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Topic: Homozygosity

In the News (Mon 28 Dec 09)

Northern Trust

Marvin Harrison

Peter Chernin

Gary Locke

Match Play

Penelope Cruz

Mickey Rourke

AR Rahman

Danny Boyle

Hugh Jackman

	Homozygosity mapping and linkage analysis demonstrate that autosomal recessive congenital hereditary endothelial ...
		Homozygosity mapping and linkage analysis demonstrate that autosomal recessive congenital hereditary endothelial dystrophy (CHED) and autosomal dominant CHED are genetically distinct -- Callaghan et al.
		Homozygosity mapping and linkage analysis demonstrate that autosomal recessive congenital hereditary endothelial dystrophy (CHED) and autosomal dominant CHED are genetically distinct
		The underlying principle of homozygosity mapping is that a fraction of the genome of offspring of consanguineous matings is
	www.bjophthalmol.com /cgi/content/full/83/1/115 (2471 words)

	NSAE NEWS 12/12/97 To The Post Part 2
		This increase in homozygosity is directly related to the appearance of both desirable and detrimental characteristics that were not necessarily apparent in the sire and dam.
		The effect of increased homozygosity is a decrease in the number of heterozygous gene pairs and, subsequently, a decline in heterosis (i.e., loss of vigor and fertility).
		Because of the overall effect of inbreeding is an increase in homozygosity, it increases the number of homozygous recessives.
	www.netpets.com /horses/reference/nsaenews/nsae121297ab.html (1493 words)

	Abstracts of Past and Current Research [M.Tevfik Dorak]
		The female-specific homozygosity rate for the uncut LTA allele LTA*2 (50.9%) was non-significantly increased compared to the male patients (35.9%) and controls (40.6%).
		The HLA class II supertypical (DRB3/4/5) homozygosity rates corresponding to HLA-DR52/53/51 homozygosity were increased in HD (39.8%, p<0.003); BC (31.4%; p<0.01) and males with ALL (p<0.03) compared to corresponding control frequencies: 25.5% in adults, 20.9% in adult females, 28.0% in newborns and 22.9% in newborn boys.
		The increase was mainly due to homozygosity for HLA-DR53 in males with ALL (p=0.000001; Dorak et al, Blood-in press); and for HLA-DR52 in HD (p=0.002; Dorak et al, ASHI99) but not attributable to any specific genotype in BC.
	dorakmt.tripod.com /hla/abstract.html (2220 words)

	PubMed medline query (Site not responding. Last check: 2007-10-09)
		HLA-DQA10501 and DQB102 homozygosity and disease susceptibility in Spanish coeliac patients.
		Patients homozygosity or heterozygosity was estimated by assessing-in each case-whether one or both parents were carriers of the allele of risk.
		These findings suggest that the frequency of homozygosity is increased among CD patients, and therefore, homozygosity for either DQA10501 or DQB102 represents a risk factor added to the fact of being a carrier.
	www.est.cie.uva.es /~paco/ab18.htm (199 words)

	Homozygosity Mapping of a Gene Locus for Primary Ciliary Dyskinesia on Chromosome 5p and Identification of the Heavy ...
		Homozygosity Mapping of a Gene Locus for Primary Ciliary Dyskinesia on Chromosome 5p and Identification of the Heavy Dynein Chain DNAH5 as a Candidate Gene -- Omran et al.
		Homozygosity Mapping of a Gene Locus for Primary Ciliary Dyskinesia on Chromosome 5p and Identification of the Heavy Dynein Chain DNAH5 as a Candidate Gene
		Homozygosity mapping: a way to map human recessive traits with the DNA of inbred children.
	www.ajrcmb.org /cgi/content/full/23/5/696 (3776 words)

	craw4.htm
		Homozygosity and heterozygosity can not be differentiated by pedigree, visual inspection, or laboratory test.
		It is, however, possible to be fairly certain of homozygosity and to assign a relative value to that certainty.
		Note that the birth of only 'complete-belts' in a test for belted homozygosity does not indicated that the a test animal is 'modifier-free'.
	www.galloway-world.org /intconf/craw4.htm (890 words)

	Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations (Site not responding. Last check: 2007-10-09)
		Objective: To identify the gene causing Andermann syndrome using homozygosity mapping in a large founder population.
		Homozygosity mapping is a technique which takes advantage of this founder effect by assuming that a single ancestral mutation is responsible for the disease.
		Conclusion: Homozygosity mapping is an efficient strategy that allows rapid analysis of a minimal number of individuals for the purposes of screening the entire genome in rare recessive disorders.
	www.osti.gov /energycitations/product.biblio.jsp?osti_id=134706 (334 words)

