| | Genetics in psychiatry: HOPA is one of the likely genes for schizophrenia: Currents: UI Health Care |
 | | In the period 1994-1996, using a reverse genetic approach in two independent cohorts of schizophrenic patients, we have identified variations in a newly discovered X-chromosome-coded nuclear receptor co-activator, which are strongly associated with increased risk of psychosis and hypothyroidism. |
 | | We termed this co-activator HOPA; the protein is also known as TRAP 230, since it belongs to the group of thyroid receptor-activated proteins (TRAPs) that play a critical role in transducing all nuclear receptor-activated gene transcription and, thus, in certain critical aspects of neurodevelopment. |
 | | Ironically, since TRAP activity is also necessary for the production of TSH, defects in HOPA appear to produce a peripheral resistance syndrome to thyroid hormone while simultaneously preventing the pituitary from producing more TSH to overcome the peripheral resistance, thus reinforcing the hypothyroid condition. |
| www.uihealthcare.com /news/currents/vol4issue1/6hopa.html (1018 words) |