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Hyaluronan - Wikipedia, the free encyclopedia Hyaluronan is naturally found in many tissues of the body such as skin, cartilage, and the vitreous humor. Hyaluronan is also used to treat osteoarthritis of the knee [4][5][6]. Hyaluronan is also now a common skin care ingredient, due to its moisturizing effects. en.wikipedia.org /wiki/Hyaluronic_acid   (786 words)

GlycoForum/GlycoScience/Science of Hyaluronan Hyaluronan is moderately abundant in colonic tissue and plays an important role in tissue osmosis. Although smooth muscle cells constitutively synthesize hyaluronan as part of their normal function, they respond to virus infection by elaborating cell surface-bound hyaluronan in a form that is highly adhesive for mononuclear leukocytes (i.e., T- and B-lymphocytes, monocytes, and mast cells). The factors that contribute to the organization of hyaluronan into these macromolecular structures that favor the binding of non-activated leukocytes are yet to be defined, but likely include several of the hyaluronan-binding proteins. www.glycoforum.gr.jp /science/hyaluronan/HA12/HA12E.html   (2968 words)

Organization and Adhesive Properties of the Hyaluronan Pericellular Coat of Chondrocytes and Epithelial Cells -- Cohen ...   (Site not responding. Last check: 2007-11-05) Hyaluronan is a megadalton glycosaminoglycan composed of repeating hyaluronan coat in the adhesion of cells to external surfaces. of hyaluronan in cartilage, synovial fluid, and the extracellular www.biophysj.org /cgi/content/full/85/3/1996   (5352 words)

Hyaluronan Bound to CD44 on Keratinocytes Is Displaced by Hyaluronan Decasaccharides and Not Hexasaccharides -- Tammi ...   (Site not responding. Last check: 2007-11-05) The hyaluronan content, calculated from the double label method, was determined in the medium, trypsinate, and intracellular compartments as described under "Experimental Procedures." The content of newly synthesized hyaluronan at the end of the indicated labeling periods is shown. Hyaluronan displacement from the cell surface of keratinocytes by hyaluronan oligosaccharides. Time-dependent increase of hyaluronan on keratinocytes incubated in the presence of the OX50 antibody. www.jbc.org /cgi/content/full/273/44/28878   (6309 words)

Proteoglycans - Hyaluronan Hyaluronan is an unsulphated glycosaminoglycan, made of repeating disaccharide units of GlcUA and GlcNAc. In articular cartilage, hyaluronan and aggrecan form large aggregates, the structures important for the function of cartilage. A significant property of hyaluronan is its capacity to bind huge amount of water (1000-fold of its own weight). www.uku.fi /laitokset/anat/PG/ha.htm   (142 words)

HYALURONAN Hyaluronan (HA), a high molecular weight fraction of hyaluronic acid sodium salt (10mg/ml) for intra-articular injection, was recently marketed for sustained relief of pain in OA of the knee. Intra-articular hyaluronan injections in the treatment of osteoarthritis of the knee: a randomised, double-blind, placebo-controlled multicentre trial. Dahlberg L, Intraarticular injections of hyaluronan in patients with cartilage abnormalities and knee pain. www.keele.ac.uk /depts/mm/MTRAC/ProductInfo/summaries/H/HYALURONANs.html   (1287 words)

Hyaluronan and Homeostasis: A Balancing Act -- Tammi et al. 277 (7): 4581 -- Journal of Biological Chemistry   (Site not responding. Last check: 2007-11-05) Hyaluronan was first described as the mucus of the vitreous body of the eye (1). Uptake and Catabolism of Hyaluronan: Hyaladherins and Hyaluronidases-- The removal of hyaluronan appears to be as important as its synthesis in both morphogenesis and tissue homeostasis. Hyaluronan is present in the extracellular matrix, on the cell surface, and inside the cell (Fig. www.jbc.org /cgi/content/full/277/7/4581   (4895 words)

