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Topic: IL1

In the News (Sat 12 Dec 09)

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	HON Allergy Glossary Interleukin1 (IL1)
		IL1 is produced mainly by macrophages (most important source) as well as some other cell types.
		Inducing adhesion molecule expression on vascular endothelium is part of the inflammation syndrome - IL1 induces ICAM 1 expression, while TNFalpha induces ELAM 1 expression on endothelium.
		Corticosteroids, produced by the adrenals in response to signals from the brain (cortisone), inhibit the action of IL1 and are therefore used to reduce inflammation.
	www.hon.ch /Library/Theme/Allergy/Glossary/il1.html (189 words)

	IL1
		IL1 is a set of six ciliated neurons with striated rootlets, each of which is one of the two component neurons of the inner labial sensilla.
		IL1 dendrite does not protrude through the hole in the socket cell to the outside.
		They run into their cell bodies, which are anterior to the ring; posteriorly directed processes from the cell bodies rejoin the process bundles, which pass down outside the ring, turn, and then run anteriorly near the inside of the ring (b) until the processes disperse in the anterior regions of the neuropile.
	www.wormatlas.org /MoW_built0.92/cells/il1.html (182 words)

	Heart Health
		The IL1 genetic test can be used to differentiate certain IL1 genotypes associated with varying inflammatory responses to identify individuals at risk for cardiovascular disease and heart attacks even before age 60.
		The IL1 genetic test for heart health is based on scientific data from genetic association studies obtained through research collaborations with scientific experts in cardiovascular disease at leading academic institutions.
		A positive result means that the DNA pattern in your IL1 genes is associated with a tendency to increased inflammation and to heart disease before you reach the age of 60.
	www.ilgenetics.com /content/products-services/gensona/heart-health.jsp (454 words)

	MDA Research \| Blocking Immune System IL1 Helps Mice With MG
		Blocking Immune System IL1 Helps Mice With MG Erdem Tuzun and Premkumar Christadoss, both MDA-funded investigators at the University of Texas Medical Branch in Galveston, were part of a group that recently demonstrated the potential value of blocking the action of interleukin 1 (IL1) in treating myasthenia gravis (MG).
		IL1 and several other substances associated with the immune system combine to destroy or block acetylcholine receptors, causing the fluctuating weakness of MG.
		The authors say that compounds that block IL1 activity, perhaps in combination with etanercept, which blocks the activity of another immune-system compound, might be beneficial in the treatment of human MG.
	www.mda.org /research/051107il1_mg.html (265 words)

	Epitomics IL-1 Beta rabbit antibody - 1743-1
		The IL1 beta precursor form is not biologically active, while IL1 alpha is. Expressed mainly by stimulated macrophages and monocytes, IL1 beta precursor is cleaved by Caspase 1/ICE and other proteases (2-3).
		IL1 beta is known to be a mediator in inflammatory response and to be involved in a variety of cellular activities, proliferation, differentiation and apoptosis.
		Recent studies have shown IL1 beta to be a major cause of severe inflammation in the mouse model of Crohn’s disease, implicating IL1 beta as a potential marker for this disease (4).
	www.epitomics.com /products/1743-1.php (231 words)

	Interleukin (IL) 1{alpha}, IL1{beta}, IL receptor antagonist, and IL10 polymorphisms in psoriatic arthritis -- Peddle ...
		, IL1ß, IL receptor antagonist, and IL10 polymorphisms in psoriatic arthritis
		receptor and is inhibited by IL1 receptor antagonist (ILRa).
		, IL1ß, ILRa, and IL10 in the Newfoundland PsA
	ard.bmjjournals.com /cgi/content/full/64/7/1093 (594 words)

	Anti-interleukin 1{alpha} autoantibodies -- Miossec 61 (7): 577 -- Annals of the Rheumatic Diseases
		IL1ß was demonstrated in relation to a high affinity
		The other regulators of IL1 are IL1ra and soluble IL1 receptors.
		Cell response to IL1 is controlled by two types of receptors.
	ard.bmj.com /cgi/content/full/61/7/577 (1888 words)

	Potential therapeutic uses of interleukin 1 receptor antagonists in human diseases -- Hallegua and Weisman 61 (11): 960 ...
		IL1 in the colon and is ameliorated by exogenous administration
		IL1 receptors (sIL1R), and neutralising antibodies to IL1
		IL1 is implicated in the aetiopathogenesis of several human
	ard.bmj.com /cgi/content/full/61/11/960 (5348 words)

	SEPIC Equations and Component Ratings - Maxim/Dallas
		Total loss, however, is lowest when losses are distributed equally between the two windings, so it is useful to set each winding's cross section according to the current it carries.
		The purpose of the output capacitor (Cout) is to average the current pulses supplied by D1 during Toff.
		Using Equation 6, we obtain IL1 values of 0.659A, 0.491A and 0.334A as Vin varies from minimum to maximum.
	www.maxim-ic.com /appnotes.cfm/appnote_number/1051 (2031 words)

