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	Howard Martin Temin - Wikipedia, the free encyclopedia
		Howard Martin Temin ( December 10, 1934 - February 9, 1994) was a U.S. geneticist.
		The discovery of reverse transcriptase is one of the most important of the modern era of medicine, as reverse transcriptase is the central enzyme in several widespread human diseases, such as HIV, the virus that causes AIDS, and Hepatitis B.
		A long-time advocate against smoking, Temin died at the age of 59 from lung cancer, although he himself was never a smoker.
	en.wikipedia.org /wiki/Howard_Martin_Temin (311 words)

	Nat' Academies Press, Biographical Memoirs V.79 (2001)
		Temin and Rubin6 established the previously suspected model that cells in which RSV infection is established pass on to their progeny the capacity to release RSV.
		Howard concluded that “the virus becomes equivalent to a cellular gene controlling cellular morphology.” He also contemplated the possibility that the ability of RSV to control the morphology of cells infected in vitro was related to the virus’s tumorigenic capacity in vivo.
		Howard analyzed the effects of serum on the proliferation of CEF cells in culture and recognized that the removal of serum inhibited the cells’ proliferation.12 He used this insight to manipulate cultures of cells such that they were partially synchronized within their proliferative cycle.
	www.nap.edu /openbook/0309075726/html/336.html (4550 words)

	Temin's path
		Dozens of Dr. Temin's family members, friends and co-workers were invited to the attend the ceremony and reception celebrating his many contributions to the university and to the world.
		Dozens of Dr. Temin's family members, friends and colleagues were invited to attend the ceremony and reception celebrating his many contributions to the university and to the world.
		Howard Temin's path in life was deliberate, forceful and, fortunately, ran along the shore of Lake Mendota.
	www.news.wisc.edu /wire/i090998/temin.html (1046 words)

	Howard M. Temin, December 10, 1934–February 9, 1994 \| By Bill Sugden \| Biographical Memoirs
		Howard analyzed the effects of serum on the proliferation of CEF cells in culture and recognized that the removal of serum inhibited the cells' proliferation.
		Howard Temin's research on RNA tumor viruses, his contributions to the elucidation of their replication, and his enunciation of and experimental support for the provirus hypothesis were not conducted in a vacuum.
		Howard interpreted the high frequency of detected recombination during retroviral replication to result from the inherent ability of reverse transcriptase to switch its templates, an event essential to synthesis of the proviral precursor.
	stills.nap.edu /readingroom/books/biomems/htemin.html (9448 words)

	The Lasker Foundation \| Former Award Winners, Basic Medical Research 1974, Obituary
		Howard M. Temin, a cancer researcher, who won the Nobel Prize for discovering an enzyme, reverse transcriptase, that overturned a central tenet of molecular biology, died of lung cancer Wednesday, at his home in Madison, Wis. He was 59.
		Temin was an ardent crusader against smoking, even admonishing members of the audience at the Nobel Prize ceremony for smoking when he was being honored for his efforts to combat cancer.
		Temin was puzzled why RNA viruses were an exception to the central dogma, and suggested in 1964, that some animal viruses may harbor reverse transcriptase, which would permit duplication of the virus's RNA into DNA for better biological adjustment after the virus entered a DNA-dominated animal cell.
	www.laskerfoundation.org /awards/obits/teminobit.shtml (647 words)

	[No title]
		David Baltimore, Howard Temin and Renato Dulbecco shared the 1975 Nobel Prize in Physiology or Medicine for the discoveries concerning the interaction between tumor viruses and the genetic material of the cell.
		Baltimore, Temin and Renato Dulbecco shared the 1975 Nobel Prize in Physiology or Medicine for their discoveries concerning the interaction between tumor viruses and the genetic material of the cell.
		Temin was interested in biology and during high school, he was accepted into the summer research program at Jackson Memorial Laboratory in Bar Harbor, Maine.
	www.dnaftb.org /dnaftb/concept_25/con25bio.html (808 words)

	Zickler Lecture (Site not responding. Last check: 2007-11-04)
		Howard Temin was born in 1934 in Philadelphia.
		In subsequent years, Temin accumulated indirect evidence supporting his theory, but the major breakthrough occurred in 1970 when he and, independently, David Baltimore, documented the presence of an enzyme in RNA tumor virus particles -- reverse transcriptase -- capable of making a DNA copy from RNA.
		In 1975, Howard Temin received the Nobel Prize in Medicine or Physiology, along with Baltimore and Dulbecco, his Ph.D. adviser, for their work in understanding the role played by viruses in the initiation of cancer.
	www.pharm.sunysb.edu /zickler/1989.htm (243 words)

