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Olympus MIC-D: Brightfield Gallery - Human Lung Tissue Human lungs are paired in the chest with the heart in between. The respiratory system of the lungs branches similarly to a tree, with about 17 levels of branching between the trachea and the bronchioles, and terminates in about 130,000 bronchioles in the average pair of human lungs. Lung transplants are performed on some with diseases, and the promise of lung tissue culture using human stem cells may hold hope for others. www.olympusmicro.com /micd/galleries/brightfield/humanlung.html   (383 words)

Lung cancer - Wikipedia, the free encyclopedia Currently, lung cancer is the leading causing of cancer death in women, overshadowing breast cancer, ovarian cancer and uterine cancers combined. Lung cancer staging is an important part of the assessment of prognosis and potential treatment for lung cancer. Lung cancer is the second most commonly occurring form of cancer in most western countries, and it is the leading cancer-related cause of death for men and women. en.wikipedia.org /wiki/Lung_cancer   (4216 words)

Human lung - Wikipedia, the free encyclopedia The human lungs are the human organs of respiration. Pneumonia is an infection of the lung, caused by bacteria, viruses or fungi. Lung pinprick condition is a hereditary disease which results in decreased lung capacity and occasional shortness of breath. en.wikipedia.org /wiki/Human_lung   (1033 words)

Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2 -- Akers et al. 278 ... inhibition of tryptase-induced human fetal lung fibroblast proliferation Human mast cells activate fibroblasts: tryptase is a fibrogenic factor stimulating collagen messenger ribonucleic acid synthesis and fibroblast chemotaxis. Human tryptase as a potent, cell-specific mitogen: role of signaling pathways in synergistic responses. ajplung.physiology.org /cgi/content/full/278/1/L193   (5471 words)

Genomics|HuGENet|e-Journal|Lung cancer, smoking & OGG1 Lung cancer is the most common form of cancer in the world today, accounting for 12.3% of all cancers and 17.8% of cancer- related deaths worldwide in 2000. There is a known dose- response relationship between lung cancer risk and the number of cigarettes smoked per day, the degree of inhalation, and the age at initiation; a lifetime smoker has a lung cancer risk 20-30 times that of a non- smoker (1). The human 8- oxoguanine DNA glycosylase gene (OGG1), is localized on chromosome 3p26 and encodes a DNA glycosylase (OGG) that excises 8-OG from damaged DNA (12). www.cdc.gov /genomics/hugenet/ejournal/OGGSmoke.htm   (1427 words)

Lung Cancer Research on PCBs and Humans For more lung cancer studies, visit the TOXNET database operated by the National Library of Medicine (the source of these abstracts.) Keep in mind that these studies are not all equal in size or quality. Samples of human epithelial lining fluid and a variety of pulmonary alveolar macrophage (PAM) preparations were tested for their ability to reduce hexavalent chromium (7440473) (Cr-VI), and were compared with preparations of other human or adult Sprague-Dawley rat cells. Since the lung is a known target tissue for the carcinogenic action of polycyclic nitroaromatic hydrocarbons, we investigated the metabolism and DNA binding of [3H]6-nitrochrysene in 11 specimens of human bronchus. www.foxriverwatch.com /lung_cancer_pcbs_humanstudies.html   (5593 words)

eMedicine - Lung Transplantation : Article by Albert Faro, MD Indications for lung transplantation in children have expanded, and referral to a transplant center should be considered in virtually any child with limited life expectancy because of lung disease. Lung transplantation is a procedure of last resort and, when performed, it should give the patient an improved likelihood of survival and an improved QOL. Other factors that should be considered in evaluating a patient with CF for lung transplantation are arterial blood gas values in room air, the emergence of resistant organisms, the degree of exercise intolerance, and the presence of cor pulmonale. www.emedicine.com /ped/topic2844.htm   (6760 words)

ScienceDaily: Radiation-armed Robot Rapidly Destroys Human Lung Tumors Lung cancer -- Lung cancer is a malignant tumour of the lungs. Lung cancer is the most lethal malignant tumour worldwide, causing up to 3 million deaths... Lung cancer remains the leading cause of cancer-related death in men, and in women, it has surpassed even breast cancer. www.sciencedaily.com /releases/2006/07/060725092306.htm   (1732 words)

ScienceDaily: Targeting Lung Cancer Lung cancer patients who harbor mutations in the human epidermal growth factor receptor (EGFR) gene generally have a better response to drugs that inhibit EGFR (like Iressa and Tarceva). Lung Cancer Now Leading Cause Of Cancer Death In Women (April 14, 2004) -- Tobacco use in American women rose dramatically during the 20th century, resulting in a 600 percent increase by the year 2003 in the number of women who died of lung cancer. BRCA2 -- BRCA2 is a human gene that is involved in the repair of chromosomal damage and belongs to a class of genes known as tumor suppressor genes. www.sciencedaily.com /releases/2006/05/060517180153.htm   (1644 words)

