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Topic: Hypodontia

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	Nonsyndromic Oligodontia in Permanent Dentition
		Hypodontia is an anomaly that may result in dental malpositioning, periodontal damage, lack of development of maxillary and mandibular bone height and has significant psychological, aesthetic and functional consequences.
		Hypodontia and oligodontia are classified as isolated or non-syndromic, where as hypodontia/oligodontia and syndromic hypodontia/oligodontia or hypodontia/oligodontia are associated with syndromes.
		In familial hypodontia, the type of inheritance in the majority of families seems to be autosomal dominant with incomplete penetration and variable expressivity.
	www.ispub.com /ostia/index.php?xmlFilePath=journals/ijds/vol3n2/dentition.xml (1466 words)

	Gene expression in tooth: references (Site not responding. Last check: 2007-10-06)
		Hypodontia in twins discordant or concordant for cleft lip and/or palate.
		The aims of this study were to determine the frequency of hypodontia of permanent teeth in twins discordant or concordant for clefts in each type of cleft, to determine the concordance of hypodontia in mono- and dizygotic twins, and to compare the findings with some earlier data.
		The prevalence of hypodontia was 37% for monozygotic and 32.7% for dizygotic twins, 16.7% in the noncleft and cleft lip groups, 41.1% in the cleft palate group, and 64.3% in the cleft lip and palate group.
	bite-it.helsinki.fi /REF1785.htm (242 words)

	Gene expression in tooth, note (Site not responding. Last check: 2007-10-06)
		Prevalence of hypodontia ranges from 10% to 68% in different cleft types in Finland, being 10% in cleft lip, 33% in cleft palate, 49% in unilateral, and 68% in bilateral cleft lip and palate groups, and even higher in twins with clefts (Ranta, 1986; Laatikainen et al, 1994).
		A higher incidence of hypodontia in the maxilla has been reported, and has been suggested to be a result of the same factors as for the cleft (Ranta et al, 1988).
		Hypodontia in the mandible is more frequent in Pierre Robin patients than in that of the cleft patients (Ranta, 1986).
	bite-it.helsinki.fi /LN11.HTM (388 words)

	Witkop¹s tooth-and nail syndrome
		Hereditary hypodontia and onychorrhexis of the fingernails and toenail koilonychia: Witkop's tooth-and nail syndrome.
		The tooth-and-nail syndrome (Witkop's syndrome) is a rare autosomal dominant ectodermal dysplasia manifest by defects of the nail plates of the fingers and toes and hypodontia with normal hair and sweat gland function.
		Children with conical teeth, hypodontia or anodontia without some other readily apparent etiology should undergo a detailed examination to determine if abnormal nail plates on the fingers and toes are present.
	dermatology.cdlib.org /DOJvol5num1/case_reports/zabawski.html (865 words)

	Brazilian Dental Journal - Analysis of MMP-9 and TIMP-2 gene promoter polymorphisms in individuals with hypodontia (Site not responding. Last check: 2007-10-06)
		Hypodontia, the congenital absence of one or a few teeth, is one of the most common developmental alterations of human dentition.
		In this sense, studies that investigate possible associations between gene polymorphisms and hypodontia may help to elucidate the genetic mechanisms responsible for the variation in the frequency of tooth agenesis that occur in distinct human populations and ethnic groups (20).
		The incidence of tooth agenesis and polygenesis in the primate dentition.
	www.scielo.br /scielo.php?script=sci_arttext&pid=S0103-64402005000300011&lng=pt&nrm=iso&tlng=en (2880 words)

	A unique form of hypodontia seen in Vietnamese patients: cinical and molecular analysis -- Frazier-Bowers et al. 40 ...
		Hypodontia in the permanent dentition: a study of its prevalence in Malaysian children.
		Hypodontia of permanent teeth in a Kenyan population.
		Hypodontia in the permanent dentition: a clinical and genetic investigation.
	jmg.bmj.com /cgi/content/full/40/6/e79 (1939 words)

