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	isoniazid, INH - Skin diseases, conditions and procedures on MedicineNet.com
		Tuberculosis is an infectious diseased caused by a bacterium.
		INH can increase the effect of certain benzodiazepines, such as diazepam (Valium), triazolam (Halcion), and others, by interfering with the enzymes in the liver that eliminate benzodiazepines.
		INH can decrease the rate at which the liver eliminates phenytoin (Dilantin), which can raise the blood levels and result in side effects of phenytoin.
	www.medicinenet.com /isoniazid_inh/article.htm (1070 words)

	OCC-ENV-MED-L archives -- August 2000 (#306)
		Patients found to have INH monoresistant organisms after induction therapy is complete (e.g., during continuation phase of therapy with INH and rifampin) should be evaluated for treatment failure clinically and with cultures.
		Patients who are identified as infected with INH monoresistant organisms before the induction phase of therapy is completed may be treated with a combination of rifampin, pyrazinamide, and ethambutol (or streptomycin) for 6 months.
		Patients with unrecognized INH monoresistance who were treated with the two-drug regimen of INH and rifampin and those treated initially with INH, rifampin, and pyrazinamide are at increased risk for treatment failure and/or relapse after treatment, possibly associated with acquired rifampin resistance.
	list.mc.duke.edu /cgi-bin/wa?A2=ind0008&L=occ-env-med-l&F=&S=&P=33562 (1633 words)

	University of Miami School of Medicine - Glossary - isoniazid, INH
		The mechanism of action of INH is not known, but it is thought to work through its effects on lipids (fats) and DNA within the tuberculosis bacterium.
		It is best to take INH on an empty stomach for maximum absorption into the body, but if it causes abdominal discomfort, it may be taken with food or with a non-aluminum antacid such as Tums or Titralac.
		Because rifampin can be toxic to the liver, the use of rifampin and INH together increases the risk of liver toxicity to a level that is greater than with either drug alone.
	www.med.miami.edu /glossary/art.asp?articlekey=19562 (1076 words)

	Multidrug-Resistant Mycobacterium tuberculosis: Molecular Perspectives
		INH and RIF, the two most potent antituberculous drugs, kill more than 99% of tubercule bacilli within 2 months of initiation of therapy (16,17).
		Efforts to determine the factors involved in resistance to INH led to the discovery of the inhA locus, which was proposed as the primary target for coresistance to INH and ethionamide (54).
		INH susceptibility could result from incorporation of iso-NAD, which is formed as a consequence of the action of KatG on INH, and thus hinders the enzymatic activity of InhA and blocking fatty acid synthesis (56).
	www.cdc.gov /ncidod/eid/vol4no2/rattan.htm (9047 words)

	CHEST: Perspective: preventive isoniazid therapy and the liver (Site not responding. Last check: 2007-09-02)
		Current recommendations that encourage wide use of preventive INH therapy are unwise becuase they inflict a risk of fatal hepatitis on compliant adults and older children who have little danger of tuberculosis while being difficult to deliver to the alcohol- and drug-addicted persons whose risk is high.
		She had been given monthly allotments of INH and was well until the acute onset of nausea, vomiting, and jaundice on August 2, 1990.
		Preventive INH therapy had been recommended despite her age because of "close contact and recent tuberculin conversion." Her physician could not document the date of a previous negative tuberculin test and she was not a household contact.
	www.findarticles.com /p/articles/mi_m0984/is_n5_v101/ai_12765422 (1229 words)

	Apple IIe Technical Note #5
		When the /INH line, pin 32 in slots 1-7, is pulled low, all memory on the motherboard and in the auxiliary slot is disabled (including memory on the 80-column and extended 80-column cards).
		If the /INH line is pulled during a processor instruction fetch from the monitor ROM at $F800, the 6502 will read the wrong instruction (or a floating bus) and probably crash the program.
		The INH line can be pulled low (or high) after the addresses are valid at 190 ns, but before 300 ns (from 0o).
	web.pdx.edu /~heiss/technotes/aiie/tn.aiie.05.html (1494 words)

