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Topic: Hypolipidaemic agent

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Statin

Pharmacology

Hyperlipidemia

Competitive inhibitor

	Gugulipid (Gum Guggul): Nature's Safe, Effective Cholesterol-Lowering Supplement
		It has been used for many years as a hypocholesterolemic agent in India, where it is has received prescription drug status, due to its high level of efficacy as determined by clinical trials.
		A promising hypolipidaemic agent from gum guggul (Commiphora Wightii).
		Guggulipid: a promising hypolipidemic agent from gum guggul (commiphora wightii).
	www.chiroweb.com /archives/21/10/13.html (1321 words)

	Supplement Update: Guggulipid
		One study entitled Clinical Trials On Guggulipid: A Hypolipidaemic Agent published in The Journal of Association of Physicians in India in 1989 (2) showed that guggulipid had a very strong effect in decreasing triglycerides (fats) as well as LDL (bad cholesterol) levels while increasing HDL (good cholesterol) levels in human subjects.
		A new hypolipidaemic agent," J Assoc Physicians India 37.5 (1989): 323-328.
		Agarwal, et al., " Clinical trials of gugulipid—a new hypolipidemic agent of plant origin in primary hyperlipidemia," Indian J Med Res 84 (1986): 626-634.
	www.thinkmuscle.com /articles/jalali/guggulipids.htm (540 words)

	Guggul Commiphora - Research, abstracts, studies
		The decrease in serum cholesterol is associated with enhanced uptake of LDL by the liver through receptor mediated endocytosis, located on the surface of the cell membrane.
		Anti-inflammatory agents such as phenylbutazone, ibuprofen and fraction "A" of gum-guggual from Commiphora mukkul were administered orally at a daily dose of 100, 100 and 500 mg/kg, respectively, for a period of five months.
		Myrrhanol A is a plausible candidate for a potent anti-inflammatory agent.
	www.guggul.net /show/guggul-research (3534 words)

	Cardiovascular (Site not responding. Last check: 2007-09-30)
		Gemfibrozil usually increases the HDL-cholesterol fraction in healthy individuals and in patients with hyperlipoproteinemia, an action that may be beneficial in slowing the progression of atherosclerosis and in reducing the risk of coronary heart disease.
		is used as a hypolipidaemic agent in conjunction with dietary modification.
		Its anti-anginal effect is based on the dilation of the coronary arteries; it reduces the peripheral vascular resistance, and is an antiarrhythmic agent for dysrhythmias of atrial and ventricular origin.
	www.beximco-pharma.com /product/Cardiovascular.asp (1987 words)

	>Conditions We Treat \| NYU Oncology Division
		Recently, guggul has been promoted as a weight-loss agent.
		However, there is little evidence that guggul actually affects the thyroid, and one small double-blind, placebo-controlled trial failed to find it effective for weight loss.
		Clinical trial of gugulipid—a new hyperlipidemic agent of plant origin in primary hyperlipidemia.
	www.med.nyu.edu /medicine/oncology/patient/conditions/article.html?ChunkIID=21773 (911 words)

	Cholesterol Reduction Page 4 (Site not responding. Last check: 2007-09-30)
		Nicotinic acid appears to be an effective agent for an isolated low HDL-C. A large clinical trial evaluating the effect of treating an isolated low HDL-C for primary and secondary prevention of coronary events is needed.
		Unfortunately, the side effect profile of this agent warrants its use only in patients with marked dyslipidemia in whom side effects and potential toxicity are closely monitored.
		The effects of curcumin, an anti-inflammatory agent from Curcuma longa, on the proliferation of blood mononuclear cells and vascular smooth muscle cells were studied.
	www.lef.org /protocols/abstracts/abstr-032c.html (10764 words)

	Hypolipidaemic compositions - Patent 4080474
		A composition according to claim 7 wherein the active hypolipidaemic ingredient is a compound of the formula: ##STR16## and R.sup.1, R.sup.6, R.sup.7 and q are as defined in claim 7.
		A composition according to claim 7 wherein the active hypolipidaemic ingredient is a compound of the formula: ##STR17## and R.sup.1, Z and R.sup.6 are as defined in claim 34, r is an integer from 1 to 12 and R.sup.8 is lower alkyl.
		For a compound to have maximum potential as a hypolipidaemic agent, it must significantly decrease serum lipid levels and have little or no effect on growth, liver weight and liver lipid.
	www.freepatentsonline.com /4080474.html (5068 words)

