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Topic: Hyperforin

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Hypericin

Serotonin

Flavonoid

Cytochrome p450

Endoplasmic reticulum

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	Hyperforin - Hyperforin is the antibiotic in St. John Wort.
		Hyperforin - Hyperforin is the antibiotic in St. John Wort.
		Hyperforin acts as a "reuptake inhibitor" and increases the levels of these neurotransmitters in the brain, which further improves mood and restore emotional balance.
		Hyperforin also inhibits the reuptake of GABA which is a neurotransmitter associated with increasing relaxation and reducing anxiety.
	www.depression-guide.com /hyperforin.htm (645 words)

	Hypericum Buyers Club
		The phloroglucinol derivative hyperforin has been recently shown to be a major antidepressant component in the extract of Hypericum perforatum.
		The uptake inhibition by hyperforin does not involve specific binding sites at the transporter molecules; its mechanism of action seems to be related to sodium conductive pathways, leading to an elevation in intracellular Na(+) concentration.
		Hyperforin seems to be responsible for the induction of liver cytochrome oxidase enzymes and intestinal P-glycoprotein.
	www.hbcprotocols.com /sjw-hyperforin2.html (315 words)

	AMORYN - Hyperforin - Standardized St. John's Wort Extract with 5% Hyperforin (Pharmaceutical-Grade) - Proven for ...
		Hyperforin also inhibits the reuptake of GABA, a neurotransmitter that increases relaxation and reduces anxiety.
		Hyperforin is not a drug, but a natural compound extracted from the St.
		Only in the past few years have researchers discovered that hyperforin is the primary compound responsible for the antidepressant effect of St. John's Wort.
	www.amoryn.com /formula_hyperforin.html (1077 words)

	Vitamins and Mineral Supplements and Herbal Supplements for your Health
		Hyperforin appears to be the first compound in a new class of antidepressants with a completely novel mechanism of action.
		Hyperforin is a broad-spectrum uptake inhibitor; it inhibits the uptake of serotonin, dopamine, norepinephrine, L-glutamate, and GABA and raises the extraneuronal concentrations of all of these substances, with the exception of GABA.
		Hyperforin is a broad-spectrum inhibitor of neurotransmitter uptake with a novel mechanism of action.
	www.herbalgram.org /naturemade/herbclip/review.asp?i=43444 (773 words)

	Hyperforin - Wikipedia, the free encyclopedia
		Hyperforin is one of the principal constituents identified in St John's wort.
		Hyperforin is a prenylated phloroglucinol believed to be the main active constituent responsible for its antidepressant effects.
		Hyperforin as a possible antidepressant component of hypericum extracts.
	en.wikipedia.org /wiki/Hyperforin (155 words)

	HYPERFORIN- A NATURAL PRODUCT WITH ANTIDEPRESSANT ACTIVITY, by Samir Malhotra and Amrit Pal Singh
		Hyperforin is a structurally novel anti-depressant isolated from Hypericum perforatum commonly known as St.John’s Wort.Hyperforin belong to group of compound known as acylphloroglucinols.
		The peculiarity of Hyperforin is that it is chemically unrelated to synthetic antidepressants.
		Hyperforin is photo and oxygen labile compound that is highly unstable and difficult to isolate in pure form.
	www.selfgrowth.com /articles/Malhotra1.html (1166 words)

	[No title]
		Hyperforin is a component in SJW that is thought by some to be essential for its antidepressant activity and is often standardized in some commercial SJW extracts to levels of 3-5%.
		Hyperforin is reported to enhance cytochrome P450 (CYP3A4) enzymes and the P-glycoprotein transporter, which are responsible for drug absorption and metabolism.
		The low hyperforin SJW formulation from the Swiss company Zeller (Ze 117) has also been shown to lack interaction with drugs that are substrates of P450 enzymes and P-glycoprotein transporters.
	www.herbalgram.org /youngliving/herbclip/review.asp?i=44133 (673 words)

	ThirdAge: St. John's Wort
		Hyperforin was first identified as a constituent of Hypericum perforatum in 1971 by Russian researchers, but it was incorrectly believed to be too unstable to play a major role in the herb's action.
		Hyperforin represents the neurotransmitter reuptake inhibiting constituent of hypericum extract.
		John's wort in mild to moderate depression: the relevance of hyperforin for the clinical efficacy.
	www.thirdage.com /healthgate/files/31050.html (5286 words)

