| | eMedicine - Hypothyroidism : Article by Robert J Ferry, Jr, MD (Site not responding. Last check: 2007-10-12) |
 | | Congenital hypothyroidism most commonly results from agenesis, dysplasia, or ectopy of the thyroid; however, it is also caused by autosomal recessive defects in the organification of iodine (thyroid hormone synthesis) and defects in other enzymatic steps in T4 synthesis and release. |
 | | Detection of congenital hypothyroidism based on signs and symptoms alone may be delayed until age 6-12 weeks or older given the protean clinical presentation and requires a high index of suspicion by the health care provider. |
 | | Congenital hypothyroidism: Approximately 75% of infants with congenital hypothyroidism have defects in thyroid gland development, 10% have hereditary defects in thyroid hormone synthesis or uptake, 5% have secondary (pituitary) or tertiary (hypothalamus) hypothyroidism, and 10% have transient hypothyroidism. |
| www.emedicine.com /ped/topic1141.htm (5883 words) |