	A zinc metalloprotease inhibitor, Inh, from the insect pathogen Photorhabdus luminescens -- Valens et al. 148 (8): 2427 ...
		A zinc metalloprotease inhibitor, Inh, from the insect pathogen Photorhabdus luminescens -- Valens et al.
		A zinc metalloprotease inhibitor, Inh, from the insect pathogen Photorhabdus luminescens
		Inh is a specific inhibitor of the protease PrtA.
	mic.sgmjournals.org /cgi/content/abstract/148/8/2427 (235 words)

	eMedicine - Toxicity, Isoniazid : Article Excerpt by: C Crawford Mechem, MD (Site not responding. Last check: 2007-09-02)
		In vitro studies of a variety of animal cell lines demonstrated that INH toxicity results from the induction of apoptosis with associated disruption of mitochondrial membrane potential and DNA strand breaks.
		In the US: A surveillance of cases of INH poisoning by the American Association of Poison Control Centers from 1985-1993 revealed a low number of 138 cases in 1985, with no fatalities, and a high number of 2656 cases in 1991, with 6 fatalities.
		Race: The rate of acetylation of INH in the liver is race-dependent, with 60% of African Americans and whites being slow acetylators, compared with 10-20% of Asians.
	www.emedicine.com /emerg/byname/toxicity-isoniazid.htm (596 words)

	High-Dose Isoniazid Therapy for Isoniazid-Resistant Murine Mycobacterium tuberculosis Infection -- Cynamon et al. 43 ...
		INH is a prodrug which is activated by a catalase-peroxidase enzyme (KatG) (17).
		INH at 100 mg/kg was compared to INH at 25 mg/kg against an isogenic mutant of ATCC 35801 and R3 (INH MIC, 2 µg/ml) and the
		INH has been the most important agent for the treatment of tuberculosis since its introduction in the early 1950s.
	aac.asm.org /cgi/content/full/43/12/2922 (1913 words)

	Enzyme-catalyzed Mechanism of Isoniazid Activation in Class I and Class III Peroxidases -- Pierattelli et al. 279 (37): ...
		In all panels the heme (in gray) and protein main chains and side chains are depicted in yellow (for the NMR models of INH complexes) or dark green (for the x-ray coordinates of the HRPC-BHA complex) (16).
		Carbon atoms of INH are shown in light green (panels A, B, and D), whereas carbon atoms of BHA are shown in dark green (panels C and D).
		Protein main chains and side chains are depicted in dark green for the HRPC NMR model of INH complex, pink for the mtCP crystal structure (2), orange for the APX crystal structure (29), and light green for the CcP crystal structure (30).
	www.jbc.org /cgi/content/full/279/37/39000 (5371 words)

	PS 63
		INH doses were delivered as 1-2 inhalations of 1 or 3 mg prior to meals.
		INH doses were delivered as 1-2 inhalations of 1 or 3 mg.
		Cough was seen more frequently in the INH group (27% vs 5%) but was judged ‘mild to moderate’, and decreased in incidence and prevalence over the study period.
	www.easd.org /customfiles/easd/38th/abstracts/PS63.html (3060 words)

	Proteinase inhibitors I and II from potatoes block UVB-induced AP-1 activity by regulating the AP-1 protein ... (Site not responding. Last check: 2007-09-02)
		Inh I and Inh II are effective proteinase inhibitors of chymotrypsin and trypsin (3, 4) and have been reported to display
		Inh I (40-80 µM) or Inh II (20-80 µM) significantly inhibited AP-1 activity in response to UVB.
		Inh I and Inh II have been shown to prevent x-ray irradiation-induced mammalian cell transformation (6).
	www.pnas.org /cgi/content/full/98/10/5786 (3889 words)

	The Susceptibility of Mycobacterium tuberculosis to Isoniazid and the Arg{right-arrow}Leu Mutation at Codon 463 of katG ...
		INH was measured with the MIC method using 0.1, 0.2, 0.5, 1, 2,
		to INH and the 100 INH-susceptible isolates, 21 (30%) and 32 (32%)
		In contrast, the Arg463Leu mutation and INH resistance are not as strictly associated.
	jcm.asm.org /cgi/content/full/39/4/1591 (2159 words)

	INH.html
		In the INH budget for 1943, which totalled 15 million francs, 5 million went to the support of existing laboratories and institutes (including 1.5 million for the Marseille institute), and 5 million went to fellowships for medical researchers at medical schools.
		The INH statistics also revealed the spread of an epidemic of polio in the Auvergne in 1944, as well as a few cases of the plague in Corsica.
		The studies by the INH between 1941 and 1943 showed that the nutritional consumption varied greatly by region, and generally between the cities and the countryside.
	picardp1.ivry.cnrs.fr /INH.html (3706 words)

