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	(BETA) DRUG WATCH: Hydroxyurea
		Hydroxyurea, a drug developed over 30 years ago and used as a treatment for cancer and sickle-cell anemia, continues to demonstrate significant promise as a component of anti-HIV drug regimens.
		Another of hydroxyurea’s benefits is the fact that, to date, there are no documented reports of resistance to the drug, compared to the high level of drug-resistance mutations associated with the prolonged use of all the currently approved anti-HIV agents.
		Hydroxyurea combinations appear somewhat unique in that viral load rebound has not occurred in several cases after therapy was discontinued Hydroxyurea.
	www.aegis.com /pubs/beta/1998/BE981002.html (808 words)

	Hydroxyurea in Sickle Cell Disease
		Hydroxyurea is a chemotherapy agent with potent effects on the bone marrow.
		The primary side-effect of hydroxyurea is suppression of blood counts, particularly the white blood cells (neutropenia) and platelets (thrombocytopenia).
		hydroxyurea blood levels- Blood levels of hydroxyurea are difficult to interpret because of fluctations that reflect, among other things, the pattern of drug use (e.g., once a day versus twice a day) and the timing of the blood test relative to ingestion of the HU.
	sickle.bwh.harvard.edu /hyguid.html (1454 words)

	AIDS Fact Sheet: Hydroxyurea
		Hydroxyurea has been studied in combination with the antiviral drugs ddI and d4T.
		Hydroxyurea is most effective if taken with reverse transcriptase inhibitors such as ddI or d4T.
		Hydroxyurea's side effects may be worse if taken with AZT, because both drugs can damage the bone marrow.
	www.aids.org /factSheets/469-Hydroxyurea.html (699 words)

	Gale Encyclopedia of Cancer: Hydroxyurea
		Hydroxyurea, also known by its trade name Hydrea, is an antineoplastic agent, meaning it is used to treat cancer.
		Hydroxyurea should not be administered to pregnant women, and women taking the drug should use birth control methods to prevent pregnancy.
		Hydroxyurea causes red blood cell abnormalities that are not severe and that do not reduce the red blood cell survival time.
	www.findarticles.com /p/articles/mi_gGEC/is_0012/ai_2699001213 (874 words)

	Hydroxyurea - Drugs & Vitamins - Drug Library - DrugDigest
		Hydroxyurea is used for treating cancers of the blood, skin, ovary and head and neck.
		Hydroxyurea is also used to decrease the painful episodes associated with sickle cell disease.
		Hydroxyurea does not cure sickle cell disease, but may help to control the symptoms when used on a regular basis.
	www.drugdigest.org /DD/DVH/Uses/0,3915,332\|Hydroxyurea,00.html (1004 words)

	NATAP: Hydroxyurea with ddI or ddI/d4T
		Hydroxyurea has been used as a treatment for several types of cancer for many years, but at significantly higher doses than is being used in its application to HIV disease.
		Hydroxyurea is cytostatic at the doses being investigated for HIV disease; that is, it keeps cells from replicating.
		Hydroxyurea lowered the levels of the cellular competitor of ddI, namely dATP, and this favored the incorporation of ddI, even if the reverse transcriptase was resistant to this nucleoside analogue." The authors concluded that the use of hydroxyurea with nucleosides may generate treatments which are simple, well-tolerated and inexpensive.
	www.natap.org /1998/drug/hydrox.html (1752 words)

	Hydroxyurea. DermNet NZ
		Hydroxyurea is more frequently prescribed for patients with chronic myeloid leukaemia, cervical cancer and a variety of other malignancies and myeloproliferative disorders.
		Hydroxyurea should not be taken in pregnancy as it is likely to cause fetal abnormalities.
		Hydroxyurea interferes with DNA synthesis and could therefore be unsafe in pregnancy.
	dermnetnz.org /treatments/hydroxyurea.html (507 words)

