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Topic: Hydrolase


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In the News (Wed 26 Jun 19)

  
  Hydrolase - Wikipedia, the free encyclopedia
In biochemistry, a hydrolase is an enzyme that catalyzes the hydrolysis of a chemical bond.
Systematic names of hydrolases are formed as "substrate hydrolase." However, common names are common, using only "substratease." For example, a nuclease is a hydrolase that cleaves nucleic acids.
Hydrolases are classified as EC 3 in the EC number classification of enzymes.
en.wikipedia.org /wiki/Hydrolase   (153 words)

  
 FAAH - Fatty-acid amide hydrolase
The enzyme fatty acid amide hydrolase (FAAH) catalyses hydrolysis of oleamide, a sleep-inducing lipid whose concentration in the cerebrospinal fluid (CSF) is elevated in sleep-deprived mammals.
The distribution in the rat brain of fatty acid amide hydrolase (FAAH) an enzyme that catalyzes the hydrolysis of the endogenous cannabinoid anandamide was studied by immunohistochemistry.
Moreover, we observed a decreased activity of the anandamide membrane transporter (AMT) and of the anandamide hydrolase [ fatty acid amide hydrolase (FAAH)], whereas the binding of anandamide to cannabinoid receptors was unaffected.
www.ihop-net.org /UniPub/iHOP/gg/88118.html   (5532 words)

  
 Rat Serum Carboxylesterase -- Yan et al. 270 (32): 19128 -- Journal of Biological Chemistry
High levels of hydrolase A are present in testis, whereas high levels of hydrolase B are present in kidney, as determined by enzyme kinetics and Western immunoblotting (12, 13).
Hydrolases A, B, and C all have the COOH-terminal HXEL consensus sequence and are found in rat liver microsomes(15).
To determine whether hydrolase S is expressed in extrahepatic tissues, microsomes from kidney, testis, prostate, intestine, lung, heart, and brain were analyzed by immunoblotting with antibody against hydrolase S. None of the extrahepatic tissues examined expressed the 67-kDa protein, as shown in Fig.8.
www.jbc.org /cgi/content/full/270/32/19128   (7022 words)

  
 Cloning and Expression of a Phloretin Hydrolase Gene from Eubacterium ramulus and Characterization of the Recombinant ...
Cloning and Expression of a Phloretin Hydrolase Gene from Eubacterium ramulus and Characterization of the Recombinant Enzyme -- Schoefer et al.
Cloning and Expression of a Phloretin Hydrolase Gene from Eubacterium ramulus and Characterization of the Recombinant Enzyme
Phloretin hydrolase was assayed in 50 mM potassium phosphate
aem.asm.org /cgi/content/full/70/10/6131   (3260 words)

  
 Asp[IMAGE], Asp[IMAGE], and His[IMAGE] Form the Catalytic Triad of Rat Soluble Epoxide Hydrolase -- Arand et al. 271 ...
In mammals, the two EH implicated in the xenobiotic metabolism are the microsomal epoxide hydrolase (mEH) (3) and the soluble epoxide hydrolase (sEH)(4).
The recent advances in molecular cloning of soluble epoxide hydrolases from several different mammalian (17, 29, 30, 31) and plant (32, 33) species have significantly enhanced the understanding of the relationship between the different epoxide hydrolases and other proteins with structural similarity.
in sEH and the corresponding region in the hydroxymuconic semialdehyde hydrolases from Pseudomonas putida and, to a somewhat lesser extent, the haloalkane dehalogenase(9).
www.jbc.org /cgi/content/full/271/8/4223   (6067 words)

  
 Epoxide Hydrolase Bibliography
0 epoxide by a cytosolic epoxide hydrolase from mouse liver.
  Regio- and enantioselective hydrolysis of phenyloxiranes catalyzed by soluble epoxide hydrolase.
  Inhibition of microsomal epoxide hydrolases by ureas, amides and amines.
www.biopestlab.ucdavis.edu /BIB-EH.htm   (4580 words)

  
 Title of Invention: Herbicide-tolerant plants expre ssing carbamate hydrolase
A process for the isolation and characterization of a gene enzyme system for the inactivation of the herbicide phenmedipham, wherein the enzyme is a carbamate hydrolase of Arthrobacter oxidans, which is responsible for the cleavage of the carbamate bond between the benzene rings of phenmedipham.
The carbamate hydrolase responsible for the cleavage of phenmedipham is isolated by ultrasound cell destruction, centrifugation and purification by anion exchange chromatography, gradient elution, ammonium sulphate precipitation and FPLC separation until electrophoretic homogeneity is achieved.
From the data from the blot-hybridisations, it appears that the carbamate hydrolase gene is localised on a PstI restriction fragment with a size of 3.3 kb.
www.nal.usda.gov /bic/Biotech_Patents/1994patents/05347076.html   (6522 words)

