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Topic: IL6

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	Resource Library: Human IL6 (Site not responding. Last check: 2007-10-13)
		IL6 is a prototypic pleiotropic cytokine produced by a variety of cells, and acts on a wide range of tissues far beyond the immune system.
		IL6 is a single chain protein of MW 21 to 28 kDa, depending on the cellular source.
		Human IL6 cDNA predicts a precursor of 212 residues, whereas the secreted form is composed of 184 amino acids after cleavage of the single peptide.
	www.htrf-assays.com /resources/details/?tid=6&rid=89 (280 words)

	IL1 alpha, IL6 and MMP13 are required for invasion by the human pituitary cell line HP75
		IL6 has been shown to have conflicting effects on growth of human pituitary adenoma cells in culture but may act not only with mitogenic effects but on facilitating tumour invasion into surrounding tissue.
		IL6 and IL1 are known to stimulate bone resorption.
		Cells incubated with IL6 neutralising antibody (300 micrograms/ml) inhibited cell invasion by 51% (basal 51 plus/minus 5 cells/field; IL6Ab 26 plus/minus 3.1 cells/field p<0.0001)[mean plus/minus sem]).
	www.endocrine-abstracts.org /ea/0005/ea0005p122.htm (351 words)

	Abstract
		The proposed role of interleukin 6 (IL6) in athero-thrombotic disease is to stimulate the acute phase reactants, fibrinogen and CRP, both themselves independent vascular risk factors, as well as having a proinflammatory role in the atherosclerotic plaque.
		Our aim was to analyse the impact of IL6 promoter haplotype on IL6 expression in cell types relevant to atherosclerosis and in the atherosclerotic plaque itself.
		Haplotype-specific IL6 expression was not determined by the -174G/C polymorphism alone, strongly suggesting that it would be optimal to genotype for the -597G/A, -572G/C and -373AnTn polymorphisms as well as -174G/C in future genetic epidemiological studies.
	www.blackwellpublishing.com /isth2005/abstract.asp?id=45926 (267 words)

	【IL6】について
		IL6 is involved in a variety of processes such as development, differentiation, and inflammation [0720].
		IL6 is implicated in chronic inflammatory disease and cancer, and this pathway is one potential therapeutic target fo...
		This study was based on the hypothesis that IL6 is the activating cytokine for Stat3, the transcription facto...
	www.nursing-lab.com /494C36 (2606 words)

	MEDLINE_1966-1995 - Resultado de la búsqueda <página 1>
		In the present study we demonstrate that the cultured human keratinocyte cell line (SK-v cells) harboring and expressing integrated human papillomavirus type 16 (HPV16) DNA sequences constitutively releases IL6, which is known as a pleiotropic immunoregulatory cytokine of potential antitumor properties.
		The presence of IL6 activity in SK-v cell-conditioned media (SK-v CM) was demonstrated by tritiated thymidine incorporation into IL6-dependent B9 murine plasmacytoma cells.
		IL6 did not affect SK-v cell growth; however, it significantly augmented NK cell activity of human peripheral blood lymphocytes against both K562 erytholeukemic and SK-v cells as assessed by 51Cr release assay.
	www.bireme.br /cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&nextAction=lnk&base=MEDLINE_1966-1995&exprSearch=1647881&indexSearch=UI&lang=e (240 words)

	Anti-interleukin 6 receptor antibody treatment in rheumatic disease -- Nishimoto et al. 59 (Supplement 1): 21 -- Annals ...
		IL6 was originally identified as a B cell differentiation factor (BCDF) in the culture supernatants of mitogen or antigen
		C57BL/6J human IL6 transgenic mice (tgm) were first intraveneously treated with 2 mg/body of rat antimouse IL6R antibody (MR16-1) at 4 weeks of age to induce tolerance to the mice against rat IgG, then subcutaneously treated with 100 µg/body twice weekly from 5 to 17 weeks of age.
		C57BL/6J human IL6 transgenic mice (tgm) were treated with rat antimouse IL6R antibody (MR16-1) similarly to that of figure 2.
	ard.bmj.com /cgi/content/full/59/suppl_1/i21 (4155 words)

	HIV-1 Tat Induces the Expression of the Interleukin-6 (IL6) Gene by Binding to the IL6 Leader RNA and by Interacting ...
		IL6 RNA, was able to compete for the binding to Tat.
		of Tat to TAR RNA was displaced by wild-type IL6 RNA and by M3-RNA,
		IL6 leader RNA or to the relative mutant RNAs (shown in Fig.
	www.jbc.org /cgi/content/full/272/23/14883 (6334 words)

