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Topic: Homozygous

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In the News (Tue 25 Jun 19)

  Homozygote - Wikipedia, the free encyclopedia   (Site not responding. Last check: 2007-10-07)
When an organism is referred to as being homozygous for a specific gene, it means that it carries two identical copies of that gene for a given trait on the two corresponding chromosomes (e.g., the genotype is AA or aa).
A homozygous recessive genotype occurs when a particular locus has two copies of the recessive allele (e.g., aa).
In humans and many other animals it refers in particular to X-linked genes in males who under usual circumstances have only one X chromosome and are homozygous for all genes that are located on the X-chromosome.
en.wikipedia.org /wiki/Homozygous   (167 words)

 AGA Fact Sheet - The Inheritance of Horns and Scurs   (Site not responding. Last check: 2007-10-07)
Identifying homozygous polled bulls is especially important because each calf crop sired by a homozygous polled bull will have a frequency for the horned gene that is half that of their dams'.
Breeding homozygous polled bulls to double-polled females should produce all polled calves, and two-thirds of the calves should be homozygous polled.
Breeding homozygous polled bulls to polled females that are daughters of homozygous polled bulls should produce all polled calves, and three-fourths of the calves should be homozygous polled.
www.gelbvieh.org /fsinheri.html   (1604 words)

 Homozygous Paint Horses
The homozygous horse has two identical tobiano genes and must be sired by a tobiano, and have a tobiano for a mother.
Test breeding on solid mares is used to confirm the status of individuals thought to be homozygous, as it is possible for these genes to be 'unhooked' and not passed together.
It cannot, however, be a homozygous tobiano, since both parents are not tobiano horses.
www.stallingspainthorses.com /homozygous-paints.htm   (909 words)

 Past Issues of A Lil Bit of Color   (Site not responding. Last check: 2007-10-07)
A horse who is homozygous for the tobiano gene means that it has two copies of the tobiano gene, one inherited from EACH parent.
Whenever we breed a homozygous tobiano to another homozygous, all of the resulting foals will also be homozygous as there are no recessive "t" genes available to be passed down from either parent.
The homozygous "phenotype" (think photo type) is a tobiano with "cat tracks" or "ink spots" in the white areas not necessarily connected to the larger blocks of dark color.
www.geocities.com /Heartland/Hills/3619/homozygous.html   (1086 words)

 Influence of nutrient deprivation on gene expressivity in the homozygous lanceolate mutant.   (Site not responding. Last check: 2007-10-07)
The homozygous lanceolate mutant in L. esculentum ranges in phenotype from a small and leafless hypocotyl (reduced) to a bushy plant (narrow) with small leaves and sterile inflorescences.
Homozygous mutant progeny of fertilized and nonfertilized plants were classified into leafy and leafless categories (Table 1).
The hypothesis that environmental stress influences expressivity of the La gene in the homozygous lanceolate mutant was supported by the earlier study of Stettler and Alldredge (1967) as well as by the present study.
tgc.ifas.ufl.edu /vol35/v35p4.html   (384 words)

Both BB and bb are homozygous for the genes that determine hair color, but one is homozygous dominant (BB) while the other is homozygous recessive (bb).
With three kinds of individuals (homozygous dominant, homozygous recessive, and heterozygous) and one pair of genes being considered, six types of mating are possible.
The heterozygous animal is indistinguishable from the homozygous dominant phenotypically.
www2.msstate.edu /~brude/courses/ads/overhead/genetics.htm   (1972 words)

 Clinical Trial: SCH-58235 (Ezetimibe) to Treat Homozygous Sitosterolemia
Homozygous sitosterolemia is an inherited disorder of sterol metabolism in which an excess of many plant sterols, including sitosterol, is absorbed and not enough excreted.
Homozygous sitosterolemia is an autosomally inherited recessive disorder of sterol metabolism.
Patients with a diagnosis of homozygous sitosterolemia who have an elevated plasma sitosterol level on their current regimen will be studied.
clinicaltrials.gov /show/NCT00045812   (1243 words)

