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Topic: Homeobox

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	The homeobox page
		Hox genes: Hox genes are a subgroup of homeobox genes.
		A Comprehensive Classification of Homeobox Genes, Bürglin, T.R. (1994) in Guidebook to the Homeobox Genes.
		The cut superclass of homeobox genes is comprised of four classes: Cux (with 3 cut domains and 1 homeodomain), ONECUT (with 1 cut domain and 1 homeodomain), CMP (Compass, with 1 Compass domain and 2 homeodomains), and SATB (with 1 COMPASS domain, 2 cut domains, and 1 homeodomain).
	homeobox.biosci.ki.se (1847 words)

	Homeobox - Encyclopedia, History, Geography and Biography
		A homeobox (or homoeobox) is a DNA sequence found within genes that are involved in the regulation of development (morphogenesis) of animals, fungi and plants.
		Homeobox genes encode transcription factors which typically switch on cascades of other genes, for instance all the ones needed to make a leg.
		The homeobox genes were first found in the fruit fly Drosophila melanogaster and have subsequently been identified in many other species, from insects to reptiles and mammals.
	www.arikah.com /encyclopedia/Hox (526 words)

	Homeobox
		A homeobox is a certain DNA sequence that is part of many genes involved in the regulation of the development (morphogenesis) of animals.
		Genes that have a homeobox are called Hox genes and form the Hox gene family.
		A homeobox is about 180 base pairs long; it encodes a protein domain (the homeodomain) which can bind to DNA.
	www.ebroadcast.com.au /lookup/encyclopedia/ho/Homeobox.html (271 words)

	Discovering the Homeobox
		Central to this architectural plan are genes containing the so-called homeobox, a DNA-binding element that was discovered independently in 1983 by Walter Gehring and his colleagues at the University of Basel, Switzerland, and Matthew Scott and Amy Weiner, who were then working with Thomas Kaufman at Indiana University in Bloomington.
		Homeobox genes encode proteins that tell the cells in the various segments of the developing embryo "what kind of structures to make—antennae for the head, for example, and legs for the three thoracic segments," says Scott.
		Almost identical homeobox genes were quickly found in the genomes of mice and humans as well.
	www.hhmi.org /genesweshare/b120.html (624 words)

	Homeobox genes - EvoWiki (Site not responding. Last check: 2007-10-11)
		Homeobox genes are genes found in eukaryotes which play a major part in regulating development.
		A single homeobox gene can cause a cascade of other genes to be turned on, producing an entire body segment of limb.
		Homeobox genes contain a stretch of DNA approximately 180 base pairs (60 amino acids) long called a homeobox which encodes a protein domain, called a homeodomain capable of binding to DNA.
	wiki.cotch.net /index.php/Homeobox_genes (553 words)

	Biology 4A Student Resources
		The homeobox is a 180-basepair sequence of DNA that has been found in all homeotic genes (and also in many other regulatory genes).
		The discovery of homeobox genes shows that small mutations in a base pair of DNA can result in profound physical changes - most of these are lethal.
		Homeobox genes supports the Theory of Evolution and punctuated equilibrium, by showing that simple mutations can result in large changes of morphology.
	www.biologycorner.com /bio4/notes/homeobox.php (529 words)

	Teachers' Domain: Animal Body Plans: Homeobox Genes
		The homeobox genes that define the basic body plan of mice and fruit flies are illustrated in this graphic.
		The discovery of homeobox genes, their role in controlling body shape, and their astonishing similarity across widely different species has yielded new insights into both how embryos grow and how life evolved from a common ancestor.
		Homeobox genes evidently duplicated twice during the evolution of vertebrates from invertebrates; mammals have 4 clusters of about 10 genes each, while the fruit fly has only 1 group of 10.
	www.teachersdomain.org /9-12/sci/life/evo/homeobox/index.html (192 words)

	homeobox
		These are the 'homeobox' (Hox) genes, whose products bind to the DNA of other genes, triggering a cascade of processes that ultimately yield eyes, limbs...
		This suggests that OdsH, a member of the transcription factorâ“encoding homeobox gene family, is somehow involved in reproductive isolation between species.
		The study is the latest in a series in which Capecchi and his colleagues have examined the workings of homeobox or Hox genes, which act like conductors to...
	www.mongabay.com /igapo/biotech/homeobox.html (222 words)

