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Topic: Hydralazine

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	Apresoline Pharmacology, Pharmacokinetics, Studies, Metabolism - Hydralazine - RxList Monographs
		Hydralazine, by altering cellular calcium metabolism, interferes with the calcium movements within the vascular smooth muscle that are responsible for initiating or maintaining the contractile state.
		Hydralazine is subject to polymorphic acetylation; slow acetylators generally have higher plasma levels of hydralazine and require lower doses to maintain control of blood pressure.
		Hydralazine undergoes extensive hepatic metabolism; it is excreted mainly in the form of metabolites in the urine.
	www.rxlist.com /cgi/generic/hydralazine_cp.htm (273 words)

	Hydralazine for high blood pressure during pregnancy - [Medication] (Site not responding. Last check: 2007-11-03)
		Hydralazine is sometimes used to treat high blood pressure during pregnancy.
		Hydralazine is used to lower severe high blood pressure during pregnancy, with or without preeclampsia.
		Hydralazine should not be used by women who have kidney disease or who are allergic to the medication.
	www.healthnowny.com /kbase/topic/detail/drug/hw1244/detail.htm (278 words)

	Hydralazine (IARC Summary & Evaluation, Supplement7, 1987) (Site not responding. Last check: 2007-11-03)
		Hydralazine hydrochloride was tested in one experiment in mice by oral administration.
		Hydralazine induced unscheduled DNA synthesis in rat and rabbit hepatocytes in vitro and induced mutation and DNA damage in bacteria [ref: 4].
		Hydralazine is not classifiable as to its carcinogenicity to humans (Group 3).
	www.inchem.org /documents/iarc/suppl7/hydralazine.html (326 words)

	Hydralazine (PIM 264)
		Hydralazine is used to treat arterial hypertension (primary; malignant; pulmonary; pree-eclampsia and eclampsia), congestive heart failure, pulmonary hypertension in chronic obstructive pulmonary disease, and aortic regurgitation (McFadden & Braunwald, 1992; Gallager et al, 1994 ; Oates, 1995).
		Hydralazine should be used cautiously in patients with dissecting aortic aneurysm, heart failure with high output, cor pulmonale or myocardial insufficiency caused by mechanical obstruction due to valvular diseases.
		Acetylator phenotype and the antihypertensive response to hydralazine.
	www.inchem.org /documents/pims/pharm/hydral.htm (6182 words)

	MedlinePlus Drug Information: Hydralazine
		Hydralazine is used to treat high blood pressure.
		Hydralazine controls high blood pressure but does not cure it.
		Hydralazine is also used after heart valve replacement and in the treatment of congestive heart failure.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a682246.html (626 words)

	Hydralazine - Drug Interactions and Warnings
		A pre-existing deficiency of coenzyme Q10 in the myocardium of hypertensive patients could be augmented by subsequent treatment with propranolol, possibly to the "life-threatening" state described by others.
		Hydralazine hypotension in anesthetized rats was also reduced by pyridoxal pretreatment.
		These results suggest that at least part of hydralazine-induced hypotension may be related to interaction with pyridoxal, possibly through interference with an effect of the vitamer on calcium and/or sodium transport into vascular smooth muscle.
	www.personalhealthzone.com /drug_interactions/hydralazine.html (298 words)

	Hydralazine Drug Information
		Hydralazine works by relaxing blood vessels and increasing the supply of blood and oxygen to the heart while reducing its workload.
		Although hydralazine often is used to reduce high blood pressure in pregnant women, extensive studies of hydralazine in pregnant women have not been done.
		Although there is no specific information comparing use of hydralazine in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults.
	www.drugs.com /cons/Hydralazine.html (1757 words)

	NOW Foods - Hydralazine
		Hydralazine relaxes the muscles that control the diameter of blood vessels.
		Vitamin B6 can bind to hydralazine to form a complex that is excreted in the urine, increasing vitamin B6 loss.
		For the convenience of the reader, the information in the summary is categorized as follows: “Depletion or interference” indicates the drug may deplete or interfere with the absorption or function of the supplement or herb.
	www.nowfoods.com /?action=itemdetail&item_id=5293&CSPID=c32238aca82aecf51a3914b28d9633ae (493 words)

	News - Hydralazine Questioned as First Line Treatment for Severe Hypertension During Pregnancy
		Hydralazine therapy was associated with more maternal side effects than labetalol or ketanserin, and with more maternal tachycardia, palpitations, and headache than other antihypertensives.
		Data from 12 trials show that hydralazine resulted in more adverse effects on foetal heart rate (relative risk 2.04) while data from 3 trials indicates an increased relative risk of 2.70 for low Apgar scores at 1 minute after birth with hydralazine compared with other antihypertensives.
		"Hydralazine was found to be a less effective antihypertensive than nifedipine or isradipine, and did not clearly differ from labetalol," the authors write, adding that hydralazine was more poorly tolerated and was associated with more of several adverse outcomes when compared with all other antihypertensives.
	www.docguide.com /news/content.nsf/news/BF5821BD35E1DA0285256DCC00761F56?OpenDocument&c=Hypertension&count=10 (554 words)