 Horse Tests - Tobiano
To identify horses likely to be homozygous for the tobiano gene the dam and sire's blood types must be compared with that of the subject horse.
Many horses that are homozygous for tobiano have a secondary spotting pattern of small clustered dark spots with roan edges breaking through in the white areas of the body.
The minimum requirement for a horse to be homozygous for tobiano, is that it must have two tobiano parents.
www.vgl.ucdavis.edu /horse/tobiano.htm   (1301 words)

 Detection of homozygous deletions in tumors by hybridization of representational difference analysis (RDA) products to ...
The candidate region for a homozygous deletion is characterized by an accumulation of overlapping YACs highlighting a region irrespective of the enzyme that was used to generate the representation.
Screening for homozygous deletions in several tumors by STS-PCR analysis (25) is an expensive and time consuming procedure if a large region of interest has to be investigated.
Furthermore, a homozygous deletion but not simple loss of a polymorphic fragment will result in RDA products that consistently highlight a region irrespective of the restriction enzyme that was used to create the representations.
nar.oxfordjournals.org /cgi/content/full/27/21/e30   (4951 words)

 The Australian Shepherd - Homozygous Merles   (Site not responding. Last check: 2007-10-07)
Lethal whites (known hereafter as homozygous because lethal white is a misnomer) are a result of a merle to merle breeding, but not every puppy in the litter is a homozygous white.
Betty Nelson (long the chair of ASCA's former Genetics Committee) had a homozygous merle bitch who was a medium blue with a stripe down her nose, a white throat and chest, one white foreleg and white toes.
If you want to keep a homozygous merle, you had better be willing to devote yourself to keeping it safe from dangers it cannot hear or see for its entire lifetime.
www.maculated.com /1/3.html   (1262 words)

 NCSU: Animal Science - Inheritance of Polledness, Horns and Scurs in Beef Cattle
Table 1 illustrates the expression of polledness or horns and what genes and traits can be expected to be passed to the offspring from the various matings.
Cattle producers should also keep in mind that a proven homozygous bull will produce some horned calves if he is bred to horned or polled cows that carry the African horn gene.
As you can see there are ultimately three pair of genes that may determine if cattle have horn-like tissue on their head in the form of horns or scurs.
www.cals.ncsu.edu /an_sci/extension/animal/news/aug96/aug96-3.html   (1025 words)

 Tobiano FAQ
From Mendelian genetics, we predict that for every 3 tobianos from heterozygous tobiano parents, one is homozygous for tobiano and two are heterozygous.
The odds that the candidate is homozygous increase with every spotted foal, as long as no solids are produced.
The horse could be homozygous, but the markers now provide only the information that the horse is equally likely to be homozygous or heterozygous.
www.vgl.ucdavis.edu /~lvmillon/tobiano_FAQ.html   (446 words)

 American Gelbvieh Association Fact Sheet - The Genetics of Color   (Site not responding. Last check: 2007-10-07)
For example, 10 fl calves from 10 red cows means that there is a 99.9 percent probability that the sire is homozygous fl.
The parents could be either heterozygous or homozygous fl to show fl color.
You may hear someone say there is an 87 percent chance that the bull is homozygous, meaning that the bull has three progeny on the ground out of red dams, and all of them are fl.
www.gelbvieh.org /fscolor.html   (1188 words)

 Test Cross   (Site not responding. Last check: 2007-10-07)
In a test cross to determine whether a fruit fly is homozygous (WW) or heterozygous (Ww) for long wings, 7 long-winged flies and 1 short winged-fly are produced.
A student wishes to perform a test cross to determine whether a female long-tailed hamster is homozygous or heterozygous for long tail length.
A student wishes to perform a test cross to determine whether a female long-tailed hamster is homozygous or heterozygous for tail length.
www.borg.com /~lubehawk/testcrss.htm   (2177 words)

