
	Where results make sense

Topic: Hsp70

Related Topics

Heat shock protein

Chaperone

GroEL

In the News (Tue 29 Dec 09)

Northern Trust

Marvin Harrison

Peter Chernin

Gary Locke

Match Play

Penelope Cruz

Mickey Rourke

AR Rahman

Danny Boyle

Hugh Jackman

	[No title]
		A family of heat shock proteins, the hsp70 proteins have an average molecular weight of 70 kDa [1, 2, 3].
		Hsp70 proteins can be found in different cellular compartments (nuclear, cytosolic, mitochondrial, endoplasmic reticulum, etc...).
		Some evidence suggests that the constitutive members have a role in the disassembly of clathrin cages [4], and may also participate in the post-translational transmembrane targetting of proteins to cellular organelles.
	www.ebi.ac.uk /interpro/IEntry?ac=IPR001023 (593 words)

	Hsp70 - Wikipedia, the free encyclopedia
		Members of the Hsp70 family are strongly upregulated by heat stress and toxic chemicals, particularly heavy metals such as arsenic, cadmium, copper, mercury, etc. Hsp70 was originally discovered by FM Rotissa in the 1960s when a lab worker accidentally boosted the incubation temperature of Drosophila (fruit flies).
		Further speeding ATP hydrolysis are the so-called J-domain cochaperones: primarily Hsp40 in eukaryotes, and DnaJ in prokaryotes.
		Interaction with CHIP (Carboyl-terminus of Hsp70 Interacting Protein)–an E3 ubiquitin ligase–allows Hsp70 to pass proteins to the cell's ubiquitination and proteolysis pathways.
	en.wikipedia.org /wiki/Hsp70 (730 words)

	Heat Shock Protein as a Vaccine Vehicle
		We have found that immunization with antigens genetically fused to hsp70 elicits strong and long-lived humoral and cellular immune responses in the absence of adjuvant (Suzue et al., 1996).
		Hsp70 fusion proteins elicit antigen-specific CTL responses and protect mice from tumor challenge (Suzue et al., 1997).
		Whatever the underlying mechanism, the ability of hsp70 fusion proteins to elicit CTL responses in the absence of CD4+ cells suggests that hsp70 may be a useful vehicle for the development of prophylaxis and therapy of HIV-1 and its opportunistic infections.
	web.wi.mit.edu /young/hsp (2328 words)

	HSP70 Sequence Database
		The HSP70 multigene family is composed of genes related to the major heat shock protein of 70,000 daltons.
		It includes distantly related members of the HSP70 Multigene Family and proposed family members that may or may not be homologous.
		The emphasis is on the evolution of HSP70 genes.
	bioinfo.med.utoronto.ca /HSP70 (211 words)

	HSP70, antibody
		The HSP70 family may be the most abundant HSP induced in cell response to stress - up to 20% of the total cellular protein after appropriate stimulation.
		HSP70 is localized in the cytosol, mitochondria and endoplasmic reticulum and exhibit constitutive and inducible regulation.
		The activity of HSP70 appears to be regulated by co-factor chaperones.
	www.hytest.fi /tuotteet300.php (161 words)

	97-043 (Chaperone Proteins) (Site not responding. Last check: 2007-11-05)
		Flies bred to contain extra copies of hsp70 genes responded to the warmth by producing a lot of hsp70, which substantially increased their life span over a two-week period after heat treatment.
		Hsp70 is one of the body's many "chaperone" proteins, which promote the proper folding and shaping of other proteins during biological processes.
		Molecular chaperones, such as hsp70 or "heat-shock proteins," are thought to combat stress-related damage to protein function caused by exposure to heat or cold.
	www.brown.edu /Administration/News_Bureau/1997-98/97-043.html (435 words)

	Hsp70 (Site not responding. Last check: 2007-11-05)
		The affinity of Hsp70 for substrates is tightly regulated by ATP and co-chaperones, which control key points of the ATPase cycle.
		This high degree of sequence conservation in hsp70 members has lead to the determination of three signature patterns for the hsp70 family of proteins.
		Low affinity binding of peptides to Hsp70 may be reversed quickly and spontaneously, while peptides bound with high affinity may require ATP hydrolysis mediated by the N-terminal domain, or be effected by intervention of another cellular component.
	pps98.man.poznan.pl /assignment/projects/johnston/hsp70a~1.htm (1133 words)

	Characterization of the Immunostimulatory Properties of Leishmania infantum HSP70 by Fusion to the Escherichia coli ...
		Since HSP70 is considered to be the most conserved protein present in all organisms (16), we analyzed the humoral response
		Homology of the 70-kilodalton antigens from Mycobacterium leprae and Mycobacterium bovis with the Mycobacterium tuberculosis 71-kilodalton antigen and with the conserved heat shock protein 70 of eucaryotes.
		Hsp70 in parasites: as an inducible protective protein and as an antigen.
	iai.asm.org /cgi/content/full/66/1/347 (3463 words)