	Simple Facts Sheets: hydroxyurea (Hydrea)
		Hydroxyurea is a 30 year old anticancer drug that may help certain anti-HIV drugs work better.
		Hydroxyurea works by reducing the number of nucleotides inside cells, making it harder for HIV to make more viruses.
		Hydroxyurea has been shown to cause birth defects in animals and should not be taken by pregnant women.
	www.atdn.org /simple/hydr.html (803 words)

	An Overview of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia (MSH)
		The NHLBI organized the multicenter study of hydroxyurea in sickle cell anemia to answer the question of whether hydroxyurea was clinically useful to patients with sickle cell disease.
		Further supporting the efficacy of hydroxyurea in preventing sickle cell crises, the median time to the first vaso-occlusive crisis was 3.0 months in the hydroxyurea group compared to 1.5 months in the placebo controls.
		The median time to the second crisis was likewise greater in the patients on hydroxyurea relative to the controls (8.8 versus 4.6 months.) At the end of the study, 51% of the patients on hydroxyurea were receiving maximal tolerated doses.
	sickle.bwh.harvard.edu /msh.html (858 words)

	Positive Living - Hydroxyurea (Site not responding. Last check: 2007-10-20)
		Hydroxyurea (HU), a drug that has been approved in the U.S. to treat leukemia and sickle-cell anemia, was discussed by researchers at the 12th World AIDS Conference.
		Poster 12371 explored the suppression of HIV replication in 24 treatment-naive individuals who were treated with ddI, hydroxyurea and indinavir, and had an average viral load of 455,700 copies/ml.
		Approximately 50 percent of the participants in the hydroxyurea group achieved an undetectable viral load by week 4 and 80 percent by week 12 compared to 80 percent by week 4 in the nelfinavir group.
	www.apla.org /apla/positiveliving/9808/hydroxyurea.html (875 words)

	Hydroxyurea Treatment for Sickle Cell Disease
		Worries that hydroxyurea might interfere with growth or development has not been borne out in study findings, leading to a wider acceptance of its use in pediatric patients with sickle cell.
		Hydroxyurea is a chemical compound that has been used as a medication for more than a century.
		Hydroxyurea treatment generally is reserved for children whose sickle cell disease is particularly severe, requiring frequent hospitalizations for pain or lung problems.
	www.drspock.com /article/0,1510,5073,00.html?r=related (703 words)

	Preliminary report of a toxicity study of hydroxyurea in sickle cell disease -- de Montalembert et al. 81 (5): 437 -- ...
		Hydroxyurea was stopped for medical reasons in 11 patients: 6 failures, 1 pregnancy, 1 cutaneous rash, 1 leg ulcer, 1 lupus.
		Hydroxyurea was stopped in 17 children, for reasons indicated in table 2.
		Hydroxyurea was temporarily stopped in a 17 year old patient because the treatment had provoked a 20 g/l increase in haemoglobin.
	adc.bmjjournals.com /cgi/content/full/81/5/437 (2237 words)

	SF AIDS Fdn: BETA 4/98 -- Conf. on Retroviruses and Opp. Infections (Hydroxyurea)
		Hydroxyurea is an FDA-approved anti-cancer drug that has been used in the U.S. for many years.
		Because hydroxyurea blocks a human cellular enzyme called ribonucleotide reductase -- and because HIV enzymes are not involved -- resistance to hydroxyurea is extremely uncommon.
		Hydroxyurea and ddI both target resting cells, while d4T and indinavir target cells that are actively replicating.
	www.sfaf.org /treatment/beta/b36/b36croi-hydrox.html (788 words)

	Hydroxyurea — Hydrea, Droxia, Mylocel — Chemotherapy Drugs - Chemo (Site not responding. Last check: 2007-10-20)
		The amount of hydroxyurea that you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition being treated.
		The side effects of hydroxyurea and their severity depend on how much of the drug is given.
		Before starting hydroxyurea treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.).
	www.chemocare.com /bio/bio.sps?iBiographyID=7924 (1477 words)

