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Topic: Homozygote

Related Topics

Heterozygote

Recombinant frequency

Genetic recombination

Genotype

Mendelian inheritance

Fanconi anemia

Cousin

Hemochromatosis

Incest

Population genetics

MoFo

Inbreeding

Familial dysautonomia

Hypogonadism

Westermarck effect

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	Phenotypic consequences of a deletion of exons 2 and 3 of the LDL receptor gene -- Rødningen et al. 40 (2): 213 ...
		The FH homozygote proband was a male born in 1979.
		The FH homozygote proband is indicated by an arrow.
		Degradation of LDL by fibroblasts from the FH homozygote proband
	www.jlr.org /cgi/content/full/40/2/213 (4810 words)

	Homozygote - Wikipedia, the free encyclopedia
		A homozygote's cells are diploid or polyploid and have the same alleles at a locus (position) on homologous chromosomes.
		When an organism is referred to as being homozygous for a specific gene, it means that it carries two identical copies of that gene for a given trait on the two corresponding chromosomes (e.g., the genotype is AA or aa).
		Sickle-cell Anemia as an example of a Lethal Homozygote.
	en.wikipedia.org /wiki/Homozygote (207 words)

	Reduced Neuromuscular Quantal Content With Normal Synaptic Release Time Course and Depression in Canine Motor Neuron ...
		No significant differences between homozygote and normal were observed for these data as well as for decay time constants, 10-90% rise times, and half-maximal durations (data not shown).
		Homozygote mEPC frequencies appear to be shifted to the left of the normal sample.
		Homozygote synapses release similar fractions of a reduced supply of initially available quanta during repetitive activity compared with normal synapses.
	jn.physiology.org /cgi/content/full/88/6/3305 (7194 words)

	The Genetic Limits of Evolution
		A pure-breed is a genetic homozygote, or an individual which no longer possesses alternative variations for the genes in question.
		Animals evolve because nature selects from a pool of alleles, and the resulting homozygotes are genetically pure bred for the features which gave the organisms the specific adaptation.
		The variety of breeds that was later isolated from the wolf lineage appears to have accumulated gradually because we eliminated the natural selection which previously kept the genome pure of this variability.
	www.nwcreation.net /geneticlimits.html (1014 words)

	Homozygote definition - Medical Dictionary definitions of popular medical terms
		Homozygote: A person who has two identical forms of a particular gene, one inherited from each parent.
		For example, a girl who is a homozygote for cystic fibrosis (CF) received the CF gene from both of her parents and therefore has CF.
		The opposite of a homozygote is a heterozygote, a person who has two different forms of a particular gene.
	www.medterms.com /script/main/art.asp?articlekey=12729 (152 words)

	Hyperabsorption and retention of campestanol in a sitosterolemic homozygote: comparison with her mother and three ...
		Hyperabsorption and retention of campestanol in a sitosterolemic homozygote: comparison with her mother and three control subjects -- Salen et al.
		or 31% of intake in the homozygote, 2.1 mg/day or 0.3% of intake
		h and represented 31% of intake (2 mg/day) in the homozygote,
	www.jlr.org /cgi/content/full/41/11/1883 (3792 words)

	Results
		The concentration of amino acids is much larger in the homozygote samples of seeds and stalks, and a similar trend can be seen when looking at the total amino acid content of each plant genotype.
		The heterozygote plants have a concentration that is in between the wild type and the homozygote, this suggests that only one allele is necasary, or that chomosome 5 may compensate for the lack of an allele.
		The homozygote plant that lacked chromosome 4 PEPCK was much taller than the others.
	www.shef.ac.uk /aps/mbiolsci/kelly/results.html (537 words)

	The Basis of Dominance (2/4)
		Much later, Haldane14 drew on his investigations into the evolution of industrial melanism (in which the melanic form is both advantageous and dominant) and suggested that dominance might have evolved from a low level, conceivably by a Fisher-type process, concomitantly with the spread of the allele.
		The first is that it does not explain why, in the heterozygous state, the presence of a strongly deleterious allele is not as apparent as the presence of a weak allele.
		for the normal homozygote, heterozygote and abnormal homozygote respectively of the gene for an enzyme normally located in the typical position on the hyperbola, as shown in Fig.
	bip.cnrs-mrs.fr /bip10/vidya2.htm (3077 words)