	Hydralazine Prevents Nitroglycerin Tolerance by Inhibiting Activation of a Membrane-bound NADH Oxidase . A New Action ...
		Hydralazine has been shown to prevent nitrate tolerance and to improve mortality when given in combination with isosorbide dinitrate in patients with congestive heart failure (7).
		Hydralazine has been shown to prevent the development of nitroglycerin tolerance in both experimental animals and in humans with congestive heart failure (18, 19).
		Hydralazine also has beneficial effects on mortality when administered concomitantly with long-acting nitrates to patients with congestive heart failure (20, 21).
	www.jci.org /cgi/content/full/98/6/1465 (5598 words)

	Hydralazine
		Abstract: To help clarify whether food or enteral nutrients decrease hydralazine relative bioavailability, eight subjects were given oral hydralazine under four nutritional conditions: fasted (F), with a standard breakfast (SB), with a bolus of enteral nutrients (EB), and with a slow infusion of enteral nutrients administered by nasogastric tube (EI).
		A case of acute hydralazine overdose associated with marked ECG ST segment depression in a young adult is presented.
		Clinical and experimental data on acute hydralazine exposure suggest that the possibility of direct drug effects, including positive inotropic and chronotropic effects and myocardial cell injury, should be considered.
	home.caregroup.org /clinical/altmed/interactions/Drugs/Hydralazine.htm (810 words)

	Cardiopulmonary control in sleeping Sprague-Dawley rats treated with hydralazine -- Carley et al. 83 (6): 1954 -- ...
		injection of 1) saline or 2) 2 mg/kg hydralazine.
		Hydralazine is believed to exert its primary effects on the circulatory system.
		Hydralazine reduces elevated sleep apnea index in spontaneously hypertensive (SHR) rats to equivalence with normotensive Wistar-Kyoto rats.
	jap.physiology.org /cgi/content/full/83/6/1954 (3805 words)

	MedlinePlus Drug Information: Hydralazine (Systemic) (Site not responding. Last check: 2007-11-03)
		Pregnancy—Although hydralazine often is used to reduce high blood pressure in pregnant women, extensive studies of hydralazine in pregnant women have not been done.
		Children—Although there is no specific information comparing use of hydralazine in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults.
		Hydralazine may cause some people to have headaches or to feel dizzy.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/202285.html (1724 words)

	MedlinePlus Drug Information: Reserpine, Hydralazine, and Hydrochlorothiazide (Systemic ) (Site not responding. Last check: 2007-11-03)
		Hydralazine works by relaxing blood vessels and increasing the supply of blood to the heart while reducing its work load.
		Although there is no specific information comparing use of reserpine, hydralazine, and hydrochlorothiazide combination in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults.
		Effects of hydralazine may be increased because of slower removal from the body.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/202506.html (2741 words)

	Hydralazine and HCTZ - Drugs & Vitamins - Drug Library - DrugDigest (Site not responding. Last check: 2007-11-03)
		HYDRALAZINE; HYDROCHLOROTHIAZIDE, HCTZ (Apresazide®, Hydra-Zide®) is a combination of two drugs used to treat hypertension.
		Hydralazine controls high blood pressure (hypertension) by relaxing blood vessels.
		Hydralazine; hydrochlorothiazide can increase the amount of sugar in blood or urine.
	drugdigest.org /DD/DVH/Uses/0,3915,8344\|Hydralazine+and+HCTZ,00.html (904 words)

	hydralazine of Augusta, Georgia
		Hydralazine is in the FDA pregnancy category C. This means that it is not known whether hydralazine will harm an unborn baby.
		Symptoms of a hydralazine overdose include very low blood pressure (fainting, dizziness, confusion), an irregular heartbeat, headache, and flushing of the skin.
		Hydralazine is available with a prescription under the brand name Apresoline.
	www.universityhealth.org /16427.cfm (1142 words)

	Hydralazine - Patient UK
		Hydralazine is taken by mouth to treat high blood pressure.
		Most people suffering from high blood pressure do not feel unwell, but it is crucial high blood pressure is not left untreated and that you continue to take this medicine even if you feel fine.
		Hydralazine is available in tablet and injection form.
	www.patient.co.uk /showdoc/30002312 (576 words)

	Hydralazine for treatment of severe hypertension in pregnancy: meta-analysis -- Magee et al. 327 (7421): 955 -- BMJ
		Hydralazine for treatment of severe hypertension in pregnancy: meta-analysis -- Magee et al.
		to parenteral hydralazine) on perinatal, maternal, and neonatal
		Hydralazine was more poorly tolerated than other antihypertensives.
	bmj.bmjjournals.com /cgi/content/full/327/7421/955 (4362 words)

	Novel Mechanism of Action for Hydralazine: Induction of Hypoxia-Inducible Factor-1 {alpha}, Vascular Endothelial Growth ... (Site not responding. Last check: 2007-11-03)
		Mechanisms of hydralazine induced vasodilation in rabbit aorta and pulmonary artery.
		Hydralazine prevents nitroglycerin tolerance by inhibiting activation of a membrane-bound NADH oxidase—a new action for an old drug.
		Hydralazine and isosorbide dinitrate: comparative central and regional haemodyamic effects when administered alone or in combination.
	circres.ahajournals.org /cgi/content/full/95/2/162 (3899 words)

