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| | Hypoxia and Mitochondrial Inhibitors Regulate Expression of Glucose Transporter-1 via Distinct Cis-acting Sequences -- ... |
 | | In particular, the response to hypoxia is mimicked by transition metal ions such as cobalt (4) and by iron chelating agents (5) but not by inhibitors of mitochondrial respiration(6, 7, 8). |
 | | Both inhibition of mitochondrial respiration and cellular hypoxia are accompanied by an increase in the rate of glucose uptake, which is largely mediated by increased Glut-1 activity(18, 19, 20, 21, 22, 23). |
 | | In the case of erythropoietin regulation, this is not the case, indicating that the mechanism of oxygen sensing is not dependent on the consequences of hypoxic limitation of mitochondrial metabolism(6, 7, 8). |
| www.jbc.org /cgi/content/full/270/49/29083 (6458 words) |
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