 Australian Shepherd Health & Genetics Institute, Inc.   (Site not responding. Last check: 2007-10-07)
The eye defects result from improper development of the tissues of the eye while the loss of hearing is attributable to a lack of pigment in the inner ear.
Homozygous merle Aussies are usually, but not always, predominantly white.
If you want to keep a homozygous merle, you must be willing to devote yourself to keeping it safe from dangers it cannot hear or see for its entire lifetime.
www.ashgi.org /articles/color_white_fright.htm   (1069 words)

 A pedigree of homozygous familial hyperalphalipoproteinemia.   (Site not responding. Last check: 2007-10-07)
In the homozygotes, the lipid composition of HDL was found to be normal while the ratio of HDL lipids to apoproteins A-I and A-II tended to be increased.
All five children of the two homozygous individuals and two additional first degree relatives were considered to be heterozygous, since their HDL-C values were moderately elevated, with other lipid levels being normal.
The family study thus substantiated the hypothesis, as Glueck et al insisted in 1975, that this lipoprotein disorder is inherited by autosomal dominant transmission.
www.arclab.org /medlineupdates/abstract_6738363.html   (213 words)

 The 630-kb Lung Cancer Homozygous Deletion Region on Human Chromosome 3p21.3: Identification and Evaluation of the ...   (Site not responding. Last check: 2007-10-07)
The physical map is followed by a diagrammatic representation of the overlapping homozygous deletions discovered in SCLC cell lines (NCI H1450 in blue, NCI H740 in magenta, and GLC20 in green) and a nested deletion in a breast cancer tumor sample and corresponding cell line (H1500 in brick).
The sizes of the homozygous deletions, deletion overlaps, and the precisely mapped breakpoints are indicated.
The 6 genes outside of the critical region in the centromeric portion are in magenta, the 8 genes in the combined breast and lung 120-kb critical region are in blue, whereas the remaining 11 genes still within the rest of the lung cancer nested homozygous deletions (and additional 250 kb) are all in green.
cancerres.aacrjournals.org /cgi/content/full/60/21/6116   (10280 words)

 Liver Transplantation for Homozygous Protein C Deficiency?
Ashokkumar Jain, MD, Assistant Professor in the Department of Surgery in the Division of Transplant Surgery at the Thomas E. Starzl Transplantation Institute and an Adjunct Assistant Professor in the School of Pharmacy, Division of Pharmaceutical Sciences at the University of Pittsburgh in Pittsburgh, Pennsylvania.
Homozygous protein C deficiency is fatal if not treated.
En bloc heterotopic auxiliary liver and bilateral renal transplant in a patient with homozygous protein C deficiency.
www.medscape.com /content/2001/00/41/42/414268/414268.xml   (464 words)

In a living organism, having two identical alleles for a given trait.
Individuals homozygous for a trait always breed true; that is, they produce offspring that resemble them in appearance when bred with a genetically similar individual; inbred varieties or species are homozygous for almost all traits.
Recessive alleles are only expressed in the homozygous condition.
www.tiscali.co.uk /reference/encyclopaedia/hutchinson/m0008033.html   (149 words)

 Clinical Trial: Higher-Dose Ezetimibe to Treat Homozygous Sitosterolemia
Patients with homozygous sitosterolemia who are between 18 and 85 years of age have completed NHLBI's 1-year study of ezetimibe at 10 mg a day may be eligible for this study.
Current treatment of homozygous sitosterolemia consists of ezetimibe 10 mg, dietary restriction of plant and shellfish sterols, as well as the use of bile salt binding resins.
Ezetimibe is the first member of a new class of cholesterol-lowering agents that inhibits the intestinal absorption of cholesterol and structurally-related noncholesterol sterols (plant sterols) across the intestinal wall.
clinicaltrials.gov /ct/gui/show/NCT00099996   (1467 words)