	College of Dentistry > Students > Orthodontics
		The purpose of this retrospective study was to compare the prevalence and severity of hypodontia in Kentucky to geographically distant Colorado.
		ANOVA and Fisher's LSD tests showed severity of hypodontia was significantly higher in University of Kentucky patients primarily due to the high degree of severity found in UKO population (3.74 missing teeth/affected individual).
		The purpose of this paper is to determine the prevalence and degree of severity of hypodontia in rural SEKA region compared to the urban central Kentucky area (UK).
	www.mc.uky.edu /dentistry/students/ortho/research.html (3661 words)

	XXVI Foro Anual de Investigacion y Educacion 2006 (Site not responding. Last check: 2007-10-06)
		Hypodontia may lead to dental malpositioning, periodontal damage and lack of development of the alveolar bone height.
		The prevalence of hypodontia in Puerto Rico (PR) is unknown.
		The aim of this study is to report the prevalence of hypodontia in PR children between 10 to 14 years of age as well as the prevalence per tooth, the differences between genders and clinics.
	foro2006.rcm.upr.edu /resu_SextO.htm (873 words)

	Recessively inherited lower incisor hypodontia -- Pirinen et al. 38 (8): 551 -- Journal of Medical Genetics
		The population prevalence of the common incisor-premolar hypodontia (IPH, MIM 106600) is 8-10% in healthy European children.
		Absence of mutations in the homeodomain of the MSX1 gene in patients with hypodontia.
		On the genetics of hypodontia and microdontia: synergism or allelism of major genes in a family with six affected members.
	jmg.bmj.com /cgi/content/full/38/8/551 (2482 words)

	Tooth Size and Morphology in Hypodontia (Site not responding. Last check: 2007-10-06)
		Hypodontia patients were divided into three groups of mild (≤2 teeth missing), moderate (3-5 teeth missing) and severe (≥6 teeth missing) hypodontia.
		Conclusions: Patients with hypodontia have smaller tooth dimensions and smaller Carabelli's cusp and hypocone.
		Tooth size appears to be affected by the degree of hypodontia, with severe hypodontia having a greater effect.
	iadr.confex.com /iadr/pef06/techprogram/abstract_83760.htm (314 words)

	Dental Branch, Hypodontia and Oligodontia
		Researchers in the D'Souza laboratory at the UTHSC-Houston Dental Branch, in collaboration with researchers at Baylor College of Medicine, have identified a gene responsible for congenitally missing teeth (teeth that never developed) in a Houston family.
		Hypodontia is characterized by the absence of six or fewer permanent teeth, while oligodontia is characterized by the absence of more than six permanent teeth.
		The researchers' efforts revealed that a mutation in the PAX9 gene was responsible for a rare form of oligodontia, missing molars, in the Houston family (published in the January 2000 issue of Nature Genetics).
	www.db.uth.tmc.edu /faculty/sfrazier (472 words)

	Shimooka,S
		Materials and Methods: A total of 50 girls with hypodontia (the total group) were selected and categorized into anterior, posterior, and anterior-posterior groups according to the location of the congenitally missing teeth.
		Introduction: The purpose of this retrospective study was to assess the prevalence and distribution of hypodontia in the permanent dentition, excluding the third molars, in a sample of Japanese orthodontic patients.
		Conclusions: The distinct characteristic of hypodontia in the Japanese population compared with other populations was a higher prevalence of both advanced hypodontia and mandibular lateral incisor agenesis in children with minor hypodontia.
	lib.bioinfo.pl /auth:Shimooka,S (1967 words)

	WSAVA 2001 - Developmental Disturbances of Teeth
		Hypodontia (one or a few teeth missing) is a common condition.
		Hypodontia in the permanent dentition is more frequent than in the primary dentition.
		Clinical importance: In hypodontia mainly cosmetic, differentiation between possible hereditary and proven traumatic causes is important for breeding dogs.
	www.vin.com /VINDBPub/SearchPB/Proceedings/PR05000/PR00070.htm (1443 words)

	IngentaConnect Tooth dimensions in hypodontia patients, their unaffected relativ...
		Tooth dimensions were compared between index patients with severe hypodontia (six or more congenitally missing teeth), their relatives with a full complement of teeth, and a control group.
		In the relatives without hypodontia compared with the control group, mesiodistal dimensions from the buccal view were significantly smaller (P < 0.001) for the central incisors and maxillary first and second premolars, and for the maxillary and mandibular first premolars for all dimensions from the occlusal view.
		The tooth dimensions of the relatives without hypodontia also tended to be smaller than the control group, but were larger than those of the index cases.
	www.ingentaconnect.com /content/oup/eortho/2002/00000024/00000002/art00131 (305 words)