	Pfam 21.0 : IL1 (Site not responding. Last check: 2007-11-02)
		Both IL1A and IL1B bind to the same IL1-specific receptor on the target cell, which is then internalised to initiate the relevant effects.
		IL1RA binds to the IL1 receptor, blocking the effects of IL1A and IL1B whilst eliciting no response of its own.
		From sequence comparisons it seems to have arisen by gene duplication before IL1 diverged into IL1A and IL1B PUBMED:1828896.
	pfam.janelia.org /cgi-bin/getdesc?name=IL1 (302 words)

	The Precursor but Not the Mature Form of IL1alpha Blocks the Release of FGF1 in Response to Heat Shock -- Tarantini et ...
		Amino acid sequence (10) and x-ray crystallographic analysis (11) of the IL1 and FGF prototypes have revealed rather striking
		It is well established that the precursor forms of the IL1 prototypes are cell-associated polypeptides whereas the mature
		the mature forms of the IL1 prototypes may be preferred for release.
	www.jbc.org /cgi/content/full/276/7/5147 (4183 words)

	Quixtar - 102052 - New IL1 Heart Health Nutrigenomic Dietary Supplement
		IL1 Heart Health Supplement is the first and only natural supplement formulated to specifically address the phytonutrient needs of individuals who have an over expression of the IL1 gene, to help them maintain a healthy heart and cardiovascular system.* Now available in bottles.
		It helps balance IL1 gene expression and helps maintain normal C-reactive protein levels that are already within the normal range.* This unique combination of ingredients includes rosehips, grape stem and vine extract, flberries, and blueberries, all powerful antioxidants.
		However, the product was developed for people with specific genotypes, and there is no evidence that the product will be effective for you if you do not have one of these genotypes.
	www.quixtar.com /products/product.aspx?pid=628&ctg=841&itemno=102052 (417 words)

	Genomics\|HuGENet\|e-Journal\|Abstract\|Lupus and interleukin 1 genes
		+4845(C-->T), IL1ß -511(C-->T), IL1ß +3953(G-->T), and IL1R a (86 bp VNTR) in a population based study of SLE in North Carolina and South Carolina: 1) To estimate the effects of these polymorphisms on SLE individually and after adjusting for variation at all five loci.
		There was evidence of linkage disequilibrium between IL1 a -889 and IL1 b -511 in African American cases and controls.
		The authors concluded that two IL1 gene promoter regions were significantly associated with SLE in this study sample, supporting the hypothesis that altered or imbalanced IL1 production may affect the risk of developing SLE.
	www.cdc.gov /genomics/hugenet/ejournal/lupusabst.htm (1137 words)

	hoffman disruptor il1 (Site not responding. Last check: 2007-11-02)
		The IL1 complete bike comes with the pro-level aftermarket frame with all the bells and whistles, built up with a selection of Hoffman (and others) finer parts into a total package.
		The frame here is dialled too -- it has a 20.5 inch long toptube, 14 inch back end, 11.5 inch BB height, and balanced and true geometry.
		You get cassette wheels, 3pc cranks, double-butted frame with press-fit bearings, with all the modern features on the full cromoly frame, and all for less than a return plane ticket to Los Angeles.
	www.ridebmxmag.co.uk /bikes/hoffmandisruptoa.html (713 words)

	Personalize Your Health. Enrich Your Life.
		IL1 Heart Health Nutrigenomic Dietary Supplement is an important part of the Personalized Health program, especially for those who test positive for the IL1 gene on the Gensona™ Heart Health Genetic Test.
		IL1 Heart Health combines four powerful antioxidants in its exclusive formula: rosehips, grape stem and vine extract, flberries, and blueberries.
		It is the first and only nutritional supplement shown to meet the phytonutrient needs of individuals who have an over-expression of the IL1 gene.
	www.iboai.com /Quixtar-Info-News-QuixtarNews-PersonalizedHealth.asp (408 words)

	IL1 receptor accessory protein like, a protein involved in X-linked mental retardation, interacts with Neuronal Calcium ...
		IL1 receptor accessory protein like, a protein involved in X-linked mental retardation, interacts with Neuronal Calcium Sensor-1 and regulates exocytosis -- Bahi et al.
		IL1 receptor accessory protein like, a protein involved in X-linked mental retardation, interacts with Neuronal Calcium Sensor-1 and regulates exocytosis
		Families are composed of transmembrane receptors related either to Toll-like or to IL1 receptors and these latter ones can be further distinguished by the presence or the absence of a C-terminal domain similar to the one identified in ILRAPL.
	hmg.oxfordjournals.org /cgi/content/full/12/12/1415 (6245 words)

	Association of an interleukin 1B gene polymorphism (-511) with Parkinson's disease in Finnish patients -- Mattila et ...
		1 (IL1) is one of the mediators suggested to be involved.
		1A (IL1A), IL1B, and IL1 receptor antagonist (IL1RN) genes are
		of IL1ß, and indeed the in vitro synthesis capacity
	jmg.bmjjournals.com /cgi/content/full/39/6/400 (2214 words)