	Hyperforin
		The recent availability of hyperforin in quantity and sufficient purity allowed investigations to the range of antibacterial activity.
		Preliminary tests indicate that hyperforin may be suitable to be orally administered in addition to local treatment of skin lesions.
		The structure of hyperforin is derived from phloroglucinol which is expanded into a bicyclo [3,3,1] nonaendionol, substituted with several lipophilic isoprene chains.
	www.biologie.uni-hamburg.de /lehre/bza/molnews/hyperforin/hyperf.htm (149 words)

	St. John's Wort - MUST READ INFO
		One of the active ingredients of St John's wort, the phloroglucin-derivative hyperforin, is a natural antibiotic that inhibits the growth of several Gram-positive bacteria.
		Instead, the treatment of cells with hyperforin induced a rapid release of cytochrome c from the mitochondria (the release of cytochrome c is essential for the initiation of mitochondria-mediated apoptosis).
		Hyperforin, however, appears to fulfill several prerequisites for a good drug candidate: (1) it seems to have activity against a wide spectrum of cancer cells, (2) it has little or no toxicity, and (3) it can be easily obtained in large quantities from St John's wort which is abundant throughout the world.
	www.annieappleseedproject.org /stjohworfigc.html (592 words)

	Hypericum Buyers Club (Site not responding. Last check: 2007-10-22)
		Hyperforin is one of the key phytochemical actives found in St. John's Wort.
		Clinical trials show that hyperforin taken over a period of 2 - 6 weeks can help to improve the function of neurotransmitters like serotonin, which are closely linked to feelings of anxiety.
		Moreover, pesticides are rampant and it is Xrayed at strategic points for Give the difficultiy of harvesting a high hyperforin extract at this time (Winter of 2005) there is a world paucity of research-grade rawmaterial high in hyperforin.
	www.hbcprotocols.com /hyperforin2.html (413 words)

	Depression - Herbal Remedies, Symptoms, Types and Natural Remedies (Site not responding. Last check: 2007-10-22)
		The finding that hyperforin is one of the main active components of St. John's Wort is so significant that Pharmacopsychiatry, a prestigious German journal of clinical pharmacology and psychiatry, recently devoted an entire supplemental issue to hyperforin.
		Scientists hypothesize that this is physical evidence that hyperforin is inhibiting the re-uptake of seratonin, noradrenaline and dopamine.
		Hyperforin is an extremely fragile compound that typically degrades rapidly.
	www.depressionremedy.com /article.php?sid=10 (1578 words)

	HealthWWWeb (Site not responding. Last check: 2007-10-22)
		Using this method, plasma levels of hyperforin could be followed for up to 24 h in healthy volunteers after administration of film coated tablets containing 300 mg hypericum extracts representing 14.8 mg hyperforin.
		Assuming that the effects of hyperforin were due to its actions on serotoninergic 5-HT3/5-HT4 receptors, further studies were conducted to investigate its effects on the CNS.
		In both verum groups (0.5% and 5.0% hyperforin content), reproducible central pharmacodynamic effects were apparent in comparison to placebo, in particular with the extract containing 5.0% of hyperforin.
	www.healthwwweb.com /herbmed/hypericum.html (3102 words)

	Hyperforin : by Ray Sahelian, M.D., hyperforin and depression
		Hyperforin plasma level as a marker of treatment adherence in the National Institutes of Health Hypericum Depression Trial.
		Samples from the placebo and H. perforatum groups were assayed for hyperforin, and samples from the sertraline group for sertraline/N-desmethyl-sertraline.
		They are uniquely standardized to hyperforin, the key constituent within St. John's Wort responsible for its mood balancing effect.
	www.raysahelian.com /hyperforin.html (706 words)

	Herb World News Online · Research Reviews
		During the course of the randomized, double-blind study, subjects received six weeks of treatment with either placebo, the 5 percent hyperforin extract at a daily dose of 300 mg, or the 0.5 percent hyperforin extract at a daily dose of 300 mg.
		According to the results, the 5 percent hyperforin extract was significantly more effective than placebo in alleviating symptoms of depression.
		The investigators concluded that the Hypericum extract standardized to 5 percent hyperforin was "an effective option in the treatment of mildly or moderately depressed patients, which avoids the well-known side effects of other antidepressant agents like tricyclics or SSRIs" as well as the abuse potential of benzodiazepine drugs.
	www.herbs.org /current/stjefficacy.html (409 words)