	The Howard Temin Award (K01) (Site not responding. Last check: 2007-11-04)
		The goal of the National Cancer Institute's (NCI) Howard Temin Award is to bridge the transition from a mentored research environment to an independent basic cancer research career for scientists who have demonstrated unusually high potential.
		To achieve this objective, the Howard Temin Award offers candidates up to 5 years to gain additional skills and knowledge in human cancer research, including up to 3 years in a mentored environment followed by transition to the equivalent of a junior faculty position to develop an independent research program.
		At least 75 percent of the recipient's full-time professional effort must be devoted to the career development plan/research proposed in the Temin application and the remainder must be devoted to activities related to the development of a successful research career focused on human cancer research.
	deainfo.nci.nih.gov /concepts/howardteminaward.htm (481 words)

	1970 - Hamilton Smith & Howard Temin & David Baltimore
		Temin realized that this might mean the RSV replicated through a DNA intermediate, which he called the provirus.
		That is, Temin was proposing the sequence RNA (of the RSV) to DNA (provirus) to RNA (replicated RSV) which, while not actually excluded by the Central Dogma, was not implied by it either.
		In June 1970 Baltimore and, quite independently, Howard Temin announced the discovery of an enzyme later to be known as reverse transcriptase, which is capable of transcribing RNA into DNA.
	www.laskerfoundation.com /news/gnn/timeline/1970a.html (489 words)

	NIH Guide: THE HOWARD TEMIN AWARD
		FUNDS AVAILABLE The Howard Temin award is a highly competitive award, with the intent of providing support to outstanding junior scientists during their transition to an independent investigator status.
		The Howard Temin Award not only offers continuing encouragement to clinicians for training in basic research, but additionally represents a complementary new effort to encourage scientists trained in the basic sciences to focus on problems of direct high relevance to the clinical sciences or the prevention, control and population sciences as they relate to cancer.
		Specifically, the Howard Temin Award provides an opportunity for medically trained individuals and basic scientists to initially work under a mentor in an institutional environment that will enable them to transition to an independent research position and acquire research support focused on issues and problems directly relevant to human cancer.
	grants.nih.gov /grants/guide/pa-files/PAR-00-066.html (4328 words)

	PAR-03-104: THE HOWARD TEMIN AWARD
		To achieve this objective, the Howard Temin Award offers candidates up to five years to gain additional skills and knowledge in human cancer research during a period of one to three years in a mentored environment, followed by transition to the equivalent of a junior faculty position to develop an independent research program.
		The Howard Temin Award also encourages postdoctoral individuals exclusively trained in the basic sciences to refocus their research careers on problems of direct relevance to human cancer prevention, detection, diagnosis, and treatment.
		Specifically, the Howard Temin Award provides an opportunity for basic scientists to train under a mentor experienced in human cancer research, transition to an independent research position and acquire research support focused on issues and problems directly relevant to human cancer.
	grants1.nih.gov /grants/guide/pa-files/PAR-03-104.html (6776 words)

	Ahead of the Curve: CHAPTER ONE
		Howard knew that anyone accepted to the program had to be bright.
		Temin was a link for Baltimore between the unformed teenage summer interns like himself and the older, established faculty scientists.
		Through his contact with Temin, Baltimore had the chance to ask, "Do I have what it takes to compare to Howard Temin?" Temin's accomplishments and rapid success set the bar for Baltimore; and, consciously or not, Baltimore would spend years working to match the skills of his first scientific role model.
	www.ucpress.edu /books/pages/9029/9029.ch01.html (3298 words)

	the Genetics Society (Site not responding. Last check: 2007-11-04)
		December 12th 2000 marks the 25th anniversary of the award of 1975 Nobel Prizes of Renato Dulbecco, Howard Temin and David Baltimore.
		Howard Temin (1970, 1980) suggested that RNA-retroviruses evolved from cellular moveable genetic elements of eukaryotes.
		TEMIN H.M. RNA-directed DNA polymerase in virions of Rous sarcoma virus.
	www.genetics.org.uk /?page=issue_44_e (401 words)