Intracellular Localization of Hyaluronan in Proliferating Cells -- Evanko and Wight 47 (10): 1331 -- Journal of ...   (Site not responding. Last check: 2007-11-05) Hyaluronan is associated with nuclear clefts in fibroblasts. In serum-stimulated cells (E,F), the fluorescein-labeled hyaluronan bound extensively in the cytoplasm, throughout the nucleus, and to the nuclear periphery, and co-localized with endogenous cytoplasmic hyaluronan. exogenous fluoresceinated hyaluronan was confined to the endosomes www.jhc.org /cgi/content/full/47/10/1331   (5066 words)

Changed lamellipodial extension, adhesion plaques and migration in epidermal keratinocytes containing constitutively ... hyaluronan exerts its influence is shielded from the hyaluronidase Note the higher hyaluronan signal of the wound edge areas in M3 cultures, a low signal in the A21 cells in both intact and edge areas and a high signal in the S29 cells in both intact and edge areas. Influence of exogenous hyaluronan, hyaluronidase and hyaluronan oligosaccharides on the migration of the REK cells. jcs.biologists.org /cgi/content/full/115/18/3633   (7867 words)

Hyaluronan synthase in trabecular meshwork cells -- Usui et al. 87 (3): 357 -- British Journal of Ophthalmology   (Site not responding. Last check: 2007-11-05) Hyaluronan synthase in trabecular meshwork cells -- Usui et al. Hyaluronan is a key molecule in the extracellular matrices and Hyaluronan synthase immunoreactivity in the anterior segment of the primate eye.. bjo.bmjjournals.com /cgi/content/full/87/3/357   (2321 words)

Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of ...   (Site not responding. Last check: 2007-11-05) Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme -- Camenisch et al. Haddon, C.M., and Lewis, J.H. Hyaluronan as a propellant for epithelial movement: the development of semicircular canals in the inner ear of Xenopus. Tirone, E., D’Alessandris, C., Hascall, V.C., Siracusa, G., and Salustri, A. Hyaluronan synthesis by mouse cumulus cells is regulated by interactions between follicle-stimulating hormone (or epidermal growth factor) and a soluble oocyte factor (or transforming growth factor beta1). www.jci.org /cgi/content/full/106/3/349   (6676 words)

Hyaluronan . Is Bigger Better? -- Camenisch and McDonald 23 (4): 431 -- American Journal of Respiratory Cell and ... Characterisation of the murine gene encoding the intracellular hyaluronan receptor IHABP (RHAMM). Purification and subunit characterization of the rat liver endocytic hyaluronan receptor. Stimulation of inducible nitric oxide synthase in rat liver by hyaluronan fragments. www.ajrcmb.org /cgi/content/full/23/4/431   (2136 words)

Hyaluronan promotes the malignant phenotype -- Toole 12 (3): 37 -- Glycobiology   (Site not responding. Last check: 2007-11-05) DeAngelis, P.L. (1999) Hyaluronan synthases: fascinating glycosyltransferases from vertebrates, bacterial pathogens, and algal viruses. Evanko, S.P., Angello, J.C., and Wight, T.N. (1999) Formation of hyaluronan- and versican-rich pericellular matrix is required for proliferation and migration of vascular smooth muscle cells. Slevin, M., Krupinski, J., Kumar, S., and Gaffney, J. (1998) Angiogenic oligosaccharides of hyaluronan induce protein tyrosine kinase activity in endothelial cells and activate a cytoplasmic signal transduction pathway resulting in proliferation. glycob.oxfordjournals.org /cgi/content/full/12/3/37R   (4427 words)

