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Topic: Hypocretin

	Scientific American: Feature Article: Narcolepsy: January 2000
		His research group has determined that the dogs carry a mutation in the receptor for a neurotransmitter variously called hypocretin or orexin.
		Mignot's group found that the mutation harbored by the narcoleptic dogs produces hypocretin/orexin receptors that are missing a critical part, so that they cannot respond normally to the messages they receive.
		Mutations that affect the hypocretin/orexin system might be responsible for some cases of narcolepsy in humans, but it is unlikely that most human narcoleptics have mutations in the genes responsible for synthesizing hypocretin/ orexin or its receptor.
	www.npi.ucla.edu /sleepresearch/sciam.htm (3596 words)

	Narcolepsy - Definition, Description, Demographics, Causes and symptoms, Diagnosis, Treatment, Prognosis, Prevention
		The nerve cells, or neurons, in this part of the hypothalamus secrete substances known as hypocretins or orexins, which regulate the sleep/wake cycle in humans.
		There are two of these compounds, known as orexin-A and orexin-B, or as hypocretin-1 and hypocretin-2.
		Orexin—Another name for hypocretin, a chemical secreted in the hypothalmus that regulates the sleep/wake cycle.
	www.healthofchildren.com /N-O/Narcolepsy.html (2437 words)

	Narcolepsy Information on Healthline
		Sleep lab study -- recording of observed sleep cycle including episodes of REM sleep (the part of the cycle where dreaming occurs)
		Recently, patients with narcolepsy have been found to have low levels of hypocretin (a protein made by the brain) in their spinal fluid.
		More research will determine how useful this test is in diagnosing narcolepsy.
	www.healthline.com /health/sleep/000802.html (755 words)

	TeenFX.com Interview with Michael J. Thorpy MD (Site not responding. Last check: 2007-10-31)
		Recently the cause for Narcolepsy has been discovered.
		It is due to the loss of certain cells in the brain that release a chemical called hypocretin.
		People with Narcolepsy usually do not have hypocretin.
	www.teenfx.com /interview.cfm?prod=&sec=&inter_id=12 (1740 words)

	ScienceDaily: A Link Is Found Between Morphine Addiction And The Tendency To Explore
		Research Shows Way To Boost Morphine's Pain-Killing Benefits (February 4, 2002) -- Challenging a decades-old understanding of why morphine-like drugs lose effectiveness with increased use, UCSF scientists have demonstrated in animals how morphine's potent painkilling powers can be...
		Neurotransmitter Orexin Associated With Pleasure And Reward Pathways In The Brain (August 28, 2005) -- Researchers at the University of Pennsylvania School of Medicine have discovered that the recently identified neurotransmitter orexin (also known as hypocretin) influences reward processing by...
		Antipsychotic Drug May Block Addiction, Researchers Find (February 13, 2006) -- Researchers at the University of Illinois at Chicago have discovered that a long-approved oral antipsychotic drug can stop the addictive properties of opioid painkillers in...
	www.sciencedaily.com /releases/2006/02/060221235606.htm (1913 words)

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