	Constitutive and Inducible Heat Shock Protein 70 Immunoreactivity in the Normal Rat Eye -- Dean et al. 40 (12): 2952 -- ...
		Distribution of Hsc70 and Hsp70 immunoreactivity in the central region of the cornea.
		Comparison of this cytoplasmic staining with the distribution of Hsc70 and Hsp70 reactivity in the basal cells (solid arrows) indicated that it was localized to the cytoplasm around the nucleus.
		of Hsc70 was coextensive with that of Hsp70.
	www.iovs.org /cgi/content/full/40/12/2952 (6111 words)

	iHOP - Information Hyperlinked over Proteins [ HSPA4 ]
		APG-2, Heat shock 70 kDa protein 4, Heat shock 70-related protein APG-2, HS24/P52, hsp70, hsp70RY, HSP70RY, MGC131852, RY Homo sapiens
		WARNING: Please keep in mind that gene detection is done automatically and can exhibit a certain error.
		Stress gene ([)}\" hsp70\", \"GENE\",89207,\"name\",\"heat shock 70kDa protein 4\",\"org_name\",\"Homo sapiens\",\"rz\",\"0\",\"org_id\",\"1\",\"symbol\",\"HSPA4\",\"z\",\"0\",\"\", \"GENE\",89202,\"name\",\"heat shock 70kDa protein 1A\",\"org_name\",\"Homo sapiens\",\"rz\",\"0\",\"org_id\",\"1\",\"symbol\",\"HSPA1A\",\"z\",\"0\",\"\"[(}) sequences and quantitative expression in Milensium tardigradum (Tardigrade) during active and cryptobiotic stages.
	www.ihop-net.org /UniPub/iHOP/gs/89207.html (167 words)

	Tissue- and development-specific induction and turnover of hsp70 transcripts from loci 87A and 87C after heat shock and ...
		Interestingly, the 3'UTRs of the proximal and the distal-1 hsp70
		Heat-shock-induced expression of hsp70 genes from the 87A and 87C loci in wild-type embryos of developmental stages 5–16 as revealed by RNA:RNA in situ hybridization (RISH) using 3'UTR riboprobes of hsp70 genes from the 87A (A,C,E,G,I,K,N,Q,T,W) or the 87C (B,D,F,H,J,L,O,R,U,X) locus.
		locus-specific hsp70 3'UTR riboprobes was that the hsp70 genes
	jeb.biologists.org /cgi/content/full/205/3/345 (7172 words)

	Ectopic expression of Hsp70 confers resistance and silencing its expression sensitizes human colon cancer cells to ...
		pSV-hsp70-tag (with hsp70 cDNA in the sense orientation) or
		(C) SW480 cells (neo, hsp70 or Ashsp70) grown on 96-well plates were exposed to curcumin (25 µM) for 16, 24 or 48 h and the cell viability (expressed as a percentage of the untreated control) was determined by MTT assay as described in Materials and methods.
		(A) neo, hsp70 or Ashsp70 cells were seeded onto coverslips, treated with or without curcumin (25 µM) for 24 h, fixed using 3% paraformaldehyde and stained with DAPI as described in Materials and methods and representative fluorescent micrographs from untreated (control) and curcumin-treated cells are shown.
	carcin.oxfordjournals.org /cgi/content/full/25/2/179 (5095 words)

	Targeted hsp70.1 Disruption Increases Infarction Volume After Focal Cerebral Ischemia in Mice -- Lee et al. 32 (12): ... (Site not responding. Last check: 2007-11-05)
		HSP70 is a 70-kDa HSP family known to have cytoprotective effects
		HSP70 immunoreactivity was higher in the cerebral cortex (A and B) than in the basal ganglia (C and D).
		In contrast to scant immunoreactivity in basal ganglionic neurons, HSP70 immunoreactivity was prominent in the endothelial cells (D).
	stroke.ahajournals.org /cgi/content/full/32/12/2905 (4420 words)

	Hsp70 promotes TNF-mediated apoptosis by binding IKK{gamma} and impairing NF-{kappa}B survival signaling -- Ran et al. ...
		that it is HSF1 induction of Hsp70 that inhibits NF-
		C2, and Hsp70 in the whole-cell lysates were immunoblotted with the appropriate antibodies.
		Therefore, once Hsp70 levels are sufficient to significantly block the formation of the IKK complex, this plays an important role in shifting cells from survival to death in response to TNF challenge.
	www.genesdev.org /cgi/content/full/18/12/1466 (5370 words)