	Simultaneous flow cytometric analysis of surface markers and intracellular IL6 in HIV.
		OBJECTIVES: Interleukin 6 (IL6) is a multi-functional cytokine and the overproduction of which may play an important role in the immunogenesis of AIDS.
		In HIV positive donors (n = 15) 9.3% of monocytes produced IL6 compared to 3.9% (p less than 0.0001) of HIV negative donors (n = 15); and 4.4% (P less than 0.0008) in healthy controls (n = 15).
		IL6 appeared as a local, polar accumulation in the cytoplasm in a juxtanuclear position identical to the Golgi apparatus.
	gateway.nlm.nih.gov /MeetingAbstracts/102198376.html (334 words)

	Stop the Colds and Flu Virus from Attacking You :: Holistic Healing :: Herbal Remedies :: G-L :: ginseng (Panax ginseng)
		IL6 reduces the good immune factors responsible for halting viruses from reproducing themselves.
		Now with confirmation that IL6 causes immune suppression and allows viruses to replicate, they are confident that stress reduction will reduce the occurrence of respiratory illness.
		Remember, IL6 is the culprit responsible for suppressing the immune system and letting the common cold and other viruses survive and thrive.
	www.alive.com /54a1a2.php?subject_bread_cramb=536 (2181 words)

	Clinical Studies on Champagne Effervescent Cellulite Treatment Mousse
		As we age, DHEA is reduced and this directly leads to cytokine deregulation and the over-production of some interleukins and the under-production of others.
		The researchers' goal thus became to find a peptide that would mimic the effects of DHEA without DHEA's potential for being converted into estrogen, since estrogen is a hormone that is not licensed for cosmetic purposes.
		IL6 is marketed by Sederma as a molecule that can restore cytokine equilibrium, which characterizes youthful skin.
	www.heranswer.com /Champagne_studies.asp (988 words)

	AEGiS-07IAC: Effects of AZT and ddI on TNF alpha and IL6 production.
		IL6 was measured by a functional assay (Bg cell line), IL6 and TNF by ELISA.
		In vivo: IL6 and TNF serum levels, and spontaneous monocytes production were studied in patients (AZT: n=10, ddI: n=8) before and after drug therapy (months 0, 1, 3).
		In contrast after in vivo drug therapy IL6 and TNF serum levels are significantly decreased as well as spontaneous cytokines production by HIV infected monocytes.
	www.aegis.org /conferences/iac/1991/WB2135.html (397 words)

	vgn-ext-hidden_PubMed (Site not responding. Last check: 2007-10-13)
		A common polymorphism within the gene encoding IL-6 (IL6) is known to alter IL-6 protein expression and has been associated with patients' prognosis in various malignancies.
		METHODS: The IL6 promoter polymorphism was investigated in 81 Caucasian patients with surgically treated squamous cell vulvar cancer using pyrosequencing.
		In a multivariate analysis, including tumor stage and lymph node involvement as established prognostic factors and the IL6 promoter polymorphism, lymph node involvement, and the presence of at least one mutant allele, but not tumor stage, were associated with increased disease-free and overall survival.
	www.asco.org /portal/site/ASCO/menuitem.a3fb42726842a82627c4c291ee37a01d/?vgnextoid=d70b3608f9958010VgnVCM100000f2730ad1RCRD&index=n&pmid=16198606 (291 words)

	Androgen And Il6 (Site not responding. Last check: 2007-10-13)
		IL6 is a pleiotropic cytokine which has been implicated in ligand-independent...
		6 (IL6) are significantly elevated in patients with metastatic and androgen-refractory prostate cancer...
		Interleukin-6 (IL6) genotype is associated with fat-free mass in men but not women...
	www.testosterone-pro.info /testosterone/androgen-and-il6.html (490 words)

	Genetic variation in IL6 gene and type 2 diabetes: tagging-SNP haplotype analysis in large-scale case-control study and ...
		Genetic variation in IL6 gene and type 2 diabetes: tagging-SNP haplotype analysis in large-scale case-control study and meta-analysis -- Qi et al.
		Interleukin-6 (IL-6, gene symbol IL6) is a proinflammatory cytokine.
		IL6 polymorphisms was significantly associated with the plasma
	hmg.oxfordjournals.org /cgi/content/abstract/15/11/1914 (415 words)

