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Topic: Hypoxanthine-guanine phosphoribosyltransferase

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Hypoxanthine - Wikipedia, the free encyclopedia Hypoxanthine is a naturally occurring purine derivative, and one of the products of the action of xanthine oxidase on xanthine, though more normally in purine degradation, hypoxanthine is oxidized by xanthine oxidase to form xanthine. It is very occasionally found as a constituent of nucleic acids where it is present in the anticodon of tRNA in the form of its nucleoside inosine. en.wikipedia.org /wiki/Hypoxanthine   (98 words)

GDA - guanine deaminase Neither guanine deaminase nor hypoxanthine-guanine phosphoribosyltransferase activity was detected in 24 and 96 h cultures. Six enzymes were assayed both in vitro and in vivo: adenosine deaminase, guanine deaminase, purine nucleoside phosphorylase, xanthine oxidase, hypoxanthine-guanine phosphoribosyltransferase and adenine phosphoribosyltransferase. Adenosine is deaminated by adenosine deaminase (ADA) and guanosine is converted to guanine and deaminated by guanase. www.ihop-net.org /UniPub/iHOP/gg/94803.html   (1759 words)

Expression of the Methanobacterium thermoautotrophicum hpt Gene, Encoding Hypoxanthine (Guanine) Phosphoribosyltransferase, in Escherichia coli -- Sauer and Nygaard 181 (6): 1958 -- The Journal of Bacteriology Purification and characterization of the recombinant hypoxanthine guanine phosphoribosyltransferase. The hpt gene from the archaeon Methanobacterium thermoautotrophicum, encoding hypoxanthine (guanine) phosphoribosyltransferase, Molecular characterization and overexpression of the hypoxanthine-guanine phosphoribosyltransferase gene from Trypanosoma cruzi. jb.asm.org /cgi/content/full/181/6/1958   (2959 words)

guanine on Encyclopedia.com Guanine is said to account for the iridescence of fish scales and the white, shiny appearance of the skin of many amphibians and reptiles. When combined with the sugar ribose in a glycosidic linkage, guanine forms a derivative called guanosine (a nucleoside), which in turn can be phosphorylated with from one to three phosphoric acid groups, yielding the three nucleotides GMP (guanosine monophosphate), GDP (guanosine diphosphate), and GTP (guanosine triphosphate). GUANINE [guanine], organic base of the purine family. www.encyclopedia.com /html/g1/guanine.asp   (565 words)

Biochemistry Hypoxanthine and guanine are natural products of the breakdown of DNA and RNA, and our bodies have developed a way to conserve energy and resources by recycling these nucleotides through a recycling pathway. In addition, without HPRT’s activity hypoxanthine and guanine are not converted into their nucleotides, IMP and GMP, but instead they build up to toxic levels in the cell. In the absence of HPRT, the enzyme PPRP, which would normally be used in recycling hypoxanthine and guanine, accumulates in the cell. www.macalester.edu /psychology/whathap/UBNRP/lesch04/Jessica.html   (297 words)

Nucleotide Metabolism The free purine bases---adenine, guanine, and hypoxanthine---can be reconverted to their corresponding nucleotides by phosphoribosylation. This compound is a structural analog of hypoxanthine that strongly inhibits xanthine oxidase. The structure of the nucleobase of IMP (hypoxanthine) is shown. web.indstate.edu /thcme/mwking/nucleotide-metabolism.html   (3070 words)

For Biol 461: Hypoxanthine-guanine phosphoribosyl transferase Novel nonsense mutation in the hypoxanthine guanine phosphoribosyltransferase gene and nonrandom X-inactivation causing Lesch-Nyhan syndrome in a female patient. Postnatal expression of hypoxanthine guanine phosphoribosyltransferase in the mouse brain. Garcia, Puig J. Clinical spectrum of hypoxanthine-guanine phosphoribosyltransferase deficiency: study of 12 cases. publish.uwo.ca /~amerkxja/biology/hgprt.html   (1851 words)

Hypoxanthine-guanine phosphoribosyltransferase deficiency Gross uric acid overproduction results from the inability to recycle either hypoxanthine or guanine, which interrupts the inosinate cycle producing a lack of feedback control of synthesis, accompanied by rapid catabolism of these bases to uric acid (Fig. 8) catalyses the transfer of the phosphoribosyl moiety of PP-ribose-P to the 9 position of the purine ring of the bases hypoxanthine and guanine to form inosine monophospate (IMP) and guanosine monophosphate (GMP) respectively (Fig. Urinary hypoxanthine excretion on a creatinine basis is also elevated in HPRT-deficient patients. www.amg.gda.pl /~essppmm/ppd/ppd_pu_hprt.html   (1633 words)