	Comparative effect of dietary sitosterol on plasma sterols and cholesterol and bile acid synthesis in a sitosterolemic ...
		Comparative effect of dietary sitosterol on plasma sterols and cholesterol and bile acid synthesis in a sitosterolemic homozygote and heterozygote subject -- Cobb et al.
		Comparative effect of dietary sitosterol on plasma sterols and cholesterol and bile acid synthesis in a sitosterolemic homozygote and heterozygote subject
		homozygote compared to the heterozygous parent, whereas plasma sitosterol
	www.jacn.org /cgi/content/abstract/16/6/605 (374 words)

	10.5-kb homozygote of tumor necrosis factor beta gene...
		10.5-kb homozygote of tumor necrosis factor beta gene is associated with a better prognosis in lung and stomach
		We have reported that the frequency of 10.5-kb homozygote of the TNFB gene is low in patients with lung cancer compared to normal controls and it was found to be associated with a better prognosis.
		Conclusion: The 10.5-kb homozygote of TNFB gene could be a prognostic factor in patients with gastric cancer as has been shown in patients with lung cancer.
	www.cancerprev.org /Journal/Issues/22/101/682 (360 words)

	Activity-Driven Synaptic and Axonal Degeneration in Canine Motor Neuron Disease -- Carrasco et al. 92 (2): 1175 -- ...
		Motor-unit force records are from 2 units in the same hereditary canine spinal muscular atrophy (HCSMA) homozygote and approximate the average motor-unit force and tetanic failure for the medial gastrocnemius (MG) muscle with synergist denervation (A) and for the control MG muscle in the unoperated, opposite limb (B).
		Many axons in homozygote MG muscles showed a discontinuous, fragmented appearance of immunolabeling after synergist denervation, whereas axons in control muscles retained a continuous labeled appearance.
		Example of a multiply innervated endplate from a homozygote MG muscle after 4 wk of synergist denervation.
	jn.physiology.org /cgi/content/full/92/2/1175 (4231 words)

	The Basis of Dominance (3/4)
		If this represents the activity of an enzyme in the normal homozygote, then the point aa represents an abnormal homozygote in which the enzyme activity is entirely lacking, and the point labelled Aa represent the heterozygote.
		Note that the heterozygote phenotype is much closer to that of the normal homozygote than to that of the abnormal homozygote.
		Now the heterozygote phenotype is very close to halfway between the homozygote phenotypes, as it was assumed to be in early models.
	bip.cnrs-mrs.fr /bip10/vidya3.htm (1569 words)

	Mutation of a Novel Gene Results in Abnormal Development of Spermatid Flagella, Loss of Intermale Aggression and ...
		Expression of the mutant allele was examined by X-gal staining of fixed tissue from ROSA22 homozygote and control mice.
		from the testis of a ROSA22 homozygote (Fig 4C).
		The graphic indicates the position of the primers used for RT (c and y) and amplification of transcripts from the wild-type (a and b) or mutant (a and x) alleles, as well as the predicted size of the amplification products.
	www.genetics.org /cgi/content/full/162/1/307 (7533 words)

	Aggressive behaviour in patients with schizophrenia is associated with catechol-O-methyltransferase genotype -- JONES ...
		homozygotes was 2.07 (95% Cl=1.03-4.15), whereas that for
		homozygote genotypes in males were 25%, 48% and 27%, respectively,
		homozygote genotype, 91 (50%) were heterozygotes and 46 (26%)
	bjp.rcpsych.org /cgi/content/full/179/4/351 (2424 words)

	Zoology 510, Equation Notes for Ridley, Chapter 5
		This equation is derived by algebraic simplification from the definition for mean fitness, the ratio of survivors to starting population (when selection acts against the recessive homozygote), or.
		Equation 5.4 For selection acting against the recessive homozygote, the frequency p' of the dominant allele in the next generation is,
		For this two-allele model, any change in the frequency of one allele must be matched by the opposite change in the other allele.
	www.science.siu.edu /zoology/king/510/mr05eq.htm (905 words)

	homozygote
		homozygote An individual that has two copies of the same allele for a given gene on its two homologous chromosomes.
		...a highly significant association between autism and a two-single-nucleotide-polymorphism haplotype in the SLC25A12 gene, with a homozygote genotype relative...
		Also in some severe cases like Homozygote hyper cholestrolemia, serum cholesterol rises above 6 g/l due to a total deficiency of LDL-receptors.
	www.mongabay.com /igapo/biotech/homozygote.html (78 words)

	Korean Lupus Support Group
		To evaluate the association of TNFB NcoI polymorphism with SLE in the Korean population, we investigated the frequencies of the TNFB and HLADRB1 alleles in 281 controls and 97 SLE patients, including 56 patients with nephritis and 41 patients without nephritis.
		RESULTS: The genotypic frequency of TNFB2 homozygote* was significantly increased in patients with SLE compared with controls(RR = 2.36, P = 0.011).
		However, the increased frequency of TNFB2 homozygote* was apparently increased in nephritis group (RR = 2.79, P = 0.035), whereas the significance of TNFB2 homozygote* was weakened in non-nephritis group.
	members.tripod.com /KoreanLupus/research.html (840 words)