	CMGS-Non syndromic deafness/13.1.98 (Site not responding. Last check: 2007-10-09)
		Homozygosity mapping refined the locus to a 6cM interval that also contained the olfactory marker protein gene (OMP).
		A direct genome wide disequilibrium search strategy was used along with allele frequency dependent homozygosity mapping and analysis of historical recombinants to map DFNB3 relative to flanking markers.
		Homozygosity mapping localised DFNB12 to 10q21-22, with all affected individuals in isolated consanguineous families homozygous for markers in this region.
	www.ich.ucl.ac.uk /cmgs/deafness.htm (1198 words)

	Fuzzywunkle--Understanding Inbred Pedigrees
		Breeders need to come to terms with how much homozygosity they are willing to create in order to produce the stock desired.
		In his work, Systems of Breeding, Sewell Wright developed a formula to determine the degree of homozygosity likely to be present in an inbred individual.
		Wright’s Formula states that the coefficient of inbreeding is equal to the sum of one-half raised to a power equal to the number of generations from the sire to the common ancestor and back to the dam times one plus the coefficient of inbreeding, if any, of the common ancestor.
	www.fuzzywunkle.net /inbreeding.htm (1954 words)

	Evolution - Random events in population genetics (Site not responding. Last check: 2007-10-09)
		Over the long term, pure random drift causes the population to 'march' to homozygosity at a locus.
		The march to homozygosity in a small population proceeds because two copies of the same gene may combine in a single individual.
		There are 2N gamete types but because each individual produces many more than two gametes, there is a 1/(2N) chance that a gamete will combine with another gamete of the same gamete type as itself.
	www.blackwellpublishing.com /ridley/tutorials/Random_events_in_population_genetics15.asp (226 words)

	Inbreeding and homozygosity in a closed population of chicken (Site not responding. Last check: 2007-10-09)
		A New Hampshire line at the research station of the Institute of Animal Sciences was subject of the investigation since 1955.Divided into 15 sublines, the hens (10 to 15 per subline) were mated in a system of rotation in order to avoid inbreeding.
		Mean degree of homozygosity increased from 56,4% in 1982 to 61,6% in 1994.
		In contrast to the majority of 17 markers located in non-coding regions with increasing homozygosity, the 6 microsatellites located within coding regions showed on average an increase of heterozygosity in the New Hampshire line.
	www.hu-berlin.de:54321 /forschung/fdb/english/PJ/PJ4744.html (375 words)

	Crop Science : Molecular marker analysis of the approach to homozygosity by selfing in diploid alfalfa. @ HighBeam ... (Site not responding. Last check: 2007-10-09)
		Crop Science : Molecular marker analysis of the approach to homozygosity by selfing in diploid alfalfa.
		Start / C / Crop Science / July 01, 1997 / Molecular marker analysis of the approach to homozygosity by selfing in diploid alfalfa.
		Molecular marker analysis of the approach to homozygosity by selfing in diploid alfalfa.
	static.elibrary.com /c/cropscience/july011997/molecularmarkeranalysisoftheapproachtohomozygosity/index.html (247 words)

	Genomics\|Genetic Testing\|FBR\|HH\|Clinical Validity\|Page 2
		The rate of homozygosity in the general population can then be used to place limits around the false positive rate.
		For example, if the rate of homozygosity were found to be 50 per 10,000, then the false positive rate must be no more than 0.5 percent (assuming 0% penetrance and no analytic false positive results).
		The final consensus estimate for the rate of homozygosity is estimated using the 6.4 percent allele frequency and assumes Hardy-Weinberg equilibrium.
	www.cdc.gov /genomics/gtesting/ACCE/FBR/HH/HHCliVal_19.htm (2883 words)

	Is disomic homozygosity at the APECED locus the cause of increased autoimmunity in Down's syndrome? -- Shield et al. 81 ...
		Is disomic homozygosity at the APECED locus the cause of increased autoimmunity in Down's syndrome?
		Children with Down's syndrome and IDDM were identified through the Down's syndrome association newsletter and from paediatricians.
		Figure 2 Comparison of the level of disomic homozygosity in individuals with Down's syndrome and insulin dependent diabetes mellitus and individuals with Down's syndrome not known to have IDDM at seven marker sets spanning the long arm of chromosome 21.
	adc.bmjjournals.com /cgi/content/full/81/2/147 (2073 words)

