverse disorders with the common primary event of the accumulation and infiltration of monocytes, macrophages, and dendritic cells in the affected tissues.
		Other histiocytosis disorders, such as sinus hyperplasia and sinus histiocytosis with SHML, or Rosai-Dorfman disease, must be differentiated from viral, bacterial, acid-fast bacterial, and parasitic infections.
		The aim of therapy in histiocytosis is to relieve clinical symptoms and prevent complications of the disease.
	www.emedicine.com /ped/topic1997.htm (10015 words)

	Malignant histiocytosis (Site not responding. Last check: 2007-10-07)
		A relatively uncommon form of histiocytosis is the malignant or atypical histiocytosis.
		Unlike the more common form of cutaneous histiocytosis in which there is usually a single lesion, this form becomes multiple thus precluding surgical resection.
		The condition of malignant histiocytosis is almost invariably fatal with survival times generally being less than three years from presentation.
	www.petcancer.co.uk /cgi-bin/articles/055.htm (184 words)

	jennyLous.com Histiocytosis Awareness - a hip little boutique - THE boutique for your Mothers bracelet, name bracelet, ...
		Pam saw the great work I was doing for the Leukemia Society and asked if I would help her spread awareness and raise funds for the Histiocytosis Association of America.
		Histiocytosis is such a rare disease that it gets little funding.
		A portion of the proceeds from the sale of this bracelet is donated to the Histiocytosis Association.
	www.jennylous.com /histiocytosis_awareness_bracelet.html (380 words)

	[No title]
		Histiocytes are normally only present in these tissues but in histiocytosis they wander elsewhere in the body. The most common form of histiocytosis (Langerhans Cell Histiocytosis - LCH) involves cells normally found in the skin.
		Only a very tiny percentage of cases of histiocytosis are truly a form of cancer.
		It is not infectious, and it cannot be inherited. Signs and symptoms The symptoms of histiocytosis are caused by substances called cytokines and prostaglandins.
	www.lrf.org.uk /images/Histiocytosis_1113.doc (579 words)

	Histiocytosis News - News and Information on Histiocytosis, Online Support Community
		Alternate names for Histiocytosis X:eosinophilic granuloma; nonlipid reticuloendotheliosis; Langerhans Cell Histiocytosis (LCH); Letterer-Siwe disease; Hand-Schuller-Christian disease; pulmonary langerhans cell granulomatosis; pulmonary histiosytosis X; There are three common types of Histiocytosis X which all characterizes an increase in the number of histiocyte cells in the blood.
		In the case of patients with Histiocytosis X, the histiocytes in their bodies multiply uncontrollably for an unknown reason, forming masses of tumor like tissue, attacking and causing damage to the patients bones, spleen, liver, lungs, skin and lymph nodes.
		In Histiocytosis, there is an increase in number of these histiocytes in the patient.
	www.histiocytosisnews.com (1133 words)

	The Histiocytosis Research Trust (UK) (Site not responding. Last check: 2007-10-07)
		Histiocytosis is often considered to be a disease that affects only children, however there has recently been much more awareness of the large number of adults affected by it.
		Gary Lakritz, whose mum, Rose suffered from Langerhans Cell Histiocytosis has started up a new group, The Rose Margaret Foundation, in her memory and will be donating the money raised from his 900 mile "Walk with Me" tour.
		After several years of active fund-raising by families and friends affected by Histiocytosis, the Histiocytosis Research Trust (HRT) has joined with the Artemis Society of Greece and LCH Belgium to fund significant scientific research.
	www.hrtrust.org (811 words)

	eMedicine - Langerhans Cell Histiocytosis : Article by M Angelica Selim, MD (Site not responding. Last check: 2007-10-07)
		Background: Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the proliferation of specialized bone marrow–derived Langerhans cells (LCs) and mature eosinophils.
		The term LCH is generally preferred to the older term, histiocytosis X. This new name emphasizes the histogenesis of the condition by specifying the type of lesional cell and removes the connotation of the unknown (X) because its cellular basis has now been clarified.
		Congenital self-healing histiocytosis presents at birth or during the early neonatal period with firm, red-brown, painless, papulonodules (1-10 mm in diameter) or vesicles and crusts that are scattered over the scalp, the face, and, to a lesser extent, the trunk and the extremities.
	www.emedicine.com /derm/topic216.htm (6285 words)

	Histiocytosis
		SH is a generalized histiocytic proliferative disease with a marked tendency to involve skin, ocular and nasal mucosa, and peripheral lymph nodes.
		The nasal apex is swollen and depigmented; there is a crusty nasal discharge and the dog had stertorous respiration indicating infiltration and swelling of the internal nasal mucosa.
		Cutaneous histiocytosis (CH) is a histiocytic proliferative disorder that primarily involves skin and s ubcutis and does not extend beyond the local draining lymph nodes.
	www.histiocytosis.ucdavis.edu /reactive.html (1548 words)

	[No title] (Site not responding. Last check: 2007-10-07)
		Langerhans cell histiocytosis (LCH) is a rare disorder that primarily affects one in 200,000 children.
		The goal of an overall treatment plan is to use as little treatment as possible to keep the disease under control.
		Although this disease is not considered to be a cancer, cancer treatments have been used in patients with histiocytosis.
	www.utoronto.ca /kids/LCH.htm (399 words)

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