	The interdisciplinary management of hypodontia: restorative dentistry
		The paper describes the general restorative considerations common to patients with hypodontia and illustrates the variety of restorative techniques available in the restorative management of hypodontia and oligodontia.
		The treatment options available for the management of young hypodontia patients are essentially those available for the replacement of missing teeth in adults and will include removable partial dentures, conventional and adhesive bridges and implant supported prostheses.
		This is commonly the case for patients with severe hypodontia where the use of simple mucosal borne and overlay partial dentures to replace teeth and restore occlusal face height can effect a considerable improvement to appearance and function (Fig.
	www.nature.com /bdj/journal/v194/n6/full/4809940a.html (5025 words)

	CIGNA - Anodontia
		Anodontia is a genetic disorder commonly defined as the absence of all teeth, and is extremely rarely encountered in a pure form without any associated abnormalities.
		Hypodontia is genetic in origin and usually involves the absence of from 1 to 6 teeth.
		If only front teeth are missing, in hypodontia or oligodontia, a flexible system allowing slight movement of a bridge can be created by bonding an acrylic tooth to the supporting structure (abutments) by means of three orthodontic wires.
	www.cigna.com /healthinfo/nord510.html (1625 words)

	Characteristics of incisor-premolar hypodontia in families -- Arte et al. 80 (5): 1445 -- Journal of Dental Research
		Characteristics of incisor-premolar hypodontia in families -- Arte et al.
		Nonsyndromic tooth agenesis is a genetically and phenotypically
		incisor-premolar hypodontia is a genetic condition with autosomal-dominant
	jdr.iadrjournals.org /cgi/content/abstract/80/5/1445 (273 words)

	Government and academic resources on Hypodontia
		...is to identify gene(s) underlying various forms of inherited hypodontia.
		...in autosomal recessive hypodontia (tooth malformations) to chromosome 16,
		Hypodontia is a term used by British dentists.
	books.mongabay.com /health/conditions/Hypodontia.html (298 words)

	Genetic Mutations in Certain Head and Neck Conditions of Interest to the Dentist
		Hypodontia is a condition in which the affected individual develops fewer than the normal complement of teeth.
		21,384 children ages 12 to 18 were examined for general signs of hypodontia and then specifically for hypodontia of the maxillary lateral incisors, the second premolars and the mandibular incisors.
		The prevalence of any type of hypodontia in the general population was 4.61%, and there was no significant difference between males and females in the sample.
	www.cda-adc.ca /jcda/vol-67/issue-10/594.html (4341 words)

	Gene expression in tooth: references (Site not responding. Last check: 2007-10-06)
		Fifty- two patients met inclusion criteria into the comparison study in which the prevalence of hypodontia was compared with a group of patients from the Department of Orthodontics at Harvard School of Dental Medicine.
		A Fisher's exact test was conducted to test the hypothesis that HFM patients have a greater prevalence of missing teeth than individuals without the anomaly.
		A chi-square test for trend was conducted to determine whether hypodontia was more prevalent with increasing severity of the mandibular deformity in HFM.
	bite-it.helsinki.fi /REF1804.htm (208 words)

	eMedicine - van der Woude Syndrome : Article Excerpt by: Gregory P Conners, MD, MPH, MBA (Site not responding. Last check: 2007-10-06)
		Hypodontia (absent teeth) has been increasingly recognized as a frequently associated anomaly.
		Lip pits often are associated with accessory salivary glands that empty into the pits, sometimes leading to embarrassing visible discharge.
		Hypodontia is present in 10-81% of affected patients.
	www.emedicine.com /ped/byname/van-der-woude-syndrome.htm (392 words)

