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Topic: Human herpesvirus 6

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Herpesviridae

Herpes simplex

Cytomegalovirus

Steve Fossett

Amy Fisher

	Human Herpesvirus 6: An Emerging Pathogen
		Alphaherpesvirus origin-binding protein homolog encoded by human herpesvirus 6B, a betaherpesvirus, binds to nucleotide sequences that are similar to ori regions of alphaherpesviruses.
		Human herpesvirus 6 reactivation is associated with cytomegalovirus infection and syndromes in kidney transplant recipients at risk for primary cytomegalovirus infection.
		Detection of human herpesvirus 6 in plasma of children with primary infection and immunosuppressed patients by polymerase chain reaction.
	www.encyclopedia.com /doc/1G1-65644863.html (7153 words)

	HHV-6 (Human Herpesvirus 6) Abstracts & Publications : ViraCor Laboratories
		Human ?-herpesvirus DNA was found in 65% of critically ill patients (60% men; mean age, 63 years) who required admission to an intensive care unit for medical (40%) or surgical (53%) indications or trauma (7%).
		Human herpesvirus (HHV)-6 and -7 are novel members of the B-herpesvirus family that maintain latency in the human host after primary infection.
		The replication of -herpesviruses-cytomegalovirus (CMV), human herpesvirus (HHV)-6 and HHV-7-and their association with CMV disease and response to antiviral therapy were prospectively investigated in 33 liver transplant recipients not given antiviral prophylaxis.
	www.viracor.com /diagnostic-virals-hhv6_links.htm (1643 words)

	Human herpesvirus 6
		Human herpesvirus 6 (HHV-6), initially labelled Human B-Lymphotropic Virus (HBLV), was first isolated from the blood of 6 patients with lymphoma or lymphoproliferative disorders during investigations for new viral agents.
		Human herpesvirus 7 (HHV-7) was first isolated from the purified, activated T cells of a healthy donor (Frenkel et al.
		Susceptibility of Human Herpesvirus 6 to Acyclovir and Ganciclovir.
	www.uq.edu.au /vdu/VDUHHV67.htm (4823 words)

	CDC - Human Herpesvirus 6-Associated Hemophagocytic Syndrome in a Healthy Adult
		This is the first report of a previously healthy adult in whom Human herpesvirus 6 reactivation induced this syndrome with severe hemodynamic and respiratory distress.
		Human herpesvirus-6 associated with fatal haemophagocytic syndrome [letter].
		Clinical and serological features of human herpesvirus-6 infection in three adults.
	www.cdc.gov /ncidod/eid/vol8no1/01-0149.htm (1019 words)

	Inverse relationship between human herpesvirus-6 and -7 detection after allogeneic and autologous stem cell ...
		Human herpesvirus-6 (HHV-6) and -7 were analyzed in 25 and 18 patients with allogeneic (allo) and autologous (auto) stem cell transplantation (SCT), respectively, by weekly examination of viral DNA in peripheral mononuclear cells using semiquantitative PCR and serologic tests up to 12 weeks after SCT.
		Latent human herpesvirus 6 infection of human monocytes
		Human herpesvirus 6: a survey of presence and variant distribution in normal peripheral lymphocytes and lymphoproliferative disorders.
	www.nature.com /bmt/journal/v27/n10/full/1703033a.html (3091 words)

	MSN Encarta - Romania
	encarta.msn.com /encyclopedia_761559516/Romania.html (1012 words)

	[No title]
	www.rotravel.com /romania/history/cap1.php (262 words)

	Romania - VisitEurope.com (Site not responding. Last check: 2007-11-06)
	www.visiteurope.com /romania.html (285 words)

	Romania (Site not responding. Last check: 2007-11-06)
	flagspot.net /flags/ro.html (1633 words)

	ICL - Romania - Constitution (Site not responding. Last check: 2007-11-06)
	www.oefre.unibe.ch /law/icl/ro00000_.html (10035 words)