Buddy Ullman's Lab Allen, T.E. and Ullman, B. Molecular Characterization and Overexpression of the Hypoxanthine-Guanine Phosphoribosyltransferase Gene from Trypanosoma cruzi. Allen, T.E. and Ullman, B. Cloning and Expression of the Hypoxanthine-Guanine Phosphoribosyltransferase Gene from Trypanosoma brucei. Jardim, A. and Ullman, B. The Conserved Serine-Tyrosine Dipeptide in Leishmania donovani Hypoxanthine-Guanine Phosphoribosyltransferase is Essential for Catalytic Activity. www.ohsu.edu /biochem/faculty/ullmanlab/publications.shtml   (3409 words)

Hypoxanthine-guanine phosphoribosyltransferase - Wikipedia, the free encyclopedia Hypoxanthine-guanine phosphoribosyltransferase (HPRT) is an enzyme (EC 2.4.2.8) in purine metabolism. In this role, it acts as a catalyst in the reaction between guanine and phosphoribosyl pyrophosphate (PRPP) to form GMP. It converts hypoxanthine to inosine monophosphate, adenosine monophosphate to adenine and xanthine monophosphate to xanthine. en.wikipedia.org /wiki/Hypoxanthine-guanine_phosphoribosyltransferase   (119 words)

Plasmodium falciparum hypoxanthine guanine phosphoribosyltransferase: Stability studies on the product-activated enzyme -- Raman et al. 272 (8): 1900 -- FEBS Journal Plasmodium falciparum hypoxanthine guanine phosphoribosyltransferase: Stability studies on the product-activated enzyme -- Raman et al. Abbreviations: HGPRT, hypoxanthine guanine phosphoribosyltransferase; IMP, inosine monophosphate; PfHGPRT, Plasmodium falciparum HGPRT; PRPP, Keywords: active state stability; hypoxanthine guanine phosphoribosyltransferase; Plasmodium falciparum; product activation; thermal stability. content.febsjournal.org /cgi/content/abstract/272/8/1900   (277 words)

Annual Report 98 Two enzymes, adenosine kinase and hypoxanthine-guanine phosphoribosyltransferase, can reconvert, respectively, adenosine and hypoxanthine into their corresponding nucleotides. In liver, xanthine dehydrogenase catalyses the conversion of hypoxanthine into xanthine and that of xanthine into uric acid, the poorly soluble end-product of purine catabolism in man and higher apes. Inosine, the common product of both pathways is split into hypoxanthine and ribose 1-P by purine nucleoside phosphorylase. www.icp.ucl.ac.be /annrep98/puri/puri98.html   (560 words)

Crystal structures of free, IMP-, and GMP-bound Escherichia coli hypoxanthine phosphoribosyltransferase -- Guddat et al. 11 (7): 1626 -- Protein Science Ullman, B. Hypoxanthine-guanine phosphoribosyltransferase as a therapeutic target in protozoal infections. Crystal structures of free, IMP-, and GMP-bound Escherichia coli hypoxanthine phosphoribosyltransferase Crystal structures of free, IMP-, and GMP-bound Escherichia coli hypoxanthine phosphoribosyltransferase -- Guddat et al. www.proteinscience.org /cgi/content/full/11/7/1626   (6114 words)

Lesch Nyhan Syndrome Lesch-Nyhan syndrome is a rare inborn error of purine metabolism characterized by the absence or deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT). The absence of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT) from red blood cells confirms the diagnosis of this disorder. Symptoms of Lesch-Nyhan syndrome develop due to absence or deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT) and the abnormal accumulation of uric acid in the blood. hw.healthdialog.com /kbase/nord/nord255.htm   (2728 words)

ORPHANET® : Base de données sur les maladies rares et les médicaments orphelins Rossiter BJF, Caskey CT. Hypoxanthine-guanine phosphoribosyltransferase deficiency: Lesch-Nyhan syndrome and gout. Hypoxanthine-guanine phosphoribosyltransferase variants: correlation of clinical phenotype with enzyme activity. The crystal structure of human hypoxanthine-guanine phosphoribosyltransferase with bound GMP. www.orpha.net /data/patho/GB/uk-lesch.html   (2435 words)

wwwdbp.pl?Db=Parachlamydia_sp_UWE25&Name=cogs&String=1241&Cmd=Fetch 63 3e-10 COG0461 (Rv0382c) Orotate phosphoribosyltransferase 62 5e-10 COG0634 (aq_544) Hypoxanthine-guanine phosphoribosyltransferase 62 5e-10 COG2236 (APE0490) Predicted phosphoribosyltransferases 62 7e-10 COG0634 (DR1376) Hypoxanthine-guanine phosphoribosyltransferase 62 8e-10 COG1040 (aq_2059) Predicted amidophosphoribosyltransferases 61 1e-09 COG0035 (TP0448) Uracil phosphoribosyltransferase 60 2e-09 COG0503 (DR1617) Adenine/guanine phosphoribosyltransferases and re... 60 3e-09 COG0634 (BU195) Hypoxanthine-guanine phosphoribosyltransferase 60 3e-09 COG0503 (BH0062) Adenine/guanine phosphoribosyltransferases and re... 87 2e-17 COG0461 (pyrE) Orotate phosphoribosyltransferase 86 3e-17 COG0461 (BH2532) Orotate phosphoribosyltransferase 86 5e-17 COG0503 (BB0777) Adenine/guanine phosphoribosyltransferases and re... pedant.gsf.de /cgi-bin/wwwdbp.pl?Db=Parachlamydia_sp_UWE25&Name=cogs&String=1241&Cmd=Fetch   (893 words)

