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Topic: IGF


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In the News (Tue 22 Dec 09)

  
  Insulin-like growth factor - Wikipedia, the free encyclopedia
IGFs are part of a complex system that cells use to communicate with their physiologic environment.
The IGF axis has been shown to play roles in the promotion of cell proliferation and the inhibition of cell death (apoptosis).
The IGF's are known to bind the IGF-1 receptor, the insulin receptor, the IGF-2 receptor, the insulin-related receptor and possible other receptors.
en.wikipedia.org /wiki/Insulin-like_growth_factor   (984 words)

  
 Aurogen: IGF for the treatment of peripheral neuropathies
The IGF genes are turned on during the regeneration of damaged nerves in adult mammals.
IGF gene expression is greatly reduced in brain, spinal cord, nerves and livers of Type I and Type II diabetic rats.
Loss of IGF activity in nondiabetic rodents (IGF null mice, anti-IGF antibodies) causes neuropathy similar to that in diabetes such as reduced axonal diameters, nerve conduction velocity, nerve regeneration, and death of neurons.
www.aurogen.com   (2359 words)

  
 IGF-1 and milk statement from FDA   (Site not responding. Last check: 2007-10-16)
IGF-I is a protein normally found in all humans, and is not intrinsically harmful.
FDA determined that this modest increase in milk IGF-I concentration was not a human food safety concern because it was less than the natural variation in milk IGF-I levels observed during lactation and was less than the fluctuation observed in milk from treated and control cows prior to rbGH administration.
These studies have demonstrated that the levels of IGF-I found in milk from treated cows are within the range of those normally found in milk from untreated cows.
www.igf-1-and-milk.com /igf-1-fda.htm   (1026 words)

  
 LR3 IGF-1 - PremierMuscle   (Site not responding. Last check: 2007-10-16)
IGF-I is considered to be the main post-natal growth-promoting factor and IGF-II has major effects during fetal development.
IGF-I is similar in structure to pro-insulin, the precursor of insulin.
IGF binding proteins bind IGFs with high affinity and generally inhibit the actions of IGFs on cells.
www.premiermuscle.com /forum/showthread.php?t=3490   (1340 words)

  
 Study Links IGF-1 to Prostate Cancer
IGF-I was significantly associated with prostate cancer risk in a univariate analysis; men in the highest quartile had an RR of 2.4 (95% CI 1.2 to 4.7) as compared with men in the lowest quartile (Table 2).
Men over age 60 and in the highest quartile of IGF-I had an RR of 7.9 (95% CI 2.1 to 30.7) with adjustment for IGFBP-3, compared with men of similar age and in the lowest quartile; the comparable RR among men age 60 or less was 1.6 (95% CI 0.4 to 6.1).
However, plasma IGF-I level was strongly related to risk of developing prostate cancer even among men with a baseline PSA level less than or equal to 4 ng/ml (the multivariate RR of clinical diagnosis during followup increased from 1.0 to 4.6 across quartiles of IGF-I, adjusted for IGFBP-3, age, and smoking).
www.ejnet.org /bgh/igf-1science.html   (2828 words)

  
 International Grating & Flanges, Inc.   (Site not responding. Last check: 2007-10-16)
IGF, Inc. is committed to providing a variety of quality fiberglass products with the highest quality service.
The factory, which produces IGF molded grating and flanges, was the first in China to be granted ISO 9002 accreditation.
All IGF flanges and manways are of the integral type, all hand lay-up, monolithic construction.
www.igf.net   (255 words)

  
 IGF-I in Mammary Gland Development
Despite the fact that both GH and IGF-I can stimulate a small amount of new TEB formation in the absence of E2, and that E2 in the absence of the pituitary has no effect on induction of these structures, E2 is extremely important in pubertal development of the mammary gland [12].
In this model, IGF-I production in the mammary gland is partially under the control of the hormones of pregnancy and lactation, which cause expression of the rat whey acidic protein gene and therefore, the IGF-I gene coupled to it.
Implied in the process of understanding the effects of IGF-I on mammary gland development at various stages of life is the eventual possibility that those observations might be applicable to better understanding and treating breast cancer.
mammary.nih.gov /reviews/development/Kleinberg001   (1678 words)

  
 International Foundation For The Conservation Of Wildlife
IGF has just completed last week a major research operation on lion and tiang in Zakouma National Park, in partnership with the Chadian authorities, the CURESS project, CIRAD and the Zakouma lion project.
The IGF Foundation is launching a new project to conserve the last remaining population of Kara Tau argali ("Ovis ammon nigrimontana") under the auspices of the Almaty Academy of Science with support of the French Embassy in Kazhakstan.
The IGF Foundation has coordinated a comprehensive survey of the conservation status of the African Lion ("Panthera leo" Linnaeus, 1758) throughout the whole distribution range of the taxon.
www.wildlife-conservation.org   (1322 words)