Human Lung Fibroblasts   (Site not responding. Last check: 2007-11-06) Human Lung Fibroblasts (HLF) are derived from normal human lung parenchyma. Human cytomegalovirus (HCMV) was found to completely down-regulate EGF receptor on the surface of fetal HLF Thrombin contributes to bronchoalveola lavage fluid mitogenicity in lung disease of the premature infant www.cellapplications.com /HLF.htm   (292 words)

Lung Cancer Cell Lines: A549 human lung carcinoma cells: metastasis models: tumor models: longitudinal studies: Xenogen ... Bioware® cell line A549-luc-C8 is a light producing cell line derived from A549 human lung carcinoma cells by stable transfection of the North American Firefly Luciferase gene expressed from the CMV promoter. The A549-luc-C8 Bioware® cell line may be used in vivo to establish human non-small cell lung carcinoma tumor growth for subcutaneous tumor models and experimental metastasis models (intravenous in SCID-bg mice). Bioware® cell line LL/2-luc-M38 is a light producing cell line derived from murine lung carcinoma LL/2 cells by stable transfection of the North American Firefly Luciferase gene expressed from the PCI-luc promoter. www.xenogen.com /wt/page/cell_lung   (320 words)

Human eosinophils regulate human lung- and skin-derived fibroblast properties in vitro: A role for transforming growth ... Human eosinophils regulate human lung- and skin-derived fibroblast properties in vitro: A role for transforming growth factor beta (TGF-beta) -- Levi-Schaffer et al. Human eosinophils regulate human lung- and skin-derived fibroblast properties in vitro: A role for transforming growth factor eosinophil sonicate to the lung and dermal fibroblast monolayers www.pnas.org /cgi/content/full/96/17/9660   (4787 words)

Lung Cancer and PCBs one study showed statistically significant increased human mortality from all malignancies (33 observed, 15.5 expected), including from lung cancer (8 observed, 2.5 expected). PCB induced enzymes may alter the metabolism and the pattern of DNA adducts formed in human lung tissue as a result of certain carcinogenic pollutants PCBs are measurable in human lung and are being studied to assess enzyme induction in the lung www.foxriverwatch.com /lung_cancer_pcbs_summaryhuman.html   (600 words)

Human Lung Microsomal Cytochrome P4501A1 (CYP1A1) Activities: Impact of Smoking Status and CYP1A1, Aryl Hydrocarbon ...   (Site not responding. Last check: 2007-11-06) Human Lung Microsomal Cytochrome P4501A1 (CYP1A1) Activities: Impact of Smoking Status and CYP1A1, Aryl Hydrocarbon Receptor, and Glutathione S-Transferase M1 Genetic Polymorphisms -- Smith et al. in lung tissues (67, 68, 69, 70, 71, 72) and circulating lymphocytes Drakoulis N., Cascorbi I., Brockmoller J., Gross C. R., Roots I. Polymorphisms in the human CYP1A1 gene as susceptibility factors for lung cancer: exon-7 mutation (4889 A to G) and a T to C mutation in the 3'-flanking region. cebp.aacrjournals.org /cgi/content/full/10/8/839   (7023 words)

How many tumor suppressor genes are involved in human lung carcinogenesis? -- Kohno and Yokota1 20 (8): 1403 -- ... at chromosome 11q23 was detected in 15% of lung cancers (55). Harbour,J.W., Lai,S.-L., Whang-Peng,J., Gazdar,A.F., Minna,J.D. and Kaye,F.J. (1988) Abnormalities in structure and expression of the human retinoblastoma gene in SCLC. Sundaresan,V., Ganly,P., Hasleton,P., Rudd,R., Sinha,G., Bleehen,N.M. and Rabbitts,P. (1992) p53 and chromosome 3 abnormalities, characteristic of malignant lung tumours, are detectable in preinvasive lesions of the bronchus. carcin.oxfordjournals.org /cgi/content/full/20/8/1403   (5746 words)

ANTIMICROBIAL "BUG SPRAY" FOUND IN HUMAN LUNG CELLS   (Site not responding. Last check: 2007-11-06) Hopkins scientists studying lung damage from cystic fibrosis (CF) have found a natural "bug spray" that lung cells "squirt" on attacking bacteria. After the first such compounds were identified in cells from frog skin and cow throats by researchers at other institutions Young Hee Ko, a research associate in Pedersen's lab, suspected that CF jammed the "nozzle" on a similar bug spray. In a study funded by the National Institute of Diabetes and Digestive and Kidney Diseases and the Cystic Fibrosis Foundation, Ko exposed two batches of lung cells, one from a normal patient and one from a CF patient, to Pseudomonas aeruginosa, a bacterium that causes repeated lung infections in CF patients. www.hopkinsmedicine.org /press/1997/JUNE/970606.HTM   (346 words)

Cell specific expression of peroxiredoxins in human lung and pulmonary sarcoidosis -- Kinnula et al. 57 (2): 157 -- ... Manganese superoxide dismutase and catalase are coordinately expressed in the alveolar region in chronic interstitial pneumonia and granulomatous diseases of the lung. Transformation of human bronchial epithelial cells by infecting with SV40 or adenovirus-12 SV40 hybrid virus and transfection via strontium phosphate coprecipitation with a plasmid containing SV40 early egion genes. Localization of gamma-glutamylcysteine synthetase messenger RNA expression in lungs of smokers and patients with chronic obstructive pulmonary disease. thorax.bmj.com /cgi/content/full/57/2/157   (3944 words)

