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Topic: Howard M Temin


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In the News (Sun 29 Nov 09)

  
  Howard Martin Temin - Wikipedia, the free encyclopedia
Howard Martin Temin (December 10, 1934 – February 9, 1994) was a U.S. geneticist.
The discovery of reverse transcriptase is one of the most important of the modern era of medicine, as reverse transcriptase is the central enzyme in several widespread human diseases, such as HIV, the virus that causes AIDS, and Hepatitis B.
Born in Philadelphia, Pennsylvania, a long-time advocate against smoking, Temin died at the age of 59 from lung cancer, although he himself was never a smoker.
en.wikipedia.org /wiki/Howard_Temin   (358 words)

  
 The Lasker Foundation | Former Award Winners, Basic Medical Research 1974, Obituary
Howard M. Temin, a cancer researcher, who won the Nobel Prize for discovering an enzyme, reverse transcriptase, that overturned a central tenet of molecular biology, died of lung cancer Wednesday, at his home in Madison, Wis. He was 59.
Howard Martin Temin was born in Philadelphia in 1934.
Temin was puzzled why RNA viruses were an exception to the central dogma, and suggested in 1964, that some animal viruses may harbor reverse transcriptase, which would permit duplication of the virus's RNA into DNA for better biological adjustment after the virus entered a DNA-dominated animal cell.
www.laskerfoundation.org /awards/obits/teminobit.shtml   (647 words)

  
 Zickler Lecture
Howard Temin was born in 1934 in Philadelphia.
In subsequent years, Temin accumulated indirect evidence supporting his theory, but the major breakthrough occurred in 1970 when he and, independently, David Baltimore, documented the presence of an enzyme in RNA tumor virus particles -- reverse transcriptase -- capable of making a DNA copy from RNA.
In 1975, Howard Temin received the Nobel Prize in Medicine or Physiology, along with Baltimore and Dulbecco, his Ph.D. adviser, for their work in understanding the role played by viruses in the initiation of cancer.
www.pharm.stonybrook.edu /zickler/1989.htm   (243 words)

  
 Temin's path (Sep 9, 1998)
It may, in fact, have been one of the things that kept Howard Temin in Madison when stunning job offers trailed in the wake of his 1975 Nobel Prize in Medicine or Physiology.
Once, a few years before Temin's death from adenocarcinoma in 1994 at the age of 59, Tuerkheimer bumped into him on the Lakeshore Path, and Temin remarked that in the previous year he had walked the path every day but three.
Howard Temin's path in life was deliberate, forceful and, fortunately, ran along the shore of Lake Mendota.
www.news.wisc.edu /4290.html   (722 words)

  
 Varmus to present first Temin lecture (Apr 25, 2002)
Nobel Prize winner Harold M. Varmus, former director of the National Institutes of Health and current president and chief executive officer of Memorial Sloan-Kettering Cancer Center in New York, will give the first Howard M. Temin Lecture, Wednesday, May 1 at 2 p.m.
Temin himself bicycled or walked the trail almost every day on his way to work at the McArdle Laboratory for Cancer Research, now part of the UW Comprehensive Cancer Center.
Temin, who died in 1994 after 34 years as a McArdle faculty member, has also been memorialized with the Howard M. Temin Professorship in Cancer Research, which was created in 1997.
www.news.wisc.edu /7374.html   (325 words)

  
 The Lasker Foundation | Former Award Winners, Basic Medical Research 1974
Howard E. Skipper, Ph.D. For his contributions to biology, biochemistry and pharmacology which have laid the foundations for the chemotherapy of cancer.
Howard M. Temin, Ph.D. For his contributions to the biology of RNA-containing cancer viruses and elucidation of the mode of action of viral genes.
His ingenious experiments have analyzed the contributions of cellular and viral functions during infection and in particular have demonstrated the existence and operation of a novel viral enzyme—RNA dependent DNA polymerase (reverse transcriptase)—which is contained within the virus particle and which can mediate the synthesis of a DNA copy of the viral RNA genetic molecules.
www.laskerfoundation.org /awards/library/1974basic.shtml   (793 words)

  
 AllRefer.com - Howard Martin Temin (Cell Biology, Biography) - Encyclopedia
A professor at the Univ. of Wisconsin in Madison, Temin began his cancer research while still a student, working with his professor Renato Dulbecco and fellow student David Baltimore.
In 1970 they experimentally verified Temin's hypothesis that cancer cells affect genetic material.
For this discovery the three were awarded the 1975 Nobel Prize in Physiology or Medicine.
reference.allrefer.com /encyclopedia/T/Temin-Ho.html   (180 words)