	Government of Romania (Site not responding. Last check: 2007-11-06)
	www.gov.ro /engleza (2233 words)

	Southeastern Europe Country Analysis Brief
	www.eia.doe.gov /emeu/cabs/romania.html (2575 words)

	Amnesty International Report 2002 - Europe - ROMANIA
	web.amnesty.org /web/ar2002.nsf/eur/romania!Open (1613 words)

	Romania
	travel.state.gov /travel/romania.html (2499 words)

	Rome and Romania, Roman Emperors, Byzantine Emperors, etc.
	www.friesian.com /romania.htm (14386 words)

	Romania (Site not responding. Last check: 2007-11-06)
	www.infoplease.com /ipa/A0107905.html (1082 words)

	ROMANIA - Official Travel and Tourism Information. History
	www.romaniatourism.com /history.html (1110 words)

	Romania (Site not responding. Last check: 2007-11-06)
	www.factmonster.com /ipka/A0107905.html (875 words)

	BBC NEWS \| World \| Europe \| Country profiles \| Country profile: Romania
	news.bbc.co.uk /1/hi/world/europe/country_profiles/1057466.stm (887 words)

	ICL - Romania Index (Site not responding. Last check: 2007-11-06)
	www.oefre.unibe.ch /law/icl/ro__indx.html (672 words)

	Romania News
	www.topix.net /world/romania (1122 words)

	Romania Special Weapons (Site not responding. Last check: 2007-11-06)
	www.fas.org /nuke/guide/romania (162 words)

	Romania Travel Information \| Lonely Planet Destination Guide (Site not responding. Last check: 2007-11-06)
	www.lonelyplanet.com /worldguide/destinations/europe/romania (190 words)

	Romania - In Your Pocket (Site not responding. Last check: 2007-11-06)
	www.inyourpocket.com /Romania/index.shtml (354 words)

	CIA - The World Factbook -- Romania (Site not responding. Last check: 2007-11-06)
	www.cia.gov /cia/publications/factbook/geos/ro.html (1432 words)

	Romania Maps - Perry-Castañeda Map Collection - UT Library Online
	www.lib.utexas.edu /maps/romania.html (149 words)

	Romania News - Media Monitoring Service by EIN News (Site not responding. Last check: 2007-11-06)
	www.einnews.com /romania (675 words)

	romania map and information page
	www.worldatlas.com /webimage/countrys/europe/ro.htm (412 words)

	Ethnologue report for Romania
	www.ethnologue.com /show_country.asp?name=Romania (442 words)

	USAID Europe and Eurasia: Romania
	www.usaid.gov /locations/europe_eurasia/countries/ro (502 words)

	Romania : Country Studies - Federal Research Division, Library of Congress
	lcweb2.loc.gov /frd/cs/rotoc.html (187 words)

	WTO \| Romania - Member information
	www.wto.org /english/thewto_e/countries_e/romania_e.htm (192 words)

	About Romania - Location, Flag, Map, Weather, Transportation
	www.phpclasses.org /browse/country/ro (91 words)

	txt001sdr: Human herpesvirus 6
		Human herpesvirus 6 (HHV-6) is a T-lymphotropic herpesvirus, which infects almost all children by the age of two years and persists lifelong.
		(1991) Latent human herpesvirus 6 infection of human monocytes/macrophages.
		Genome organisation of human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7)
	www-ermm.cbcu.cam.ac.uk /sdr/txt001sdr.htm (6293 words)

	HHV-6 and Complications in Transplantation
		Human herpesviruses 6 and 7: Identification of newly recognized viral pathogens and their association with human disease.
		Human herpesvirus 6 (HHV-6) infection in allogeneic bone marrow transplant recipients: I. Evidence for a marrow suppressive role for HHV-6 in vivo.
		Human herpesvirus 6 infection in bone marrow transplantation.
	www.wisconsinlab.com /phystrans.htm (950 words)