	Hyperforin, a Major Antidepressant Constituent of St. John's Wort, Inhibits Serotonin Uptake by Elevating Free ...
		Hyperforin, a Major Antidepressant Constituent of St. John's Wort, Inhibits Serotonin Uptake by Elevating Free Intracellular Na+1 1 -- Singer et al.
		Biber A, Fischer H, Römer A and Chatterjee SS (1998) Oral bioavailability of hyperforin from hypericum extracts in rats and human volunteers.
		Kaehler ST, Sinner C, Chatterjee SS and Philippu A (1999) Hyperforin enhances the release of catecholamines, serotonin and glutamate in the rat locus coeruleus.
	jpet.aspetjournals.org /cgi/content/full/290/3/1363 (3784 words)

	Display Issue
		Because of the unstable nature of hyperforin, it was previously assumed that extracts contained only minimal amounts of this compound.
		However with the recent emergence of data highlighting the role of hyperforin in St. John's wort, Indena has analysed batches (new as well as stored samples from previous batches) of St. John's wort extract for hyperforin content.
		The hyperforin content was determined by HPLC and found to consistently range between 4 and 6%.
	www.botanicalpathways.com /issue07/Stjohnsel.html (282 words)

	Herb World News Online · Science
		Hyperforin may be the main antidepressant constituent of St. John's wort
		This study tested hyperforin, the major component of the oily extract and a component of the hydroalcoholic extract as well.
		Hypericin and kaempferol, a flavonoid present in hypericum extract, failed to show any such activity, leading to the conclusion that hyperforin is the main anti-depressant compound.
	www.herbs.org /current/stjhype.html (184 words)

	Dual Modulation of Striatal Acetylcholine Release by Hyperforin, a Constituent of St. John's Wort -- Buchholzer et al. ...
		Chatterjee SS, Biber A and Weibezahn C (2001) Stimulation of glutamate, aspartate and gamma-aminobutyric acid release from synaptosomes by hyperforin.
		Chi JD and Franklin M (1999) Measurement of hyperforin a constituent of St. John's wort in plasma by high-performance liquid chromatography.
		Kaehler ST, Sinner C, Chatterjee SS and Philippu A (1999) Hyperforin enhances the extracellular concentrations of catecholamines, serotonin and glutamate in the rat locus coeruleus.
	jpet.aspetjournals.org /cgi/content/full/301/2/714 (3483 words)

	RemedyFind: patient ratings of St. Johnâs Wort (Hypericum perforatum) for Hepatitis C (Site not responding. Last check: 2007-10-22)
		Recent studies have suggested that hyperforin is the primary bioactive ingredient responsible for the anti-depressive effects of the herb, and that it inhibits the reuptake of the neurotransmitters norepinephrine, serotonin, and dopamine in ways similar to synthetic antidepressants.
		Furthermore, it has been suggested in preclinical and clinical studies that the content of hyperforin but not of hypericin decisively contributes to the antidepressant efficacy of hypericum extracts.
		Hyperforin has been demonstrated in biochemical investigations--like synthetic antidepressants--to inhibit the reuptake of the neurotransmitters norepinephrine, serotonin, and dopamine.
	www.remedyfind.com /treatments/51/645 (1158 words)

	Hyperforin Contributes to the Hepatic CYP3A-Inducing Effect of Hypericum perforatum Extract in the Mouse -- Cantoni et ...
		Hyperforin Contributes to the Hepatic CYP3A-Inducing Effect of Hypericum perforatum Extract in the Mouse -- Cantoni et al.
		Hyperforin Contributes to the Hepatic CYP3A-Inducing Effect of Hypericum perforatum Extract in the Mouse
		Mice were treated orally with the vehicle or SJW extract (300 mg/kg suspended in 1.6% carboxymethylcellulose in water) or with hyperforin DCHA (18.1 or 36.2 mg/kg in 4% Tween 80 in water) twice daily for 3 days.
	toxsci.oxfordjournals.org /cgi/content/full/75/1/25 (3671 words)

