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Topic: Hydropathy

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	HYDROPATHY - LoveToKnow Article on HYDROPATHY (Site not responding. Last check: 2007-11-05)
		Like many descriptive names, the word hydropathy is defective and even misleading, the active agents in the treatment being heat and cold, of which water is little more than the vehicle, and not the only one.
		Hydropathy, as a f-ormal system, dates from about 1829, when Vincenz Priessn.itz (1801-1851), a farmer of Grafenberg in Silesia, Austria, began his public career in the paternal homestead, extended so as to accommodate the increasing numbers attracted by the fame of his cures.
		A useful recent work dealing comprehensively with the subject is Richard Metcalfes Rise and Progress of Hydropathy (1906).
	86.1911encyclopedia.org /H/HY/HYDROPATHY.htm (2296 words)

	From Quackery to Bacteriology, Document 3b
		One of Shew's treatments, called the "wet sheet treatment," was to wrap the patient in layers of cold, wet sheets and a woolen blanket, place him in bed until he began sweating, then remove the blanket and douse the patient with cold water.
		Hydropathy treatment was followed by walking in the open air, and as such promoted exercise at a time when frailty was the norm.
		Hydropathy was so popular that it had its own magazine, The Water-Cure Journal, published by O. Fowler's company and boasting a circulation of 50,000 in 1850.
	www.cl.utoledo.edu /canaday/quackery/quack3b.html (798 words)

	Natural Hygiene: Chapter IV (Site not responding. Last check: 2007-11-05)
		Hydropathy may be justly regarded as a convenient escape-hatch, as many physicians who turned to water-cure thought of water as an agent that could be made to take the place of drugs altogether.
		Trail complained on this occasion that he was constantly having to repel the charge of "oneideaism" and that he had to labor with equal zeal to prevent his own readers from developing the "one-ideaism" of which he and others were accused.
		Instead of being a revolutionary movement, it turned out to be a mere reform movement; instead of calling for radical changes in the ways of life, it sought merely to substitute water in the form of baths, hot and cold applications, enemas, douches, packs, fomentations, dripping wet sheets, etc., for drugs.
	www.soilandhealth.org /02/0201hyglibcat/020125shelton.pristine/020125ch4.htm (2666 words)

	Kyte-Doolittle Hydropathy Plots (Site not responding. Last check: 2007-11-05)
		The hydropathy of a molecule is one factor in determining its structure.
		A hydropathy scale is used, which has assigned a hydropathy index to each amino acid, based on its relative hydrophobicity (positive value) or hydrophilicity (negative value).
		The graph plots the average hydropathy of a moving segment of a fixed window size (which the user enters), moving along the entire sequence.
	www.bio.davidson.edu /courses/compbio/flc/home.html (515 words)

	Hydrophobic Free Energy Eigenfunctions of Pore, Channel, and Transporter Proteins Contain beta -Burst Patterns -- Selz ...
		Hydropathy plots are often used in place of missing physical data to model transmembrane proteins that are difficult to crystallize.
		Note that the hydropathy plot of halorhodopsin demonstrates the seven transmembrane segments characteristic of the general class of G-protein-coupled receptors.
		Notice that the hydropathy plots of porin, the sodium channel, and the fructose transporter demonstrate 16 maxima, whereas that of connexin 32 displays 12.
	www.biophysj.org /cgi/content/full/75/5/2332 (4708 words)

	Multidrug Resistance Protein (Mdr)-alkaline Phosphatase Hybrids in Escherichia coli Suggest a Major Revision in the ...
		The new topology is discussed with regard to the hydropathy profiles of the well characterized ABC proteins MalG and MalF, which are strikingly similar to those of the N- and C-terminal halves of Mdr, respectively.
		Hydropathy plot and the deduced secondary structure model of the C-terminal transmembrane domain of mouse Mdr1.
		In addition, the hydropathy profile of the N-terminal portion of MalF is similar to the respective region in the C-terminal membrane domain of Mdr (Fig.
	www.jbc.org /cgi/content/full/270/21/12351 (2974 words)