	Unbound MEDLINE \| Mandibular morphology and growth with and without hypodontia in subjects with Pierre Robin sequence. ...
		The hypothesis of this study is that the morphology of the mandible in subjects with PRS and mandibular hypodontia is different from that in subjects with PRS but without mandibular hypodontia.
		RESULTS: Cephalometric measurements were smaller in the group with mandibular hypodontia at T1: mandibular length (3.36 mm, P =.04), ramal length (2.78 mm, P =.04), posterior facial height (3.97 mm, P =.03), and mandibular molar eruption (1.96 mm, P =.02).
		Comparison of growth increments between the 2 groups from T1 to T2 showed a greater cranial base deflection increment in the group with mandibular hypodontia (0.88 degrees, P =.02) and a larger posterior facial height increment in the group without mandibular hypodontia (2.02 mm, P =.04).
	www.unboundmedicine.com /medline/ebm/record/16849070/abstract/Mandibular_morphology_and_growth_with_and_without_hypodontia_in_subjects_with_Pierre_Robin_sequence (420 words)

	International Conference on the Management of Ectodermal Dysplasia and Severe Hypodontia
		A clinic for the multidisciplinary management of hypodontia was established at the Eastman Dental Hospital in 1977; this paper describes its operation, the characteristics of its patients and the treatment procedures which have been carried out over its first 27 years.
		Most have severe hypodontia (oligodontia), however few have specific complaints relating to their missing teeth; those that do are usually concerned about their appearance.
		Ideally the diagnosis and treatment should be centralized to resource centres with knowledge and experience of diagnosis and planning of oral habilitation in hypodontia.
	www.eastman.ucl.ac.uk /ect04/ect04Abstracts.html (1301 words)

	Prevalence and Severity of Hypodontia in Western Kentucky (Site not responding. Last check: 2007-10-06)
		Objectives: To determine the prevalence and severity of hypodontia in the western Kentucky (WK) region in comparison to urban central Kentucky (UK), rural southeastern Kentucky Appalachia (SEKA) and previous USA studies.
		The prevalence of hypodontia was WKO=10.86%, WKP=8%, UKO=13.33%, UKP=7.94%, SEKA orthodontic=11.11% and SEKA pediatric dentistry=10.16%.
		Conclusions: This study demonstrated the average prevalence of hypodontia in Western Kentucky (9.4%) is similar to other parts of the state, and high compared to most US hypodontia prevalence studies.
	iadr.confex.com /iadr/2004Hawaii/techprogram/abstract_43892.htm (338 words)

	Press Release: Multidisciplinary Management of Hypodontia for GDPs
		The Eastman Hypodontia Clinic was established 30 years ago, and members have extensive experience of the management of the condition.
		They will be presenting this study day on the multidisciplinary management of Hypodontia especially tailored for general dental practitioners.
		Appreciate the care pathway for patients suffering from hypodontia and understand the role of the GDP in patient management
	www.eastman.ucl.ac.uk /cpd/press_releases/hypodontiaAugust06.html (251 words)

	IGM
		The lack of teeth, primary or permanent, is an important public health concern predisposing to malnutrition and secondary infections, and is of high clinical relevance.
		We are continuing to identify additional families segregating specific classes of non-syndromic hypodontia of unknown etiology and will identify the gene(s) underlying hypodontia by genome-wide linkage analysis, candidate gene identification and mutation analysis.
		Towards understanding the pathophysiology of various movement disorders, we are identifying the underlying genes, with the long-term goal of studying the regulation of these genes in the normal and disease state and to develop treatment regimens based on these findings.
	www.usc.edu /schools/medicine/research/institutes/igm/face.php?C=patel (660 words)

	ORPHANET - About rare diseases - About orphan drugs
		Congenital lack of one or more teeth is a common anomaly in man. Lack of one or a few permanent teeth, hypodontia, without any systemic disorders is the mildest and most common phenotype.
		Family studies show that, as an isolated form, both hypodontia and oligodontia are inherited as an autosomal dominant trait with incomplete penetrance and variable expression.
		It is evident that both hypodontia and oligodontia are genetically heterogeneous traits.
	www.orpha.net /consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=2227 (265 words)

	BDJ \| The interdisciplinary management of hypodontia
		This second paper in the series on hypodontia considers the role of restorative dentistry in the management of this condition.
		The paper describes the general restorative considerations common to patients with hypodontia and illustrates the variety of restorative techniques available.
		This paper describes the role of oral surgery in the management of children and adolescents with hypodontia.
	www.nature.com /bdj/series/hypodontia (291 words)

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