	AMORYN - Hyperforin vs. Paxil® (Paroxetine) - Clinically-Proven Natural Antidepressant
		At the end of the trial, the results showed the clear superiority of hyperforin over paroxetine (Paxil®) as a treatment for severe depression After six weeks of treatment, symptoms of depression were reduced by 57% in the group taking hyperforin versus 45% in the paroxetine group, a statistically significant difference.
		A greater percentage of people taking hyperforin (71% vs. 60%) experienced a positive response to treatment (defined as at least a 50% reduction in symptoms of depression).
		More importantly, AMORYN's pharmaceutical-grade SJW extract is standardized to contain a minimum of 3-5% hyperforin (yielding 22.5mg hyperforin per capsule), ensuring that AMORYN delivers doses of hyperforin similar to those in this trial.
	www.amoryn.com /tg_paxil.html (952 words)

	Topical application of St John's wort
		Topical application of St John's wort (Hypericum perforatum L.) and of its metabolite hyperforin inhibits the allostimulatory capacity of epidermal cells.
		The characteristic metabolites of St John's wort are the photodynamic active plant pigment hypericin and the phloroglucin- derivative hyperforin.
		Subsequently, we tested purified hyperforin in vivo and in vitro in a MECLR to evaluate its possible contribution to the effect of the Hypericum ointment.
	www.prostatitis.org /stjohnswortscience.html (1070 words)

	St. John's Wort and Hyperforin - The Science and Pharmacology of St. Johns Wort, Hypericin, Hyperforin and Ad-hyperforin
		Recent scientific research indicates that Hyperforin Extract, whether it is standardized to 3.0%, 5.0% or 10.0%, is highly unstable.
		Further study concluded that regardless of the particular standardization amount, Hyperforin extracts decreased to their naturally occurring level of 3.0%~4.0% concentration or less in all cases.
		Pharmacological analysis illustrates that Hyperforin clearly exhibits a broad spectrum effect on the Serotonergic, Dopaminergic, Noradrenic and GABA-ergic systems, but its action on the brain’s 5-HIAA and 5-FIT levels appears to be significantly different from the action of traditional 5-HT re-uptake blockers.
	www.clarocet.com /referencelibrary/hypericum/science.htm (497 words)

	JCE 2004 (81) 1450 [Oct] Chemistry of St. John's Wort: Hypericin and Hyperforin
		For use as antidepressant, St. John's wort is standardized to the content of hypericin, but this molecule was recently found not to be the active ingredient.
		A totally different bicyclic molecule with complex substitution pattern, hyperforin, was then studied as the causative agent.
		Hyperforin was found to activate a particular receptor in the liver that induces the production of an enzyme used for the metabolism of medications.
	jchemed.chem.wisc.edu /journal/Issues/2004/Oct/abs1450.html (332 words)

	Stress and Anxiety Relief
		Hyperforin is derived from St. Johns Wort and may be partly responsible for St. John's Worts positive health benefit.
		Clinical studies show that Hyperforin may help to influence the availability of neurotransmitters like serotonin and norepinephrine, it's anti-depressive benefits are said to be most effective after a period of 4-6 weeks of regular use.
		John's Wort is commonly used to alleviate depression and mood swings and is taken regularly by over 5 million people in the USA alone.
	www.probiogh.com /probiocf.htm (329 words)

	Tuesday
		Hyperforin, the active component of St. John's wort, induces IL-8 expression in human intestinal epithelial cells via a MAPK-dependent, NF-kappa B-independent pathway
		Stimulation of hippocampal acetylcholine release by hyperforin, a constituent of St.
		Aristoforin, a novel stable derivative of hyperforin, is a potent anticancer agent
	home.wlu.edu /~hawsb/bio182/log.html (1733 words)

	Hypericin- A Napthodianthrone from Hypericum perforatum
		Hyperforin in comparison inhibits the neuronal uptake of serotonin, norepinephrine and dopamine antidepressants, but also inhibits GABA and L-glutamate uptake.
		Research on hyperforin has been intensified and most of the published studies strongly indicate hyperforin to be the antidepressant constituent of
		Effects of hyperforin on the fluidity of brain membranes.
	www.siu.edu /~ebl/leaflets/article.htm (796 words)

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