	Membrane Protein Explorer (MPEx)
		We have constructed a database of membrane proteins of known topology (MPtopo), accessible from MPEx, that is useful for comparing the hydropathy behavior of proteins of unknown topology with the behavior of similar proteins of known topology.
		The hydropathy plot is calculated and displayed automatically when a sequence is entered.
		To move the cursor within the hydropathy plot and select residues of interest, use the right and left arrow button on your keyboard, or drag the mouse within the plotting region while holding down the left mouse button.
	blanco.biomol.uci.edu /mpex (1809 words)

	Experimentally Determined Hydrophobicity Scales
		An example of hydropathy plots of a membrane protein using the interfacial and octanol scales is shown.
		The whole-residue octanol scale may therefore be useful for identifying TM segments in hydropathy plots of MPs, as illustrated below.
		The idea that the octanol scale is useful for identifying TM segments is supported by the whole-residue octanol-scale hydropathy plot for the L-subunit of the photosynthetic reaction center of Rhodobacter sphaeroides shown in Figure 4 (dark yellow solid line).
	blanco.biomol.uci.edu /hydrophobicity_scales.html (691 words)

	Membrane Topology Analysis (Site not responding. Last check: 2007-11-05)
		We combine dot plot analysis, transmembrane segment (TMS) analysis, and hydropathy analysis to elucidate topological similarities and differences among sequences of the PTR polytopic membrane protein family.
		Examination of hydropathy profiles reveals that several peaks occur around the threshold GES score of 1, raising ambiguities as to the presence or location of TMSs.
		From the hydropathy profiles shown in Figure 2.3D, it appears that pet1 has an additional TMS, occurring between TMS2 and 3 of dtpt.
	itsa.ucsf.edu /~gram/home/graul/publications/dissertation/chapter-2.html (3325 words)

	Amino Acid Volume and Hydropathy of a Transmembrane Site Determine Glycine and Anesthetic Sensitivity of Glycine ...
		The obtained log EC value of each GlyR was correlated with the volume (40), polarity (41), hydropathy (28), and hydrophilicity (42) of the substituted amino acid residues.
		B-F, correlations of the volume (B), polarity (C), hydropathy (D), hydrophilicity (E) of mutated amino acids, or log(EC) values of mutant receptors for glycine (F) with F3 potentiation.
		B-F, correlations of the volume (B), polarity (C), hydropathy (D), hydrophilicity (E) of mutated amino acids, or log(EC) values of mutant receptors for glycine (F) with F6 actions.
	www.jbc.org /cgi/content/full/274/33/23006 (4396 words)

	Global Peptide Services, LLC: Hydropathy Plot (Site not responding. Last check: 2007-11-05)
		Hydropathy plots allow for the visualization of hydrophobicity over the length of a peptide sequence.
		A hydropathy scale which is based on the hydrophobic and hydrophilic properties of the 20 amino acids is used.
		A moving “window” determines the summed hydropathy at each point in the sequence (Y coordinate).
	www.globalpeptide.com /plot.html (156 words)

	Sequence-derived hydropathy
		This immediately raises the problem of what weight to apply to the hydropathy component in order for the correct balance of information to be present.
		The map vector hydropathy component is shown for each unit by the shading of the circles: white=hydrophilic, fl=hydrophobic.
		The result is a less interpretable map (a), however the mapped hydrophobicities displayed in (b) on the structure now exhibit the alternation we observe in the raw hydropathy information (in Figure 5.7) and these patterns of hydropathy are largely confined to structurally important
	www.sbc.su.se /~maccallr/thesis/node146.html (725 words)

	Conservation of amino acid properties (Site not responding. Last check: 2007-11-05)
		Within a single SP j, the variation (the inverse of conservation) is the a(max,k) - a(min,k) difference between the hydropathy values of the most and least hydrophobic residues that are present (k) in SPj.
		The v(i) overall variation of hydropathy is obtained by summing all SP's variation, each weighted by the f(j) frequency of SP j:
		To compare variations of widely different properties, normalization is necessary by the difference between the hydropathy values of 6th and 15th most hydropathic residues.
	falco.elte.hu /~ladunga/conserved.html (394 words)