 Dilated cardiomyopathy in homozygous myosin-binding protein-C mutant mice
Mice that are homozygous for the mutated MyBP-C alleles express less than 10% of truncated protein in M-bands of otherwise normal sarcomeres.
Homozygous mice bearing mutated MyBP-C alleles are viable but exhibit neonatal onset of a progressive dilated cardiomyopathy with prominent histopathology of myocyte hypertrophy, myofibrillar disarray, fibrosis, and dystrophic calcification.
Echocardiography of homozygous mutant mice showed left ventricular dilation and reduced contractile function at birth; myocardial hypertrophy increased as the animals matured.
cardiogenomics.med.harvard.edu /publication-detail?publication_id=373   (264 words)

 Sex Determination In Ficus Carica
If you eliminate the "less likely" homozygous pollen parents (GA/GA) and the "less likely" caprifig seed parents (GA/GA and GA/ga), there would be a 50/50 ratio of zygotic combinations resulting in heterozygous caprifigs and homozygous female trees (1/2 GA/ga and 1/2 ga/ga).
Smyrna-type figs are homozygous recessive for the caducous (early deciduous) trait [pp] and require pollination in order for the fruit to set.
Since [P] is lethal to the egg receiving it, homozygous dominant offspring [PP] are not possible; caprifigs may be caducous [pp] or persistent [Pp].
waynesword.palomar.edu /pljun99b.htm   (2616 words)

 MedlinePlus Medical Encyclopedia: Genetics
If two parents are each heterozygous for a particular recessive disease gene, then each child has a 25% chance of being homozygous for that gene and therefore, of showing the disease.
If one parent is homozygous and the other heterozygous, then each child has a 50% chance of being homozygous.
Homozygous individuals (about 1 out of 1,000,000 births) have extremely high levels of LDL and develop coronary heart disease in childhood.
www.nlm.nih.gov /medlineplus/ency/article/002048.htm   (2274 words)

 SACRED PHANTOM. Homozygous Paint Stallion, Standing at Stud at Little Hawk Ranch, located 36 miles NW of Fort Collins, ...
Therefore, if the tobiano gene is contributed by either the sire or the dam, it will always be visibly expressed by producing the tobiano coat pattern on the foal.
A homozygous horse is one that has two tobiano parents, with each of those parents having contributed a tobiano gene to the offspring.
Therefore, when breeding this 'homozygous' horse, it will always contribute a tobiano gene, because it has 'only' tobiano genes to give.
ourworld.compuserve.com /homepages/lhawkpaints/page3.html   (264 words)

 Homozygous Horses
Owners of tobiano horses interested to know whether their animals are homozygous for the tobiano spotting gene (TOTO) need to assemble several kinds of information.
A: From Mendelian genetics, we predict that for every three tobianos from heterozygous tobiano parents, one is homozygous for tobiano and two are heterozygous.
RESULTS: Required genetic factors relating to homozygous tobiano coloration are homozygous B (BB) in the Albumin and homozygous S (SS) in the GC systems.
foxtrotters.tripod.com /homozy.htm   (981 words)

 Punnett Squares   (Site not responding. Last check: 2007-10-07)
When both the alleles of a gene pair are the same, the organism is said to be homozygous for that characteristic.
Let's use the Punnett square to predict the results of a monohybrid cross between the homozygous dominant gray-bodied male with a homozygous recessive ebony-bodied female.
Represent the alleles contributed by the homozygous recessive female parent by writing a lower case g next to each row (see diagram).
www.accessexcellence.org /AE/AEPC/WWC/1994/punnett.html   (572 words)

 Biology 115L Project - Input Form
If the end segment of your thumb extends at an angle of less than 90 degrees from the thumb, then you are homozygous recessive for hitchhiker's thumb (hh).
If you have blue eyes, you lack pigment on the outer layer of your iris and are homozygous for this trait (ii).
A dimpled chin is caused by a dominant allele, M. If you have this feature, you are either homozygous dominant or heterozygous for this trait.
www.sonic.net /~nbs/projects/bio115l/form.html   (524 words)

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