	Analysis Isoniazid Targets (Site not responding. Last check: 2007-09-02)
		Isoniazid (isonicotinic acid hydrazide, INH) is widely used for the treatment of tuberculosis.
		INH is a prodrug that requires activation by the mycobacterial catalase-peroxidase enzyme
		Thus, the search for INH targets continued, and is the point at which our researchers began their studies.
	cats.med.uvm.edu /cats_teachingmod/microbiology/courses/genomics/experimental_analysis/7.0_prok_prot_bkgdkasA.html (318 words)

	CHEST: Tuberculosis chemoprophylaxis and physicians - Editorial (Site not responding. Last check: 2007-09-02)
		Their questionnaire data indicated that nearly two-thirds of physicians cited the reason for not starting INH chemoprophylaxis in these older patients was solely the result of "fear" of age-related side effects.
		Since their study did not address how many cases of TB were specifically prevented, they obviously could not ascribe a benefit-risk profile of INH as did Stead and coworkers[6] in their population.
		The benefits of INH chemoprophylaxis have been clearly delineated, especially in populations at risk, such as recent contacts of a known case or in recent converters.
	www.findarticles.com /p/articles/mi_m0984/is_n3_v108/ai_17479977 (1046 words)

	BD - Diagnostic Systems: Taxo™ INH Test Control
		BBL™ Taxo™ INH Test Strips are used for detecting isonicotinic acid and its metabolites in urine.
		INH test strips were developed by Kilburn et al.
		BBL Taxo INH Test Strips are absorbent paper strips impregnated with chloramine T, potassium thiocyanate, citric acid and barbituric acid as described by Kilburn et al.
	www.bd.com /ds/productCenter/231736.asp (480 words)

	Boynton Health Service: International Students Check List
		Isoniazid (INH) is a medication used to treat latent TB infection.
		It is very important that INH be taken daily and for the full 9 months of treatment to kill the TB bacteria and prevent development of resistant strains of TB.
		Liver problems are more likely to occur and INH may not work effectively in the presence of alcohol.
	www.bhs.umn.edu /services/TBtreatment.htm (699 words)

	AADMC: In The News 2004: Acquired C1 INH deficiency disorders
		Acquired C1 INH deficiency states were discussed in a lecture at the World Allergy Organization meeting in Vancouver, Canada.
		Treatment approaches vary in congenital and acquired C1 INH deficiency: 1) Congenital (with either markedly reduced levels or normal levels but dysfunctional C1 INH) is best treated by altered androgen preparations (danazol, stanazolol).
		Acquired C1 INH deficiency states can usually be differentiated from congenital C1 INH deficiency states by mearirement of the serum C1 levels (decreased in acquired, not in congenital).
	www.aaaai.org /AADMC/inthenews/news/2004archive/acquired_disorders.html (300 words)

	Allergy & Asthma Disease Management Center: November 2004 Quiz of the Month
		An acquired variant of hereditary angioedema is associated with increased serum levels of anti-C1 INH antibodies.
		When C1 INH levels are deficient or the C1 INH molecule is dysfunctional in congenital HAE, the C4 levels are markedly decreased when patients are symptomatic.
		Acquired angioedema (AA) variants of HAE are due to either: 1) immune reaction associated with certain lymphoproliferative disorders and malignancies that consume the C1 INH as a result of increased complement activity or 2) an anti-C1 INH antibody.
	www.aaaai.org /AADMC/quiz/2004/1104answer.html (375 words)

	Nitric Oxide Generated from Isoniazid Activation by KatG: Source of Nitric Oxide and Activity against Mycobacterium ...
		Nitric oxide is generated from oxidation hydrazide nitrogen atoms during INH activation by KatG.
		Conditions are the same as in panel a except that the concentration of INH is 10 mM.
		bovis BCG (as in panel a) were treated overnight with 73 µM INH with or without 1 mM plumbagin at 37°C. Cell extracts (obtained by bead beating with 0.1-mm ZrSi beads) were assayed for nitrotyrosine by using the Hycult Biotechnology Hbt nitrotyrosine ELISA.
	aac.asm.org /cgi/content/full/48/8/3006 (2505 words)