	Natual Hygiene: Chapter LIII (Site not responding. Last check: 2007-11-05)
		Hygiene and hydropathy became so intermingled and confused that it was not possible to tell where one ended and the other began.
		He was not among the hydropathists who thought of the water cure as a universal panacea, but did think that hydropathy and hygiene would rejuvenate the world.
		But it is still a fact that he gave predominance to hydropathy and regarded Hygienic means as secondary and subsidiary factors in the care of the sick, while crediting "water cure" with powers that belong only to the living organism.
	www.soilandhealth.org /02/0201hyglibcat/020125shelton.pristine/020125ch53.htm (1453 words)

	HYDROPATHY - Online Information article about HYDROPATHY (Site not responding. Last check: 2007-11-05)
		Like many descriptive names, the word " hydropathy " is defective and even misleading, the active agents in the treatment being See also:
		general practice of water drinking, is the most noteworthy of the many contributions by hydropathy to public See also:
		The appliances and arrangements by means of which heat and cold are brought to bear on the See also:
	encyclopedia.jrank.org /HOR_I25/HYDROPATHY.html (2132 words)

	Chemical characteristics of dimer interfaces in the legume lectin family -- Elgavish and Shaanan 10 (4): 753 -- Protein ...
		Hydropathy and amino acid composition of native and virtual dimers
		The hydropathy of the interface of native ConA resembles that
		The hydropathy of the EcorL and GS4 interfaces is
	www.proteinscience.org /cgi/content/full/10/4/753 (4494 words)

	Protein Hydrophilic Search and Comparison Server Help Page (Site not responding. Last check: 2007-11-05)
		The hydropathic profile of a protein is calculated by assigning each amino acid a numerical value ("hydropathy index") and then repetitively averaging these values along the peptide chain.
		This changes the hydropathy of the protein and will effect which and how many proteins are returned in the protein search.
		The numbers are then assigned a letter, and the fasta program is used to either compare the two proteins or search the Swiss-Prot database for proteins with similar profiles.
	bioinformatics.weizmann.ac.il /hydroph/hydroph_help.html (713 words)

	Identification of novel membrane proteins by searching for patterns in hydropathy profiles -- Clements and Martin 269 ... (Site not responding. Last check: 2007-11-05)
		Hydropathy profiles of four proteins that were retrieved from the human proteome by a search strategy designed to detect LGICs, but were not annotated as receptors.
		(A) The hydropathy profile of a rat dopamine symporter reveals a pair of peaks followed by a deep valley, then a cluster of nine peaks.
		Lolkema, J.S. and Slotboom, D.J. (1998) Estimation of structural similarity of membrane proteins by hydropathy profile alignment.
	content.febsjournal.org /cgi/content/full/269/8/2101 (4453 words)

	Structural Features of the Glutamate Transporter Family -- Slotboom et al. 63 (2): 293 -- Microbiology and Molecular ...
		Alignment of the average hydropathy profiles of the subfamily of bacterial glutamate transporters (thin line) and the subfamily consisting of b1729 of E.
		The average hydropathy profile derived from the multiple sequence alignment of a subset of 35 members of the family (Fig.
		Average profiles of hydropathy (A) and hydrophobic moment (B) of the glutamate transporter family.
	mmbr.asm.org /cgi/content/full/63/2/293 (6609 words)

	MedFriendly.com: Hydropathy
		Hydropathy is the use of water to treat and cure disease.
		Hydropathy comes from the Greek word "hydor" meaning "water," and the Greek word "pathos" meaning "suffering." Put the words together and you get "water suffering."
		You may not reprint or redisplay this material for commercial use without the express written consent of MedFriendly.com.
	www.medfriendly.com /hydropathy.html (94 words)

	Hydropathy plot (Site not responding. Last check: 2007-11-05)
		A graph which shows how hydrophobic each amino acid in a polypeptide is versus where it is located on the polypeptide.
		The hydropathy plot is used to find clusters of hydrophobic amino acids, which could indicate that the polypeptide in question is a transmembrane protein.
		A transmembrane protein has hydrophilic parts which protrude out on either side of the cellular membrane, and a hydrophobic center which lies within the membrane.
	www.cartage.org.lb /en/themes/Reference/dictionary/Biologie/H/317.html (70 words)