	New species right out of the box
		Called homeobox genes, they comprise a universal box of tools that shape development from the time an embryo is but a small collection of cells.
		Molecular biologists, who discovered homeobox genes 15 years ago, have used fruit flies and other laboratory animals to show that features can be added or subtracted from an animal by changing the activation of one or more homeobox genes.
		Homeobox genes might actually be the least likely mechanism for speciation, suggests the University of Chicago's Wu, because they are so slow to mutate.
	www.post-gazette.com /healthscience/19990221evo3.asp (2554 words)

	Homeobox - definition from Biology-Online.org
		The homeobox consists of about 180 nucleotides coding for a sequence of 60 amino acids in a protein, sometimes termed the homeodomain, of which about 80-90% are identical in the various homeodomains identified from drosophila.
		Homeoboxes have also been detected in the genomes of vertebrates, with about 75% amino acid homology and a similar sequence has been found in the mat gene of yeast.
		The homeobox codes for a protein domain that is involved in binding to dna.
	www.biology-online.org /dictionary/Homeobox (229 words)

	Interactive Fly, Drosophila
		The homeobrain (hbn) gene is a new paired-like homeobox gene that is expressed in the embryonic brain and the ventral nerve cord.
		Xrx1 is expressed in the anterior neural plate, and subsequently in the neural structures of the developing eye (neural retina and pigmented epithelium), and in other forebrain structures deriving from the anterior neural plate: in the pineal gland, throughout its development; in the diencephalon floor, and in the hypophysis.
		Several homeobox genes are known to be specifically expressed in subsets of neurons in the forebrain, exclusively, or in distinct combinations.
	www.sdbonline.org /fly/hjmuller/rx2.htm (4480 words)

	Homeobox Genes: A New Class of Human Breast Oncogenes?
		Candidates for breast cancer genes now include a large class of developmental regulators known as homeobox genes, based on our recent discovery that some of these are expressed in the development of the mouse mammary glad and are misexpressed (inappropriately turned on or off) in mouse mammary cancer relative to the normal mouse mammary gland.
		Homeobox genes normally function to establish cell identity and to provide positional information to the cell for proper patterning of the body and its organs as an animal grows from a fertilized egg to an adult.
		Because homeobox genes are known to be critically important in the normal development of organisms ranging from flies to humans, and because cancer is a consequence of normal development gone awry, mutations in these genes may contribute to cancer.
	www.cbcrp.org /research/PageGrantPrintPage.asp?grant_id=95 (810 words)

	Homeobox genes: going for growth -- Playford 50 (4): 447 -- Gut
		Stimulation of the intestinal Cdx2 homeobox gene by butyrate in colon cancer cells.
		Homeobox gene Cdx1 regulates Ras, Rho and PI3 kinase pathways leading to transformation and tumorigenesis of intestinal epithelial cells.
		The Cdx1 and Cdx2 homeobox genes in the intestine.
	gut.bmjjournals.com /cgi/content/full/50/4/447 (1114 words)

	In Defense of Evolution: The Homeobox (Site not responding. Last check: 2007-10-11)
		Yes, we believe the homeobox to be a monumental discovery, and if you have heard anything about the homeobox, you know why.
		The homeobox is a sequence of 180 base pairs that codes for 60 amino acids in a fruit fly, and it has been found in eight different loci on the third chromosome, which is known to contain the homeotic genes responsible for development.
		Therefore, it is the homeobox that guides the fly through development after the maternal transcripts have performed their tasks.
	journalofscience.wlu.edu /archive/winter1999/articles/misc/homeobox.html (495 words)

	Homeobox Gene
		A gene containing a 180-base-pair segment (the “homeobox”) that encodes a protein domain involved in binding to (and thus regulating the expression of) DNA.
		This homeobox is remarkably similar in many genes with different functions.
		Guidebook to the Homeobox Genes by Denis Duboule
	www.iscid.org /encyclopedia/Homeobox_Gene (83 words)

	Homeobox - Glossary Entry - Genetics Home Reference
		A short stretch of nucleotides whose base sequence is virtually identical in all the genes that contain it.
		Homeoboxes have been found in many organisms from fruit flies to human beings.
		In the fruit fly, a homeobox appears to determine when particular groups of genes are expressed during development.
	ghr.nlm.nih.gov /ghr/glossary/homeobox (84 words)

