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| | Insulin Resistance and Hyperglycemia |
 | | Hyperglycemia with or without diabetes has been reported in 3-17% of patients and has occurred at a median of about 60 days, with a range of 2 days to more than a year, after starting therapy. |
 | | The etiology of insulin resistance and hyperglycemia in HIV-infected patients is probably multifactorial, with varying contributions from traditional risk factors (eg, obesity, family history), comorbid conditions (eg, hepatitis C virus infection), and antiretroviral-related factors (eg, direct effects of PIs, hepatic steatosis, and fat redistribution). |
 | | For hyperglycemia that is associated with the use of PIs, switching to an alternative agent (eg, a nonnucleoside reverse transcriptase inhibitor or a different PI) may be effective if the HIV treatment history and resistance profile permit. |
| aidsetc.org /aetc/aetc?page=cm-310_insulin (1218 words) |
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