	Alternative Health Dictionary - h (Site not responding. Last check: 2007-11-05)
		hydropathy (water cure): Near-panacean, purificatory use of water internally and externally.
		Silesian farmer Vincenz (Vincent) Priessnitz (1791-1851) originated hydropathy early in the nineteenth century in Germany.
		Hydropathy survives mainly in the context of kneipping.
	www.canoe.ca /AltmedDictionary/h.html (3370 words)

	kyte-doolittle entry form (Site not responding. Last check: 2007-11-05)
		You can change the window size to adjust the number of amino acids that are averaged to obtain the hydropathy score at each position.
		You can also zoom in on a section of your protein by entering a range of amino acids you wish to analyze.
		You may enter a starting and/or ending position, and your hydropathy plot will be scaled accordingly.
	occawlonline.pearsoned.com /bookbind/pubbooks/bc_mcampbell_genomics_1/medialib/activities/kd/kyte-doolittle.htm (189 words)

	Structure prediction
		Originally, Hydropathy Plots were used to predict membrane proteins.
		The algorithm used by this prediction program calculates an average hydropathy value for each position in the given sequence.
		A hydropathy scale is used, which has assigned a hydropathy index to each amino acid (see below), based on its relative hydrophobicity (positive value) or hydrophilicity (negative value).
	www.ucd.ie /biochem/ugrad/3yr/B3009/Practical_5.htm (1586 words)

	Kyte-Doolittle hydropathy plot (Site not responding. Last check: 2007-11-05)
		There are many ways to assess protein location experimentally; however, in 1980 the researchers Kyte and Doolittle produced an algorithm that assessed a protein's location using hydropathy based on amino acid sequence.
		This method, the Kyte-Doolittle hydropathy plot, has since become a standard tool in molecular biology.
		Using these hydropathy calulations, we can measure how hydrophobic or hydrophillic a protein is expected to be in certain regions.
	www.bio.davidson.edu /courses/compbio/plat/home.html (153 words)

	17 (Site not responding. Last check: 2007-11-05)
		The correlation between some of the scales most used and those calculated here provides criteria for selecting the most appropriate methods for a given type of protein.
		The parameters used in the evaluation of the hydropathy profiles have been carefully ascertained in order to develop a reliable methodology for hydropathy analysis.
		Finally, an integrated hydropathy analysis using different methods has been applied to several sequences of related proteins.
	profs.sci.univr.it /~crimi/abstracts/6.html (116 words)

	Laminin Receptor
		Using a technique called complementary hydropathy to develop a peptide that binds to PrPC, a team of Brazilian researchers has developed a protein that recognizes a distinct site on mouse neurons which is thought to be the transforming receptor.
		They identified a protein fragment from a prion that appears to be particularly toxic to brain cells in culture and reasoned that it might play an important role in disease.
		The complementary hydropathy scheme based on the anti-gene sequence is less than persuasive, yet sometimes it has given results, due to the duality structure of the genetic code vis-a-vis hydrophobicity.
	www.mad-cow.org /laminin.html (5028 words)

	Complementary hydropathy identifies a cellular prion protein receptor - Nature Medicine
		Complementary hydropathy let us generate a hypothetical peptide mimicking the receptor binding site.
		Brentani, R.R. Biological implications of complementary hydropathy of amino acids.
		Brentani, R.R. Complementary hydropathy and the evolution of interacting polypeptides.
	www.nature.com /doifinder/10.1038/nm1297-1376 (619 words)

	hydropathy - OneLook Dictionary Search
		Tip: Click on the first link on a line below to go directly to a page where "hydropathy" is defined.
		Hydropathy : Online Plain Text English Dictionary [home, info]
		HYDROPATHY : 1911 edition of the Encyclopedia Britannica [home, info]
	www.onelook.com /?w=hydropathy&ls=all (205 words)

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