	The Marshall W. Nirenberg Papers: From Neuroblastoma to Homeobox Genes, 1976-1992
		Homeobox genes, discovered by Walter Gehring of the University of Basel in 1983, influence the expression of other genes important in physical development.
		Since homeobox genes influence the process by which hereditary information is converted into physical characteristics during development, Nirenberg recognized that understanding their function could provide new avenues for research.
		Knowledge of homeobox genes brings the promise of understanding their role in development and may eventually prove to be beneficial in combating cancers, neurological diseases, and metabolic and immune-system disorders.
	profiles.nlm.nih.gov /JJ/Views/Exhibit/narrative/homeobox.html (1697 words)

	homeobox.html
		One family of homeobox genes, called MSX genes, seem to play a crucial role in development.
		Knowing that homeobox genes are important in the development of the skull and face, and that craniosynostosis travels from generation to generation, the group sought to link at least one variety of the disease to a particular gene.
		The publication earned the group the honor of being the first to show that a mutation in a homeobox gene was the direct cause of a human developmental abnormality.
	www.usc.edu /hsc/info/pr/hmm/97spring/homeobox.html (1484 words)

	Key Role of the Cdx2 Homeobox Gene in Extracellular Matrix-mediated Intestinal Cell Differentiation -- Lorentz et al. ...
		Homeobox genes of the caudal family, Cdx1 and Cdx2, are expressed in the intestinal epithelium (James and Kazenwadel, 1991
		Isolation and characterization of the murine homeobox gene Cdx-1.
		Homeobox gene expression in the intestinal epithelium of adult mice.
	www.jcb.org /cgi/content/full/139/6/1553 (6964 words)

	Research Thomas Burglin
		Homeobox genes are transcription factors that play key roles in development.
		Presently, we are studying the developmental role of the Otd homeobox genes ceh-36, ceh-37, and ttx-1 and their role in embryogenesis.
		We are interested in the evolution of homeobox genes to understand so as to correlate and correctly identify orthologs when comparing the functions of these genes across different animal phyla.
	www.biosci.ki.se /groups/tbu/research (809 words)

	Homeobox gene Prx3 expression in rodent brain and extraneural tissues -- van Schaick et al. 94 (24): 12993 -- ...
		Homeobox gene Prx3 expression in rodent brain and extraneural tissues -- van Schaick et al.
		Homeobox gene Prx3 expression in rodent brain and extraneural tissues
		Although the role of homeobox genes in patterning of the neural axis at the level of the spinal cord and the rhombencephalon
	www.pnas.org /cgi/content/full/94/24/12993 (3780 words)

	IngentaConnect Primary Phloem-Specific Expression of a Zinnia elegans Homeobox G... (Site not responding. Last check: 2007-10-11)
		Some plant homeobox genes are expressed specifically in vascular cells and are assumed to function in the differentiation of specific types of vascular cells.
		However, homeobox genes exhibiting primary phloem-specific expression have not been reported.
		Zinnia elegans Homeobox Gene" title="post to CiteUlike">Post to CiteUlike
	www.ingentaconnect.com /content/oup/pcp/2001/00000042/00000011/art01210 (266 words)

	Presence of isl-1-related LIM Domain Homeobox Genes in Teleost and Their Similar Patterns of Expression in Brain and ...
		Screening for salmon homeobox cDNA clones was carried out by hybridization at a low stringency (55 °C, 0.3 M Na) using a partial homeobox cDNA probe from a randomly tagged clone from a pituitary cDNA library of the winter flounder, Pleuronectes americanus (Gong et al., 1994).
		Using primers 1L and a degenerated homeobox right primer HbR, the region including part of the 2nd LIM motif, the most variable region, and the homeobox was amplified and cloned from the pituitary RNA by RT-PCR.
		Although the expression patterns of the three isl genes in medulla oblongata and spinal cord have been carefully examined and compared by in situ hybridization on adjacent embryo sections, the question whether their expression is in the same set of neurons or in different sets of neurons in the same region remains unsolved.
	www.jbc.org /cgi/content/full/270/7/3335 (8647 words)

	Vertebrate homologs of tinman and bagpipe: roles of the homeobox genes in cardiovascular development.
		In Drosophila, dorsal mesodermal specification is regulated by the homeobox genes tinman and bagpipe.
		One of the murine homologs of tinman is the cardiac homeobox gene Csx or Nkx2.5.
		The overlapping expression pattern of NK2 class homeobox genes in the heart and the pharynx may suggest a common origin of these two organs.
	cardiogenomics.med.harvard.edu /publication-detail?publication_id=174 (434 words)

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