	Null mutation in the rhodopsin kinase gene slows recovery kinetics of rod and cone phototransduction in man -- ...
		the homozygote (1.0) and normal in the heterozygote (1.55).
		At 300 sec, the homozygote had recovered to 14% of baseline.
		In the homozygote, rod mediated increment thresholds were normal at low backgrounds (Fig.
	www.pnas.org /cgi/content/full/95/1/328 (5499 words)

	The Type 1 Inositol 1,4,5-Trisphosphate Receptor Gene Is Altered in the opisthotonos Mouse -- Street et al. 17 (2): ...
		A, IP transcript size is reduced in opt homozygote mice.
		Expression of IP R1 mRNA in the brains of opt mice was examined by Northern blot analysis.
		To investigate the underlying cause of the aberrant splicing of the opt IP R1 mRNA, the genomic structure of the gene from
	www.jneurosci.org /cgi/content/full/17/2/635 (6165 words)

	Directed Expression of Keratin 16 to the Progenitor Basal Cells of Transgenic Mouse Skin Delays Skin Maturation -- ...
		In the K16 homozygote, however, K17 expression was detected in all layers of the epidermis.
		Desmoplakin staining in the homozygote was not only reduced at regions of cell- cell contact but was also prevalent in the cytoplasm of cells (asterisks, compare B and A).
		Keratinocytes were isolated from the epidermides of newborn control, K16 heterozygote, and K16 homozygote littermates, cultured, and processed for indirect, double-immunofluorescence to analyze the keratin filament networks.
	www.jcb.org /cgi/content/full/142/4/1035 (9765 words)

	what is the level of gene expression in a homozygote and heterozygote?
		I would like to know about the level of gene expression in homozygote and heterozygote with respect to a transgenic loci and a wild type loci?
		I am under the impression that the level of gene expression in a homozygote and a heterozygote in the case of a dominant charcter is the same.
		Re: what is the level of gene expression in a homozygote and heterozygote?
	www.madsci.org /posts/archives/oct98/904867873.Ge.q.html (103 words)

	Le Curly homozygote
		Un cheval est homozygote quand il a deux gênes dominants.
		Dans le cas du Curly, si on croise un curly homozygote avec un cheval non curly ou un cheval straight, on obtiendra toujours un poulain curly aux poils bouclés.
		Certains prétendent que les curlies "extreme" sont homozygote, de ce fait une recherche est en cours afin de vérifier cela.
	www.lecurly.com /g.html (344 words)

	Genetic dominance, the heat-shock response, and X chromosome dosage compensation
		For a particular pair of such alleles possible populations include a wild-type homozygote population, a heterozygote population, and a mutant homozygote population.
		In the case of the wild-type homozygote it is postulated that the normal amount of gene product corresponds to a point well along the plateau of the curve (indicated by point Y).
		It is in the case of non-rate-limiting enzymes that a further explanation must be sought.
	post.queensu.ca /~forsdyke/dominanc.htm (10537 words)

	JAX®Mice Database - 003628 B6.Cg cub-Mcub/J
		For cub: Homozygote x Homozygote; for Mcub: Homozygote x Homozygote
		Mice homozygous for both curly bare (cub) and the recessive, C57BL/6 allele at the modifier of curly bare locus (mcub) appear hairless or "fuzzy." cub homozygotes that are either heterozygous or homozygous for the dominant, V/Le-derived Mcub allele have wavy fur.
		To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
	jaxmice.jax.org /strain/003628.html (572 words)

	Search for tag Homozygote - postgenomic.com
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		The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient.
		Items tagged 'Homozygote' have also been tagged with:
	www.ghastlyfop.com /tag_search.php?tag=Homozygote (69 words)

	Spondylo-epi-metaphyseal dysplasia (SEMD) matrilin 3 type: homozygote matrilin 3 mutation in a novel form of SEMD -- ...
		Spondylo-epi-metaphyseal dysplasia (SEMD) matrilin 3 type: homozygote matrilin 3 mutation in a novel form of SEMD -- Borochowitz et al.
		The Simon Winter Institute for Human Genetics, Bnai-Zion Medical Center, Rappaport - Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel
		Copyright © 2004 by the BMJ Publishing Group Ltd.
	jmg.bmjjournals.com /cgi/content/extract/41/5/366 (465 words)

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