	Bulk Nutrition - Guggulsterones Guide by David Tolson
		Two constituents of guggul, guggulsterones E and Z, have been identified as primarily responsible for its hypolipidemic properties, although these are definitely not the only active constituents in guggulipid (8, 9).
		The compound primarily responsible for the anti-inflammatory properties of guggul is myrrhanol A, which is found in the acidic fraction of the extract (1, 8).
		Since these are the primary hypolipidemic agents, it is probable that they are also primarily responsible for some of guggul's other effects.
	www.bulknutrition.com /?ingredients_id=3 (1561 words)

	Technical Report No. 24 (Site not responding. Last check: 2007-09-30)
		As this growth depends on continued administration of a peroxisomal proliferating agent, it is not an inherent property of the preneoplastic cells.
		The purpose of a short-term biological marker is to identify the potential carcinogenic nature of an agent and not necessarily to serve as a quantitative indicator of carcinogenicity.
		-oxidation and peroxisome proliferation in the liver of rhesus monkeys by DL-040, a new hypolipidemic agent.
	monographs.iarc.fr /htdocs/iarcpubs/techrep24/consensus.html (7586 words)

	Welcome to The Supplement Research Foundation
		One study entitled Clinical Trials On Guggulipid: A Hypolipidaemic Agent published in The Journal of Association of Physicians in India in 1989 (3) showed that guggulipid had a very strong effect in decreasing triglycerides (fats) as well as LDL (bad cholesterol) levels while increasing HDL (good cholesterol) levels in human subjects.
		A new hypolipidaemic agent,” J Assoc Physicians India 37.5 (1989): 323-328.
		Agarwal, et al., “ Clinical trials of gugulipid—a new hypolipidemic agent of plant origin in primary hyperlipidemia,” Indian J Med Res 84 (1986): 626-634.
	www.tsrf.com /articles/article_obesity.htm (1060 words)

	Guggul - Bodybuilding Supplements - Nutritional Supplements - Sports Supplements (Site not responding. Last check: 2007-09-30)
		Anti-inflammatory - Guggulipid is a potent anti-inflammatory agent, as evidenced by many studies done on individuals with arthritis (8, 9, 10).
		The compound primarily responsible for the anti-inflammatory properties of guggul is myrrhanol A, which is found in the acidic fraction of the extract (1, 8).
		Since these are the primary hypolipidemic agents, it is probable that they are also primarily responsible for some of guggul's other effects.
	www.ironmaglabs.com /articles_guggul.html (1447 words)

	Ancient-Modern Concordance in Ayurvedic Plants: Some Examples (Site not responding. Last check: 2007-09-30)
		These drugs include several anticancer agents such as podophyllotoxin, paclitaxel, camptothecin, or compounds based on these as lead structures; each of these classes of compounds exhibit their anticancer activity by distinct mechanisms (3).
		Thus, plant-based therapeutic agents continue to have scientific, social, and commercial significance and appear to be gathering a momentum in health-relevant areas.
		Guggulipid: a promising hypolipidaemic agent from gum guggul (Commiphora mukul).
	www.ehponline.org /members/1999/107p783-789dev/dev-full.html (5247 words)

	CHOLEST (Site not responding. Last check: 2007-09-30)
		The Guggulsterone Z and E, the active components of the resin, are believed to be responsible for both the cholesterol and triglyceride lowering effect of gugulipides.
		In the medical tradition the active component of red yeast, Lovastatin, is considered to be an effective cholesterol-lowering agent.
		Plant sterols as cholesterol-lowering agents: Clinical trials in patients with hypercholesterolemia and studies of sterol balance.
	vitazanpro.com /id13.html (672 words)

	Managing Cholesterol: Naturally (Site not responding. Last check: 2007-09-30)
		The role of nicotinic acid and inositol hexaniacinate as anticholesterolemic and antilipemic agents.
		Maggi G, Donati C, and Criscuoli G. Pantethine: a physiological lipomodulating agent, in the treatment of hyperlipidemias.
		Silagy C and Neil A. Garlic as a lipid lowering agent- a meta-analysis.
	www.iprogressivemed.com /thestandard/cholesterol.html (3391 words)

