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| | Hypopharyngeal cancer: Treatment - Health Professional Information [Cancer.gov] This information is produced and, ... |
 | | Clinically, cancers of the hypopharynx tend to be aggressive and demonstrate a natural history that is characterized by diffuse local spread, early metastasis, and a relatively high rate of distant spread. |
 | | The primary prognostic factors for hypopharyngeal SCC are stage, age, and performance status.[1,25,26] Presentation at a late stage, multisite involvement within the hypopharynx, unrestricted soft tissue tumor growth, an extensive regional lymphatic network allowing development of metastases, and restricted surgical options for complete resection, contribute to an overall poor prognosis. |
 | | In addition to the risk of delayed regional metastases, the risk of developing a second primary tumor in patients with tumors of the upper aerodigestive tract has been estimated to be 4% to 7% per year.[20,26,27,28] Because of these risks, surveillance of patients with hypopharyngeal cancer should be lifelong. |
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