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| | Stilbenes and fenamates rescue the loss of IKS channel function induced by an LQT5 mutation and other IsK mutants (Site not responding. Last check: 2007-10-24) |
 | | The LQT syndrome is characterized by abnormal ventricular repolarization, as reflected by a prolonged QT interval on a surface electrocardiogram. |
 | | Mutations in KvLQT1 and IsK genes were found to be associated with both dominant and recessive forms of LQT (Neyroud et al., 1997; Schulze-Bahr et al., 1997; Splawski et al., 1997a,b; Tyson et al., 1997; Wollnik et al., 1997; Duggal et al., 1998). |
 | | For the IsK C-terminal mutants, the conformational equilibrium is shifted towards the inactivatable closed state, Ci, producing a current phenotype with marked rightward shift of the voltage-dependence of activation, faster deactivation and lower unitary conductance (Sesti and Goldstein, 1998). |
| www.nature.com /emboj/journal/v18/n15/full/7591829a.html (6993 words) |
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