  
 M. D. Anderson Cancer Center - Current Research/Awards
It is the oldest award conferred by The University of Texas M. Anderson Cancer Center, and its presentation highlights the annual Symposium on Fundamental Cancer Research.
M. Anderson Cancer Center was fortunate to have been able to claim this outstanding clinician as one of its own for 5 years.
Joining the M. Anderson staff in 1970, Dr. Gottlieb brought with him the dedication that quickly established his impeccable scientific reputation and earned him the title of administrative chief of the Chemotherapy Service in the Department of Developmental Therapeutics.
www.mdanderson.org /~resrep/awards.htm   (1046 words)

  
 Donations
Howard M. Temin joined the faculty at the McArdle Laboratory for Cancer Research at the University of Wisconsin-Madison in 1960 and immediately began to stir the scientific world.
Temin's early work focused on his revolutionary "provirus hypothesis" that the Rous Sarcoma Virus infection of cells, and their subsequent conversions to the cancerous state, involved a reversal of the flow of genetic information.
Temin's provirus hypothesis challenged what was then considered the central dogma of molecular biology ­ that genetic information always flows from DNA to RNA.
www.mcardle.wisc.edu /donations.html   (703 words)

  
 The Howard Temin Award (K01)   (Site not responding. Last check: 2007-10-31)
The goal of the National Cancer Institute's (NCI) Howard Temin Award is to bridge the transition from a mentored research environment to an independent basic cancer research career for scientists who have demonstrated unusually high potential.
To achieve this objective, the Howard Temin Award offers candidates up to 5 years to gain additional skills and knowledge in human cancer research, including up to 3 years in a mentored environment followed by transition to the equivalent of a junior faculty position to develop an independent research program.
At least 75 percent of the recipient's full-time professional effort must be devoted to the career development plan/research proposed in the Temin application and the remainder must be devoted to activities related to the development of a successful research career focused on human cancer research.
deainfo.nci.nih.gov /concepts/howardteminaward.htm   (481 words)

  
 Appointment of Howard M. Temin as a Member of the National Cancer Advisory Board   (Site not responding. Last check: 2007-10-31)
The President today announced his intention to appoint Howard M. Temin to be a member of the National Cancer Advisory Board for the term expiring March 9, 1988.
Temin has been American Cancer Society professor of viral oncology and cell biology at the University of Wisconsin.
Temin graduated from Swarthmore College (B.A., 1955) and the California Institute of Technology (Ph.D., 1959).
www.reagan.utexas.edu /archives/speeches/1987/051387d.htm   (126 words)

  
 Highbeam Encyclopedia - Search Results for Temin,   (Site not responding. Last check: 2007-10-31)
Temin at Amazon.com Buy books at Amazon.com and save.
Temin, Howard Martin TEMIN, HOWARD MARTIN [Temin, Howard Martin] 1934-94, American virologist, b.
A professor at the Univ. of Wisconsin in Madison, Temin began his cancer research while still a student, working with his professor Renato Dulbecco and fellow
www.encyclopedia.com /SearchResults.aspx?Q=Temin,   (345 words)

  
 Alkaitis.com Dr.Saulius Antony Alkaitis
With Professor Howard M. Temin at the University of Wisconsin at Madison, Dr.
Temin received his Nobel for showing how a whole new live form, namely the retrovirus (the AIDS virus is one of them), could use RNA for their genes, demonstrating that a feedback loop in the transfer of genetic information did exist in nature.
In the 70's, Dr. Alkaitis was invited, with 19 other young scientists from all over the world, for the very first month-long workshop at Cold Springs Harbor Laboratory, Long Island.
www.alkaitis.com /people.html   (347 words)

  
 BookRags: David Baltimore Biography
In 1965, Temin, an assistant professor of oncology at the University of Wisconsin, proposed for the first time a process called reverse transcription.
Temin also found a similar enzyme in the Rous-sarcoma virus.
Baltimore and Temin's work on reverse transcriptase showed how a retrovirus disrupts a cell's replication mechanism and causes cancer.
www.bookrags.com /biography/david-baltimore-wsd   (622 words)