	GM-CSF
		It has been shown that IL6 at the hepatic level stimulates the synthesis of acute phase proteins among which is the Creactive protein (CRP).
		Furthermore, serum Creactive protein level was shown to be a highly significant prognostic factor and was independent of serum beta2 micro globulin.
		IL6 has been shown to be a synergistic factor with rHuGMCSF on normal hematopoietic stem cells and on leukemia myeloid cells.
	www.clevelandclinic.org /myeloma/gm-mmcyc.html (2066 words)

	Correlation of VEGF production with IL1 alpha and IL6 secretion by human pituitary adenoma cells.
		Interleukin (IL)1 and IL6 have both been shown to regulate VEGF levels in a variety of tissues.
		We have examined the expression of VEGF and its relationships with IL1 and IL6 in the human pituitary tumour cell line HP75 and a series of human pituitary tumours.
		CONCLUSIONS: The significant associations between VEGF and the levels of IL6 and IL1 alpha suggest an important role for these cytokines in the development of these tumours.
	braintumors.researchtoday.net /archive/2/3/725.htm (374 words)

	Addition of interleukin 1 (IL1) and IL17 soluble receptors to a tumour necrosis factor {alpha} soluble receptor more ...
		Supernatants (SN) of activated RA PBMC were incubated with synoviocytes and increasing concentrations of sTNFR sIL1R, and sIL17R ranging from 0.1 to 100 µg/ml, used alone or in combination.
		IL6 levels were measured by ELISA in 48 hour supernatants.
		Results represent the mean of the effect of supernatants from two different patients with RA on the same RA synoviocytes.
	ard.bmj.com /cgi/content/full/61/8/730 (2175 words)

	Absolute Miracle Cream
		Palmitoyl Tetrapeptide-3 is a synthetic peptide that is a fragment of immunoglobulin G that has been combined with palmitic acid to make it more lipophillic and thus enhance its affinity towards human skin.
		At concentrations from 10 ppm, Palmitoyl Tetrapeptide-3 induces a marked reduction in the secretion of the cytokine IL6.
		Palmitoyl Tetrapeptide-3 reduced levels of IL6 after cells were exposed to UV radiation by up to 86% even though IL6 had been increased by about 20 fold by the UV.
	www.absolutemiraclecream.com /ingredients/pt3.htm (482 words)

	The IL6 gene and its putative association with human ageing
		Its levels appear to increase with age, possibly associating IL6 with age-related changes, such as chronic inflammatory diseases [0717].
		Polymorphisms in the human IL6 gene have been linked to age-related diseases, such as cardiovascular diseases [1050], though they have not been associated with longevity [0221].
		A role for IL6 in human ageing is plausible though largely obscure.
	genomics.senescence.info /genes/entry.php?hugo=IL6 (496 words)

	An IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in men infected with ...
		An IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in men infected with human immunodeficiency virus -- Foster et al.
		An IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in men infected with human immunodeficiency virus
		The association between IL6 genotype and KS is interesting for several reasons.
	www.bloodjournal.org /cgi/content/full/96/7/2562 (4413 words)

	The interleukin-6/interleukin-6-receptorsystem is activated in donor hearts -- Plenz et al. 39 (9): 1508 -- Journal of ...
		Table 1 Expression Levels of IL6, IL6R and gp130 in CTRL Biopsies, All Chambers of Donor Hearts and RV of FH Immunohistochemical demonstration of the IL6, IL6R and gp130 distribution patterns.
		Figure 1 Immunohistochemistry demonstrating the distribution patterns of interleukin-6 (IL6), interleukin-6-receptor (IL6R) and glycoprotein 130 (gp130) in donor hearts and controls.
		IL6 in donor hearts may be induced by the sequelae of brain
	content.onlinejacc.org /cgi/content/full/39/9/1508 (3388 words)

	Critical Care \| Full text \| Correlation of cytokine levels with clinical markers of organ hypoperfusion in sepsis ...
		The baseline levels of cytokines such as TNF and IL6 correlate with the number of organ hypoperfusions and with well known clinical laboratory markers for these metabolic changes.
		At baseline there was a significant correlation between cytokine levels, particularly IL6, and the number of organ hypoperfusions (TNF: 55.0 pg/ml for I organ hypoperfusion to 100.0 pg/ml for 5 organ hypoperfusions, P = 0.0002; IL6: 1.69 ng/ml for I organ hypoperfusion to 25.02 ng/ml for 5 organ hypoperfusions, P < 0.0001).
		P = 0.0544; IL6: r = -0.1642, P = 0.0031) or urea (TNF: r = 0.2517, P < 0.0001; IL6: r = 0.0561, P = 0.2815), as well as with laboratory markers for renal failure and DIC such as serum creatinine (TNF: r = 0.3716, P < 0.0001: IL6: r = 0.1903.
	www.ccforum.com /content/1/S1/P014 (445 words)