	A pilot study of the predictive value of plasma tumor necrosis factor alpha and interleukin 1 beta for Streptococcus ...
		for analysis by enzyme-linked immunosorbent assays for TNF and IL1.
		either TNF or IL1 gave an NPV of 100%, with PPVs of 8.5% for TNF and 9.9%
		TNF or IL1 levels would add little to emergency physicians' ability to
	www.aemj.org /cgi/content/abstract/4/1/44 (541 words)

	/ Department of Biology / University of Northern Iowa
		Acute-phase responses are induced mainly by IL1, IL6, and TNF-.
		LPS in the bacterial cell walls overinduces IL1 and TNF-.
		A large proportion of the T cells are activated nonspecifically overproduce IL1 and TNF-.
	www.bio.uni.edu /immuno/cyto.html (1676 words)

	S MEREZAK et al.: Maternal diet, b-cell death and taurine (Journal of Endocrinology)
		To understand the effect of taurine in vivo, LP or C pregnant rats received 2.5% of taurine in the drinking water.
		LP islets were more sensitive than C islets to IL1-
		However, our studies indicate through in vitro and in vivo experiments that such effects can be rescued using amino acids like Taurine.
	journals.endocrinology.org /joe/171/joe1710299.htm (359 words)

	Correlation of VEGF production with IL1{alpha} and IL6 secretion by human pituitary adenoma cells -- Borg et al. 152 ...
		One tumour was treated with a single dose of IL1
		HP75 cells were treated with either an IL6 or an IL1
		FS cells are a potential source of IL1
	www.eje-online.org /cgi/content/full/152/2/293 (4263 words)

	Effects of anakinra on clinical and radiological outcomes in rheumatoid arthritis -- Bresnihan 61 (Supplement 2): 74 -- ...
		Interleukin 1 (IL1) plays a central part in the pathophysiology
		IL1Ra is the third member of the IL1 gene
		The agonistic effects of IL1 are partially blocked by
	ard.bmjjournals.com /cgi/content/full/61/suppl_2/ii74 (1506 words)

	Antiinflammatory Steroid Action in Human Ovarian Surface Epithelial Cells -- Rae et al. 89 (9): 4538 -- Journal of ...
		OSE cell cultures from three individuals were treated with 500 pg/ml IL1
		Cultured OSE cells were treated for 48 h with 500 pg/ml IL1
		Cultured OSE cells were treated for 48 h with IL1
	jcem.endojournals.org /cgi/content/full/89/9/4538 (3584 words)

	Influenza A mutant viruses with altered NS1 protein function provoke caspase-1 activation in primary human macrophages, ...
		The intensity of the colour reaction was determined by using
		At 18 h p.i., cell-culture supernatants were harvested and assessed by ELISA for the presence of IL1
		appeared to be crucial for the inhibition of IL1
	vir.sgmjournals.org /cgi/content/full/86/1/185 (4780 words)

	Inactivation of the viral interleukin 1{beta} receptor improves CD8+ T-cell memory responses elicited upon immunization ...
		Interleukin 1 (IL1) is an important regulator of inflammatory
		One such example is the coding sequence for the viral IL1
		active area of ongoing research on IL1 function is to elucidate
	vir.sgmjournals.org /cgi/content/full/86/7/1997 (5173 words)

	Indiana Electrical Sales - Products - Louvers - Fullreflex (IL1)
		Indiana Electrical Sales - Products - Louvers - Fullreflex (IL1)
		The IL1, Fullreflex™ louver is undoubtedly the most widely accepted parabolic louver available.
		Use of this louver, in combination with the IL6 provides the opportunity to retain design continuity throughout a job, while customizing the lighting to optimize the visual task.
	www.indianaelectricalsales.com /louvers/IL1.htm (89 words)

	InterPro: IPR000975 Interleukin-1
		From sequence comparisons it seems to have arisen by gene duplication before IL1 diverged into IL1A and IL1B [ 2 ].
		The crystal structures of IL1A and IL1B [ 3 ] have been solved, they share the same 12-stranded beta-sheet structure as both the heparin binding growth factors and the Kunitz-type soybean trypsin inhibitors [ 4 ].
		O18999 Interleukin-1 receptor antagonist protein precursor (IL-1ra) (IRAP) (IL1 inhibitor) (IL-1RN)
	www.ebi.ac.uk /interpro/IEntry?ac=IPR000975 (3348 words)

	MtbREVIEW - Freestyle Dirt Jumper - Hoffman Bikes Disrupter IL1
		MtbREVIEW - Freestyle Dirt Jumper - Hoffman Bikes Disrupter IL1
		Please be detailed and descriptive when writing your review.
		Before submitting your review, please follow these guidelines.
	partner.consumerreview.com /reviews/postreview.asp?ProductID=123562 (136 words)

	Correlation of VEGF production with IL1{alpha} and IL6 secretion by human pituitary adenoma cells -- Borg et al. 152 ...
		Interleukin (IL)1 and IL6 have both been shown
		with IL1 and IL6 in the human pituitary tumour cell line HP75
		0.001 (P values based on Spearman’s test)) and IL1
	www.eje-online.org /cgi/content/abstract/152/2/293 (365 words)

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