  
 The Internet Governance Forum (IGF)
The Inaugural Meeting of the IGF is taking place in Athens, Greece from 30 October - 2 November at the Divani Apollon Palace.
The IGF Advisory Group held two meetings in Geneva on 22 - 23 May and 7 - 8 September 2006 to prepare the agenda and the programme as well as the structure and format of the IGF meeting in Athens.
Two rounds of consultations on the convening of the IGF were held in Geneva on 16 - 17 February and on 19 May 2006.
www.intgovforum.org   (1327 words)

  
 IGF-I binding in primary culture of muscle cells of rainbow trout: changes during in vitro development -- Castillo et ...
IGF-I binding in primary culture of muscle cells of rainbow trout: changes during in vitro development -- Castillo et al.
I-IGF-I with a specific activity of 260 µCi/µg was purchased from Amersham Pharmacia Biotech Europe GmBH.
Isolation and culture of fetal porcine myogenic cells and the effect of insulin, IGF-I, and sera on protein turnover in porcine myotube cultures.
ajpregu.physiology.org /cgi/content/full/283/3/R647   (4292 words)

  
 Kits : Assay Panel   (Site not responding. Last check: 2007-10-16)
Less than 25% of total IGF circulates bound to IGFBPs in a binary complex, while the majority circulate in a ternary complex consisting of IGFs bound to either IGFBP-3 or BP-5 and the glycoprotein known as the acid labile subunit (ALS).
The formation of the ternary complex prolongs the half-life of both the IGFs and IGFBP-3 in the circulation, maintaining IGFs in the intravascular space for steady delivery and distribution to target tissues.
In the tissues, ALS is absent, and most of the IGFs are bound to IGFBPs as heterodimers with only a small fraction of IGFs in the free form.
www.dslabs.com /kits/assay_panel.aspx?id=14   (521 words)

  
 Aurintricarboxylic Acid Induces a Distinct Activation of the IGF-I Receptor Signaling within MDA-231 Cells -- Haimsohn ...
tyrosine phosphorylation of the IGF-I receptor (IGF-IR) and
IGF-I in the absence or presence of CHX or ADR.
Cells were treated without (CON) or with IGF-I (100 ng/ml), ATA (200 µg/ml), or EB (300 µg/ml) for 4 h in the absence (NONE) or presence of ADR (300 ng/ml) or CHX (30 µg/ml).
endo.endojournals.org /cgi/content/full/143/3/837   (4715 words)

  
 Independent Games Festival - Audience Award
Similar to the film industry's Sundance Film Festival, the IGF serves as a showcase for quality games that are created without the financial backing of a major publisher.
The finalists in the IGF Main Competition are eligible for the IGF Audience Award.
The GDC is March 20-24 at the San Jose Convention Center.
www.gamespot.com /igf   (340 words)

  
 Internet Governance Forum - Wikipedia, the free encyclopedia
During the negotiations in the second phase of WSIS in Tunis, all four proposals were discussed and a compromised decision was reached for the convening of the IGF by the second quarter of 2006.
The IGF is a venue of dialogue which functions on a global level with the aim to co-ordinate international cooperation of all relevant stakeholders on an equal footing and through open, participatory and transparent procedures.
To some the IGF might prove to be the process, which through loose consensus of all involved players will elaborate on the definition and the scope of internet governance, further delineate its key issues and determine its principles, by issuing agendas, plans of action or even recommendations.
en.wikipedia.org /wiki/Internet_Governance_Forum   (1447 words)

  
 Internet Governance Forum - Greece 2006
IGF 2006 is available for anyone through Internet webcasting...
The Official Program of IGF 2006 Athens Meeting is available here more...
A delegation comprised of members of the “Steering Committee” was dispatched to Geneva and Paris for the purpose of holding consultations regarding the state of preparations and to explore possible dates for the inaugural meeting of the IGF...
www.igfgreece2006.gr   (462 words)

  
 The 9th Annual Independent Games Festival
The first of the deadlines for the 2007 IGF is rapidly approaching, so this is an all-hands reminder that September 8, 2006 at 11:59pm PDT is the final date to enter your game into the IGF Main Competition.
- the IGF Student Showcase, which continues to be one of the most hotly contested parts of the Festival, we're continuing to honor the ten Student Showcase Winners with $500 travel stipends and a chance to show their game at GDC 2007.
The IGF Pavilion and Mod Pavilions were buzzing for the entire show, a plethora of press (from the Wall Street Journal through Yahoo!, MTV, and Spike TV) covered the finalists and winners, and we had a defining moment to rival 2005's marriage proposal, in Introversion's Grand Prize acceptance speech.
www.igf.com   (1846 words)