	Curcuma longa
		Ethnobotany of India brought attention to Commiphora (used as a hypolipidaemic agent), Picrorhiza (hepatoprotective), Bacopa (used as a brain tonic), Curcuma (antiinflammatory) and Asclepias (cardiotonic) Jain 1994
		Curcumin was an effective radioprotective agent which had inhibitory effect on formation of urinary 8-hydroxy-2'-deoxyguanosine, tumorigenesis but did not protect mortality induced by exposure to radiation in female rats.
		Curcumin, a yellow colouring agent from turmeric has been shown to inhibit tumor formation in diverse animal models and diarylheptanoids which are structurally related to curcumin obtained from Alpinia oxyphylla also had Anti-tumor promoting potential.
	www.herbmed.org /herbs/herb9.htm (6131 words)

	Applied Health Gugulipid
		It is also better than all of these agents at boosting HDL cholesterol by up to 16%.
		Agarwal, RC et al., Clinical trial of gugulipid a new hypolipidemic agent of plant origin in primary hyperlipidmia.
		Satyavati, GV: Gugulipid: a promising hypolipidaemic agent from gum guggul (Commiphora wightii).
	www.appliedhealth.com /nutri/page7047.php (853 words)

	Principles of Pediatric Dermatology - Chapter 33 : PSORIASIS
		Although sunlight is generally beneficial, a small minority of cases of psoriasis is provoked by strong flares up during summer time on the sun exposed areas.
		Lithium, beta-adrenergic blocking agents, practolol, Clonidine, potassium iodide, amiodarone, digoxin, the antidepressants, trazodone, hypolipidaemic agent, penicillin, terfenadine, antimalarials may be complicated by psoriasiform drug reaction.
		This drug may be the treatment of choice for retinoid-resistant, AIDS-associated psoriasis, as agents such as methotrexate, Cyclosporin, PUVA and possibly even topical steroids may be contra-indicated.
	www.drmhijazy.com /english/chapters/chapter33.htm (3651 words)

	Hypothyroidism - Mild
		The lipid lowering effects continue after discontinuation of therapy and has been reported in a range of 6 to20 weeks to return time to baseline lipid profile (6).
		Recent studies have shown that these compounds are antagonist ligands for the bile acid receptor farnesoid X receptor (FXR), which regulates bile acid production in the liver.
		Bladderwrack is a seaweed found attached to rocks along the coasts of the North Atlantic ocean; it occurs as a flat, mucilaginous, olive brown thallus with spherical air vesicles.
	restorativemedicine.com /pages/hypothyroidism_mild.html (1172 words)

	美国专利申请公开说明书 20040138193 - Oestrogen fatty acid monoester as a hypolipidaemic and antidiabetic ... (Site not responding. Last check: 2007-09-30)
		Oestrogen fatty acid monoester as a hypolipidaemic and antidiabetic agent
		The effectiveness of oleoyl-estrone as oral antidiabetic is conspicuous since it does not act as a simple hypoglycemic agent, but goes to the root of the problem lowering insulin resistance.
		The additional hypolipemic effect allows to extend its use for the treatment of dislipemias.
	cxp.paterra.com /uspregrant20040138193cn.html (90 words)

	Hypolipidaemic compounds and compositions - Patent 4206145 (Site not responding. Last check: 2007-09-30)
		This invention relates to compounds which have hypolipidaemic activity and in particular to a class of aralkyl anilines, to a method for their preparation and to pharmaceutical compositions comprising them.
		It may be convenient to generate the intermediate (V) in situ, by reacting an amine of formula (VI) with an aldehyde of formula (VII) in the presence of a reducing agent.
		In such a case, a suitable reducing agent is hydrogen on a platinum oxide catalyst in a suitable solvent such as a mixture of methanol and dioxan.
	www.freepatentsonline.com /4206145.html (2663 words)

	HARVESTING OF NON-WOOD FOREST PRODUCTS
		Gum is used as suspending agent for insoluble drugs, demulcent agent, emulsification, antiseptic preparations, binder for tablets and tablet coating, jelly lubricants, spermicidal jellies and to mask the unpleasant taste of syrups.
		Gum is used as a bulking agent and for the preparation of special purpose food (those for diabetics).
		A promising hypolipidaemic agent from guggul (Commiphora wightii) In: H. Wagner (ed), Economic and Medicinal Plant Research Vol.
	www.fao.org /DOCREP/005/Y4496E/Y4496E29.htm (4628 words)

	Enzyme Formulas
		Lactoferrin has been shown to be an effective antibacterial agent, being found even in tears as one component of the defense of the outer eye".
		Regardless of the causitive agent, tissue injury results in inflammation^.
		Clinical studies have shown that proteolytic enzymes ameliorate the detrimental effects of inflammation on the body.
	www.nutritiondynamics.com /products/advanced/formulas.htm (5095 words)