IngentaConnect Expression of peroxiredoxin and thioredoxin in human lung cancer ... IngentaConnect Expression of peroxiredoxin and thioredoxin in human lung cancer... Therefore, the authors investigated the distribution and expression of various Prx isoforms in lung cancer and compared this with normal lung from human and mouse. The upregulation of Prx I, Prx III and thioredoxin in lung cancer tissue may represent an attempt by tumour cells to adjust to the microenvironment in a manner that is advantageous to survival and proliferation. www.ingentaconnect.com /content/bsc/res/2006/00000011/00000003/art00007   (356 words)

HHMI News: Building a Better Mouse Model of Lung Cancer Mutations in K-ras are highly prevalent in human cancers, occurring in 90 percent of pancreatic tumors, 50 percent of colon tumors and 30 percent of non-small cell lung cancers. This further demonstrates the relevance of their mouse model to human lung cancers, said Jacks. The only significant limitation to the technique, said Jacks, is that the lung tumors arise so rapidly that the mice are overcome by tumors before there is a chance to observe the process of metastasis, the spread of lung cancer to other tissues. www.hhmi.org /news/jacks2.html   (986 words)

Human Lung Power Limitations While they do provide us with the breath of life, which is nothing to sneer at, as a power source for smoking, human lungs are woefully inadequate. The maximum vacuum pressure that can be produced by the lungs of even the most physically fit individual is 1.3 pounds per square inch (psi). In addition, the maximum human lung inhalation volume is only about 1.8 liters. www.head-pipe.com /lungs.shtml   (705 words)

Radiation-Armed Robot Rapidly Destroys Human Lung Tumors -Lung Cancer news Super-intense radiation delivered by a robotic arm eradicated lung tumors in some human patients just 3-4 months after treatment, medical physicist Cihat Ozhasoglu, Ph.D. of the University of Pittsburgh Medical Center will report in early August at the 48th Annual Meeting of the American Association of Physicists in Medicine in Orlando. Although it is too early to determine the technique’s long-term effectiveness, Ozhasoglu and his colleagues find promise in this new approach to treat lung cancer and other tumors that move during breathing. At the University of Pittsburgh, Ozhasoglu and approximately 30 colleagues form one of the largest US teams devoted to the CyberKnife, a radiation delivery system that uses an accurate, precise robotic arm to aim highly focused x-ray beams at the site of a tumor. www.health.am /cr/more/human-lung-tumors   (775 words)

PA-06-370: Integrating Lung Genetics and Genomics in Human Populations (R01) This is important because it remains difficult to identify genes related to complex trait phenotypes in the lung. Protection of Human Subjects from Research Risk: The involvement of human subjects and protections from research risk relating to their participation in the proposed research will be assessed (see the Research Plan, Section E on Human Subjects in the PHS Form 398). Federal regulations (45CFR46) require that applications and proposals involving human subjects must be evaluated with reference to the risks to the subjects, the adequacy of protection against these risks, the potential benefits of the research to the subjects and others, and the importance of the knowledge gained or to be gained (http://www.hhs.gov/ohrp/humansubjects/guidance/45cfr46.htm). grants.nih.gov /grants/guide/pa-files/PA-06-370.html   (4744 words)

Ceramide Path in Human Lung Cell Death -- Chan and Goldkorn 22 (4): 460 -- American Journal of Respiratory Cell and ... Ceramide Path in Human Lung Cell Death -- Chan and Goldkorn 22 (4): 460 -- American Journal of Respiratory Cell and Molecular Biology Lung epithelium plays a significant role in modulating the inflammatory response to lung injury. Ceramide accumulation precedes caspase-3 activation during apoptosis of A549 human lung adenocarcinoma cells ajrcmb.atsjournals.org /cgi/content/abstract/22/4/460   (342 words)

Human Lung Poly(A) RNA from Ambion - Biocompare Buyer's Guide Triple-selected Poly(A) RNA - FirstChoice™ Poly(A) RNA is obtained from RNAlater™-treated human tissues. In vitro cultivation of human islets from expanded ductal tissue View all citations for Human Lung Poly(A) RNA from Ambion. www.biocompare.com /itemdetails.asp?itemid=17753   (169 words)

Secretory Leukoprotease Inhibitor Augments Hepatocyte Growth Factor Production in Human Lung Fibroblasts -- Kikuchi et ... the fluids of mucosal surfaces including human lung. with an intensity similar to that of human lung fibroblasts. the time-course and dose-response studies in human lung fibroblasts ajrcmb.atsjournals.org /cgi/content/abstract/23/3/364   (520 words)

Human Lung Anatomical Model Home > SHOP BY CATEGORY > Biology Life Science > Human Lung Anatomical Model Inner lung sections exposed for observation and study. Human Lung Anatomical Model, Human Lung Anatomical Model www.discoverthis.com /lung.html   (65 words)

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