	Donations
		Howard M. Temin joined the faculty at the McArdle Laboratory for Cancer Research at the University of Wisconsin-Madison in 1960 and immediately began to stir the scientific world.
		Temin's early work focused on his revolutionary "provirus hypothesis" that the Rous Sarcoma Virus infection of cells, and their subsequent conversions to the cancerous state, involved a reversal of the flow of genetic information.
		Temin's provirus hypothesis challenged what was then considered the central dogma of molecular biology that genetic information always flows from DNA to RNA.
	mcardle.oncology.wisc.edu /donations.html (703 words)

	Physiology or Medicine 1975 - Press Release
		Howard Temin was since the end of the 1950ies concerned with studies of tumour viruses which contain the alternative type of genetic material, i.e.
		In order to explain this Temin postulated that the genetic information of an RNA virus capable of giving transformation could be copied into DNA, and that this DNA in a manner similar to that described for a DNA tumour virus could become integrated into the genetic material of cells.
		Temin accumulated certain indirect evidences supporting his theory but the major breakthrough occurred in 1970 when simultaneously Temin and also David Baltimore showed the occurrence of a specific enzyme in RNA tumour virus particles which could make a DNA copy from RNA.
	www.nobel.se /medicine/laureates/1975/press.html (1031 words)

	Appointment of Howard M. Temin as a Member of the National Cancer Advisory Board (Site not responding. Last check: 2007-11-04)
		The President today announced his intention to appoint Howard M. Temin to be a member of the National Cancer Advisory Board for the term expiring March 9, 1988.
		Temin has been American Cancer Society professor of viral oncology and cell biology at the University of Wisconsin.
		Temin is married, has two children, and resides in Madison, WI.
	www.reagan.utexas.edu /archives/speeches/1987/051387d.htm (126 words)

	Temin, Howard Martin
		Temin proposed in 1964 that the virus somehow translated its RNA into DNA, which then redirected the reproductive activity of the cell, transforming it into a cancer cell.
		Skeptics pointed out that Temin's suggestion contradicted the contemporary tenet of molecular biology: that genetic information always passed from DNA to RNA, rather than the reverse.
		Temin obtained his Ph.D. in 1959, and after spending another year with Dulbecco, he joined the faculty of the University of Wisconsin in Madison, where he taught and conducted research until his death.
	wwwa.search.eb.com /nobel/micro/585_99.html (234 words)

	Caltech Nobel Site
		Howard Temin was one of his graduate students, and their work started his interest in tumor viruses.
		Howard Temin shared the 1975 Nobel Prize in Physiology or Medicine with Renato Dulbecco and David Baltimore for their joint discovery of the enzyme reverse transcriptase.
		Temin continued to teach and pursue research at the University of Wisconsin for the rest of his career.
	pr.caltech.edu /events/caltech_nobel/home2.html (2718 words)

	Boston Globe Online / Table of Contents (Site not responding. Last check: 2007-11-04)
		MADISON, Wis. -- Nobel Prize winner Howard Temin, a cancer researcher who campaigned for years against cigarette smoking, has died of lung cancer.
		Temin, a University of Wisconsin-Madison professor who specialized in cancer and AIDS research, made a brief public announcement in 1992 to discuss his illness and to note that he had never been a cigarette smoker.
		He won the Nobel Prize for physiology in 1975 when he was honored with two other scientists for their research into possible links between viruses and cancer.
	www.boston.com /globe/search/stories/nobel/1994/1994z.html (123 words)

	NIH Guide: THE HOWARD TEMIN AWARD
		PURPOSE The goal of the National Cancer Institute's (NCI) Howard Temin Award is to bridge the transition from a mentored research environment to an independent research career for scientists who have demonstrated unusually high potential during their initial stages of training and development.
		A candidate submitting an application for the Howard Temin Award may not simultaneously submit an application for any other PHS award that duplicates the provisions of this award nor have another application pending award.
		Specifically, the Howard Temin Award provides an opportunity for medically trained individuals and basic scientists to initially work under a mentor in an institutional environment that will enable them to transition to an independent research position and acquire research support focused on issues and problems highly relevant to human cancer.
	grants.nih.gov /grants/guide/pa-files/PAR-99-063.html (3831 words)