  
 Helper cell (US4650764)
Article by K. Shimotohno & H. Temin, "Loss of Intervening Sequences in Genomic Mouse Alpha Globin DNA Inserted in an Infectious Retrovirus Vector", 299 Nature 265-268 (1982).
Article by S. Watanabe & H. Temin, "Encapsidation Sequences for Spleen Necrosis Virus, An Avian Retrovirus, are Between the 5' Long Terminal Repeat and the Start of the Gag Gene", 79 Proc.
Article by J. O'Rear and H. Temin, "Spontaneous Changes in Nucleotide Sequence in Provirus of Spleen Necrosis Virus, an Avian Retrovirus", 79 Proc.
www.delphion.com /details?pn10=US04650764   (750 words)

  
 Howard M. Temin - Autobiography
I was born on December 10, 1934 in Philadelphia, Pennsylvania, United States of America, the second of three sons of Annette and Henry Temin.
My father was an attorney, and my mother has been continually active in civic affairs, especially educational ones.
Howard M. Temin died on February 9, 1994.
nobelprize.org /medicine/laureates/1975/temin-autobio.html   (723 words)

  
 C. David Pauza - Institute of Human Virology   (Site not responding. Last check: 2007-10-31)
His graduate degree was supervised by Professor Howard Schachman, a renowned biochemist and pioneer in the application of physical methods to the study of biology.
Waterman, P. M., Kitabwalla, M. M., Tikhonov, I., and Pauza, C. Simian/Human Immunodeficiency Virus 89.6 Expressing the Chemokine Genes MIP-1a, RANTES, or Lymphotactin.
Poccia, F., Gougeon, M. L., Agrati, C., Montesano, C., Martini, F., Pauza, C. D., Fisch, P., Wallace, M., and Malkovsky, M. Innate T-cell immunity in HIV infection: the role of Vgamma9Vdelta2 T lymphocytes.
www.ihv.org /bios/pauza.html   (900 words)

  
 Harvard Gazette: Anthrax toxin receptor discovered
This is because antibiotic-insensitive toxin is already circulating and once in the cell, causing irreparable damage.
"Our short-term goals are to study the mechanism of toxin uptake through ATR and to make enough of the toxin-blocking form of the receptor so that it can be tested in animal systems," said senior author John A. Young, the Howard M. Temin professor of cancer research at Wisconsin.
This is the third time in six months that scientists working with R. John Collier, the study's co-author and the Maude and Lillian Presley professor of microbiology and molecular genetics at the Medical School, have devised a strategy to block toxin action.
www.hno.harvard.edu /gazette/2001/10.25/13-anthrax.html   (317 words)

  
 Howard Martin Temin Winner of the 1975 Nobel Prize in Medicine
Howard Martin Temin Winner of the 1975 Nobel Prize in Medicine
Howard M. Temin — Autobiography (submitted by George)
Howard M. Temin Biography from Encyclopedia Britannica (submitted by www.britannica.com)
almaz.com /nobel/medicine/1975c.html   (78 words)

  
 Britannica India: Biographies
Baltimore also conducted research that led to an understanding of the interaction between viruses and the genetic material of the cell.
The research of all three men contributed to an understanding of the role of viruses in the development of cancer.
Baltimore and Temin both studied the process by which certain tumour-causing RNA viruses (those whose genetic material is composed of RNA) replicate after they infect a cell.
www.britannicaindia.com /biographies_newtry.asp?id=191   (359 words)

  
 Louis Mansky - Academic Health Center, University of Minnesota
Postdoctoral Research: Laboratory of Howard M Temin, University of Wisconsin-Madison
Chen, R., Yokohama M., Sato H., Reilly C. Mansky, LM.
Human immunodeficiency virus mutagenesis during antiviral therapy: impact of drug-resistant reverse transcriptase and nucleoside and nonnucleoside reverse transcriptase inhibitors on human immunodeficiency virus type 1 mutation frequencies, Journal of Virology 79:12045-57.
www.ahc.umn.edu /virology/Investigators/mansky.html   (605 words)

  
 National Academy of Sciences: NAS Award in Molecular Biology
For his ingenious studies of the topological properties of the DNA double helix and his discovery of the important class of enzymes know as DNA topoisomerases.
Geoffrey M. Cooper and Robert A. Weinberg (1984)
For adding a new dimension to eukaryotic genetics and developmental biology by developing a method to introduce and stably integrate cloned genes into the germ cells of living Drosophila.
www.nasonline.org /site/PageServer?pagename=AWARDS_molbio   (1057 words)