	Search:inh - OXiDE (Site not responding. Last check: 2007-09-02)
		INHS - Restoration of Muskellunge and Pike Spawning Habitats
		Isoniazid (INH) is the established treatment used for preventive treatment.
		The genetic basis of isoniazid (INH) resistance remains unknown for a significant proportion...
	search.oxide.com /fma.main1/search/web/inh (319 words)

	Inhibition of InhA Activity, but Not KasA Activity, Induces Formation of a KasA-containing Complex in Mycobacteria -- ...
		INH was used, KatG was diluted to 80 µg/ml in 30 m
		INH was added at the same time, and the mixture was held
		A, M. smegmatis strains were grown to mid-log phase and treated with increasing concentrations of INH for 6 h.
	www.jbc.org /cgi/content/full/278/23/20547 (5840 words)

	INH Tribes 2 (Site not responding. Last check: 2007-09-02)
		Tricon has teamed up with INH to put the finishing touches on the Tricon2 admin tool.
		INH is allowing the developers to use our servers to test the program as they tweak it as we usually keep full servers.
		The will still keep to the INH standards of Admin when they are thou.
	www.clannorthwind.net /INH2 (487 words)

	Novel Selection for Isoniazid (INH) Resistance Genes Supports a Role for NAD+-Binding Proteins in Mycobacterial INH ...
		Recently, Escherichia coli oxyR mutants were shown to be moderately sensitive to INH (29, 30).
		INH resistant by overexpressing genes that modify or sequester
		Further evidence suggesting the importance of NADH in INH resistance came from a study by Miesel et al.
	iai.asm.org /cgi/content/full/66/11/5099 (4183 words)

	eMedicine - Toxicity, Isoniazid : Article by C Crawford Mechem, MD (Site not responding. Last check: 2007-09-02)
		INH is known to cause a positive antinuclear antibody (ANA) in 25% of patients and clinically apparent drug-induced lupus, characterized by fever, rash, arthralgias, arthritis, and constitutional symptoms, in approximately 1% of patients.
		While INH is dialyzable, dialysis is usually unnecessary if adequate doses of anticonvulsants and pyridoxine are administered.
		Caution in using phenytoin because INH decreases metabolism of phenytoin, placing patients, especially slow-acetylators, at risk of phenytoin toxicity.
	www.emedicine.com /emerg/topic287.htm (2410 words)

	A zinc metalloprotease inhibitor, Inh, from the insect pathogen Photorhabdus luminescens -- Valens et al. 148 (8): 2427 ...
		Inh was purified from the periplasmic fraction of the supernatant
		Inh eluted at approximately 250 mM NaCl and was
		in the presence of increasing concentrations of Inh was measured.
	mic.sgmjournals.org /cgi/content/full/148/8/2427 (4994 words)

	Isoniazid (INH) (Site not responding. Last check: 2007-09-02)
		Isoniazid (INH) is a specialized antibiotic used to treat tuberculosis.
		Supplementation of B6 has been reported to protect against some of the side effects of the drug.
		Although the optimal amount remains unknown, some doctors would suggest that adults take 100 mg per day to protect against drug side effects.
	www.vitaminevi.com /Drug/Isoniazid.htm (346 words)

	Activin Induces x-Zone Apoptosis That Inhibits Luteinizing Hormone-Dependent Adrenocortical Tumor Formation in ...
		Adrenal tumor development was associated with a significant increase in plasma activin levels (G) and expression of activin beta A subunit mRNA in late-stage adrenal tumors (H).
		of a characteristic contralateral adrenal of a compound INH
		Comparable results demonstrating higher Smad2 expression levels in adrenals with a large x zone and low levels in adrenals with no x zone or with adrenal tumors were obtained by immunoblotting (N).
	mcb.asm.org /cgi/content/full/23/11/3951 (7440 words)

	Sexually Dimorphic Roles of Steroid Hormone Receptor Signaling in Gonadal Tumorigenesis -- Burns et al. 17 (10): 2039 ...
		The 50% survival of triple-knockout females is at 5 wk, and all triple-knockout females included in this study were dead by 9 wk of age.
		At this early age, there is relatively modest disruption of the seminiferous epithelium in adjacent tubules, and there is evidence of spermatogenesis.
		androgen antagonist, flutamide, prolonged the lifespan of Inh
	mend.endojournals.org /cgi/content/full/17/10/2039 (6462 words)

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