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| | Virtual Hospital: University of Iowa Family Practice Handbook, Fourth Edition: Hematologic, Electrolyte, and Metabolic ... (Site not responding. Last check: 2007-10-17) |
 | | Often idiopathic but may be caused by early diabetes, alcohol intake, status postgastrectomy, renal failure, drugs such as salicylates, beta-blockers, pentamidine, ACE inhibitors. |
 | | Complications of sulfonylureas include: hypoglycemia, which may be severe and prolonged; a disulfiram-like effect, which may be seen when taken with alcohol, with flushing, headache, tachycardia, nausea, and vomiting; and severe hyponatremia and fluid retention, which may result from the use of chlorpropamide in the elderly (drug-induced SIADH). |
 | | Drug interactions include: propranolol and clonidine may mask the signs and symptoms of hypoglycemia; thiazide diuretics, chlorthalidone, furosemide, ethacrynic acid, and phenytoin may have antagonistic effects on sulfonylureas; and hypoglycemic effects of the sulfonylureas may be potentiated by beta-blockers, ACE inhibitors, salicylates, sulfonamides, phenylbutazone, methyldopa, clofibrate, warfarin, monoamine oxidase inhibitors, and chloramphenicol. |
| www.vh.org /adult/provider/familymedicine/FPHandbook/Chapter06/12-6.html (4813 words) |
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