	Human Herpesvirus 6: An Emerging Pathogen
		Her research interests focus on human herpesviruses 6 and 7; identification, mapping, and expression studies of the major viral glycoproteins and immunodominant tegument proteins; and definition of the natural history of the infections.
		Human herpesvirus 6 and multiple sclerosis: survey of anti-HHV-6 antibodies by immunofluorescence analysis and of viral sequences by polymerase chain reaction.
		Persistence of human herpesvirus 7 in normal tissues detected by expression of a structural antigen.
	www.cdc.gov /ncidod/EID/vol5no3/campadelli.htm (8058 words)

	Human herpesvirus-6 in transplantation: an emerging pathogen.
		Human herpesvirus-6 has two variants, designated variant A and variant B; transplant recipients were infected almost exclusively with variant B. Bone marrow suppression, interstitial pneumonitis, and encephalitis were the most commonly reported types of clinical disease caused by human herpesvirus-6.
		The marrow-suppressive effect of human herpesvirus-6 ranged from transient or self-limited bone marrow suppression to chronic or fatal aplastic anemia; bone marrow suppression was thought to be partially cytokine-mediated.
		Human herpesvirus-6 resembles cytomegalovirus in its antiviral susceptibilities: It is resistant to acyclovir but susceptible to ganciclovir and foscarnet.
	www.medscape.com /medline/abstract/8633821?src=emed_ckb_ref_0 (387 words)

	HHV6 and HIV - AIDS
		Human herpesvirus six (HHV-6) may serve as an important cofactor in the pathogenesis of AIDS and may provide an alternative target for therapeutic intervention.
		Human herpesvirus 6 in immunodeficiency virus infected individuals: association with early histologic phases of lymphadenopathy syndrome but not with malignant lymphoproliferative disorders.
		Primary infection of human herpesvirus 6 in children with vertical infection of human immunodeficiency virus type 1.
	www.wisconsinlab.com /hiv.htm (918 words)

	Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders -- Salahuddin et al. 234 (4776): 596 -- ...
		Role of the Human Herpesvirus 6 U69-Encoded Kinase in the Phosphorylation of Ganciclovir.
		Real-Time PCR for Quantification of Human Herpesvirus 6 DNA from Lymph Nodes and Saliva.
		Expression of Human Herpesvirus-6 Antigens in Benign and Malignant Lymphoproliferative Diseases.
	www.sciencemag.org /cgi/content/short/234/4776/596 (2795 words)

	Herpesvirus 6, Human
		Human herpesvirus 6 (HHV-6) DNA levels in peripheral blood mononuclear cells were prospectively evaluated in 20 cytomegalovirus-seronegative allogeneic marrow transplant patients and in 10 healthy control subjects.
		Human herpesvirus 6 infection inhibits specific lymphocyte proliferation responses and is related to lymphocytopenia after allogeneic stem cell transplantation.
		The role of human herpesvirus 6 (HHV-6) infection in 227 children born to human immunodeficiency virus (HIV)-seropositive mothers was investigated.
	lib.bioinfo.pl /meid:37208 (2416 words)

	Genomic analysis of the human B-lymphotropic virus (HBLV) -- Josephs et al. 234 (4776): 601 -- Science
		The human B-lymphotropic virus (HBLV) has a double-stranded DNA genome of greater than 110 kilobase pairs, which is consistent with its morphological classification as a herpesvirus.
		This evidence, in addition to serological and morphological distinctions and the biological effects of this virus demonstrate that HBLV is a novel human herpesvirus.
		Human Cytomegalovirus and Human Herpesvirus 6 Genes That Transform and Transactivate.
	www.sciencemag.org /cgi/content/short/234/4776/601 (583 words)