	Hypolipidaemic agent - Wikipedia, the free encyclopedia
		The hypolipidaemic agents are a diverse group of pharmaceuticals that are used in treatment of hyperlipidemias.
		They are called lipid-lowering drugs (LLD) or agents.
		This page was last modified 01:30, 15 October 2005.
	en.wikipedia.org /wiki/Hypolipidaemic_agent (58 words)

	Guggul benefits and side effects
		Rhabdomyolysis caused by Commiphora mukul, a natural lipid-lowering agent.
		Gugulipid, a new hypolipidaemic agent, in patients of acute ischaemic stroke: effect on clinical outcome, platelet function and serum lipids.
		Usefulness of guggul (Commiphora mukul) for osteoarthritis of the knee: an experimental case study.
	www.zhion.com /herb/Guggul_benefits_and_side_effects.html (354 words)

	Thyro Stak: Boost Your Stagnant Metabolism Review by Dan Gwartney, M.D., IRONMAN Feb '99
		New, theoretically thermogenic combinations are being introduced almost daily, including such agents as yohimbine, tyrosine and phenylalanine.
		Typically, they are added to ECA or a chemically related compound like synephrine or pseudoephedrine, so we may end up seeing the same problems.
		Clinical trials of gugulipid-a new hypolipidemic agent of plant origin in primary hyperlipidemia.
	www.home-gym.com /thyrstakhowt.html (986 words)

	:: Sabinsa Corporation ::
		The gum resin exudate of Boswellia serrata, known in vernacular as "Salai guggul", has been used in the Ayurvedic system of medicine for the management of rheumatism, respiratory diseases, and liver disorders.
		The major use of Boswellia serrata in contemporary medicine is as an anti-arthritic and anti-inflammatory pharmacological agent.
		Satyavati, G.V. (1991) Guggulipid: A promising hypolipidaemic agent from gum guggul (Commiphora wightii).
	www.sabinsa.com /1999_may.htm (1556 words)

	Policosanol + Gugulipid - Cholesterol Formula by Designs For Health (DFH) (Site not responding. Last check: 2007-09-30)
		Satyavati, G.V., A promising hypolipidaemic agent from gum guggul (Commiphora wightii).
		Singh K, C.R., Kapoor NK, Guggulsterone, a potent hypolipidaemic, prevents oxidation of low-density lipoprotein.
		Niyanand, e.a., Clinical trials with gugulipid: a new hypolipidaemic agent.
	www.rockwellnutrition.com /policosanolgugulipid.shtml (991 words)

	Effects of combination treatment using anti-hyperuricaemic agents with fenofibrate and/or losartan on uric acid ...
		Effects of combination treatment using anti-hyperuricaemic agents with fenofibrate and/or losartan on uric acid metabolism -- Takahashi et al.
		Effects of combination treatment using anti-hyperuricaemic agents with fenofibrate and/or losartan on uric acid metabolism
		Hypolipidaemic and hypouricaemic action of fenofibrate in various types of hyperlipoproteinaemia.
	ard.bmjjournals.com /cgi/content/full/62/6/572 (1992 words)

	IngentaConnect Hypolipidaemic and Antioxidant Activity of Diallyl Disulphide in ... (Site not responding. Last check: 2007-09-30)
		IngentaConnect Hypolipidaemic and Antioxidant Activity of Diallyl Disulphide in...
		Hypolipidaemic and Antioxidant Activity of Diallyl Disulphide in Rats
		The efficacy of diallyl disulphide (DADS), a constituent of garlic oil, as a hypolipidaemic and antioxidant agent was evaluated in rats.
	api.ingentaconnect.com /content/rpsgb/ppc/1999/00000005/00000012/art00006 (254 words)

	Polycyclic oxy-aromatic acid - Patent 4098816
		This invention relates to compounds which have hypolipidaemic activity, to a method for their preparation and to pharmaceutical compositions comprising them.
		Preferred compounds of formula IV for hypolipidaemic activity include those wherein R.sub.3 is hydrogen and R.sub.4 is hydrogen, lower alkyl, especially methyl, halogen, especially fluorine or bromine, or lower alkoxy.
		We have noted preferred compounds having hypoglycaemic activity in addition to hypolipidaemic activity are those of formula (IV) wherein R.sub.1 is an alkyl or a carboxylic acid or ester group, p is 1, R.sub.2 is H, R.sub.3 is H and R.sub.4 is selected from hydrogen, 4-chloro, 4-methyl.
	www.freepatentsonline.com /4098816.html (6356 words)

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