Molecular Cloning and Functional Expression of the Rat 175-kDa Hyaluronan Receptor for Endocytosis -- Zhou et al. 13 ...   (Site not responding. Last check: 2007-11-05) Thylen, A., Wallin, J., and Martensson, G. Hyaluronan in serum as an indicator of progressive disease in hyaluronan-producing malignant mesothelioma. The endocytic hyaluronan receptor in rat liver sinusoidal endothelial cells is Ca(+2)-independent and distinct from a Ca(+2)-dependent hyaluronan binding activity. Zhou, B., Oka, J.A., Singh, A., and Weigel, P.H. Purification and subunit characterization of the rat liver endocytic hyaluronan receptor. www.molbiolcell.org /cgi/content/full/13/8/2853   (8593 words)

Hyaluronan-Cell Interactions in Cancer and Vascular Disease -- Toole et al. 277 (7): 4593 -- Journal of Biological ...   (Site not responding. Last check: 2007-11-05) Hyaluronan Increases in Atherosclerotic and Restenotic Lesions-- Atherosclerosis and restenosis are characterized by marked changes in the content and distribution of hyaluronan. Hyaluronan Is a Component of the Inflammatory Phase of Vascular Disease-- Hyaluronan is also present in regions of atherosclerotic lesions that contain inflammatory cells such as macrophages and lymphocytes Hyaluronan is also present in areas of atherosclerotic lesions that contain extracellular lipid deposits (37, 56). www.jbc.org /cgi/content/full/277/7/4593   (4527 words)

Hyaluronan and Tumor Growth -- Toole and Hascall 161 (3): 745 -- American Journal of Pathology   (Site not responding. Last check: 2007-11-05) of the exogenous hyaluronan caused reconstitution of a pericellular Simpson MA, Wilson CM, McCarthy JB: Inhibition of prostate tumor cell hyaluronan synthesis impairs subcutaneous growth and vascularization in immunocompromised mice. Simpson MA, Reiland J, Burger SR, Furcht LT, Spicer AP, Oegema J, McCarthy JB: Hyaluronan synthase elevation in metastatic prostate carcinoma cells correlates with hyaluronan surface retention, a prerequisite for rapid adhesion to bone marrow endothelial cells. ajp.amjpathol.org /cgi/content/full/161/3/745   (2160 words)

Hyaluronan serves a novel role in airway mucosal host defense -- FORTEZA et al. 15 (12): 2179 -- The FASEB Journal Hyaluronan serves a novel role in airway mucosal host defense -- FORTEZA et al. Hyaluronan serves a novel role in airway mucosal host defense Expression of Hyaluronan Synthases and Corresponding Hyaluronan Receptors Is Differentially Regulated During Oocyte Maturation in Cattle www.fasebj.org /cgi/content/abstract/15/12/2179   (533 words)

Enhanced levels of hyaluronan in lungs of patients with COPD: relationship with lung function and local inflammation -- ...   (Site not responding. Last check: 2007-11-05) Enhanced levels of hyaluronan in lungs of patients with COPD: relationship with lung function and local inflammation -- Dentener et al. Enhanced levels of hyaluronan in lungs of patients with COPD: relationship with lung function and local inflammation Hyaluronan (HA) is an extracellular matrix compound with proinflammatory www.thoraxjnl.com /cgi/content/abstract/60/2/114   (254 words)

Effects of TGF-{beta} on Hyaluronan Anabolism in Fibroblasts Derived from the Synovial Membrane of the Rabbit ... Effects of TGF-{beta} on Hyaluronan Anabolism in Fibroblasts Derived from the Synovial Membrane of the Rabbit Temporomandibular Joint -- Tanimoto et al. Effects of TGF-ß on Hyaluronan Anabolism in Fibroblasts Derived from the Synovial Membrane of the Rabbit Temporomandibular Joint Hyaluronan (HA) synthesis in the synovial membrane is affected jdr.iadrjournals.org /cgi/content/abstract/83/1/40   (230 words)