  
 Resection upregulates the IGF-I system of parenterally fed rats with jejunocolic anastomosis -- Gillingham et al. 281 ...
IGF-I is an anabolic peptide hormone with enterotrophic effects on the gut.
Immunoreactive IGF-I. Jejunum and colon (100-400 mg) were homogenized in 2 ml of 0.1 M ammonium formate (pH 7.0) and spun at 14,000 g for 15 min.
Investigation of insulin-like growth factor (IGF)-I and insulin receptor binding and expression in jejunum of parenterally fed rats treated with IGF-I or growth hormone.
ajpgi.physiology.org /cgi/content/full/281/5/G1158   (6112 words)

  
 Water Cooler Games - IGF Award Controversy   (Site not responding. Last check: 2007-10-16)
I was an IGF judge this year, so deliberately or indeliberately I contributed to the outcome.
With the inclusion of mainstream or Triple A studios in the IGF, the innovation of the indie developers is ignored.
Savage's IGF submission form indicated that they had been developing since 9/13/2001, or "approximately two years," which would support the latter release date.
www.watercoolergames.org /archives/000106.shtml   (1716 words)

  
 Distinct Sites of Insulin-Like Growth Factor (IGF)-II Expression and Localization in Lesioned Rat Brain: Possible Roles ...
with IGF-I, IGF-IR, and IGFBP-1, -2, -3, and -6, to neurons,
IGF transport and bioactivity are regulated by a family of six
Ayer-le-Lievre C, Stahlbom PA, Sara VR 1991 Expression of IGF-I and -II mRNA in the brain and craniofacial region of the rat fetus.
endo.endojournals.org /cgi/content/full/140/1/520   (7553 words)

  
 IGF Society Home   (Site not responding. Last check: 2007-10-16)
The insulin-like growth factor system is complex with two major IGF ligands and at least three receptors mediating ligand-induced cell proliferation, survival, differentiation, metabolism and migration.
This conference will cover the spectrum of the IGF system from basic biology to clinical interventions, with emphasis on current ‘burning questions’ and novel findings.
The conference will present new insights into the role of the IGFs in development, organ system physiology and aging, and will focus on recent developments in IGF research relevant to major health issues including cancer, diabetes, cardiovascular disease and neurodegeneration.
www.igf-society.org /h/meetings.html   (408 words)

  
 Igf-1 deer elk velvet antler supplements, anti-aging at new iq.   (Site not responding. Last check: 2007-10-16)
As its name indicates IGF-I, or insulin like growth factor-I, has similar properties to insulin, and it has improved blood sugar profiles in type 2 diabetic patients.
In the latter study Nelly Mauras and Bernard Beaufrere of the Nemours Children’s Clinic in Jacksonville, Florida, were looking at several different things: the effect of IGF-I on protein metabolism; its ability to stop the protein-wasting caused by glucocorticosteroid drugs like prednisone, and its effect on insulin and glucose metabolism.
The study found that IGF-I at 100 micrograms per kilogram of body weight given twice daily enhanced the body’s protein metabolism in the same way as growth hormone.
www.igf-1.info /human_growth-hormone_1.html   (1859 words)

  
 Acute Treatment with Corticosteroids Decreases IGF-1 and IGF-2 Expression in the Rat Diaphragm and Gastrocnemius -- ...
Insulin and IGF-I induce pronounced hypertrophy of skeletal myofibers in tissue culture.
Serum somatomedin/ insulin-like growth factor (IGF) and IGF carrier levels in patients with Cushing's syndrome or receiving glucocorticoid therapy.
IGF-I, a marker of undernutrition in hemodialysis patients.
ajrccm.atsjournals.org /cgi/content/full/159/1/283   (4662 words)

  
 Insulin-like growth factor (IGF)-binding proteins: interactions with IGFs and intrinsic bioactivities -- Baxter 278 ...
Differential effects of insulin-like growth factor (IGF)-I and IGF-II on the expression of IGF binding proteins (IGFBPs) in a rat neuroblastoma cell line: isolation and characterization of two forms of IGFBP-4.
Mohseni-Zadeh, S, and Binoux M. Insulin-like growth factor (IGF) binding protein-3 interacts with the type 1 IGF receptor, reducing the affinity of the receptor for its ligand: an alternative mechanism in the regulation of IGF action.
Zadeh, SM, and Binoux M. The 16-kDa proteolytic fragment of insulin-like growth factor (IGF) binding protein-3 inhibits the mitogenic action of fibroblast growth factor on mouse fibroblasts with a targeted disruption of the type I IGF receptor gene.
ajpendo.physiology.org /cgi/content/full/278/6/E967   (7554 words)