  
 Books about DNA
Robertson, James, Ross, Alistair M., and Burgoyne, Leigh Alexander, (editors), DNA in Forensic Science: Theory, Techniques, and Applications, Ellis Horwood series in forensic science, (Ellis Horwood, New York, 1990).
Sutherland, Betsy M., and Woodhead, Arvril D., DNA Damage and Repari in Human Tissues, Proceedings of Brookhaven Symposium in Biology, number 36, on DNA Damage and Repair in Human Tissues, held 1-4 October, 1989, at Brookhaven National Laboratory, Upton, New York, (Plenum Press, New York, 1990).
Temin, Howard M., The DNA Provirus: Howard Temin's Scientific Legacy, Cooper, Geoffrey M, temin, Rayla Greenberg, and Sugden, Bill, (editors), this book includes selected papers of Howard M. Temin and proceedings of the Howard Temin commemorative Symposium, held in Madison, Wisconsin, 13-15 October, 1994, (ASM Press, Washington, D.C., 1995).
www.cbs.dtu.dk /staff/dave/DNArefs_1990s.html   (13207 words)

  
 Find in a Library: Howard M. Temin : December 10, 1934-February 9, 1994
Find in a Library: Howard M. Temin : December 10, 1934-February 9, 1994
Howard M. Temin : December 10, 1934-February 9, 1994
WorldCat is provided by OCLC Online Computer Library Center, Inc. on behalf of its member libraries.
worldcatlibraries.org /wcpa/ow/b06e88482880b5dba19afeb4da09e526.html   (66 words)

  
 Nobel Laureates - National Institutes of Health (NIH)   (Site not responding. Last check: 2007-10-31)
Howard M. Temin, U.S.A. (shared with D. Baltimore and R. Dulbecco, U.S.A.)
Gerald M. Edelman, U.S.A. (shared with R. Porter, U.K.)
John C. Kendrew, U.K. (shared with M. Perutz, U.K.)
www.nih.gov /about/almanac/nobel   (1496 words)

  
 Biochemistry Faculty   (Site not responding. Last check: 2007-10-31)
B regulation and relevant target genes may also provide important insights into novel approaches for therapeutic intervention.
Edelstein, L.C., Lagos, L., Simmons, M., Tirumalai, H. and
Jui Dutta, M.S. Nupur Gupta, B.S. Lynn Lagos, B.A. Matthew Simmons, B.S. Postdoctoral Fellows:
www2.umdnj.edu /bchemweb/HTML/GelinasNEW.html   (647 words)

  
 Amazon.com: The DNA Provirus: Howard Temin's Scientific Legacy: Books: Geoffrey M. Cooper,Howard M. Temin,Rayla ...   (Site not responding. Last check: 2007-10-31)
Amazon.com: The DNA Provirus: Howard Temin's Scientific Legacy: Books: Geoffrey M. Cooper,Howard M. Temin,Rayla Greenberg Temin,Bill Sugden
The DNA Provirus: Howard Temin's Scientific Legacy (Hardcover)
by Geoffrey M. Cooper (Author), Howard M. Temin (Editor), Rayla Greenberg Temin (Editor), Bill Sugden (Editor)
www.amazon.com /exec/obidos/tg/detail/-/1555810985?v=glance   (437 words)

  
 University of Michigan
Researchers receive Temin Award for fighting HIV, AIDS
ANN ARBOR---University of Michigan researchers have received the Howard M. Temin Award in Epidemiology for Scientific Excellence in the Fight Against HIV/AIDS.
Announced in October at the VIIth International Conference on Human Retrovirology in Paris, France, the award was for an article, "Role of the Primary Infection in Epidemics of HIV Infection in Gay Cohorts," published in the Journal of AIDS and Human Retrovirology.
www.umich.edu /news/?Releases/1995/Nov95/chr110295a   (144 words)

  
 The Role of RNA in Reproduction and Development.   (Site not responding. Last check: 2007-10-31)
Transforming RNA as a template directing RNA and DNA synthesis in bacteria, by M. Beljansky and M. Plawecki
Appearance and decay of ribonucleic acids in the cytoplasm of salivary gland cells of chironomus tentans, by J.-E. Edstrom
RNA-directed DNA synthesis in viruses and normal cells: a possible mechanism in differentiation, by C.-Y. Kang and Howard M. Temin
www.euchromatin.net /Niu01.htm   (1817 words)

  
 nature erratum   (Site not responding. Last check: 2007-10-31)
Meir J. Stampfer, Robert M. Califf, Bert Vogelstein, and John C. Reed are #1 in the Clinical Medicine/Epidemiology, Cardiology, Oncology, and General Biomedicine categories, respectively.
Harvard, Johns Hopkins, and the Howard Hughes Medical Institute made strong showings.
February 09, 2006 in The Big Prize
www.natureerratum.com   (2506 words)

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