	IngentaConnect Hydralazine treatment alters body composition in the rabbit model...
		Hydralazine treatment alters body composition in the rabbit model of obesity
		While hydralazine is commonly used as monotherapy in animal studies, its potential side effects are seldom acknowledged.
		Hydralazine was administered at 6 and 10–14 mg kg
	www.ingentaconnect.com /content/bsc/aps/2004/00000181/00000002/art00004 (361 words)

	Hydralazine and Hydralazine Hydrochloride (IARC Summary & Evaluation, Volume 24, 1980) (Site not responding. Last check: 2007-11-03)
		Hydralazine is used in the long-term treatment of essential and early malignant hypertension.
		One was confined to patients with and without hydralazine toxicity, and potential confounding factors were not controlled for.
		The other involved a small number of subjects exposed to hydralazine, and the possibility of selection bias could not be excluded.
	www.inchem.org /documents/iarc/vol24/hydralazine.html (172 words)

	Hydralazine >>> Guanethidine (Site not responding. Last check: 2007-11-03)
		Before using this drug consult with your doctor if you have a peptic ulcer, gastritis, high blood pressure, heart disease, liver or kidney Hydralazine problems, or are taking drugs for gout.
		Hydralazine Caution: Do Not Double the Dose.This drug is an Antihistamine used to treat allergic symptoms such as hives, skin rash, a
		No Retards cell growth in affected areas.May vary, consult with your doctor or pharmacist for specifics.Reapply as soon as you remember.This drug is an Antiseborrheic used to treat seborrheic dermatitis of the Hydralazine scalp.On rare occasion, some may experience skin irritation and hair discoloration when using this drug.
	medicine.pisem.net /Hydralazine.htm (146 words)

	Hydralazine Hcl and Hydrochlorothiazide at Absolute Authority :: Hydralazine Hcl and Hydrochlorothiazide Information, ...
		This is your central hub for exploring the world of Hydralazine Hcl and Hydrochlorothiazide.
		If you would like to contribute any articles or resources on Hydralazine Hcl and Hydrochlorothiazide just use the submission form.
		Hydralazine Hcl and Hydrochlorothiazide - This is your central hub for exploring the world of Hydralazine Hcl and Hydrochlorothiazide on the web.
	www.absoluteauthority.com /on/hydralazine-hcl-and-hydrochlorothiazide.htm (334 words)

	Hydralazine Hydrochloride news articles (Site not responding. Last check: 2007-11-03)
		The same combination of drugs that are the components of BiDil -- isosorbide dinitrate and hydralazine hydrochloride â“ was used in at-large population trials...
		But one of its two key ingredients, a generic compound known as hydralazine hydrochloride, long has been known to cause lupus in some patients, according to...
		Still, one of its two key ingredients, a generic compound known as hydralazine hydrochloride, long has been known to cause lupus in some patients, according to...
	www.mongabay.com /drugs/drugs/Hydralazine_Hydrochloride.html (853 words)

	HYDRALAZINE WITH HCTZ - ORAL (Apresazide) side effects, medical uses, and drug interactions.
		HYDRALAZINE WITH HCTZ - ORAL (Apresazide) side effects, medical uses, and drug interactions.
		USES: Hydralazine helps to widen arteries and veins so blood flows better.
		Read 7 more hydralazine with hctz-oral related articles...
	www.medicinenet.com /hydralazine_with_hctz-oral/article.htm (490 words)

	Isosorbide Dintrate and Hydralazine
		The results of the study were presented at the 2004 American Heart Association Scientific Session and published in the November 11, 2004 issue of the New England Journal of Medicine by Anne L. Taylor, et.
		Patients selected for the randomized, placebo-controlled, double blind trial came from 161 centers in the U.S., were over eighteen years of age, were self-identified as fl, and had NYHA class III or IV heart failure for at least three months prior to randomization.
		The primary end point for the trial was a composite score of weighted values for death from any cause, first hospitalization for heart failure, and change in quality of life according to the Minnesota Living with Heart Failure questionnaire.
	www.cardiologyonline.com /journal_articles/Isosorbide_dinitrate.htm (437 words)

	Hydralazine (Site not responding. Last check: 2007-11-03)
		Hydralazine controls high blood pressure by relaxing the blood vessels so that blood can flow more easily through the body.
		Hydralazine is usually taken two to four times a day.
		You may have to take hydralazine for several weeks before feeling its full effect.
	clevelandclinic.org /health/health-info/docs/0600/0695.asp?index=4850 (682 words)

	Hydralazin (Hydralazine) - Buy Hydralazin online, no prescription slips
		Hydralazin (Hydralazine) is a vasodilator used to treat high blood pressure.
		Hydralazin (Hydralazine) may also be used to treat other conditions as determined by your doctor.
		The local name is listed when you order discount Hydralazin (Hydralazine) if it differs from the US name.
	www.buy-online-prescription.com /Hydralazin.htm (297 words)

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