	[No title] (Site not responding. Last check: 2007-11-04)
		Howard Temin was one of my professors, before he received his Nobel Prize.
		I was intrigued by your choice of honoring Howard.
		I doubt there are many people outside of the genetics research community familiar with Howard Temin's name or his work.
	www.visualcti.com /A55885/Contact.nsf/Contact?OpenForm&r=63ECED48A73EAFC18625701B005F0F51 (181 words)

	Temin, Howard Martin (Site not responding. Last check: 2007-11-04)
		For his work on the genetic inheritance of viral elements he shared the 1975 Nobel Prize for Physiology or Medicine with David Baltimore (1938-) and Renato Dulbecco (1914-).
		Temin was born in Philadelphia and educated at Swarthmore College, Pennsylvania, and the California Institute of Technology.
		Temin's prizewinning research was on a virus that has a mechanism which incorporates its material into mammalian genes.
	www.cartage.org.lb /en/themes/Biographies/MainBiographies/T/Temin/1.html (100 words)

	Rayla G. Temin (Site not responding. Last check: 2007-11-04)
		Temin, H. Cooper, R. Temin and B. Sugden.
		Temin, R. The independent distorting ability of the Enhancer of Segregation Distortion, E(SD), in Drosophila melanogaster.
		Temin, R. Homozygous viability and fertility loads in Drosophila melanogaster.
	www.genetics.wisc.edu /CATG/temin (129 words)

	HISTORY (Site not responding. Last check: 2007-11-04)
		Howard Temin, the late professor of virology and oncology, was a beloved campus figure whose outstanding research was recognized by the Nobel Prize.
		Dedication (in 1998) of the Lakeshore Path to Professor Temin is especially fitting because of his strong devotion to walking and bicycling.
		The native plant garden at the entrance to the Lakeshore Path just west of the Limnology Building was established in honor of Arthur Davis Hasler, the distinguished emeritus professor of limnology, on his 90th birthday.
	www.ies.wisc.edu /cna/history.htm (1383 words)

	MSN Encarta - Search Results - Howard Florey
		Florey, Sir Howard Walter, Baron Florey (1898-1968), Australian pathologist and codiscoverer of penicillin.
		Its head is the duke of Norfolk and earl marshal of England; other titles held by members of the family...
		Exclusively for MSN Encarta Premium Subscribers--quickly search thousands of articles from magazines such as Time, Newsweek, The Atlantic Monthly, and Smithsonian.
	encarta.msn.com /Howard_Florey.html (130 words)

	7 October 1998 (Site not responding. Last check: 2007-11-04)
		Wednesday, in recognition of that symbiosis, and for his many contributions to the life of the university, the Lakeshore Path officially became the Howard M. Temin Lakeshore Path.
		At a late afternoon ceremony on the west end of the 1.6-mile path, friends and colleagues gathered to remember a remarkable scientist and human being, and to commemorate the path in his name.
		As stated on the two identical bronze plaques denoting the trail--set in boulders at each end of the path--Howard Temin was responsible for enlarging our understanding of how genetic information flows in cells.
	www.ies.wisc.edu /cna/path.htm (2003 words)

	Dept of MCB, Harvard U: News and Events - MCB News
		Xiaoqi Liu of the Raymond Erikson lab in MCB has been awarded the prestigious Howard Temin Award from the National Cancer Institute.
		The Temin Award is targeted for young scientists, and is specificially designed to encourage and promote the transition from mentored postdoctoral research to independent investigator status.
		Liu’s Howard Temin Award is an early milestone in what promises to be a fruitful research program.
	golgi.harvard.edu /NewsEvents/News/Erikson.html (596 words)

	DSR Sources - BioMedical
		The purpose of the Howard Temin Award is to encourage basic scientists to focus their research on human cancer and to bridge the transition of these scientists from a mentored postdoctoral research environment to an independent cancer research career.
		The award is primarily for basic scientists who already have received considerable postdoctoral mentoring, who are demonstrating unusually high potential as independent scientists, and who wish to develop research directly relevant to understanding the biology, etiology, pathogenesis, prevention, diagnosis, and treatment of human cancer.
		Specifically, the Howard Temin Award provides an opportunity for basic scientists to initially work under a mentor in an institutional environment that will enable them to transition to an independent research position and acquire research support focused on issues and problems directly relevant to human cancer.
	www.research.usf.edu /sr/sources/Funding/Biomedical/11a2002.htm (1884 words)

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