	Hsp70 accumulation in chondrocytic cells exposed to high continuous hydrostatic pressure coincides with mRNA ...
		Hsp70 accumulation in chondrocytic cells exposed to high continuous hydrostatic pressure coincides with mRNA stabilization rather than transcriptional activation -- Kaarniranta et al.
		Hsp70 accumulation in chondrocytic cells exposed to high continuous hydrostatic pressure coincides with mRNA stabilization rather than transcriptional activation
		Because the accumulation of Hsp70 was not due to transcriptional activation, the steady-state levels of the corresponding
	www.pnas.org /cgi/content/full/95/5/2319 (4321 words)

	Induction of HSP70 promotes {Delta}F508 CFTR trafficking -- Choo-Kang and Zeitlin 281 (1): 58 -- AJP - Lung Cellular ...
		Aggregation of Hsp70 and Hsc70 in vivo is distinct and temperature-dependent and their chaperone function is directly related to non-aggregated forms.
		The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj-1 have distinct roles in recognition of a non-native protein and protein refolding.
		The common variant of cystic fibrosis transmembrane conductance regulator is recognized by hsp70 and degraded in a pre-Golgi nonlysosomal compartment.
	ajplung.physiology.org /cgi/content/full/281/1/L58 (6830 words)

	Stress Genes and Proteins in the Archaea -- Macario et al. 63 (4): 923 -- Microbiology and Molecular Biology Reviews
		The first hsp70 gene identified by cloning and sequencing within the domain Archaea was reported in 1991 (182).
		The archaeal proteins all have the universal markers for Hsp70 and DnaK and the bacterial markers (Table 4).
		Hsp70 molecules are close to each other and have a common ancestor.
	mmbr.asm.org /cgi/content/full/63/4/923 (9165 words)

	Regulation of Signaling Protein Function and Trafficking by the hsp90/hsp70-Based Chaperone Machinery -- Pratt and Toft ...
		hsp70 when it is bound to a substrate protein (216).
		Some hsp70 also leaves the intermediate complex, and the broken line for hsp70 in the final heterocomplex indicates that it is present at substoichiometric levels with respect to the receptor.
		The mechanism is derived from stepwise assembly experiments in which hsp70 binds to the GR in an ATP-dependent and hsp40-dependent step to form a ‘‘primed’’ GR•hsp70 complex that can then bind Hop and hsp90.
	www.ebmonline.org /cgi/content/full/228/2/111 (8922 words)

	Aggregation of hsp70 and hsc70 in vivo is distinct and temperature-dependent and their chaperone function is directly ... (Site not responding. Last check: 2007-11-05)
		Aggregation of hsp70 and hsc70 in vivo is distinct and temperature-dependent and their chaperone function is directly related to non-aggregated forms -- Angelidis et al.
		The hsp70 levels detected in the fractions obtained from hsp70-enriched cell lysates (lane hsp70-C) and hsp70-enriched and subsequently heat-shocked cell lysates (lane hsp70-HS) are shown.
		molecules of hsp70 and hsc70 unable to bind to denatured substrates.
	content.febsjournal.org /cgi/content/full/259/1/505 (5288 words)

	Confocal Microscopic Localization of Constitutive and Heat Shock-Induced Proteins HSP70 and HSP27 in the Rat Heart -- ... (Site not responding. Last check: 2007-11-05)
		A and B, Immunoreactive HSP70 was detected on cellulose membrane.
		Micrographs demonstrating localization of immunoreactive HSP70 in blood vessels of ventricles of control (A) and 24 hours post–heat-shock (B) rats.
		Cell specific expression of Hsp70 in neurons and glia of the rat hippocampus after hyperthermia and kainic acid-induced seizure activity.
	circ.ahajournals.org /cgi/content/full/102/14/1703 (3805 words)

	Modulation of in Vivo HSP70 Chaperone Activity by Hip and Bag-1 -- Nollen et al. 276 (7): 4677 -- Journal of Biological ...
		The chaperone activity of Hsp70 is influenced by the activities of both positive and negative regulatory proteins.
		The homo-oligomeric protein Hip cooperates with Hsp70 in protein folding by stabilizing the ADP-bound state of Hsp70.
		Hsp70 and Hsp40 to the nucleus (29-32), whereas the localization
	www.jbc.org /cgi/content/full/276/7/4677 (4779 words)

	Insights into Regulation and Function of the Major Stress-Induced hsp70 Molecular Chaperone In Vivo: Analysis of Mice ...
		3 gene locus and a 1.2-kb (BamHI-BamHI) fragment for the hsp70.
		Cumulative expression of both hsp70 genes after heat shock is essential for maximal levels of thermotolerance development and maintenance.
		proposed that spontaneous expression of hsp70 in the embryo is
	mcb.asm.org /cgi/content/full/21/24/8575 (7420 words)

Try your search on: Qwika (all wikis)