lesch-nyhan03.html ABSTRACT: Lesch-Nyhan disease is a neurogenetic disorder caused by deficiency of the purine salvage enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT). The sensitivity of 24-h urinary hypoxanthine and xanthine excretion rates was 86% and 77%, respectively, and the specificity 100% for both tests. Plasma and 24-h urinary concentrations of hypoxanthine, xanthine and uric acid were measured while subjects were on a purine-restricted diet. www.indiana.edu /~pietsch/lesch-nyhan03.html   (2249 words)

HPT1 - Mutants deficient in adenine aminohydrolase (EC 3,5,4,2) activity, aah1, and hypoxanthine:guanine phosphoribosyltransferase (EC 2,4,2,8) activity, hpt1, were used to synthesize the genotypes apt1 hpt1 aah+ and apt1 hpt+ aah1. Several lines of evidence indicate that the decrease in GMP kinase activity in the bra3 mutants results in GMP accumulation and feedback inhibition of hypoxanthine-guanine phosphoribosyltransferase (HGPRT), encoded by the HPT1 gene. BRA6 and BRA1 are new genes encoding, respectively, hypoxanthine guanine phosphoribosyl transferase and adenylosuccinate lyase. www.ihop-net.org /UniPub/iHOP/gg/32415.html   (240 words)

Uric Acid, Urine Patients with complete hypoxanthine-guanine phosphoribosyltransferase deficiency are reported to have urinary uric acid:creatinine ratios of 1.98-5.35, as compared to 0.62-2.00 for patients with gout accompanied by partial enzyme deficiency. The ratio of uric acid:creatinine in morning samples of urine has been used as a test for detection of the Lesch-Nyhan syndrome, which is associated with virtually complete absence of activity of the enzyme hypoxanthine-guanine phosphoribosyltransferase. This ratio has also been applied to 24-hour urine samples from adult patients with gout for detection of partial deficiency of the same enzyme. www.labcorp.com /datasets/labcorp/html/chapter/mono/pr009300.htm   (381 words)

webpage Structure-function studies on successive purine salvage pathway enzymes- Hypoxanthine guanine phosphoribosyltransferase and Adenylosuccinate synthetase. Protein structure and dynamics : Studies on the plasmodial proteins- Triosephosphate Isomerase, Hypoxanthine guanine phosphoribosyltransferase and Plasmepsin II. Investigations on the Plasmodium falciparum, human and chimeric Hypoxanthine guanine phosphoribosyltransferases. www.jncasr.ac.in /pel/theses.html   (43 words)

Yeast GMP Kinase Mutants Constitutively Express AMP Biosynthesis Genes by Phenocopying a Hypoxanthine-Guanine Phosphoribosyltransferase Defect -- Lecoq et al. 156 (3): 953 -- Genetics In vivo hypoxanthine utilization is affected in the guk1-2 mutant. for hypoxanthine were determined in the absence of GMP and in the presence of either 50, 100, or 200 µ Transformants were grown on SC medium or on the same medium supplemented with 8AG, adenine (Ade), or hypoxanthine (Hyp). www.genetics.org /cgi/content/full/156/3/953   (4582 words)

Kinetic Mechanism of Human Hypoxanthine-Guanine Phosphoribosyltransferase: Rapid Phosphoribosyl Transfer Chemistry Hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) is the locus of Lesch-Nyhan syndrome, the activator of the prodrugs 6-mercaptopurine and allopurinol, and a target for antiparasitic chemotherapy. Kinetic Mechanism of Human Hypoxanthine-Guanine Phosphoribosyltransferase: Rapid Phosphoribosyl Transfer Chemistry The more rapid rate of utilization of guanine than hypoxanthine in the forward reaction is the result of the faster release of product GMP rather than the result of differences in the rate of the chemical step. pubs.acs.org /cgi-bin/abstract.cgi/bichaw/1997/36/i12/abs/bi9616007.html   (363 words)