	CDC - Successful Treatment of Human Herpesvirus 6 Encephalomyelitis in Immunocompetent Patient
		We report a case of human herpesvirus 6 (HHV-6) encephalomyelitis in an immunocompetent patient, which was confirmed by viral amplification from cerebrospinal fluid.
		Humans are widely exposed to HHV-6 during childhood, and the seroprevalence is up to 100% in adults.
		IgM neutralizing antibody responses to human herpesvirus-6 in patients with exanthem subitum or organ transplantation.
	www.cdc.gov /Ncidod/eid/vol10no4/03-0587.htm (1672 words)

	Human Herpesvirus 6 Encephalomyelitis (Replies) \| CDC EID
		Neuroinvasion and persistence of human herpesvirus 6 in children.
		Persistence of human herpesvirus 6 according to site and variant: possible greater neurotropism of variant A. Clin Infect Dis.
		Hydrocortisone activation of human herpesvirus 8 viral DNA replication and gene expression in vitro.
	www.cdc.gov /ncidod/EID/vol10no9/04-0365_04-0522.htm (1630 words)

	eMedicine - Herpesvirus 6 Infection : Article by Ruchir Agrawal, MD
		The discovery of human herpesvirus 6 (HHV-6) is a result of this pursuit.
		HH-6 was isolated from interleukin-2–stimulated peripheral leukocytes of HIV and lymphoproliferative disorders.
		Later, several strains of HHV-6 were isolated from the lymphocytes of children with exanthem subitum and patients with chronic fatigue syndrome and from the saliva of patients with HIV and healthy individuals.
	www.emedicine.com /PED/topic998.htm (2255 words)

	HHV-6 Testing
		6 The variant detected is almost always variant B (>97%), which is different from other conditions such as MS where the variant detected is primarily variant A. Antibody tests are not as useful because they may take weeks to show a change in titer.
		Since so many healthy individuals have detectable levels of latent virus in their white blood cells, PCR DNA tests of whole blood are not useful unless the test is quantitative, and the absolute level of virus can be compared to a healthy population.
		Development of a real-time polymerase chain reaction assay for the diagnosis of human herpesvirus-6 infection and application to bone marrow transplant patients.
	www.hhv-6foundation.org /testing.html (2661 words)

	AEGiS-AIDSWeekly: AIDS and HIV Vertical Transmission: Human herpesvirus 6 variant linked to heightened risk
		NewsRx -- A highly prevalent form of human herpesvirus could increase the risk of vertical HIV transmission, researchers in Europe report.
		"Human herpesvirus 6 (HHV-6) and human immunodeficiency virus type 1 (HIV-1) may interact during transplacental transmission of HIV-1," according to Eszter Csoma and colleagues at the University of Debrecen in Debrecen, Hungary, and the Danish Cancer Society in Aarhus, Denmark.
		Coinfection of placental cells had no effect on HHV-6A virulence (Human herpesvirus 6 variant a infects human term syncytiotrophoblasts in vitro and induces replication of human immunodeficiency virus type 1 in dually infected cells, J Med Virol 2002 May;67(1):67-87.
	www.aegis.com /pubs/aidswkly/2002/AW020411.html (578 words)

	vgn-ext-hidden_PubMed
		Human herpesvirus 6 and cytomegalovirus infections in children with human immunodeficiency virus infection and cancer.
		AIM: Measure the prevalence of human herpesvirus 6 (HHV-6) and cytomegalovirus (CMV) infections in children and adolescents with HIV infection and malignancy.
		METHODS: Semiquantitative polymerase chain reaction and serology were used to test for HHV-6 and CMV infections in 31 cases (HIV-infected children with cancer), 56 HIV controls (HIV-infected children without cancer) and 30 cancer controls (HIV-uninfected children with cancer).
	www.plwc.org /portal/site/ASCO/menuitem.a3fb42726842a82627c4c291ee37a01d/?vgnextoid=d70b3608f9958010VgnVCM100000f2730ad1RCRD&index=n&pmid=11840079 (375 words)

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