Hyaluronan serves a novel role in airway mucosal host defense -- FORTEZA et al. 15 (12): 2179 -- The FASEB Journal Paraffin sections of trachea were stained with a biotinylated hyaluronan binding protein and avidin-alkaline phosphatase (d–g) showing that hyaluronan is localized to the ciliary border of the epithelium in addition to its known localization in the submucosal interstitium. Expression of hyaluronan, RHAMM and hyaluronan-regulated CBF in cultured cells. The normal turnover rate of hyaluronan at the airway surface remains to be determined. www.fasebj.org /cgi/content/full/15/12/2179   (5238 words)

Development of a Peptide Inhibitor of Hyaluronan-mediated Leukocyte Trafficking -- Mummert et al. 192 (6): 769 -- The ...   (Site not responding. Last check: 2007-11-05) Yannariello-Brown, J., Frost, S.J., and Weigel, P.H. Identification of the Ca -independent endocytic hyaluronan receptor in rat liver sinusoidal endothelial cells using a photoaffinity cross-linking reagent. Tammi, R., MacCallum, D., Hascall, V.C., Pienimaki, J.P., Hyttinen, M., and Tammi, M. Hyaluronan bound to CD44 on keratinocytes is displaced by hyaluronan decasaccharides and not hexasaccharides. Heatley, F., and Scott, J.E. A water molecule participates in the secondary structure of hyaluronan. www.jem.org /cgi/content/full/192/6/769   (7634 words)

Expression Regulation of Hyaluronan Synthase in Corneal Endothelial Cells -- Usui et al. 41 (11): 3261 -- Investigative ...   (Site not responding. Last check: 2007-11-05) Expression Regulation of Hyaluronan Synthase in Corneal Endothelial Cells -- Usui et al. Jacobson, A, Brinck, J, Briskin, MJ, et al (2000) Expression of human hyaluronan synthases in response to external stimuli Biochem J 348,29-35 Hyaluronan Synthase Elevation in Metastatic Prostate Carcinoma Cells Correlates with Hyaluronan Surface Retention, a Prerequisite for Rapid Adhesion to Bone Marrow Endothelial Cells www.iovs.org /cgi/content/full/41/11/3261   (4005 words)

Development of a Peptide Inhibitor of Hyaluronan-mediated Leukocyte Trafficking -- Mummert et al. 192 (6): 769 -- The ...   (Site not responding. Last check: 2007-11-05) Expression and Role of the Hyaluronan Receptor RHAMM in Inflammation after Bleomycin Injury Functional Roles of Hyaluronan in B16-F10 Melanoma Growth and Experimental Metastasis in Mice Synthesis and Surface Expression of Hyaluronan by Dendritic Cells and Its Potential Role in Antigen Presentation www.jem.org /cgi/content/abstract/192/6/769   (818 words)

Molecular Cloning and Functional Expression of the Rat 175-kDa Hyaluronan Receptor for Endocytosis -- Zhou et al. 13 ...   (Site not responding. Last check: 2007-11-05) Characterization of the Recombinant Rat 175-kDa Hyaluronan Receptor for Endocytosis (HARE) Purification and molecular identification of the human hyaluronan receptor for endocytosis A Blocking Antibody to the Hyaluronan Receptor for Endocytosis (HARE) Inhibits Hyaluronan Clearance by Perfused Liver www.molbiolcell.org /cgi/content/abstract/13/8/2853   (452 words)

Publish or Perish: Some Published Works on Biochemical Evolution Here are a number of articles from a quick search of the Journal of Biological Chemistry using the word "evolution" at Andrew P. Spicer and John A. McDonald Characterization and Molecular Evolution of a Vertebrate Hyaluronan Synthase Gene Family J. Biol. Catherine TomHon, Wei Zhu, David Millinoff, Kenji Hayasaka, Jerry L. Slightom, Morris Goodman, and Deborah L. Gumucio Evolution of a Fetal Expression Pattern via cis Changes near the Globin Gene J. Biol. www.talkorigins.org /faqs/behe/publish.html   (3923 words)

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