  
 Detoxification of Protoanemonin by Dienelactone Hydrolase -- Brückmann et al. 180 (2): 400 -- The Journal of ...
cis-Dienelactone and protoanemonin conversion by the dienelactone hydrolase of Pseudomonas sp.
The dienelactone hydrolase of B13 and the pJP4-encoded enzyme
Nucleotide sequence and expression of clcD, a plasmid-borne dienelactone hydrolase gene from Pseudomonas sp.
jb.asm.org /cgi/content/full/180/2/400   (1690 words)

  
 A polymorphism in the gene for microsomal epoxide hydrolase is associated with pre-eclampsia -- Zusterzeel et al. 38 ...
A polymorphism in the gene for microsomal epoxide hydrolase is associated with pre-eclampsia -- Zusterzeel et al.
A polymorphism in the gene for microsomal epoxide hydrolase is associated with pre-eclampsia
Microsomal epoxide hydrolase is an important enzyme involved in the metabolism of endogenous and exogenous toxicants.
jmg.bmjjournals.com /cgi/content/abstract/38/4/234   (427 words)

  
 Bacterial 2,4-Dioxygenases: New Members of the alpha /beta Hydrolase-Fold Superfamily of Enzymes Functionally Related ...
catalytic acidic residue of the hydrolases and cofactor-free haloperoxidases
of dienelactone hydrolase whereas the C123A dienelactone hydrolase
Nucleotide sequences of the meta-cleavage pathway enzymes 2-hydroxymuconic semialdehyde dehydrogenase and 2-hydroxymuconic semialdehyde hydrolase from Pseudomonas CF600.
jb.asm.org /cgi/content/full/181/18/5725   (5613 words)

  
 Evaluation of Fish Models of Soluble Epoxide Hydrolase Inhibition
Substituted ureas and carbamates are mechanistic inhibitors of the soluble epoxide hydrolase (sEH).
Soluble epoxide hydrolase is a highly conserved, ubiquitous enzyme that hydrolyzes aliphatic epoxides to their corresponding vicinal diols (2).
A rapid radiometric assay for mammalian cytosolic epoxide hydrolase.
ehp.niehs.nih.gov /members/2001/109p61-66newman/newman-full.html   (5285 words)

  
 Structure, Function, and Regulation of Leukotriene A4 Hydrolase -- HAEGGSTRÖM 161 (2): 25 -- American Journal of ...
hydrolase are reversibly inhibited by zinc in a dose-dependent manner, with median inhibitory
hydrolase is consistently recovered as a soluble protein and therefore it is generally assumed that
hydrolase: abrogation of the peptidase activity by mutation of glutamic acid-296.
ajrccm.atsjournals.org /cgi/content/full/161/2/S1/S25   (3466 words)

  
 Purification and properties of a cholesteryl ester hydrolase from rat liver microsomes -- Cristóbal et al. 40 ...
and retinyl palmitate hydrolase, from the hepatic lipase that
Abbreviations: CEH, cholesteryl ester hydrolase; ConA, concanavalin A; DTNB,
(EC 3.1.1.3); cholesteryl ester hydrolase (EC 3.1.1.13); retinyl
www.jlr.org /cgi/content/full/40/4/715   (6334 words)

  
 hydrolase --  Encyclopædia Britannica
Esterases include lipases, which break ester bonds (between a carboxylic acid and an alcohol) in lipids, and phosphatases, which act analogously upon phosphates; a narrower category comprises the nucleases, which are phosphatases that hydrolyze nucleic acids.
Nucleases, which belong to the class of enzymes called hydrolases, are usually specific in action, ribonucleases acting only upon ribonucleic acids (RNA) and deoxyribonucleases acting only upon deoxyribonucleic acids (DNA).
Lysosomes contain a wide variety of hydrolytic enzymes (acid hydrolases) that break down macromolecules such as...
www.britannica.com /eb/article-9041737?tocId=9041737   (416 words)