	Psoriasis - Wikipedia, the free encyclopedia
		This drug must also be avoided by pregnant women and by women who are planning to become pregnant, because it may cause birth defects.
		Compared with methotrexate and cyclosporine, hydroxyurea is somewhat less effective.
		Like methotrexate and retinoids, hydroxyurea must be avoided by pregnant women or those who are planning to become pregnant, because it may cause birth defects.
	en.wikipedia.org /wiki/Psoriasis (3220 words)

	hydroxyurea, Eastern Carolina
		Hydroxyurea is used to treat melanoma (a type of skin cancer), chronic myelocytic leukemia (CML), cancer of the ovary, and primary squamous cell (skin) cancer of the head and neck.
		Hydroxyurea is in the FDA pregnancy category D. This means that hydroxyurea is known to be harmful to an unborn baby.
		Hydroxyurea is available with a prescription generically and under the brand names Hydrea and Droxia.
	www.uhseast.com /115388.cfm (1301 words)

	In Vitro Hydroxyurea Decreases Th1 Cell-Mediated Immunity -- Weinberg 8 (4): 702 -- Clinical and Diagnostic Laboratory ...
		Hydroxyurea (HU) is used in the treatment of hematologic disorders and is sometimes added to antiretroviral combination therapy
		Treatment of human immunodeficiency virus infection with hydroxyurea, didanosine, and a protease inhibitor before seroconversion is associated with normalized immune parameters and limited viral reservoir.
		Hydroxyurea interferes with antigen-dependent T-cell actiation in vitro.
	cdli.asm.org /cgi/content/full/8/4/702 (2177 words)

	Hydroxyurea (Site not responding. Last check: 2007-10-20)
		Hydroxyurea (brand name: Hydrea) has been on the market as an anti-cancer drug for over 30 years.
		Indications: Hydroxyurea is prescribed in some instances for leukemia, ovarian cancer, sickle cell anemia, and HIV.
		Finally, as Hydroxyurea suppresses T cell maturation, it is unlikely that this will be an effective treatment of patients with end-stage HIV infection.
	www.stanford.edu /group/virus/toga/2000/g.html (283 words)

	MedlinePlus Drug Information: Hydroxyurea (Systemic) (Site not responding. Last check: 2007-10-20)
		Hydroxyurea seems to interfere with the growth of cancer cells, which are eventually destroyed.
		Because hydroxyurea may cause serious side effects, breast-feeding is not recommended while you are taking it.
		Hydroxyurea may lower your body's resistance and there is a chance you might get the infection the immunization is meant to prevent.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/202291.html (1973 words)

	HYDROXYUREA STUDIES: Licensed cancer treatment boosts effects of some anti-HIV drugs
		Hydroxyurea is a cheap, licensed drug used in the treatment of some forms of leukaemia.
		Most studies testing hydroxyurea are using it in combination with ddI, since this combination seemed to be the most effective in the test-tube.
		People adding hydroxyurea to their ddI-containing regimen may experience a greater reduction in viral load because of the increased antiviral effects, but any CD4 count rise may be smaller because of hydroxyurea's toxic effects on blood cells.
	www.aegis.com /pubs/atu/1998/ATU6403.html (946 words)

	Buy Hydrea (Hydroxyurea) Online Without Prescription Needed
		Hydroxyurea also is used to treat polycythemia vera, psoriasis, hypereosinophilic syndrome, lung cancer, and a variety of other cancers.
		In addition, hydroxyurea has been used along with anti-infective and surgical therapy to treat chronic urinary tract infections caused by certain bacteria.
		The most common side effect of hydroxyurea is a decrease in the number of blood cells.
	www.1meds.com /Hydrea.html (577 words)