	Correlation of VEGF production with IL1{alpha} and IL6 secretion by human pituitary adenoma cells -- Borg et al. 152 ...
		IL6 is known to be expressed in the normal pituitary gland by
		IL6 was measured from cell-culture supernatants by ELISA with
		S-100 antigen-positive folliculo-stellate cells are not the source of IL6 gene expression in human pituitary adenomas.
	www.eje-online.org /cgi/content/full/152/2/293 (4263 words)

	Accidental hypothermia and active rewarming: the metabolic and inflammatory changes observed above and below ...
		Abbreviations: PTH, parathyroid hormone; IL1, interleukin 1; IL6, interleukin 6; TNF
		IL6 has been implicated as a mediator of PTH action
		Hypothermia as in indicator of the acute effects of lipopolysaccharides: comparison with serum levels of IL1ß, IL6 and TNF
	emj.bmjjournals.com /cgi/content/full/19/3/219 (2051 words)

	Cytokine Panel - Il1B, Il6,Il8, Tnf Alpha
		This panel is used to identify elevated levels of specific cytokines.
		While inflammation is an important homeostatic mechanism that limits the effects of infectious agents, inflammation itself has the potential for inducing damage.
		This test is used to identify elevated levels of Interleukin-1 beta.
	www.lef.org /newshop/items/itemLCCYT.html (454 words)

	Effect of the Interleukin-6 (-174) G/C Promoter Polymorphism on Adiponectin and Insulin Sensitivity -- Yang et al. 13 ...
		Adipose tissue expression of IL6 and adiponectin was examined
		IL6 gene expression was significantly higher in the G allele-carrying
		Hulkkonen, J, Pertovaara, M, Antonen, J, Pasternack, A, Hurme, M. (2001) Elevated interleukin-6 plasma levels are regulated by the promoter region polymorphism of the IL6 gene in primary Sjogren’s syndrome and correlate with the clinical manifestations of the disease Rheumatology (Oxford) 40,656-661
	www.obesityresearch.org /cgi/content/full/13/5/813 (2248 words)

	SPAWN.COM >> NEWS
		SPAWN.COM >> NEWS >> and the il6 winners are...
		When we came up with the essay contest idea to win one of three complete sets of Interlink 6 action figures, we thought we'd get a handful of entries and picking three winners would be a snap.
		The essay contest required entrants to submit an original essay on why they deserved to win a set of IL6 robots.
	www.mcfarlane.com /news/news.aspx?id=5189 (290 words)

	Soluble tumour necrosis factor receptor treatment does not affect raised transforming growth factor {beta} levels in ...
		IL6 was determined in plasma samples applying the Quantikine
		IL6 and MMP-3 plasma levels was accompanied by a significant
		Table 1 Improvement of laboratory parameters (CRP, ESR, IL6, and MMP-3) and clinical activity (VAS and Thompson score) with etanercept treatment (mean (SEM)).
	ard.bmjjournals.com /cgi/content/full/61/3/254 (1567 words)

	Increased serum levels of interleukin 6 are associated with severe intraventricular haemorrhage in extremely premature ...
		IL6 levels in serum peak 3–4 hours after
		Studies on the evaluation of IL6 for early diagnosis of neonatal
		Regulation of interleukin-8 synthesis in human lower uterin segment fibroblasts by cytokines and growth factors.
	fn.bmjjournals.com /cgi/content/full/88/6/F501 (2553 words)

	ExactAntigen il6 -- reagents, researchers, and patents (Site not responding. Last check: 2007-10-13)
		il6 known il6 monoclonal antibodies webpages for: il6 antibodies, il6 phospho-specific antibodies, il6 ELISA, il6 siRNA, il6 recombinant proteins, il6 cDNA clones
		(1997) HIV-1 Tat induces the expression of the interleukin-6 (IL6) gene by binding to the IL6 leader RNA and by interacting with CAAT enhancer-binding protein beta (NF-IL6) transcription factors J Biol Chem 272:14883-92.
		il6 known il6 monoclonal antibodies webpages for: il6 antibodies
	www.exactantigen.com /gene/il6/il6.html (554 words)

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