	Assignment of the muscle-eye-brain disease gene to 1p32-p34 by linkage analysis and homozygosity mapping. (Site not responding. Last check: 2007-10-09)
		Assignment of the muscle-eye-brain disease gene to 1p32-p34 by linkage analysis and homozygosity mapping.
		Assignment of the muscle-eye-brain disease gene to 1p32-p34 by linkage analysis and homozygosity mapping.Multipoint linkage analysis gave a maximum LOD score of 6.17 at locus D1S2677.
		Here we report the assignment of the MEB gene to chromosome 1p32-p34 by linkage analysis and homozygosity mapping in eight families with 12 affected individuals.
	www.pdg.cnb.uam.es /UniPub/iHOP/gp/1746808.html (219 words)

	AEGiS-AIDS Weekly: HIV Resistance: Homozygosity For HLA Allele Confers Protection - June 2001
		Homozygosity for HLA-Bw4 alleles was significantly associated with "profound" suppression of HIV viral load, they said.
		The link between HLA-Bw4 homozygosity and protection from AIDS was independent of other genetic factors that might confer resistance ("Control of HIV 1 viremia and protection from AIDS are associated with HLA-Bw4 homozygosity," Proc Natl Acad Sci U S A 2001 Apr 24;98(9):5140-5.
		"We conclude that homozygosity for HLA-Bw4-bearing B alleles is associated with a significant advantage [for HIV patients]," Goldfeld and colleagues wrote, "and that the HLA-Bw4 motif is important in AIDS pathogenesis."
	www.aegis.com /pubs/aidswkly/2001/aw010609.html (596 words)

	Watterson's Homozygosity test for Neutrality (Site not responding. Last check: 2007-10-09)
		The homozygosity statistic is the sum of squared allele frequencies (proportions).
		The original work by Dr. Hugh Salamon incorporated a main programme using simulation to investigate the distribution of the homozygosity statistic from replicate finite-alleles neutral simulations.
		For a given sample size and number of allelic classes, the method provides the probability distribution for the homozygosity statistic using a Monte Carlo approach (Slatkin, 1994, 1996).
	allele5.biol.berkeley.edu /homozygosity/homozygosity.html (356 words)

	Novel Multilocus Measure of Linkage Disequilibrium to Estimate Past Effective Population Size -- Hayes et al. 13 (4): ...
		Chromosomal homozygosity for different lengths of chromosome (given the recombination rate) for populations: (A) CONS (constant population size), (B) LINI (linearly increasing population size), (C) LIND (linearly decreasing population size), and (D) EXPI (exponentially increasing population size).
		The expected value of chromosomal homozygosity, 1/(4Nc + 1), is given on each graph for the maximum and minimum population sizes of each population.
		Sved, J.A. Linkage disequilibrium and homozygosity of chromosome segments in finite population.
	www.genome.org /cgi/content/full/13/4/635 (4237 words)

	CHEST: Use of antithrombotic agents during pregnancy (Site not responding. Last check: 2007-10-09)
		Given that the background rate of VTE during pregnancy is approximately 1:1000, (11) the absolute risk of VTE remains modest for the majority of these thrombophilias, except antithrombin deficiency, homozygosity for the factor V Leiden mutation, and combined defects.
		However, protein C and antithrombin deficiency, as well as homozygosity for MTHFR C677T, were not associated with recurrent or nonrecurrent fetal loss.
		However, there was an association between MTHFR C677T homozygosity and IUGR in the subgroup of mothers not receiving vitamin supplements (OR, 12.3; 95% CI, 1.2 to 126.2).
	www.findarticles.com /p/articles/mi_m0984/is_3_126/ai_n7635263/pg_5 (1133 words)

	Variable phenotypic presentation of iron overload in H63D homozygotes: are genetic modifiers the cause? -- ...
		H63D homozygosity associated with hereditary IO in 25%.
		Thus H63D homozygosity can be associated with a variety of phenotypes, including severe or mild IO, or no IO.
		Homozygosity for the predominant Cys282Tyr mutation and absence of disease expression in hereditary haemochromatosis.
	gut.bmjjournals.com /cgi/content/full/48/6/836 (3981 words)

	Does homozygosity advance the onset of dentatorubral-pallidoluysian atrophy? (Site not responding. Last check: 2007-10-09)
		Does homozygosity advance the onset of dentatorubral-pallidoluysian atrophy?He showed early onset (age, 17 years) of DRPLA.
		There was good correlation of the age of onset with the number of triplet repeats.
		We confirmed a homozygous type of relatively small expansion of CAG triplet repeats (57 repeats) in the short arm of chromosome 12 in a male patient with dentatorubral-pallidoluysian atrophy (DRPLA) by polymerase chain reaction.
	www.pdg.cnb.uam.es /UniPub/iHOP/gp/393596.html (94 words)