	New Views of Sickle Cell Disease Pathophysiology and Treatment -- Rosse et al. 2000 (1): 2 -- Hematology
		Hydroxyurea in children with sickle cell disease: impact on splenic function and compliance with therapy.
		Hydroxyurea affects cell morphology cation transport and red blood cell adhesion in cultured vascular endothelial cells.
		Hydroxyurea therapy for pediatric patients with Hemoglobin SC disease: laboratory and clinical effects.
	www.asheducationbook.org /cgi/content/full/2000/1/2 (8744 words)

	MedlinePlus Drug Information: Hydroxyurea
		Hydroxyurea is in a class of drugs known as urea derivatives; it slows or stops the growth of cancer cells in your body.
		In sickle cell anemia, hydroxyurea decreases the episodes of painful crisis by decreasing the sickling of red blood cells.
		Keep hydroxyurea in the container it came in, tightly closed, and out of reach of children.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a682004.html (602 words)

	Hydroxyurea (HU) is a cytotoxic agent... (Site not responding. Last check: 2007-10-20)
		Hydroxyurea (HU) is a cytotoxic agent used in myeloproliferative disorders.
		Hydroxyurea has been used for a very long time for myeloproliferative disorders, especially chronic myelogenous leukemia.
		The dermatological changes that complicate hydroxyurea therapy have been reported in 10-15 percent of the cases in different studies.
	www.indegene.com /Int/ClinRound/indIntCase15.html (372 words)

	Droxia (hydroxyurea): a complete guide from AIDSmeds.com
		Because the use of hydroxyurea for the treatment of HIV infection is considered to be experimental, it is very important that you work closely with a healthcare provider familiar with the potential benefits and side effects of this drug.
		Hydroxyurea is in the FDA pregnancy category D. This means that hydroxyurea will harm an unborn baby.
		Caution should be used when combining hydroxyurea with other medications known to cause bone-marrow toxicity, such as decreased white blood cells, decreased red blood cells, and decreased platelets.
	www.aidsmeds.com /drugs/Droxia.htm (1132 words)

	Sustained long-term hematologic efficacy of hydroxyurea at maximum tolerated dose in children with sickle cell disease ...
		Sustained long-term hematologic efficacy of hydroxyurea at maximum tolerated dose in children with sickle cell disease -- Zimmerman et al.
		Hydroxyurea as an alternative to blood transfusions for the prevention of recurrent stroke in children with sickle cell disease.
		Hydroxyurea therapy for pediatric patients with hemoglobin SC disease.
	www.bloodjournal.org /cgi/content/full/103/6/2039 (4587 words)

	AIDS Medical Glossary: hydroxyurea (Site not responding. Last check: 2007-10-20)
		In some patients, hydroxyurea may also cause temporary reduction of kidney function, and a transient elevation of some liver enzymes, with fever and chills.
		Hydroxyurea therapy requires close supervision by a physician, with regular blood, kidney and liver function testing throughout treatment.
		However, patients interested in taking hydroxyurea should always seek their doctor's input for the most current information on dosage for this sometimes toxic drug.
	www.critpath.org /aric/gloss/body/hydroxyurea.htm (385 words)

	Hydroxyurea (Site not responding. Last check: 2007-10-20)
		Hydroxyurea is a capsule that it taken by mouth once a day.
		The most common side effects of hydroxyurea are diarrhea, drowsiness, loss of appetite, nausea, vomiting, and rash.
		It is important that you tell the clinic staff about any side effect you have while taking hydroxyurea, even if you don't think the problem is caused by the drug.
	www2.mc.duke.edu /aids/educate/hydroxy.html (309 words)

	Arch Dermatol -- Abstract: Cutaneous Adverse Reactions to Hydroxyurea in Patients With Sickle Cell Disease, April 2001, ...
		Arch Dermatol -- Abstract: Cutaneous Adverse Reactions to Hydroxyurea in Patients With Sickle Cell Disease, April 2001, Chaine et al.
		with hydroxyurea at one institution were examined by a dermatologist.
		Hydroxyurea was given for a mean of 3.04 years (range, 0.42-6.5
	archderm.ama-assn.org /cgi/content/abstract/137/4/467 (227 words)

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