  
 HaCaT human keratinocytes express IGF-II, IGFBP-6, and an acid-activated protease with activity against IGFBP-6 -- ...
The IGF system is involved in epidermal growth and development.
I-labeled IGF-I, and this IGFBP inhibits IGF-I-induced proliferation
Effects of insulin-like growth factor (IGF) binding proteins (BPs)-3 and -6 on DNA synthesis of rat osteoblasts: further evidence for a role of auto-/paracrine IGF I but not IGF II in stimulating osteoblast growth.
ajpendo.physiology.org /cgi/content/full/276/3/E536   (4492 words)

  
 Differential Regulation of Insulin-like Growth Factor-I (IGF-I) Receptor Gene Expression by IGF-I and Basic ...   (Site not responding. Last check: 2007-10-16)
IGF-I in the culture medium (7, 8), with increased IGF-I
The biological actions of the IGFs are mediated through interaction with their specific cell-surface receptor.
IGF-I is a progression factor that is required by cells to progress through the cell cycle.
www.jbc.org /cgi/content/full/272/8/4663   (4407 words)

  
 Gamasutra - IGF 2006 Modding Competition Finalists Announced
The finalists for the IGF Best Mod - Half-Life 2 category are UrbanLegend Games' 'authentic' school sports recreation Dodgeball: Source, Team Dystopia's cyberpunk-themed total conversion Dystopia, The Guildhall at SMU's lush student-created fantasy mod Eclipse, Hidden: Source Team's 'Predator'-like hunting title Hidden: Source, and Agora Games' strategic team-based shooter Plan Of Attack.
This final announcement follows the earlier announcement of the IGF Student Showcase winners, and, alongside December's IGF Main Competition finalists, comprises the final of the three main IGF Competition announcements for this year.
The finalist mods will be playable at the IGF Pavilion and a separate Mod Pavilion at Game Developers Conference in San Jose this March.
www.gamasutra.com /php-bin/news_index.php?story=7796   (462 words)

  
 Elevated Free IGF-I Levels in Prepubertal Hispanic Girls with Premature Adrenarche: Relationship with Hyperandrogenism ...
Relationship between total IGF-I, free IGF-I, and IGFBP-1 with insulin resistance status by FGIR in girls with PA and controls (CO).
IGFBP-1 in the regulation of bioavailable IGF-I (12, 35).
Homburg R, Pariente C, Lunenfeld B, Jacobs HS 1992 The role of insulin-like growth factor-I and IGF binding protein-I in the pathogenesis of polycystic ovary syndrome.
jcem.endojournals.org /cgi/content/full/87/1/398   (4247 words)

  
 Differentiated Thyroid Carcinomas from Children and Adolescents Express IGF-I and the IGF-I Receptor (IGF-I-R). Cancers ...   (Site not responding. Last check: 2007-10-16)
IGF-I was detected in 45% and IGF-I-R in 43% of
Representative Staining for IGF-I and IGF-I-R. Specific staining for IGF-I was quantified as absent (A, grade 0), mild (B, grade 1), moderate (C, grade 2), or intense (D, grade 3).
Toropainen E, Lipponen P, Syrjanen K 1995 Expression of insulin-like growth factor I (IGF-I) in female breast cancer as related to established prognostic factors and long-term prognosis.
www.pedresearch.org /cgi/content/full/55/4/709   (3689 words)

  
 Sachverständiger für Bauphysik IGF: IGF Zimmermann - Ingenieurgesellschaft für Fassadentechnik und Bauphysik - ...
It was spun off from the Institut für Bauphysik in Mülheim over fifteen years ago and has been independent ever since.
Complete independence from the partner company was achieved by IGF with the completion of ongoing joint projects with the Institut in 1990.
Our experience in the field of consulting and appraising major building construction projects is based on our activity in this area over a period of more than 30 years.
www.igf-zimmermann.de /en_untern/portrait.shtml   (429 words)

  
 About IGF, Inc.   (Site not responding. Last check: 2007-10-16)
Founded in 1998, IGF's home office is located in Harrison, Arkansas with stocking distributors located worldwide.
Although IGF is a young company, it is backed with the experience and expertise of a professional team.
Al has 16 years experience as a Professional Engineer and is licensed in 29 states.
www.igf.net /about.html   (104 words)

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