	Re: Dalmatians: homozygosity for a defective recessive gene
		I'm supposed to be studying for a psychology exam tomorrow and have just enough time for "light" argument, but not "serious" debate, LOL.
		> Homozygosity for a defective recessive gene results in all Dalmatians having > elevated concentrations of urine uric acid and predisposes them to formation > of purine uroliths.
		Dalmatians: homozygosity for a defective recessive gene Leanne Bertani
	www.mail-archive.com /ckcs-l%40apple.ease.lsoft.com/msg06446.html (296 words)

	320-W. Homozygosity for HLA-Bw4 Is Not Associated with Protection of HIV-1-Infected Persons of African Ancestry (Site not responding. Last check: 2007-10-09)
		In B*57-negatives, homozygous Bw4+ was found, respectively, in 9, 5, and 12% of Zambians with high, intermediate and low VL; in 20, 18, 20, and 12% of Rwandans with increasing intervals to recognition of abnormalities; and in 8, 12, and 0% of African Americans with progressively better virologic/immunologic control.
		Conclusions: Homozygosity for Bw4 alleles did not protect against disease progression in 3 African groups infected with different viral subtypes.
		Confirmation that homozygosity for Bw4 protects Caucasians could imply important differences from ethnic Africans in control of HIV-1 infection through Bw4 modulation of CTL response or ligation with its specific NK cell receptor 3DL1.
	www.retroconference.org /2002/Abstract/13778.htm (354 words)

	AllRefer.com - breeding (Genetics And Genetic Engineering) - Encyclopedia
		Purebreds result from one or more generations of inbreeding, or mating of close relatives, such as brother to sister or offspring to parent (backcrossing).
		Inbreeding produces families or lines with increasing degrees of genetic uniformity, or homozygosity, in successive generations.
		In highly homozygous families, dominant genes are uniformly transmitted and expressed; recessive genes are also more likely to be expressed, and to produce undesirable traits, including loss of general vigor and fertility.
	reference.allrefer.com /encyclopedia/B/breeding.html (571 words)

	BIOL 321 Lecture 11 (Site not responding. Last check: 2007-10-09)
		The homozygosity, f, is the probability that two distinct copies of a gene in a population are
		The rate to complete homozygosity without mutation and the equilibrium homozygosity with mutation have been derived assuming that all of the N individuals produced gametes which were
		Consider a population that is 2 for ten generations then 1,000,000 for the next 90 generations.
	www.biology.ualberta.ca /courses.hp/biol321/biol321.lecture11.htm (366 words)

	Homozygosity for Factor V Leiden Leads to Enhanced Thrombosis and Atherosclerosis in Mice -- Eitzman et al. 111 (14): ...
		Homozygosity for Factor V Leiden Leads to Enhanced Thrombosis and Atherosclerosis in Mice -- Eitzman et al.
		Homozygosity for Factor V Leiden Leads to Enhanced Thrombosis and Atherosclerosis in Mice
		Conclusions— In conclusion, homozygosity for the FVL mutation
	circ.ahajournals.org /cgi/content/abstract/111/14/1822 (333 words)

	Frequently Asked Questions [MT Dorak]
		This genotype more or less corresponds to homozygosity for HLA-DR53 and the current research specifically examined this genotype by PCR analysis against a newborn control group (as opposed to an adult control group in the previous RFLP study).
		The main hypothesis of the study was to investigate the homozygosity rate for HLA-DRB4*01 which was previously shown to have an association with a smaller group of patients in comparison to adult controls, and by RFLP analysis of the HLA-DQA1 locus.
		Whatever the reason for this, there is consistency in the observations that MHC homozygosity preferentially affects males in the intrauterine period.
	dorakmt.tripod.com /hla/faqs.html (4403 words)

	SELECTION (Site not responding. Last check: 2007-10-09)
		To examine the correspondence between the inbreeding coefficient estimated from the pedigree relationship and the true level and change in homozygosity.
		Potential bias in estimation of inbreeding depression when using pedigree relationships to assess the degree of homozygosity for loci under selection is indicated.
		The pedigree inbreeding may not measure the degree of homozygosity at loci of selected traits and so estimates of inbreeding depression may be biased.
	cgil.uoguelph.ca /pub/annualreport/selection/select4.html (260 words)

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