Partial Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency as the Unsuspected Cause of Renal Disease Spanning Three Generations: A Cautionary Tale -- Augoustides-Savvopoulou et al. 109 (1): 17 -- Pediatrics Partial Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency as the Unsuspected Cause of Renal Disease Spanning Three Generations: A Cautionary Tale -- Augoustides-Savvopoulou et al. Partial Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency as the Unsuspected Cause of Renal Disease Spanning Three Generations: A Cautionary Tale HPRT • hypoxanthine-guanine phosphoribosyltransferase; LND • Lesch-Nyhan disease pediatrics.aappublications.org /cgi/content/full/109/1/e17   (1773 words)

lesch-nyhan2000.msw ABSTRACT: Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8.; HPRT) catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively. ABSTRACT: We have determined the molecular basis of hypoxanthine-guanine phosphoribosyltransferase (HPRT; HPRT1) deficiency in eight Lesch-Nyhan patients and in five partially HPRT deficient patients with mild to severe neurologic symptoms. ABSTRACT: Lesch-Nyhan disease (LND) is an X-linked metabolic disorder caused by lack of activity of the purine salvage enzyme hypoxanthine phosphoribosyltransferase (HPRT) and characterized by hyperuricemia and debilitating neurological manifestations. www.indiana.edu /~pietsch/lesch-nyhan2000.html   (3372 words)

CiteULike: Tag hprt In vitro translation of hypoxanthine/guanine phosphoribosyltransferase mRNA: characterization of a mouse neuroblastoma cell line that has elevated levels of hypoxanthine/guanine phosphoribosyltransferase protein. www.citeulike.org /tag/hprt   (101 words)

Order ALLOPURINOL @ Rx Care Canada Accompanying the decrease in uric acid produced by allopurinol is an increase in serum and urine concentrations of hypoxanthine and xanthine. Along with its active metabolite, oxypurinol, allopurinol inhibits xanthine oxidase, the enzyme responsible for the conversion of hypoxanthine to xanthine and of xanthine to uric acid. After administration of allopurinol, it is composed of hypoxanthine, xanthine and uric acid. canadapharmacy.rxcarecanada.com /ALLOPURINOL.asp?prodid=ALLOPURINOL   (2547 words)

Pfam 19.0 : Pribosyltran This family includes a range of diverse phosphoribosyl transferase enzymes including adenine phosphoribosyltransferase (); hypoxanthine-guanine-xanthine phosphoribosyltransferase; hypoxanthine phosphoribosyltransferase (); ribose-phosphate pyrophosphokinase ();amidophosphoribosyltransferase (); orotate phosphoribosyltransferase ();uracil phosphoribosyltransferase (); and xanthine-guanine phosphoribosyltransferase (). The name PRT comes from phosphoribosyltransferase enzymes, which carry out phosphoryl transfer reactions on PRPP, an activated form of ribose-5-phosphate. pfam.wustl.edu /cgi-bin/getdesc?name=Pribosyltran   (217 words)

Localization and Targeting of the Leishmania donovani Hypoxanthine-Guanine Phosphoribosyltransferase to the Glycosome -- Shih et al. 273 (3): 1534 -- Journal of Biological Chemistry Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) is a key enzyme in the purine salvage pathway of many protozoan parasites. Localization and Targeting of the Leishmania donovani Hypoxanthine-Guanine Phosphoribosyltransferase to the Glycosome -- Shih et al. The abbreviations used are: HGPRT, hypoxanthine-guanine phosphoribosyltransferase; HGPRT, hypoxanthine-guanine phosphoribosyltransferase www.jbc.org /cgi/content/full/273/3/1534   (3443 words)

Molecular Markers of Ionizing Radiation-induced Gene Mutations in Mammalian Cells We have recently undertaken a study to characterize the mutation spectra and identify potential molecular markers of ionizing radiation-induced mutations at the hypoxanthine guanine phosphoribosyltransferase (hprt) locus in Chinese hamster ovary (CHO) cells as a function of radiation dose, radiation dose rate, radiation quality (linear energy transfer [LET]) and DNA repair background of CHO cells. Polymerase chain reaction-based comprehensive procedure for the analysis of the mutation spectrum at the hypoxanthine-guanine phosphoribosyltransferase locus in Chinese hamster cells. Molecular analysis of hypoxanthine phosphoribosyltransferase gene deletions induced by alpha and X-radiation in human lymphoblastoid cells. www.ehponline.org /members/1996/Suppl-3/675-678hsie/hsie-full.html   (3688 words)

Lesch-Nyhan Syndrome - Patient UK This recessive inherited condition is due to a genetic mutation on the X chromosome resulting in an almost complete dysfunction of the enzyme hypoxanthine guanine phosphoribosyltransferase-1 (HPRT) that converts hypoxanthine to inosinic acid and guanine to guanylic acid. However, some people find that they add depth to the articles found in the other sections of this website which are written for non-medical people. www.patient.co.uk /showdoc/40001407   (333 words)

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