  
 New induction of leukotriene A4 hydrolase by interleukin-4 and interleukin-13 in human polymorphonuclear leukocytes -- ...
hydrolase antibodies as described in "Materials and methods." The densities were measured and normalized by control values that were expressed as 1.0.
hydrolase was performed as described in "Materials and methods." The same membrane was rehybridized with a human beta-actin probe as a control.
hydrolase in peripheral leukocytes of patients with atopic dermatitis.
www.bloodjournal.org /cgi/content/full/96/2/601   (5501 words)

  
 InterPro: IPR001701 Glycoside hydrolase, family 9   (Site not responding. Last check: 2007-10-08)
Glycoside hydrolase family 9 GH_9 comprises enzymes with several known activities; endoglucanase (3.2.1.4); cellobiohydrolase (3.2.1.91).
These enzymes were formerly known as cellulase family E. O-Glycosyl hydrolases (EC 3.2.1.-) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety.
A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [ 1, 2, 3, 4, 5, 6 ].
www.ebi.ac.uk /interpro/IEntry?ac=IPR001701   (2849 words)

  
 S-Adenosylhomocysteine Hydrolase Inhibitors Interfere with the Replication of Human Immunodeficiency Virus Type ...
S-Adenosylhomocysteine Hydrolase Inhibitors Interfere with the Replication of Human Immunodeficiency Virus Type 1 through Inhibition of the LTR Transactivation -- Daelemans et al.
AdoHcy hydrolase was purified from murine L929 cells using affinity chromatography, and AdoHcy hydrolase activity was measured
It has been clearly established that adenosine analogues are inhibitory to AdoHcy hydrolase (3, 36, 37).
molpharm.aspetjournals.org /cgi/content/full/52/6/1157   (3168 words)

  
 GeneCard for EPHX1   (Site not responding. Last check: 2007-10-08)
Epoxide hydrolase 1 (EC 3.3.2.3) (Microsomal epoxide hydrolase) (Epoxide hydratase).
Epoxide hydrolase Tyr113His polymorphism is not associated with susceptibility to esophageal squamous cell carcinoma in population of North China.
Microsomal epoxide hydrolase polymorphism and susceptibility to ovarian cancer.
bioinfo.cnio.es /cgi-bin/genecards/carddisp?EPHX1   (612 words)

  
 Expression and Activity of Microsomal Epoxide Hydrolase in Follicles Isolated from Mouse Ovaries -- Cannady et al. 68 ...
Cho, J. Y., and Kim, S.G. Differential induction of hepatic microsomal epoxide hydrolase by alkyl sulphides and alkyl ethers in rat.
Cho, M. K., and Kim, S. Enhanced expression of rat hepatic microsomal epoxide hydrolase by methylthiazole in conjunction with liver injury.
Fretland, A. J., and Omiecinski, C. Epoxide hydrolases: Biochemistry and molecular biology.
toxsci.oxfordjournals.org /cgi/content/full/68/1/24   (4602 words)

  
 Enzyme That Detoxifies Cancer Patients Linked To Alzheimer's
They knew that bleomycin hydrolase comes from a class of enzymes called cysteine proteases, which have been thought to play a role in neurodegenerative disorders.
Then, while working on cloning the bleomycin hydrolase gene, the Pitt team learned from a group of Boston University-based investigators that they had purified bleomycin hydrolase from the brains of AD patients and had evidence indicating that this enzyme was involved in processing an amyloid precursor protein.
The genetic sequence for bleomycin hydrolase is strikingly similar among organisms.
www.docguide.com /dg.nsf/c199ac7acbf21b1b852565f30052a091/75ee690b7d52eed8852565b80050e7e1?OpenDocument   (922 words)

  
 Expression and regulation of the fatty acid amide hydrolase gene in the rat uterus during the estrous cycle and ...
Expression and regulation of the fatty acid amide hydrolase gene in the rat uterus during the estrous cycle and peri-implantation period -- Xiao et al.
Expression and regulation of the fatty acid amide hydrolase gene in the rat uterus during the estrous cycle and peri-implantation period
Paria, B.C., Zhao, X., Wang, J., Das, S.K. and Dey, S.K. (1999) Fatty-acid amide hydrolase is expressed in the mouse uterus and embryo during the peri-implantation period.
molehr.oxfordjournals.org /cgi/content/full/8/7/651   (3904 words)

