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| | Patent 6,432,450 (Site not responding. Last check: 2007-11-05) |
 | | The gas-evolving component consists of alkali hydrogen carbonate, alkali carbonate, and/or alkaline-earth carbonate particles which are coated with at least one further substance, particularly with a melt of polyethylene glycol 6000. |
 | | It is advisable then, of course, to select coarse-grained alkaline components and for instance use a coarse-crystalline form of the granular sodium carbonate or sodium hydrogen carbonate, since such particles sink more rapidly, which produces a delayed effervescent effect from the bottom. |
 | | It has been found to be advantageous in the case of sodium hydrogen carbonate to select a grain size distribution where the major sieve fraction is in the range between 0.1 and 0.4 mm, preferably to the extent of 50 to 85% and particularly preferably to the extent of 70 to 85%. |
| www.pharmcast.com /Patents/Yr2002/August2002/081302/6432450_Effervescent081302.htm (2338 words) |
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