  
 Role of Fatty Acid Amide Hydrolase in the Transport of the Endogenous Cannabinoid Anandamide -- Day et al. 59 (6): 1369 ...
Deutsch DG and Chin SA (1993) Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist.
Egertova M, Giang DK, Cravatt BF and Elphick MR (1998) A new perspective on cannabinoid signalling: complementary localization of fatty acid amide hydrolase and the cb1 receptor in rat brain.
Patterson JE, Ollmann IR, Cravatt BF, Boger DL, Wong C and Lerner RA (1996) Inhibition of oleamide hydrolase catalyzed hydrolysis of the endogenous sleep-inducing lipid cis-9-octadecenamide.
molpharm.aspetjournals.org /cgi/content/full/59/6/1369   (4987 words)

  
 The association of microsomal epoxide hydrolase polymorphisms and lung cancer risk in African-Americans and ...
The association of microsomal epoxide hydrolase polymorphisms and lung cancer risk in African-Americans and Mexican-Americans -- Wu et al.
Oesch,F., Glatt,H. and Schimassmann,H. (1977) The apparent ubiquity of epoxide hydrolase in rat organs.
Seidegard,J. and Ekstrom,G. (1997) The role of human glutathione transferases and epoxide hydrolases in the metabolism of xenobiotics.
carcin.oxfordjournals.org /cgi/content/full/22/6/923   (3309 words)

  
 The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity ...
The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity -- Newman et al.
The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity
The soluble epoxide hydrolase (sEH), first described in 1972 (1), is an ubiquitous enzyme in vertebrates that transforms
www.pnas.org /cgi/content/full/100/4/1558   (3562 words)

  
 Epoxide hydrolase polymorphisms, cigarette smoking and risk of colorectal adenoma in the Nurses' Health Study and the ...
Epoxide hydrolase polymorphisms, cigarette smoking and risk of colorectal adenoma in the Nurses' Health Study and the Health Professionals Follow-up Study -- Tranah et al.
Epoxide hydrolase polymorphisms, cigarette smoking and risk of colorectal adenoma in the Nurses' Health Study and the Health Professionals Follow-up Study
Microsomal epoxide hydrolase (mEH) is involved in the bioactivation
carcin.oxfordjournals.org /cgi/content/abstract/25/7/1211   (441 words)

  
 InterPro: IPR001540 Glycoside hydrolase, family 20
Glycoside hydrolase family 20 GH_20 comprises enzymes with several known activities; beta-hexosaminidase (3.2.1.52); lacto-N-biosidase (3.2.1.140).
O-Glycosyl hydrolases (EC 3.2.1.-) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety.
Bolhuis P.A. Ponne N.J. Bikker H. Baas F. Vianney de Jong J.M. Molecular basis of an adult form of Sandhoff disease: substitution of glutamine for arginine at position 505 of the beta-chain of beta-hexosaminidase results in a labile enzyme.
www.ebi.ac.uk /interpro/IEntry?ac=IPR001540   (3028 words)

  
 Human protein: Q92820 - Gamma-glutamyl hydrolase precursor (EC ) (Gamma-Glu-X carboxypeptidase) (Conjugase) (GH). EMBL ...
Upstream genomic sequence for Gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
Gamma-glutamyl hydrolase precursor (EC 3.4.19.9) (Gamma-Glu-X carboxypeptidase) (Conjugase) (GH).
Human gamma-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro.
harvester.embl.de /harvester/Q928/Q92820.htm   (790 words)

  
 Peptidyl-tRNA hydrolase from Sulfolobus solfataricus -- Fromant et al. 31 (12): 3227 -- Nucleic Acids Research
Menez,J., Buckingham,R.H., de Zamaroczy,M. and Campelli,C.K. (2002) Peptidyl-tRNA hydrolase in Bacillus subtilis, encoded by spoVC, is essential to vegetative growth, whereas the homologous enzyme in Saccharomyces cerevisiae is dispensable.
Rosas-Sandoval,G., Ambrogelly,A., Rinehart,J., Wei,D., Cruz-Vera,L.R., Graham,D.E., Stetter,K.O., Guarneros,G. and Söll,D. (2002) Orthologs of a novel archaeal and of the bacterial peptidyl-tRNA hydrolase are nonessential in yeast.
Jenkins,B.D. and Barkan,A. (2001) Recruitment of peptidyl-tRNA hydrolase as a facilitator of group II intron splicing in chloroplasts.
nar.oxfordjournals.org /cgi/content/full/31/12/3227   (4753 words)

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